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Showing 1 to 3 of 3 entries
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Limited expression of cytochrome p450 17α-hydroxylase/17,20-lyase in prostate cancer cell lines.

Korean journal of urology

Jeong CW, Yoon CY, Jeong SJ, Hong SK, Byun SS, Lee SE.
PMID: 21860772
Korean J Urol. 2011 Jul;52(7):494-7. doi: 10.4111/kju.2011.52.7.494. Epub 2011 Jul 24.

PURPOSE: Cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1) is a key enzyme in the androgen biosynthesis pathway. CYP17A1 has been focused on because of the promising results of a potent CYP17A1 inhibitor in the treatment of castration-resistant prostate cancer (CRPC). A hypothesis...

Seventeen Alpha-Hydroxylase Deficiency Associated with Absent Gonads and Myelolipoma: A Case Report and Review of Literature.

Iranian journal of medical sciences

Soveid M, Rais-Jalali GA.
PMID: 27853336
Iran J Med Sci. 2016 Nov;41(6):543-547.

Congenital adrenal hyperplasia comprises a group of disorders resulting from defects in enzymes required for the synthesis of cortisol. The clinical presentation depends on the specific enzyme defect. We report a rare case of congenital adrenal hyperplasia due to...

Functional Identification of Compound Heterozygous Mutations in the .

Endocrinology and metabolism (Seoul, Korea)

Mo EY, Lee JY, Kim SY, Kim MJ, Kim ES, Lee S, Han JH, Moon SD.
PMID: 30229581
Endocrinol Metab (Seoul). 2018 Sep;33(3):413-422. doi: 10.3803/EnM.2018.33.3.413.

BACKGROUND: We previously reported a patient with congenital adrenal hyperplasia (CAH) with compound heterozygous mutations in the cytochrome P450 17A1 (METHODS: To understand how p.His373Leu and p.Glu383fsX36 affect P450c17 enzymatic activity, wild type and mutant RESULTS: Production of the...

Showing 1 to 3 of 3 entries