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Showing 1 to 12 of 104 entries
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Heterozygous eNOS deficiency is associated with oxidative stress and endothelial dysfunction in diet-induced obesity.

Physiological reports

Ali MI, Chen X, Didion SP.
PMID: 26660551
Physiol Rep. 2015 Dec;3(12). doi: 10.14814/phy2.12630.

Heterozygous endothelial nitric oxide synthase (eNOS) deficiency is associated with normal endothelium-dependent responses, however, little is known regarding the mechanisms that maintain or impair endothelial function with heterozygous eNOS deficiency. The goals of this study were to (1) determine...

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Ali MI, Chen X, Didion SP. Heterozygous eNOS deficiency is associated with oxidative stress and endothelial dysfunction in diet-induced obesity. Physiol Rep. 2015;3(12)doi: 10.14814/phy2.12630.
Ali, M. I., Chen, X., & Didion, S. P. (2015). Heterozygous eNOS deficiency is associated with oxidative stress and endothelial dysfunction in diet-induced obesity. Physiological reports, 3(12), . https://doi.org/10.14814/phy2.12630
Ali, M Irfan, et al. "Heterozygous eNOS deficiency is associated with oxidative stress and endothelial dysfunction in diet-induced obesity." Physiological reports vol. 3,12 (2015). doi: https://doi.org/10.14814/phy2.12630
Ali MI, Chen X, Didion SP. Heterozygous eNOS deficiency is associated with oxidative stress and endothelial dysfunction in diet-induced obesity. Physiol Rep. 2015 Dec;3(12). doi: 10.14814/phy2.12630. PMID: 26660551; PMCID: PMC4760452.
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Negative inotropic effect of interleukin-2 in the isolated ventricular myocytes: role of NO/sGC pathway.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Wang HP, Xia Q, Jin HF, Cao CM, Lin GH.
PMID: 17271079
Conf Proc IEEE Eng Med Biol Soc. 2004;2004:3632-5. doi: 10.1109/IEMBS.2004.1404021.

The present study is to investigate the effect and possible mechanism of interleukin-2 (IL-2) on the cell contractility in isolated rat cardiomyocytes. Ventricular myocytes were isolated from adult male Sprague-Dawley rats. Contractile responses were evaluated by use of the...

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Wang HP, Xia Q, Jin HF, et al. Negative inotropic effect of interleukin-2 in the isolated ventricular myocytes: role of NO/sGC pathway. Conf Proc IEEE Eng Med Biol Soc. 2004;2004:3632-5doi: 10.1109/IEMBS.2004.1404021.
Wang, H. P., Xia, Q., Jin, H. F., Cao, C. M., & Lin, G. H. (2004). Negative inotropic effect of interleukin-2 in the isolated ventricular myocytes: role of NO/sGC pathway. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 20043632-5. https://doi.org/10.1109/IEMBS.2004.1404021
Wang, H-P, et al. "Negative inotropic effect of interleukin-2 in the isolated ventricular myocytes: role of NO/sGC pathway." Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference vol. 2004 (2004): 3632-5. doi: https://doi.org/10.1109/IEMBS.2004.1404021
Wang HP, Xia Q, Jin HF, Cao CM, Lin GH. Negative inotropic effect of interleukin-2 in the isolated ventricular myocytes: role of NO/sGC pathway. Conf Proc IEEE Eng Med Biol Soc. 2004;2004:3632-5. doi: 10.1109/IEMBS.2004.1404021. PMID: 17271079.
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Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension.

Frontiers in pharmacology

Alencar AKN, Montes GC, Barreiro EJ, Sudo RT, Zapata-Sudo G.
PMID: 29255415
Front Pharmacol. 2017 Dec 04;8:858. doi: 10.3389/fphar.2017.00858. eCollection 2017.

