Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 25 entries
Sorted by: Best Match Show Resources per page
Alternative ways of modulating JAK-STAT pathway: Looking beyond phosphorylation.

JAK-STAT

Timofeeva OA, Tarasova NI.
PMID: 24058784
JAKSTAT. 2012 Oct 01;1(4):274-84. doi: 10.4161/jkst.22313.

Most attempts to develop inhibitors of STAT transcription factors target either activating phosphorylation of tyrosine residue or SH2 domains. However, all six domains of STATs are highly conserved between the species and play important roles in the function of...

Cite
Timofeeva OA, Tarasova NI. Alternative ways of modulating JAK-STAT pathway: Looking beyond phosphorylation. JAKSTAT. 2012;1(4):274-84doi: 10.4161/jkst.22313.
Timofeeva, O. A., & Tarasova, N. I. (2012). Alternative ways of modulating JAK-STAT pathway: Looking beyond phosphorylation. JAK-STAT, 1(4), 274-84. https://doi.org/10.4161/jkst.22313
Timofeeva, Olga A, and Tarasova, Nadya I. "Alternative ways of modulating JAK-STAT pathway: Looking beyond phosphorylation." JAK-STAT vol. 1,4 (2012): 274-84. doi: https://doi.org/10.4161/jkst.22313
Timofeeva OA, Tarasova NI. Alternative ways of modulating JAK-STAT pathway: Looking beyond phosphorylation. JAKSTAT. 2012 Oct 01;1(4):274-84. doi: 10.4161/jkst.22313. PMID: 24058784; PMCID: PMC3670285.
Copy Download .nbib Format: NLM
Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication.

Frontiers in oncology

Loh CY, Arya A, Naema AF, Wong WF, Sethi G, Looi CY.
PMID: 30847297
Front Oncol. 2019 Feb 21;9:48. doi: 10.3389/fonc.2019.00048. eCollection 2019.

Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream with Janus kinases (JAK) family protein and capable of integrating inputs from different signaling pathways. Each family member plays unique functions in signal transduction and crucial in mediating...

Cite
Loh CY, Arya A, Naema AF, et al. Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication. Front Oncol. 2019;9:48doi: 10.3389/fonc.2019.00048.
Loh, C. Y., Arya, A., Naema, A. F., Wong, W. F., Sethi, G., & Looi, C. Y. (2019). Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication. Frontiers in oncology, 948. https://doi.org/10.3389/fonc.2019.00048
Loh, Chin-Yap, et al. "Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication." Frontiers in oncology vol. 9 (2019): 48. doi: https://doi.org/10.3389/fonc.2019.00048
Loh CY, Arya A, Naema AF, Wong WF, Sethi G, Looi CY. Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication. Front Oncol. 2019 Feb 21;9:48. doi: 10.3389/fonc.2019.00048. eCollection 2019. PMID: 30847297; PMCID: PMC6393348.
Copy Download .nbib Format: NLM
A Novel Type of Blood Biomarker: Distinct Changes of Cytokine-Induced STAT Phosphorylation in Blood T Cells Between Colorectal Cancer Patients and Healthy Individuals.

Cancers

Yun JW, Lee S, Kim HM, Chun S, Engleman EG, Kim HC, Kang ES.
PMID: 31409016
Cancers (Basel). 2019 Aug 12;11(8). doi: 10.3390/cancers11081157.

No abstract available.

Cite
Yun JW, Lee S, Kim HM, et al. A Novel Type of Blood Biomarker: Distinct Changes of Cytokine-Induced STAT Phosphorylation in Blood T Cells Between Colorectal Cancer Patients and Healthy Individuals. Cancers (Basel). 2019;11(8)doi: 10.3390/cancers11081157.
Yun, J. W., Lee, S., Kim, H. M., Chun, S., Engleman, E. G., Kim, H. C., & Kang, E. S. (2019). A Novel Type of Blood Biomarker: Distinct Changes of Cytokine-Induced STAT Phosphorylation in Blood T Cells Between Colorectal Cancer Patients and Healthy Individuals. Cancers, 11(8), . https://doi.org/10.3390/cancers11081157
Yun, Jae Won, et al. "A Novel Type of Blood Biomarker: Distinct Changes of Cytokine-Induced STAT Phosphorylation in Blood T Cells Between Colorectal Cancer Patients and Healthy Individuals." Cancers vol. 11,8 (2019). doi: https://doi.org/10.3390/cancers11081157
Yun JW, Lee S, Kim HM, Chun S, Engleman EG, Kim HC, Kang ES. A Novel Type of Blood Biomarker: Distinct Changes of Cytokine-Induced STAT Phosphorylation in Blood T Cells Between Colorectal Cancer Patients and Healthy Individuals. Cancers (Basel). 2019 Aug 12;11(8). doi: 10.3390/cancers11081157. PMID: 31409016; PMCID: PMC6721561.
Copy Download .nbib Format: NLM
Targeting STAT3 and STAT5 in Tumor-Associated Immune Cells to Improve Immunotherapy.

