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Sex-specific associations of adiposity with cardiometabolic traits in the UK: A multi-life stage cohort study with repeat metabolomics.

PLoS medicine

O'Keeffe LM, Bell JA, O'Neill KN, Lee MA, Woodward M, Peters SAE, Smith GD, Kearney PM.
PMID: 34990449
PLoS Med. 2022 Jan 06;19(1):e1003636. doi: 10.1371/journal.pmed.1003636. eCollection 2022 Jan.

BACKGROUND: Sex differences in cardiometabolic disease risk are commonly observed across the life course but are poorly understood and may be due to different associations of adiposity with cardiometabolic risk in females and males. We examined whether adiposity is...

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O'Keeffe LM, Bell JA, O'Neill KN, et al. Sex-specific associations of adiposity with cardiometabolic traits in the UK: A multi-life stage cohort study with repeat metabolomics. PLoS Med. 2022;19(1):e1003636doi: 10.1371/journal.pmed.1003636.
O'Keeffe, L. M., Bell, J. A., O'Neill, K. N., Lee, M. A., Woodward, M., Peters, S. A. E., Smith, G. D., & Kearney, P. M. (2022). Sex-specific associations of adiposity with cardiometabolic traits in the UK: A multi-life stage cohort study with repeat metabolomics. PLoS medicine, 19(1), e1003636. https://doi.org/10.1371/journal.pmed.1003636
O'Keeffe, Linda M, et al. "Sex-specific associations of adiposity with cardiometabolic traits in the UK: A multi-life stage cohort study with repeat metabolomics." PLoS medicine vol. 19,1 (2022): e1003636. doi: https://doi.org/10.1371/journal.pmed.1003636
O'Keeffe LM, Bell JA, O'Neill KN, Lee MA, Woodward M, Peters SAE, Smith GD, Kearney PM. Sex-specific associations of adiposity with cardiometabolic traits in the UK: A multi-life stage cohort study with repeat metabolomics. PLoS Med. 2022 Jan 06;19(1):e1003636. doi: 10.1371/journal.pmed.1003636. eCollection 2022 Jan. PMID: 34990449; PMCID: PMC8735621.
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Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health.

Hypertension (Dallas, Tex. : 1979)

Wang G, Bhatta L, Moen GH, Hwang LD, Kemp JP, Bond TA, Åsvold BO, Brumpton B, Evans DM, Warrington NM.
PMID: 34784738
Hypertension. 2022 Jan;79(1):170-177. doi: 10.1161/HYPERTENSIONAHA.121.17701. Epub 2021 Nov 17.

Observational epidemiological studies have reported that higher maternal blood pressure (BP) during pregnancy is associated with increased future risk of offspring cardiometabolic disease. However, it is unclear whether this association represents a causal relationship through intrauterine mechanisms. We used...

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Wang G, Bhatta L, Moen GH, et al. Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health. Hypertension. 2021;79(1):170-177doi: 10.1161/HYPERTENSIONAHA.121.17701.
Wang, G., Bhatta, L., Moen, G. H., Hwang, L. D., Kemp, J. P., Bond, T. A., Åsvold, B. O., Brumpton, B., Evans, D. M., & Warrington, N. M. (2022). Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health. Hypertension (Dallas, Tex. : 1979), 79(1), 170-177. https://doi.org/10.1161/HYPERTENSIONAHA.121.17701
Wang, Geng, et al. "Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health." Hypertension (Dallas, Tex. : 1979) vol. 79,1 (2022): 170-177. doi: https://doi.org/10.1161/HYPERTENSIONAHA.121.17701
Wang G, Bhatta L, Moen GH, Hwang LD, Kemp JP, Bond TA, Åsvold BO, Brumpton B, Evans DM, Warrington NM. Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health. Hypertension. 2022 Jan;79(1):170-177. doi: 10.1161/HYPERTENSIONAHA.121.17701. Epub 2021 Nov 17. PMID: 34784738; PMCID: PMC8654122.
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DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts.

