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Showing 1 to 12 of 38 entries
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A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals.

Pathogens & immunity

Cockerham LR, Yukl SA, Harvill K, Somsouk M, Joshi SK, Sinclair E, Liegler T, Hoh R, Lyons S, Hunt PW, Rupert A, Sereti I, Morcock DR, Rhodes A, Emson C, Hellerstein MK, Estes JD, Lewin S, Deeks SG, Hatano H.
PMID: 28936485
Pathog Immun. 2017;2(3):310-334. doi: 10.20411/pai.v2i3.207. Epub 2017 Aug 02.

BACKGROUND: In HIV infection, lymphoid tissue is disrupted by fibrosis. Angiotensin converting enzyme inhibitors have anti-fibrotic properties. We completed a pilot study to assess whether the addition of lisinopril to antiretroviral therapy (ART) reverses fibrosis of gut tissue, and...

Provider Adherence to Pre-exposure Prophylaxis Monitoring Guidelines in a Large Primary Care Network.

Open forum infectious diseases

Spinelli MA, Scott HM, Vittinghoff E, Liu AY, Morehead-Gee A, Gonzalez R, Buchbinder SP.
PMID: 29977959
Open Forum Infect Dis. 2018 May 04;5(6):ofy099. doi: 10.1093/ofid/ofy099. eCollection 2018 Jun.

Insufficient pre-exposure prophylaxis (PrEP) laboratory monitoring could increase HIV resistance and sexually transmitted infections. We examined test-ordering in a primary care network. Providers did not order HIV testing before almost one-quarter of PrEP initiations; panel management was associated with...

False rifampicin resistant results using Xpert MTB/RIF on urine samples in hospitalised HIV-infected patients.

Southern African journal of HIV medicine

Schutz C, Ward A, Burton R, Nicol MP, Blumenthal L, Meintjes G, Kerkhoff AD.
PMID: 31534789
South Afr J HIV Med. 2019 Aug 28;20(1):978. doi: 10.4102/sajhivmed.v20i1.978. eCollection 2019.

BACKGROUND: A small proportion of false rifampicin resistant results have previously been reported using GeneXpert MTB/RIF version G4 on sputum samples; however, this has not been investigated for urine samples in HIV-associated tuberculosis (TB).OBJECTIVES: We sought to determine the...

Universal PCR and antibody testing demonstrate little to no transmission of SARS-CoV-2 in a rural community.

medRxiv : the preprint server for health sciences

Appa A, Takahashi S, Rodriguez-Barraquer I, Chamie G, Sawyer A, Consortium C, Duarte E, Hakim J, Turcios K, Vinden J, Janson O, Manglik A, Peluso MJ, Deeks SG, Henrich TJ, Torres L, Rodgers M, Hackett J, Chiu C, Havlir D, Greenhouse B.
PMID: 32839781
medRxiv. 2020 Aug 17; doi: 10.1101/2020.08.15.20175786.

BACKGROUND: The absence of systematic surveillance for SARS-CoV-2 has curtailed accurate appraisal of transmission intensity. Our objective was to perform case detection of an entire rural community to quantify SARS-CoV-2 transmission using PCR and antibody testing.METHODS: We conducted a...

Customized registry tool for tracking adherence to clinical guidelines for head and neck cancers: protocol for a pilot study.

Pilot and feasibility studies

Hickey MD, Lisker S, Brodie S, Vittinghoff E, Russell MD, Sarkar U.
PMID: 32047648
Pilot Feasibility Stud. 2020 Feb 07;6:16. doi: 10.1186/s40814-020-0552-0. eCollection 2020.

BACKGROUND: Despite recommendations for monitoring patients with chronic and high-risk conditions, gaps still remain. These gaps are exacerbated in outpatient care, where patients and clinicians face challenges related to care coordination, multiple electronic health records, and extensive follow-up. In...

Estimation of secondary household attack rates for emergent spike L452R SARS-CoV-2 variants detected by genomic surveillance at a community-based testing site in San Francisco.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Peng J, Liu J, Mann SA, Mitchell AM, Laurie MT, Sunshine S, Pilarowski G, Ayscue P, Kistler A, Vanaerschot M, Li LM, McGeever A, Chow ED, Marquez C, Nakamura R, Rubio L, Chamie G, Jones D, Jacobo J, Rojas S, Rojas S, Tulier-Laiwa V, Black D, Martinez J, Naso J, Schwab J, Petersen M, Havlir D, DeRisi J.
PMID: 33788923
Clin Infect Dis. 2021 Mar 31; doi: 10.1093/cid/ciab283. Epub 2021 Mar 31.

BACKGROUND: Sequencing of the SARS-CoV-2 viral genome from patient samples is an important epidemiological tool for monitoring and responding to the pandemic, including the emergence of new mutations in specific communities.METHODS: SARS-CoV-2 genomic sequences were generated from positive samples...

Community-wide Screening for Tuberculosis.