Cancers

Verdeil G, Lawrence T, Schmitt-Verhulst AM, Auphan-Anezin N.
PMID: 31766350
Cancers (Basel). 2019 Nov 21;11(12). doi: 10.3390/cancers11121832.

Oncogene-induced STAT3-activation is central to tumor progression by promoting cancer cell expression of pro-angiogenic and immunosuppressive factors. STAT3 is also activated in infiltrating immune cells including tumor-associated macrophages (TAM) amplifying immune suppression. Consequently, STAT3 is considered as a target...

Cite
Verdeil G, Lawrence T, Schmitt-Verhulst AM, et al. Targeting STAT3 and STAT5 in Tumor-Associated Immune Cells to Improve Immunotherapy. Cancers (Basel). 2019;11(12)doi: 10.3390/cancers11121832.
Verdeil, G., Lawrence, T., Schmitt-Verhulst, A. M., & Auphan-Anezin, N. (2019). Targeting STAT3 and STAT5 in Tumor-Associated Immune Cells to Improve Immunotherapy. Cancers, 11(12), . https://doi.org/10.3390/cancers11121832
Verdeil, Grégory, et al. "Targeting STAT3 and STAT5 in Tumor-Associated Immune Cells to Improve Immunotherapy." Cancers vol. 11,12 (2019). doi: https://doi.org/10.3390/cancers11121832
Verdeil G, Lawrence T, Schmitt-Verhulst AM, Auphan-Anezin N. Targeting STAT3 and STAT5 in Tumor-Associated Immune Cells to Improve Immunotherapy. Cancers (Basel). 2019 Nov 21;11(12). doi: 10.3390/cancers11121832. PMID: 31766350; PMCID: PMC6966642.
Copy Download .nbib Format: NLM
Effects of Qingshen granules on Janus Kinase/ signal transducer and activator of transcription signaling pathway in rats with unilateral ureteral obstruction.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

Wang Y, Wang D, Jin H, Zhang L, Yu M.
PMID: 32186057
J Tradit Chin Med. 2018 Apr;38(2):182-189.

OBJECTIVE: To investigate the effects of Qingshen granules (QSG) on janus kinase/ signal transducer and activator of transcription (JAK/STAT) signaling pathway in a rat model of unilateral ureteral obstruction (UUO).METHODS: Sixty male Sprague-Dawley rats were randomly divided into six...

Cite
Wang Y, Wang D, Jin H, et al. Effects of Qingshen granules on Janus Kinase/ signal transducer and activator of transcription signaling pathway in rats with unilateral ureteral obstruction. J Tradit Chin Med. 2018;38(2):182-189
Wang, Y., Wang, D., Jin, H., Zhang, L., & Yu, M. (2018). Effects of Qingshen granules on Janus Kinase/ signal transducer and activator of transcription signaling pathway in rats with unilateral ureteral obstruction. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 38(2), 182-189.
Wang, Yiping, et al. "Effects of Qingshen granules on Janus Kinase/ signal transducer and activator of transcription signaling pathway in rats with unilateral ureteral obstruction." Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan vol. 38,2 (2018): 182-189.
Wang Y, Wang D, Jin H, Zhang L, Yu M. Effects of Qingshen granules on Janus Kinase/ signal transducer and activator of transcription signaling pathway in rats with unilateral ureteral obstruction. J Tradit Chin Med. 2018 Apr;38(2):182-189. PMID: 32186057.
Copy Download .nbib Format: NLM
Regulation of STATs by polycystin-1 and their role in polycystic kidney disease.