Clinical epigenetics

Juvinao-Quintero DL, Marioni RE, Ochoa-Rosales C, Russ TC, Deary IJ, van Meurs JBJ, Voortman T, Hivert MF, Sharp GC, Relton CL, Elliott HR.
PMID: 33622391
Clin Epigenetics. 2021 Feb 23;13(1):40. doi: 10.1186/s13148-021-01027-3.

BACKGROUND: Type 2 diabetes (T2D) is a heterogeneous disease with well-known genetic and environmental risk factors contributing to its prevalence. Epigenetic mechanisms related to changes in DNA methylation (DNAm), may also contribute to T2D risk, but larger studies are...

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Juvinao-Quintero DL, Marioni RE, Ochoa-Rosales C, et al. DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts. Clin Epigenetics. 2021;13(1):40doi: 10.1186/s13148-021-01027-3.
Juvinao-Quintero, D. L., Marioni, R. E., Ochoa-Rosales, C., Russ, T. C., Deary, I. J., van Meurs, J. B. J., Voortman, T., Hivert, M. F., Sharp, G. C., Relton, C. L., & Elliott, H. R. (2021). DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts. Clinical epigenetics, 13(1), 40. https://doi.org/10.1186/s13148-021-01027-3
Juvinao-Quintero, Diana L, et al. "DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts." Clinical epigenetics vol. 13,1 (2021): 40. doi: https://doi.org/10.1186/s13148-021-01027-3
Juvinao-Quintero DL, Marioni RE, Ochoa-Rosales C, Russ TC, Deary IJ, van Meurs JBJ, Voortman T, Hivert MF, Sharp GC, Relton CL, Elliott HR. DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts. Clin Epigenetics. 2021 Feb 23;13(1):40. doi: 10.1186/s13148-021-01027-3. PMID: 33622391; PMCID: PMC7903628.
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Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Frysz M, Gergei I, Scharnagl H, Smith GD, Zheng J, Lawlor DA, Herrmann M, Maerz W, Tobias JH.
PMID: 34738659
J Bone Miner Res. 2021 Nov 05; doi: 10.1002/jbmr.4467. Epub 2021 Nov 05.

Romosozumab is a newly available treatment for osteoporosis acting by sclerostin inhibition. Its cardiovascular safety has been questioned after finding excess cardiovascular disease (CVD)-related events in a pivotal phase 3 trial. Previous studies of relationships between circulating sclerostin levels...

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Frysz M, Gergei I, Scharnagl H, et al. Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors. J Bone Miner Res. 2021;doi: 10.1002/jbmr.4467.
Frysz, M., Gergei, I., Scharnagl, H., Smith, G. D., Zheng, J., Lawlor, D. A., Herrmann, M., Maerz, W., & Tobias, J. H. (2021). Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, . https://doi.org/10.1002/jbmr.4467
Frysz, Monika, et al. "Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol. (2021). doi: https://doi.org/10.1002/jbmr.4467
Frysz M, Gergei I, Scharnagl H, Smith GD, Zheng J, Lawlor DA, Herrmann M, Maerz W, Tobias JH. Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors. J Bone Miner Res. 2021 Nov 05; doi: 10.1002/jbmr.4467. Epub 2021 Nov 05. PMID: 34738659.
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Derivative estimation for longitudinal data analysis: Examining features of blood pressure measured repeatedly during pregnancy.

Statistics in medicine

Simpkin AJ, Durban M, Lawlor DA, MacDonald-Wallis C, May MT, Metcalfe C, Tilling K.
PMID: 29781174
Stat Med. 2018 May 20; doi: 10.1002/sim.7694. Epub 2018 May 20.

Estimating velocity and acceleration trajectories allows novel inferences in the field of longitudinal data analysis, such as estimating change regions rather than change points, and testing group effects on nonlinear change in an outcome (ie, a nonlinear interaction). In...

