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Showing 1 to 12 of 19 entries
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Repurposing Sitafloxacin, Prulifloxacin, Tosufloxacin, and Sisomicin as Antimicrobials Against Biofilm and Persister Cells of Pseudomonas aeruginosa.

Current microbiology

She P, Li S, Liu Y, Xu L, Zhou L, Zeng X, Li Y, Liu S, Li Z, Hussain Z, Wu Y.
PMID: 34905092
Curr Microbiol. 2021 Dec 14;79(1):12. doi: 10.1007/s00284-021-02729-w.

Pseudomonas aeruginosa is a ubiquitous bacterium found in hospitals and the surrounding environment. The ability of P. aeruginosa to form biofilms confers high-level resistance to antibiotics, and the persister cells formed in the presence of high antibacterial drug concentrations...

Semisynthetic aminoglycoside antibiotics: Development and enzymatic modifications.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

Kondo S, Hotta K.
PMID: 11810483
J Infect Chemother. 1999 Mar;5(1):1-9. doi: 10.1007/s101560050001.

The critical resistance mechanisms of aminoglycoside antibiotics in bacteria of clinical importance are the enzymatic N-acetylation, O-phosphorylation, and O-nucleotidylation that generally result in the inactivation of aminoglycosides. To overcome such resistance mechanisms, dibekacin (3',4'-dideoxykanamycin B) was developed as the...

Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides.

ACS medicinal chemistry letters

Thamban Chandrika N, Green KD, Houghton JL, Garneau-Tsodikova S.
PMID: 26617967
ACS Med Chem Lett. 2015 Sep 30;6(11):1134-9. doi: 10.1021/acsmedchemlett.5b00255. eCollection 2015 Nov 12.

Despite issues with oto/nephrotoxicity and bacterial resistance, aminoglycosides (AGs) remain an effective and widely used class of antibacterial agents. For decades now, efforts toward the development of novel AGs with potential to overcome some of these problems have been...

Screening of organic chemicals in surface water of the North River by high resolution mass spectrometry.

Chemosphere

Zhao JH, Hu LX, Wang YQ, Han Y, Liu YS, Zhao JL, Ying GG.
PMID: 34871619
Chemosphere. 2021 Dec 03;290:133174. doi: 10.1016/j.chemosphere.2021.133174. Epub 2021 Dec 03.

Wide use of various chemicals has resulted in water pollution, which has become a global environmental concern. So far limited information is available on what chemicals in our water. Here we investigated the occurrence and profiles of organic chemicals...

Screening of organic chemicals in surface water of the North River by high resolution mass spectrometry.

Chemosphere

Zhao JH, Hu LX, Wang YQ, Han Y, Liu YS, Zhao JL, Ying GG.
PMID: 34871619
Chemosphere. 2021 Dec 03;133174. doi: 10.1016/j.chemosphere.2021.133174. Epub 2021 Dec 03.

Wide use of various chemicals has resulted in water pollution, which has become a global environmental concern. So far limited information is available on what chemicals in our water. Here we investigated the occurrence and profiles of organic chemicals...

Analysis of histamine and sisomicin in gentamicin: Search for the causative agents of adverse effects.

Archiv der Pharmazie

Wohlfart J, Holzgrabe U.
PMID: 34427364
Arch Pharm (Weinheim). 2021 Dec;354(12):e2100260. doi: 10.1002/ardp.202100260. Epub 2021 Aug 24.

In 1998, the aminoglycoside antibiotic gentamicin sulfate caused several cases of deaths in the United States, after the switch from twice- to once-daily application. Endotoxins were discussed as the cause for the adverse effects and sisomicin was identified as...

Repurposing Sitafloxacin, Prulifloxacin, Tosufloxacin, and Sisomicin as Antimicrobials Against Biofilm and Persister Cells of Pseudomonas aeruginosa.

Current microbiology

She P, Li S, Liu Y, Xu L, Zhou L, Zeng X, Li Y, Liu S, Li Z, Hussain Z, Wu Y.
PMID: 34905092
Curr Microbiol. 2021 Dec 14;79(1):12. doi: 10.1007/s00284-021-02729-w.

Pseudomonas aeruginosa is a ubiquitous bacterium found in hospitals and the surrounding environment. The ability of P. aeruginosa to form biofilms confers high-level resistance to antibiotics, and the persister cells formed in the presence of high antibacterial drug concentrations...

Crystal structure and specific binding mode of sisomicin to the bacterial ribosomal decoding site.

ACS medicinal chemistry letters

Kondo J, Koganei M, Kasahara T.
PMID: 24900542
ACS Med Chem Lett. 2012 Aug 02;3(9):741-4. doi: 10.1021/ml300145y. eCollection 2012 Sep 13.

Sisomicin with an unsaturated sugar ring I displays better antibacterial activity than other structurally related aminoglycosides, such as gentamicin, tobramycin, and amikacin. In the present study, we have confirmed by X-ray analyses that the binding mode of sisomicin is...

Screening of organic chemicals in surface water of the North River by high resolution mass spectrometry.

Chemosphere

Zhao JH, Hu LX, Wang YQ, Han Y, Liu YS, Zhao JL, Ying GG.
PMID: 34871619
Chemosphere. 2021 Dec 03;290:133174. doi: 10.1016/j.chemosphere.2021.133174. Epub 2021 Dec 03.

Wide use of various chemicals has resulted in water pollution, which has become a global environmental concern. So far limited information is available on what chemicals in our water. Here we investigated the occurrence and profiles of organic chemicals...

Screening of organic chemicals in surface water of the North River by high resolution mass spectrometry.

Chemosphere

Zhao JH, Hu LX, Wang YQ, Han Y, Liu YS, Zhao JL, Ying GG.
PMID: 34871619
Chemosphere. 2021 Dec 03;290:133174. doi: 10.1016/j.chemosphere.2021.133174. Epub 2021 Dec 03.

Wide use of various chemicals has resulted in water pollution, which has become a global environmental concern. So far limited information is available on what chemicals in our water. Here we investigated the occurrence and profiles of organic chemicals...

Screening of organic chemicals in surface water of the North River by high resolution mass spectrometry.

Chemosphere

Zhao JH, Hu LX, Wang YQ, Han Y, Liu YS, Zhao JL, Ying GG.
PMID: 34871619
Chemosphere. 2021 Dec 03;290:133174. doi: 10.1016/j.chemosphere.2021.133174. Epub 2021 Dec 03.

Wide use of various chemicals has resulted in water pollution, which has become a global environmental concern. So far limited information is available on what chemicals in our water. Here we investigated the occurrence and profiles of organic chemicals...

In vitro Microbiological Evaluation of Cefuroxime and its Combinations with Gentamicin and Sisomicin.

Proceedings of the Royal Society of Medicine

Schassan HH, Sukardi A.
PMID: 20919409
Proc R Soc Med. 1977;70:200-2.

No abstract available.

Showing 1 to 12 of 19 entries