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Showing 1 to 12 of 531 entries
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Efficacy of tolvaptan in patients with refractory ascites in a clinical setting.

World journal of hepatology

Ohki T, Sato K, Yamada T, Yamagami M, Ito D, Kawanishi K, Kojima K, Seki M, Toda N, Tagawa K.
PMID: 26140088
World J Hepatol. 2015 Jun 28;7(12):1685-93. doi: 10.4254/wjh.v7.i12.1685.

AIM: To elucidate the efficacies of tolvaptan (TLV) as a treatment for refractory ascites compared with conventional treatment.METHODS: We retrospectively enrolled 120 refractory ascites patients between January 1, 2009 and September 31, 2014. Sixty patients were treated with oral...

Effect of aldosterone on epithelial-to-mesenchymal transition of human peritoneal mesothelial cells.

Kidney research and clinical practice

Yu M, Shin HS, Lee HK, Ryu DR, Kim SJ, Choi KB, Kang DH.
PMID: 26484027
Kidney Res Clin Pract. 2015 Jun;34(2):83-92. doi: 10.1016/j.krcp.2015.03.005. Epub 2015 Apr 25.

BACKGROUND: Peritoneal fibrosis is one of the major causes of technical failure in patients on peritoneal dialysis. Epithelial-to-mesenchymal transition (EMT) of the peritoneum is an early and reversible mechanism of peritoneal fibrosis. Human peritoneal mesothelial cells (HPMCs) have their...

Spironolactone Treatment and Effect on Survival in Chronic Heart Failure Patients with Reduced Renal Function: A Propensity-Matched Study.

Cardiorenal medicine

Stubnova V, Os I, Grundtvig M, Atar D, Waldum-Grevbo B.
PMID: 28611786
Cardiorenal Med. 2017 Feb;7(2):128-136. doi: 10.1159/000454933. Epub 2017 Jan 20.

BACKGROUND/AIMS: Spironolactone may be hazardous in heart failure (HF) patients with renal dysfunction due to risk of hyperkalemia and worsened renal function. We aimed to evaluate the effect of spironolactone on all-cause mortality in HF outpatients with renal dysfunction...

The Effect of Tween 20, 60, and 80 on Dissolution Behavior of Sprionolactone in Solid Dispersions Prepared by PEG 6000.

Advanced pharmaceutical bulletin

Akbari J, Saeedi M, Morteza-Semnani K, Kelidari HR, Sadegh Moghanlou F, Zareh G, Rostamkalaei S.
PMID: 26504767
Adv Pharm Bull. 2015 Sep;5(3):435-41. doi: 10.15171/apb.2015.059. Epub 2015 Sep 19.

PURPOSE: Solid dispersions have been efficient in improving the dissolution rate and bioavailability of hydrophobic drugs. The aim of the present study was enhancement of the dissolution profile of Spironolactone using solid dispersion.METHODS: Spironolactone solid dispersions (1:1, 1:2 and...

Evolving role for mineralocorticoid receptor antagonists in heart failure with preserved ejection fraction.

Current opinion in cardiology

Miller RJH, Howlett JG.
PMID: 25574896
Curr Opin Cardiol. 2015 Mar;30(2):168-172. doi: 10.1097/HCO.0000000000000147.

PURPOSE OF REVIEW: The majority of randomized clinical trials in heart failure with preserved ejection fraction (HFpEF) have failed to show meaningful improvements in clinical outcomes. Recent randomized trials have shown benefits from mineralocorticoid receptor antagonists (MRAs) in the...

Mineralocorticoid receptors in the ventral hippocampus are involved in extinction memory in rats.

PsyCh journal

Xing X, Wang H, Liang J, Bai Y, Liu Z, Zheng X.
PMID: 26271938
Psych J. 2014 Sep;3(3):201-13. doi: 10.1002/pchj.58. Epub 2014 Jul 02.

Fear extinction decreases conditioned fear responses that normally occur when a conditioned stimulus (CS) is repeatedly presented in the absence of an aversive unconditioned stimulus (US), which is the behavioral basis of exposure therapy for posttraumatic stress disorder (PTSD)....

End-stage Liver Disease in Children.

Current treatment options in gastroenterology

Squires RH.
PMID: 11560788
Curr Treat Options Gastroenterol. 2001 Oct;4(5):409-421. doi: 10.1007/s11938-001-0006-6.

The treatment of children with end-stage liver disease involves the coordinated management of nutritional deficiencies, ascites, pruritus, encephalopathy, and portal hypertension. The implementation of management strategies depends upon a parent or guardian to administer the plan in the context...

Cytomegalovirus myocarditis in a healthy infant: Complete recovery after ganciclovir treatment.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Dehtiar N, Eherlichman M, Picard E, Kleid D, Glaser J, Raveh D, Schlesinger Y.
PMID: 12793954
Pediatr Crit Care Med. 2001 Jul;2(3):271-273. doi: 10.1097/00130478-200107000-00015.

OBJECTIVES: To report a case of acute myocarditis caused by cytomegalovirus infection in a 15-month-old immunocompetent infant completely recovered with ganciclovir treatment. DESIGN: Descriptive case report. SETTING: Pediatric intensive care unit in a general hospital. Patient: A 15-month-old healthy...

Treating resistant hypertension with spironolactone.

Current hypertension reports

Berecek KH, Kimbrough D.
PMID: 18765091
Curr Hypertens Rep. 2008 Jun;10(3):211-2. doi: 10.1007/s11906-008-0039-5.

No abstract available.

Combination of drospirenone and estradiol: a new hormone therapy in postmenopausal women.

Women's health (London, England)

Huber JC.
PMID: 19804015
Womens Health (Lond). 2007 Jul;3(4):409-15. doi: 10.2217/17455057.3.4.409.

The problems that arise in connection with the menopause have been treated for many years with various hormone-replacement therapy formulations. The spironolactone derivative drospirenone is a novel progestin that, in combination with estradiol, provides a new low-dose, continuous, combined...

Eplerenone (Inspra), a new aldosterone antagonist for the treatment of systemic hypertension and heart failure.

Proceedings (Baylor University. Medical Center)

Craft J.
PMID: 16200104
Proc (Bayl Univ Med Cent). 2004 Apr;17(2):217-20. doi: 10.1080/08998280.2004.11927973.

Eplerenone is the second oral aldosterone antagonist available in the USA for the treatment of essential hypertension and heart failure. Treatment has been associated with reductions in blood pressure and improved survival (15% reduction in total mortality) for patients...

Mineralocorticoid Receptor Blocker Protects against Podocyte-Dependent Glomerulosclerosis.

Nephron extra

Takagi N, Tanizawa T, Kon V, Fogo AB, Ichikawa I, Ma J.
PMID: 22479265
Nephron Extra. 2012 Jan;2(1):17-26. doi: 10.1159/000334961. Epub 2012 Jan 31.

BACKGROUND: We previously showed that angiotensin type 1 receptor (AT1) blocker (ARB) attenuates glomerular injury in Nphs1-hCD25 (NEP25) transgenic mice, a model of selective podocyte injury. However, subsequent studies in NEP25 mice with podocyte-specific deficiency of AT1 revealed that...

Showing 1 to 12 of 531 entries