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Simpkin AJ, Durban M, Lawlor DA, et al. Derivative estimation for longitudinal data analysis: Examining features of blood pressure measured repeatedly during pregnancy. Stat Med. 2018;doi: 10.1002/sim.7694.
Simpkin, A. J., Durban, M., Lawlor, D. A., MacDonald-Wallis, C., May, M. T., Metcalfe, C., & Tilling, K. (2018). Derivative estimation for longitudinal data analysis: Examining features of blood pressure measured repeatedly during pregnancy. Statistics in medicine, . https://doi.org/10.1002/sim.7694
Simpkin, Andrew J, et al. "Derivative estimation for longitudinal data analysis: Examining features of blood pressure measured repeatedly during pregnancy." Statistics in medicine vol. (2018). doi: https://doi.org/10.1002/sim.7694
Simpkin AJ, Durban M, Lawlor DA, MacDonald-Wallis C, May MT, Metcalfe C, Tilling K. Derivative estimation for longitudinal data analysis: Examining features of blood pressure measured repeatedly during pregnancy. Stat Med. 2018 May 20; doi: 10.1002/sim.7694. Epub 2018 May 20. PMID: 29781174; PMCID: PMC6099422.
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Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Frysz M, Gergei I, Scharnagl H, Smith GD, Zheng J, Lawlor DA, Herrmann M, Maerz W, Tobias JH.
PMID: 34738659
J Bone Miner Res. 2021 Nov 05; doi: 10.1002/jbmr.4467. Epub 2021 Nov 05.

Romosozumab is a newly available treatment for osteoporosis acting by sclerostin inhibition. Its cardiovascular safety has been questioned after finding excess cardiovascular disease (CVD)-related events in a pivotal phase 3 trial. Previous studies of relationships between circulating sclerostin levels...

Cite
Frysz M, Gergei I, Scharnagl H, et al. Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors. J Bone Miner Res. 2021;doi: 10.1002/jbmr.4467.
Frysz, M., Gergei, I., Scharnagl, H., Smith, G. D., Zheng, J., Lawlor, D. A., Herrmann, M., Maerz, W., & Tobias, J. H. (2021). Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, . https://doi.org/10.1002/jbmr.4467
Frysz, Monika, et al. "Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol. (2021). doi: https://doi.org/10.1002/jbmr.4467
Frysz M, Gergei I, Scharnagl H, Smith GD, Zheng J, Lawlor DA, Herrmann M, Maerz W, Tobias JH. Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors. J Bone Miner Res. 2021 Nov 05; doi: 10.1002/jbmr.4467. Epub 2021 Nov 05. PMID: 34738659.
Copy Download .nbib Format: NLM
Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Frysz M, Gergei I, Scharnagl H, Smith GD, Zheng J, Lawlor DA, Herrmann M, Maerz W, Tobias JH.
PMID: 34738659
J Bone Miner Res. 2021 Nov 05; doi: 10.1002/jbmr.4467. Epub 2021 Nov 05.

Romosozumab is a newly available treatment for osteoporosis acting by sclerostin inhibition. Its cardiovascular safety has been questioned after finding excess cardiovascular disease (CVD)-related events in a pivotal phase 3 trial. Previous studies of relationships between circulating sclerostin levels...

Cite
Frysz M, Gergei I, Scharnagl H, et al. Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors. J Bone Miner Res. 2021;doi: 10.1002/jbmr.4467.
Frysz, M., Gergei, I., Scharnagl, H., Smith, G. D., Zheng, J., Lawlor, D. A., Herrmann, M., Maerz, W., & Tobias, J. H. (2021). Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, . https://doi.org/10.1002/jbmr.4467
Frysz, Monika, et al. "Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol. (2021). doi: https://doi.org/10.1002/jbmr.4467
Frysz M, Gergei I, Scharnagl H, Smith GD, Zheng J, Lawlor DA, Herrmann M, Maerz W, Tobias JH. Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors. J Bone Miner Res. 2021 Nov 05; doi: 10.1002/jbmr.4467. Epub 2021 Nov 05. PMID: 34738659.
Copy Download .nbib Format: NLM
Showing 1 to 7 of 7 entries