Pulmonary arterial hypertension (PAH) is a clinical condition characterized by pulmonary arterial remodeling and vasoconstriction, which promote chronic vessel obstruction and elevation of pulmonary vascular resistance. Long-term right ventricular (RV) overload leads to RV dysfunction and failure, which are...

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Alencar AKN, Montes GC, Barreiro EJ, et al. Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension. Front Pharmacol. 2017;8:858doi: 10.3389/fphar.2017.00858.
Alencar, A. K. N., Montes, G. C., Barreiro, E. J., Sudo, R. T., & Zapata-Sudo, G. (2017). Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension. Frontiers in pharmacology, 8858. https://doi.org/10.3389/fphar.2017.00858
Alencar, Allan K N, et al. "Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension." Frontiers in pharmacology vol. 8 (2017): 858. doi: https://doi.org/10.3389/fphar.2017.00858
Alencar AKN, Montes GC, Barreiro EJ, Sudo RT, Zapata-Sudo G. Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension. Front Pharmacol. 2017 Dec 04;8:858. doi: 10.3389/fphar.2017.00858. eCollection 2017. PMID: 29255415; PMCID: PMC5722832.
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Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications.

Critical care research and practice

Nossaman B, Pankey E, Kadowitz P.
PMID: 22482042
Crit Care Res Pract. 2012;2012:290805. doi: 10.1155/2012/290805. Epub 2012 Feb 28.

The heme-protein soluble guanylyl cyclase (sGC) is the intracellular receptor for nitric oxide (NO). sGC is a heterodimeric enzyme with α and β subunits and contains a heme moiety essential for binding of NO and activation of the enzyme....

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Nossaman B, Pankey E, Kadowitz P. Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications. Crit Care Res Pract. 2012;2012:290805doi: 10.1155/2012/290805.
Nossaman, B., Pankey, E., & Kadowitz, P. (2012). Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications. Critical care research and practice, 2012290805. https://doi.org/10.1155/2012/290805
Nossaman, Bobby, et al. "Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications." Critical care research and practice vol. 2012 (2012): 290805. doi: https://doi.org/10.1155/2012/290805
Nossaman B, Pankey E, Kadowitz P. Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications. Crit Care Res Pract. 2012;2012:290805. doi: 10.1155/2012/290805. Epub 2012 Feb 28. PMID: 22482042; PMCID: PMC3299283.
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Nitric Oxide: From Good to Bad.

Annals of vascular diseases

Vanhoutte PM.
PMID: 29682106
Ann Vasc Dis. 2018 Mar 25;11(1):41-51. doi: 10.3400/avd.ra.17-00134.

This essay summarizes a lecture presented on October 19th, 2017, during the 58th Annual Meeting of the Japanese College of Angiology in Nagoya, Japan. The lecture summarizes several instances where the absence of relaxations of isolated blood vessels in...

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Vanhoutte PM. Nitric Oxide: From Good to Bad. Ann Vasc Dis. 2018;11(1):41-51doi: 10.3400/avd.ra.17-00134.
Vanhoutte, P. M. (2018). Nitric Oxide: From Good to Bad. Annals of vascular diseases, 11(1), 41-51. https://doi.org/10.3400/avd.ra.17-00134
Vanhoutte, Paul M. "Nitric Oxide: From Good to Bad." Annals of vascular diseases vol. 11,1 (2018): 41-51. doi: https://doi.org/10.3400/avd.ra.17-00134
Vanhoutte PM. Nitric Oxide: From Good to Bad. Ann Vasc Dis. 2018 Mar 25;11(1):41-51. doi: 10.3400/avd.ra.17-00134. PMID: 29682106; PMCID: PMC5882356.
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Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator.

Nitric oxide : biology and chemistry

Weber RE, Schulze KM, Colburn TD, Horn AG, Hageman KS, Ade CJ, Hall SE, Sandner P, Musch TI, Poole DC.
PMID: 34871799
Nitric Oxide. 2021 Dec 04;119:1-8. doi: 10.1016/j.niox.2021.12.001. Epub 2021 Dec 04.

