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The IL-27 component EBI-3 and its receptor subunit IL-27Rα are essential for the cytoprotective action of humanin on male germ cells†.

Biology of reproduction

Jia Y, Swerdloff RS, Lue Y, Dai-Ju J, Surampudi P, Cohen P, Wang C.
PMID: 33330922
Biol Reprod. 2021 Mar 11;104(3):717-730. doi: 10.1093/biolre/ioaa225.

Humanin (HN) is a mitochondrial-derived peptide that protects many cells/tissues from damage. We previously demonstrated that HN reduces stress-induced male germ cell apoptosis in rodents. HN action in neuronal cells is mediated through its binding to a trimeric cell...

The IL-27 component EBI-3 and its receptor subunit IL-27Rα are essential for the cytoprotective action of humanin on male germ cells†.

Biology of reproduction

Jia Y, Swerdloff RS, Lue Y, Dai-Ju J, Surampudi P, Cohen P, Wang C.
PMID: 33330922
Biol Reprod. 2021 Mar 11;104(3):717-730. doi: 10.1093/biolre/ioaa225.

Humanin (HN) is a mitochondrial-derived peptide that protects many cells/tissues from damage. We previously demonstrated that HN reduces stress-induced male germ cell apoptosis in rodents. HN action in neuronal cells is mediated through its binding to a trimeric cell...

Chromatin variation associated with liver metabolism is mediated by transposable elements.

Epigenetics & chromatin

Du J, Leung A, Trac C, Lee M, Parks BW, Lusis AJ, Natarajan R, Schones DE.
PMID: 27398095
Epigenetics Chromatin. 2016 Jul 08;9:28. doi: 10.1186/s13072-016-0078-0. eCollection 2016.

BACKGROUND: Functional regulatory regions in eukaryotic genomes are characterized by the disruption of nucleosomes leading to accessible chromatin. The modulation of chromatin accessibility is one of the key mediators of transcriptional regulation, and variation in chromatin accessibility across individuals...

Showing 1 to 3 of 3 entries