JAK-STAT

Weimbs T, Olsan EE, Talbot JJ.
PMID: 24058808
JAKSTAT. 2013 Apr 01;2(2):e23650. doi: 10.4161/jkst.23650.

Autosomal-dominant polycystic kidney disease (ADPKD) is a common genetic disease caused by mutations in the gene coding for polycystin-1 (PC1). PC1 can regulate STAT transcription factors by a novel, dual mechanism. STAT3 and STAT6 are aberrantly activated in renal...

Cite
Weimbs T, Olsan EE, Talbot JJ. Regulation of STATs by polycystin-1 and their role in polycystic kidney disease. JAKSTAT. 2013;2(2):e23650doi: 10.4161/jkst.23650.
Weimbs, T., Olsan, E. E., & Talbot, J. J. (2013). Regulation of STATs by polycystin-1 and their role in polycystic kidney disease. JAK-STAT, 2(2), e23650. https://doi.org/10.4161/jkst.23650
Weimbs, Thomas, et al. "Regulation of STATs by polycystin-1 and their role in polycystic kidney disease." JAK-STAT vol. 2,2 (2013): e23650. doi: https://doi.org/10.4161/jkst.23650
Weimbs T, Olsan EE, Talbot JJ. Regulation of STATs by polycystin-1 and their role in polycystic kidney disease. JAKSTAT. 2013 Apr 01;2(2):e23650. doi: 10.4161/jkst.23650. PMID: 24058808; PMCID: PMC3710321.
Copy Download .nbib Format: NLM
STAT signaling in the pathogenesis and treatment of myeloid malignancies.

JAK-STAT

Bar-Natan M, Nelson EA, Xiang M, Frank DA.
PMID: 24058751
JAKSTAT. 2012 Apr 01;1(2):55-64. doi: 10.4161/jkst.20006.

STAT transcription factors play a critical role in mediating the effects of cytokines on myeloid cells. As STAT target genes control key processes such as survival, proliferation and self-renewal, it is not surprising that constitutive activation of STATs, particularly...

Cite
Bar-Natan M, Nelson EA, Xiang M, et al. STAT signaling in the pathogenesis and treatment of myeloid malignancies. JAKSTAT. 2012;1(2):55-64doi: 10.4161/jkst.20006.
Bar-Natan, M., Nelson, E. A., Xiang, M., & Frank, D. A. (2012). STAT signaling in the pathogenesis and treatment of myeloid malignancies. JAK-STAT, 1(2), 55-64. https://doi.org/10.4161/jkst.20006
Bar-Natan, Michal, et al. "STAT signaling in the pathogenesis and treatment of myeloid malignancies." JAK-STAT vol. 1,2 (2012): 55-64. doi: https://doi.org/10.4161/jkst.20006
Bar-Natan M, Nelson EA, Xiang M, Frank DA. STAT signaling in the pathogenesis and treatment of myeloid malignancies. JAKSTAT. 2012 Apr 01;1(2):55-64. doi: 10.4161/jkst.20006. PMID: 24058751; PMCID: PMC3670294.
Copy Download .nbib Format: NLM
STAT5 is activated in macrophages by breast cancer cell-derived factors and regulates macrophage function in the tumor microenvironment.

Breast cancer research : BCR

Jesser EA, Brady NJ, Huggins DN, Witschen PM, O'Connor CH, Schwertfeger KL.
PMID: 34743736
Breast Cancer Res. 2021 Nov 07;23(1):104. doi: 10.1186/s13058-021-01481-0.

BACKGROUND: In breast cancer, complex interactions between tumor cells and cells within the surrounding stroma, such as macrophages, are critical for tumor growth, progression, and therapeutic response. Recent studies have highlighted the complex nature and heterogeneous populations of macrophages...