In heart failure with reduced ejection fraction (HFrEF), nitric oxide-soluble guanylyl cyclase (sGC) pathway dysfunction impairs skeletal muscle arteriolar vasodilation and thus capillary hemodynamics, contributing to impaired oxygen uptake (V̇O

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Weber RE, Schulze KM, Colburn TD, et al. Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator. Nitric Oxide. 2021;119:1-8doi: 10.1016/j.niox.2021.12.001.
Weber, R. E., Schulze, K. M., Colburn, T. D., Horn, A. G., Hageman, K. S., Ade, C. J., Hall, S. E., Sandner, P., Musch, T. I., & Poole, D. C. (2021). Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator. Nitric oxide : biology and chemistry, 1191-8. https://doi.org/10.1016/j.niox.2021.12.001
Weber, Ramona E, et al. "Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator." Nitric oxide : biology and chemistry vol. 119 (2021): 1-8. doi: https://doi.org/10.1016/j.niox.2021.12.001
Weber RE, Schulze KM, Colburn TD, Horn AG, Hageman KS, Ade CJ, Hall SE, Sandner P, Musch TI, Poole DC. Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator. Nitric Oxide. 2021 Dec 04;119:1-8. doi: 10.1016/j.niox.2021.12.001. Epub 2021 Dec 04. PMID: 34871799.
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Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator.

Nitric oxide : biology and chemistry

Weber RE, Schulze KM, Colburn TD, Horn AG, Hageman KS, Ade CJ, Hall SE, Sandner P, Musch TI, Poole DC.
PMID: 34871799
Nitric Oxide. 2022 Feb 01;119:1-8. doi: 10.1016/j.niox.2021.12.001. Epub 2021 Dec 04.

In heart failure with reduced ejection fraction (HFrEF), nitric oxide-soluble guanylyl cyclase (sGC) pathway dysfunction impairs skeletal muscle arteriolar vasodilation and thus capillary hemodynamics, contributing to impaired oxygen uptake (V̇O

Cite
Weber RE, Schulze KM, Colburn TD, et al. Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator. Nitric Oxide. 2021;119:1-8doi: 10.1016/j.niox.2021.12.001.
Weber, R. E., Schulze, K. M., Colburn, T. D., Horn, A. G., Hageman, K. S., Ade, C. J., Hall, S. E., Sandner, P., Musch, T. I., & Poole, D. C. (2022). Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator. Nitric oxide : biology and chemistry, 1191-8. https://doi.org/10.1016/j.niox.2021.12.001
Weber, Ramona E, et al. "Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator." Nitric oxide : biology and chemistry vol. 119 (2022): 1-8. doi: https://doi.org/10.1016/j.niox.2021.12.001
Weber RE, Schulze KM, Colburn TD, Horn AG, Hageman KS, Ade CJ, Hall SE, Sandner P, Musch TI, Poole DC. Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator. Nitric Oxide. 2022 Feb 01;119:1-8. doi: 10.1016/j.niox.2021.12.001. Epub 2021 Dec 04. PMID: 34871799.
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Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator.

Nitric oxide : biology and chemistry

Weber RE, Schulze KM, Colburn TD, Horn AG, Hageman KS, Ade CJ, Hall SE, Sandner P, Musch TI, Poole DC.
PMID: 34871799
Nitric Oxide. 2021 Dec 03; doi: 10.1016/j.niox.2021.12.001. Epub 2021 Dec 03.

