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Estrogen signaling and the aging brain: context-dependent considerations for postmenopausal hormone therapy.

ISRN endocrinology

Mott NN, Pak TR.
PMID: 23936665
ISRN Endocrinol. 2013 Jul 07;2013:814690. doi: 10.1155/2013/814690. Print 2013.

Recent clinical studies have spurred rigorous debate about the benefits of hormone therapy (HT) for postmenopausal women. Controversy first emerged based on a sharp increase in the risk of cardiovascular disease in participants of the Women's Health Initiative (WHI)...

Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation.

Aging and disease

Nomellini V, Brubaker AL, Mahbub S, Palmer JL, Gomez CR, Kovacs EJ.
PMID: 22724082
Aging Dis. 2012 Jun;3(3):234-47. Epub 2012 Feb 28.

We have previously demonstrated that aging is associated with prolonged pulmonary inflammation in a murine model of thermal injury. To further investigate these observations, we examined lung congestion, markers of neutrophil chemotaxis and adhesion, and lung endothelia responses in...

Aging of the Innate Immune System: An Update.

Current immunology reviews

Mahbub S, Brubaker AL, Kovacs EJ.
PMID: 21461315
Curr Immunol Rev. 2011 Feb 01;7(1):104-115. doi: 10.2174/157339511794474181.

The relationship between advanced age and immunologic deficits is becoming an area of rapidly advancing research. Many of the clinical hurdles in the elderly population result from dysregulation of the immune system leading to the inability of the elderly...

Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent Models.

Aging and disease

Brubaker AL, Palmer JL, Kovacs EJ.
PMID: 22396887
Aging Dis. 2011 Oct;2(5):346-60. Epub 2011 Oct 28.

In the elderly patient population, it has become increasingly evident that immune dysregulation is a contributing factor to age-related pathologies and their associated morbidity and mortality. In particular, elderly subjects are plagued by poor responses to infectious challenge and...

Neutrophils and natural killer T cells as negative regulators of wound healing.

Expert review of dermatology

Brubaker AL, Schneider DF, Kovacs EJ.
PMID: 21442028
Expert Rev Dermatol. 2011 Feb 01;6(1):5-8. doi: 10.1586/edm.10.66.

No abstract available.

Showing 1 to 5 of 5 entries