Cite
Jesser EA, Brady NJ, Huggins DN, et al. STAT5 is activated in macrophages by breast cancer cell-derived factors and regulates macrophage function in the tumor microenvironment. Breast Cancer Res. 2021;23(1):104doi: 10.1186/s13058-021-01481-0.
Jesser, E. A., Brady, N. J., Huggins, D. N., Witschen, P. M., O'Connor, C. H., & Schwertfeger, K. L. (2021). STAT5 is activated in macrophages by breast cancer cell-derived factors and regulates macrophage function in the tumor microenvironment. Breast cancer research : BCR, 23(1), 104. https://doi.org/10.1186/s13058-021-01481-0
Jesser, Emily A, et al. "STAT5 is activated in macrophages by breast cancer cell-derived factors and regulates macrophage function in the tumor microenvironment." Breast cancer research : BCR vol. 23,1 (2021): 104. doi: https://doi.org/10.1186/s13058-021-01481-0
Jesser EA, Brady NJ, Huggins DN, Witschen PM, O'Connor CH, Schwertfeger KL. STAT5 is activated in macrophages by breast cancer cell-derived factors and regulates macrophage function in the tumor microenvironment. Breast Cancer Res. 2021 Nov 07;23(1):104. doi: 10.1186/s13058-021-01481-0. PMID: 34743736; PMCID: PMC8573892.
Copy Download .nbib Format: NLM
Bazedoxifene as a novel strategy for treatment of pancreatic and gastric adenocarcinoma.

Oncotarget

Burkhardt C, Bühler L, Tihy M, Morel P, Forni M.
PMID: 31139333
Oncotarget. 2019 May 07;10(34):3198-3202. eCollection 2019 May 07.

Experimental studies have shown that the IL6/GP130/STAT3 pathway is involved in pancreatic cancer tumorigenesis and progression as well as in the development of other tumors. Bazedoxifene, a selective estrogene receptor modulator clinically available for the treatment of osteoporosis, has...

Cite
Burkhardt C, Bühler L, Tihy M, et al. Bazedoxifene as a novel strategy for treatment of pancreatic and gastric adenocarcinoma. Oncotarget. 2019;10(34):3198-3202
Burkhardt, C., Bühler, L., Tihy, M., Morel, P., & Forni, M. (2019). Bazedoxifene as a novel strategy for treatment of pancreatic and gastric adenocarcinoma. Oncotarget, 10(34), 3198-3202.
Burkhardt, Claudia, et al. "Bazedoxifene as a novel strategy for treatment of pancreatic and gastric adenocarcinoma." Oncotarget vol. 10,34 (2019): 3198-3202.
Burkhardt C, Bühler L, Tihy M, Morel P, Forni M. Bazedoxifene as a novel strategy for treatment of pancreatic and gastric adenocarcinoma. Oncotarget. 2019 May 07;10(34):3198-3202. eCollection 2019 May 07. PMID: 31139333; PMCID: PMC6516716.
Copy Download .nbib Format: NLM
Modulation of the IL-6-Signaling Pathway in Liver Cells by miRNAs Targeting gp130, JAK1, and/or STAT3.

Molecular therapy. Nucleic acids

Servais FA, Kirchmeyer M, Hamdorf M, Minoungou NWE, Rose-John S, Kreis S, Haan C, Behrmann I.
PMID: 31026677
Mol Ther Nucleic Acids. 2019 Jun 07;16:419-433. doi: 10.1016/j.omtn.2019.03.007. Epub 2019 Apr 02.

Interleukin-6 (IL-6)-type cytokines share the common receptor glycoprotein 130 (gp130), which activates a signaling cascade involving Janus kinases (JAKs) and signal transducer and activator of transcription (STAT) transcription factors. IL-6 and/or its signaling pathway is often deregulated in diseases,...

Cite
Servais FA, Kirchmeyer M, Hamdorf M, et al. Modulation of the IL-6-Signaling Pathway in Liver Cells by miRNAs Targeting gp130, JAK1, and/or STAT3. Mol Ther Nucleic Acids. 2019;16:419-433doi: 10.1016/j.omtn.2019.03.007.
Servais, F. A., Kirchmeyer, M., Hamdorf, M., Minoungou, N. W. E., Rose-John, S., Kreis, S., Haan, C., & Behrmann, I. (2019). Modulation of the IL-6-Signaling Pathway in Liver Cells by miRNAs Targeting gp130, JAK1, and/or STAT3. Molecular therapy. Nucleic acids, 16419-433. https://doi.org/10.1016/j.omtn.2019.03.007
Servais, Florence A, et al. "Modulation of the IL-6-Signaling Pathway in Liver Cells by miRNAs Targeting gp130, JAK1, and/or STAT3." Molecular therapy. Nucleic acids vol. 16 (2019): 419-433. doi: https://doi.org/10.1016/j.omtn.2019.03.007
Servais FA, Kirchmeyer M, Hamdorf M, Minoungou NWE, Rose-John S, Kreis S, Haan C, Behrmann I. Modulation of the IL-6-Signaling Pathway in Liver Cells by miRNAs Targeting gp130, JAK1, and/or STAT3. Mol Ther Nucleic Acids. 2019 Jun 07;16:419-433. doi: 10.1016/j.omtn.2019.03.007. Epub 2019 Apr 02. PMID: 31026677; PMCID: PMC6479786.
Copy Download .nbib Format: NLM
Making sense of IL-6 signalling cues in pathophysiology.