In heart failure with reduced ejection fraction (HFrEF), nitric oxide-soluble guanylyl cyclase (sGC) pathway dysfunction impairs skeletal muscle arteriolar vasodilation and thus capillary hemodynamics, contributing to impaired oxygen uptake (V̇O

Cite
Weber RE, Schulze KM, Colburn TD, et al. Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator. Nitric Oxide. 2021;doi: 10.1016/j.niox.2021.12.001.
Weber, R. E., Schulze, K. M., Colburn, T. D., Horn, A. G., Hageman, K. S., Ade, C. J., Hall, S. E., Sandner, P., Musch, T. I., & Poole, D. C. (2021). Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator. Nitric oxide : biology and chemistry, . https://doi.org/10.1016/j.niox.2021.12.001
Weber, Ramona E, et al. "Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator." Nitric oxide : biology and chemistry vol. (2021). doi: https://doi.org/10.1016/j.niox.2021.12.001
Weber RE, Schulze KM, Colburn TD, Horn AG, Hageman KS, Ade CJ, Hall SE, Sandner P, Musch TI, Poole DC. Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator. Nitric Oxide. 2021 Dec 03; doi: 10.1016/j.niox.2021.12.001. Epub 2021 Dec 03. PMID: 34871799.
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A primer for measuring cGMP signaling and cGMP-mediated vascular relaxation.

Nitric oxide : biology and chemistry

Straub AC, Beuve A.
PMID: 34601102
Nitric Oxide. 2021 Dec 01;117:40-45. doi: 10.1016/j.niox.2021.09.008. Epub 2021 Sep 30.

Soluble guanylyl cyclase (sGC, also called GC1) is the main receptor for nitric oxide (NO) that catalyzes the production of the second messenger molecule, 3'5' cyclic guanosine monophosphate (cGMP) leading to vasorelaxation, and inhibition of leukocyte recruitment and platelet...

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Straub AC, Beuve A. A primer for measuring cGMP signaling and cGMP-mediated vascular relaxation. Nitric Oxide. 2021;117:40-45doi: 10.1016/j.niox.2021.09.008.
Straub, A. C., & Beuve, A. (2021). A primer for measuring cGMP signaling and cGMP-mediated vascular relaxation. Nitric oxide : biology and chemistry, 11740-45. https://doi.org/10.1016/j.niox.2021.09.008
Straub, Adam C, and Beuve, Annie. "A primer for measuring cGMP signaling and cGMP-mediated vascular relaxation." Nitric oxide : biology and chemistry vol. 117 (2021): 40-45. doi: https://doi.org/10.1016/j.niox.2021.09.008
Straub AC, Beuve A. A primer for measuring cGMP signaling and cGMP-mediated vascular relaxation. Nitric Oxide. 2021 Dec 01;117:40-45. doi: 10.1016/j.niox.2021.09.008. Epub 2021 Sep 30. PMID: 34601102.
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Current Advances of Nitric Oxide in Cancer and Anticancer Therapeutics.

Vaccines

Mintz J, Vedenko A, Rosete O, Shah K, Goldstein G, Hare JM, Ramasamy R, Arora H.
PMID: 33513777
Vaccines (Basel). 2021 Jan 27;9(2). doi: 10.3390/vaccines9020094.

Nitric oxide (NO) is a short-lived, ubiquitous signaling molecule that affects numerous critical functions in the body. There are markedly conflicting findings in the literature regarding the bimodal effects of NO in carcinogenesis and tumor progression, which has important...

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Mintz J, Vedenko A, Rosete O, et al. Current Advances of Nitric Oxide in Cancer and Anticancer Therapeutics. Vaccines (Basel). 2021;9(2)doi: 10.3390/vaccines9020094.
Mintz, J., Vedenko, A., Rosete, O., Shah, K., Goldstein, G., Hare, J. M., Ramasamy, R., & Arora, H. (2021). Current Advances of Nitric Oxide in Cancer and Anticancer Therapeutics. Vaccines, 9(2), . https://doi.org/10.3390/vaccines9020094
Mintz, Joel, et al. "Current Advances of Nitric Oxide in Cancer and Anticancer Therapeutics." Vaccines vol. 9,2 (2021). doi: https://doi.org/10.3390/vaccines9020094
Mintz J, Vedenko A, Rosete O, Shah K, Goldstein G, Hare JM, Ramasamy R, Arora H. Current Advances of Nitric Oxide in Cancer and Anticancer Therapeutics. Vaccines (Basel). 2021 Jan 27;9(2). doi: 10.3390/vaccines9020094. PMID: 33513777; PMCID: PMC7912608.
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Overexpression of GUCY1A2 Correlates With Poor Prognosis in Gastric Cancer Patients.

