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Effects of sidechain length and composition on the kinetic conversion and product distribution of vitamin D analogs determined by real-time NMR.

Dermato-endocrinology

Chen J, Slominski AT, Miller DD, Li W.
PMID: 24494047
Dermatoendocrinol. 2013 Jan 01;5(1):142-9. doi: 10.4161/derm.24339.

Novel pregna-5, 7-dienes were synthesized and subjected to UVB irradiation to generate the corresponding pre-D intermediates, tachysterol and lumisterol analogs. The kinetics of the conversion from each of the pre-D intermediates to the corresponding novel D analogs was investigated...

Novel vitamin D photoproducts and their precursors in the skin.

Dermato-endocrinology

Slominski A, Kim TK, Zmijewski MA, Janjetovic Z, Li W, Chen J, Kusniatsova EI, Semak I, Postlethwaite A, Miller DD, Zjawiony JK, Tuckey RC.
PMID: 24494038
Dermatoendocrinol. 2013 Jan 01;5(1):7-19. doi: 10.4161/derm.23938.

Novel metabolic pathways initiated by the enzymatic action of CYP11A1 on 7DHC (7-dehydrocholesterol), ergosterol, vitamins D3 and D2 were characterized with help of chemical synthesis, UV and mass spectrometry and NMR analyses. The first pathway follows the sequence 7DHC→22(OH)7DHC...

Recent Advances on Small-Molecule Survivin Inhibitors.

Current medicinal chemistry

Xiao M, Li W.
PMID: 25613234
Curr Med Chem. 2015 Jan 13;22(9):1136 - 1146. doi: 10.2174/0929867322666150114102146.

Survivin, a member of the inhibitor of apoptosisproteins family, is highly expressed in most human neoplasms, but its expression is very low or undetectable in terminally differentiated normal tissues. Survivin has been shown to inhibit cancer cell apoptosis and...

Showing 1 to 3 of 3 entries