The New England journal of medicine

Kerkhoff AD, Muyoyeta M, Cattamanchi A.
PMID: 32187484
N Engl J Med. 2020 Mar 19;382(12):1185-1186. doi: 10.1056/NEJMc1916666.

No abstract available.

Diagnostic accuracy of a novel point-of-care urine lipoarabinomannan assay for the detection of tuberculosis among adult outpatients in Zambia: a prospective cross-sectional study.

The European respiratory journal

Muyoyeta M, Kerkhoff AD, Chilukutu L, Moreau E, Schumacher SG, Ruhwald M.
PMID: 33926972
Eur Respir J. 2021 Nov 18;58(5). doi: 10.1183/13993003.03999-2020. Print 2021 Nov.

BACKGROUND: A novel, rapid, point-of-care urine-based lipoarabinomannan assay (Fujifilm SILVAMP TB LAM ("FujiLAM")) has previously demonstrated substantially higher sensitivity for tuberculosis (TB) compared with the commercially available Determine TB LAM assay using biobanked specimens. However, FujiLAM has not been...

Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19.

EClinicalMedicine

Shah SJ, Barish PN, Prasad PA, Kistler A, Neff N, Kamm J, Li LM, Chiu CY, Babik JM, Fang MC, Abe-Jones Y, Alipanah N, Alvarez FN, Botvinnik OB, Castaneda G, Dadasovich RM, Davis J, Deng X, DeRisi JL, Detweiler AM, Federman S, Haliburton J, Hao S, Kerkhoff AD, Kumar GR, Malcolm KB, Mann SA, Martinez S, Mary RK, Mick E, Mwakibete L, Najafi N, Peluso MJ, Phelps M, Pisco AO, Ratnasiri K, Rubio LA, Sellas A, Sherwood KD, Sheu J, Spottiswoode N, Tan M, Yu G, Kangelaris KN, Langelier C.
PMID: 32864588
EClinicalMedicine. 2020 Oct;27:100518. doi: 10.1016/j.eclinm.2020.100518. Epub 2020 Aug 26.

BACKGROUND: Most data on the clinical presentation, diagnostics, and outcomes of patients with COVID-19 have been presented as case series without comparison to patients with other acute respiratory illnesses.METHODS: We examined emergency department patients between February 3 and March...

Housing Instability Results in Increased Acute Care Utilization in an Urban HIV Clinic Cohort.

Open forum infectious diseases

Clemenzi-Allen A, Neuhaus J, Geng E, Sachdev D, Buchbinder S, Havlir D, Gandhi M, Christopoulos K.
PMID: 31139668
Open Forum Infect Dis. 2019 Mar 27;6(5):ofz148. doi: 10.1093/ofid/ofz148. eCollection 2019 May.

BACKGROUND: People living with HIV (PLWH) who experience homelessness and unstable housing (HUH) often have fragmented health care. Research that incorporates granular assessments of housing status and primary care visit adherence to understand patterns of acute care utilization can...

Sex Disparity in Cord Blood FoxP3.

Open forum infectious diseases

Prahl M, Jagannathan P, McIntyre TI, Auma A, Wamala S, Nalubega M, Musinguzi K, Naluwu K, Sikyoma E, Budker R, Odorizzi P, Kakuru A, Havlir DV, Kamya MR, Dorsey G, Feeney ME.
PMID: 28480292
Open Forum Infect Dis. 2017 Feb 11;4(1):ofx022. doi: 10.1093/ofid/ofx022. eCollection 2017.

Sex differences in the immune response and in infectious disease susceptibility have been well described, although the mechanisms underlying these differences remain incompletely understood. We evaluated the frequency of cord blood CD4 T cell subsets in a highly malaria-exposed...

Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: a comparison of patients with and without COVID-19.

medRxiv : the preprint server for health sciences

Shah SJ, Barish PN, Prasad PA, Kistler AL, Neff N, Kamm J, Li LM, Chiu CY, Babick JM, Fang MC, Abe-Jones Y, Alipanah N, Alvarez FN, Botvinnik OB, Davis JM, Castenada GD, Consortium C, Dadasovich RM, Deng X, DeRisi JL, Detweiler AM, Federman S, Haliburton JR, Hao SL, Kerkhoff AD, Kumar R, Malcolm K, Mann SA, Martinez SP, Marya R, Mick E, Mwakibete LL, Najafi N, Peluso MJ, Phelps MS, Pisco AO, Ratnasiri K, Rubio LA, Sellas AB, Sherwood KD, Sheu J, Spottiswoode N, Tan M, Yu G, Kangelaris KN, Langelier C.
PMID: 32511488
medRxiv. 2020 May 06; doi: 10.1101/2020.05.02.20082461.

BACKGROUND: Emerging data on the clinical presentation, diagnostics, and outcomes of patients with COVID-19 have largely been presented as case series. Few studies have compared these clinical features and outcomes of COVID-19 to other acute respiratory illnesses.METHODS: We examined...

Showing 1 to 12 of 38 entries