Frontiers in oncology

Li X, Chen X, Hu X, Shen Y, Xu R, Wu L, Shen X.
PMID: 34113559
Front Oncol. 2021 May 25;11:632172. doi: 10.3389/fonc.2021.632172. eCollection 2021.

BACKGROUND: Nitric oxide (NO) and cyclic guanosine phosphate (cGMP) play important roles in blood pressure regulation, neurotransmitter delivery, renal function, and tumorigenesis and development. The intermediate link of this signaling pathway, soluble guanylyl cyclase (sGC), is particularly important. However,...

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Li X, Chen X, Hu X, et al. Overexpression of GUCY1A2 Correlates With Poor Prognosis in Gastric Cancer Patients. Front Oncol. 2021;11:632172doi: 10.3389/fonc.2021.632172.
Li, X., Chen, X., Hu, X., Shen, Y., Xu, R., Wu, L., & Shen, X. (2021). Overexpression of GUCY1A2 Correlates With Poor Prognosis in Gastric Cancer Patients. Frontiers in oncology, 11632172. https://doi.org/10.3389/fonc.2021.632172
Li, Xin, et al. "Overexpression of GUCY1A2 Correlates With Poor Prognosis in Gastric Cancer Patients." Frontiers in oncology vol. 11 (2021): 632172. doi: https://doi.org/10.3389/fonc.2021.632172
Li X, Chen X, Hu X, Shen Y, Xu R, Wu L, Shen X. Overexpression of GUCY1A2 Correlates With Poor Prognosis in Gastric Cancer Patients. Front Oncol. 2021 May 25;11:632172. doi: 10.3389/fonc.2021.632172. eCollection 2021. PMID: 34113559; PMCID: PMC8185334.
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Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator.

Nitric oxide : biology and chemistry

Weber RE, Schulze KM, Colburn TD, Horn AG, Hageman KS, Ade CJ, Hall SE, Sandner P, Musch TI, Poole DC.
PMID: 34871799
Nitric Oxide. 2021 Dec 04;119:1-8. doi: 10.1016/j.niox.2021.12.001. Epub 2021 Dec 04.

In heart failure with reduced ejection fraction (HFrEF), nitric oxide-soluble guanylyl cyclase (sGC) pathway dysfunction impairs skeletal muscle arteriolar vasodilation and thus capillary hemodynamics, contributing to impaired oxygen uptake (V̇O

Cite
Weber RE, Schulze KM, Colburn TD, et al. Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator. Nitric Oxide. 2021;119:1-8doi: 10.1016/j.niox.2021.12.001.
Weber, R. E., Schulze, K. M., Colburn, T. D., Horn, A. G., Hageman, K. S., Ade, C. J., Hall, S. E., Sandner, P., Musch, T. I., & Poole, D. C. (2021). Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator. Nitric oxide : biology and chemistry, 1191-8. https://doi.org/10.1016/j.niox.2021.12.001
Weber, Ramona E, et al. "Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator." Nitric oxide : biology and chemistry vol. 119 (2021): 1-8. doi: https://doi.org/10.1016/j.niox.2021.12.001
Weber RE, Schulze KM, Colburn TD, Horn AG, Hageman KS, Ade CJ, Hall SE, Sandner P, Musch TI, Poole DC. Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator. Nitric Oxide. 2021 Dec 04;119:1-8. doi: 10.1016/j.niox.2021.12.001. Epub 2021 Dec 04. PMID: 34871799.
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Showing 1 to 12 of 104 entries