FEBS letters

Millrine D, Jenkins RH, Hughes STO, Jones SA.
PMID: 34618359
FEBS Lett. 2021 Oct 07; doi: 10.1002/1873-3468.14201. Epub 2021 Oct 07.

Unravelling the molecular mechanisms that account for functional pleiotropy is a major challenge for researchers in cytokine biology. Cytokine-receptor cross-reactivity and shared signalling pathways are considered primary drivers of cytokine pleiotropy. However, reports epitomized by studies of Jak-STAT cytokine...

Cite
Millrine D, Jenkins RH, Hughes STO, et al. Making sense of IL-6 signalling cues in pathophysiology. FEBS Lett. 2021;doi: 10.1002/1873-3468.14201.
Millrine, D., Jenkins, R. H., Hughes, S. T. O., & Jones, S. A. (2021). Making sense of IL-6 signalling cues in pathophysiology. FEBS letters, . https://doi.org/10.1002/1873-3468.14201
Millrine, David, et al. "Making sense of IL-6 signalling cues in pathophysiology." FEBS letters vol. (2021). doi: https://doi.org/10.1002/1873-3468.14201
Millrine D, Jenkins RH, Hughes STO, Jones SA. Making sense of IL-6 signalling cues in pathophysiology. FEBS Lett. 2021 Oct 07; doi: 10.1002/1873-3468.14201. Epub 2021 Oct 07. PMID: 34618359.
Copy Download .nbib Format: NLM
Myeloproliferative neoplasms and the JAK/STAT signaling pathway: an overview.

Revista brasileira de hematologia e hemoterapia

de Freitas RM, da Costa Maranduba CM.
PMID: 26408371
Rev Bras Hematol Hemoter. 2015 Sep-Oct;37(5):348-53. doi: 10.1016/j.bjhh.2014.10.001. Epub 2015 Jun 09.

Myeloproliferative neoplasms are caused by a clonal proliferation of a hematopoietic progenitor. First described in 1951 as 'Myeloproliferative Diseases' and reevaluated by the World Health Organization classification system in 2011, myeloproliferative neoplasms include polycythemia vera, essential thrombocythemia and primary...

Cite
de Freitas RM, da Costa Maranduba CM. Myeloproliferative neoplasms and the JAK/STAT signaling pathway: an overview. Rev Bras Hematol Hemoter. 2015;37(5):348-53doi: 10.1016/j.bjhh.2014.10.001.
de Freitas, R. M., & da Costa Maranduba, C. M. (2015). Myeloproliferative neoplasms and the JAK/STAT signaling pathway: an overview. Revista brasileira de hematologia e hemoterapia, 37(5), 348-53. https://doi.org/10.1016/j.bjhh.2014.10.001
de Freitas, Renata Mendes, and da Costa Maranduba, Carlos Magno. "Myeloproliferative neoplasms and the JAK/STAT signaling pathway: an overview." Revista brasileira de hematologia e hemoterapia vol. 37,5 (2015): 348-53. doi: https://doi.org/10.1016/j.bjhh.2014.10.001
de Freitas RM, da Costa Maranduba CM. Myeloproliferative neoplasms and the JAK/STAT signaling pathway: an overview. Rev Bras Hematol Hemoter. 2015 Sep-Oct;37(5):348-53. doi: 10.1016/j.bjhh.2014.10.001. Epub 2015 Jun 09. PMID: 26408371; PMCID: PMC4685044.
Copy Download .nbib Format: NLM
Showing 1 to 12 of 25 entries