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Showing 1 to 12 of 14 entries
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Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity.

Journal of clinical and translational research

Xie Y, Woolbright BL, Kos M, McGill MR, Dorko K, Kumer SC, Schmitt TM, Jaeschke H.
PMID: 26722668
J Clin Transl Res. 2015;1(2):100-106. doi: 10.18053/jctres.201502.004. Epub 2015 Sep 30.

BACKGROUND: Acetaminophen (APAP) hepatotoxicity is a major cause of acute liver failure in many countries. Mechanistic studies in mice and humans have implicated formation of a reactive metabolite, mitochondrial dysfunction and oxidant stress as critical events in the pathophysiology...

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Xie Y, Woolbright BL, Kos M, et al. Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity. J Clin Transl Res. 2015;1(2):100-106doi: 10.18053/jctres.201502.004.
Xie, Y., Woolbright, B. L., Kos, M., McGill, M. R., Dorko, K., Kumer, S. C., Schmitt, T. M., & Jaeschke, H. (2015). Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity. Journal of clinical and translational research, 1(2), 100-106. https://doi.org/10.18053/jctres.201502.004
Xie, Yuchao, et al. "Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity." Journal of clinical and translational research vol. 1,2 (2015): 100-106. doi: https://doi.org/10.18053/jctres.201502.004
Xie Y, Woolbright BL, Kos M, McGill MR, Dorko K, Kumer SC, Schmitt TM, Jaeschke H. Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity. J Clin Transl Res. 2015;1(2):100-106. doi: 10.18053/jctres.201502.004. Epub 2015 Sep 30. PMID: 26722668; PMCID: PMC4694640.
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The impact of sterile inflammation in acute liver injury.

Journal of clinical and translational research

Woolbright BL, Jaeschke H.
PMID: 28670626
J Clin Transl Res. 2017 Feb;3:170-188. doi: 10.18053/jctres.03.2017S1.003. Epub 2017 Feb 12.

BACKGROUND: The liver has a number of functions in innate immunity. These functions predispose the liver to innate immune-mediated liver injury when inflammation goes unchecked. Significant progress has been made in the last 25 years on sterile inflammatory liver...

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Woolbright BL, Jaeschke H. The impact of sterile inflammation in acute liver injury. J Clin Transl Res. 2017;3:170-188doi: 10.18053/jctres.03.2017S1.003.
Woolbright, B. L., & Jaeschke, H. (2017). The impact of sterile inflammation in acute liver injury. Journal of clinical and translational research, 3170-188. https://doi.org/10.18053/jctres.03.2017S1.003
Woolbright, Benjamin L, and Jaeschke, Hartmut. "The impact of sterile inflammation in acute liver injury." Journal of clinical and translational research vol. 3 (2017): 170-188. doi: https://doi.org/10.18053/jctres.03.2017S1.003
Woolbright BL, Jaeschke H. The impact of sterile inflammation in acute liver injury. J Clin Transl Res. 2017 Feb;3:170-188. doi: 10.18053/jctres.03.2017S1.003. Epub 2017 Feb 12. PMID: 28670626; PMCID: PMC5488807.
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Differential effects of hyaluronan synthase 3 deficiency after acute vs chronic liver injury in mice.

Fibrogenesis & tissue repair

McCracken JM, Jiang L, Deshpande KT, O'Neil MF, Pritchard MT.
PMID: 27042213
Fibrogenesis Tissue Repair. 2016 Mar 31;9:4. doi: 10.1186/s13069-016-0041-5. eCollection 2016.

BACKGROUND: Hyaluronan (HA) is a ubiquitous extracellular matrix (ECM) glycosaminoglycan synthesized by three different enzymes, hyaluronan synthase (HAS)1, 2, and 3. HA synthesis mediated by HAS3 promotes inflammation and is pathogenic in animal models of human lung and intestinal...

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McCracken JM, Jiang L, Deshpande KT, et al. Differential effects of hyaluronan synthase 3 deficiency after acute vs chronic liver injury in mice. Fibrogenesis Tissue Repair. 2016;9:4doi: 10.1186/s13069-016-0041-5.
McCracken, J. M., Jiang, L., Deshpande, K. T., O'Neil, M. F., & Pritchard, M. T. (2016). Differential effects of hyaluronan synthase 3 deficiency after acute vs chronic liver injury in mice. Fibrogenesis & tissue repair, 94. https://doi.org/10.1186/s13069-016-0041-5
McCracken, Jennifer M, et al. "Differential effects of hyaluronan synthase 3 deficiency after acute vs chronic liver injury in mice." Fibrogenesis & tissue repair vol. 9 (2016): 4. doi: https://doi.org/10.1186/s13069-016-0041-5
McCracken JM, Jiang L, Deshpande KT, O'Neil MF, Pritchard MT. Differential effects of hyaluronan synthase 3 deficiency after acute vs chronic liver injury in mice. Fibrogenesis Tissue Repair. 2016 Mar 31;9:4. doi: 10.1186/s13069-016-0041-5. eCollection 2016. PMID: 27042213; PMCID: PMC4818527.
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Noncoding RNAs as therapeutics for acetaminophen-induced liver injury.

Stem cell investigation

Woolbright BL, Jaeschke H.
PMID: 27777943
Stem Cell Investig. 2016 Oct 11;3:54. doi: 10.21037/sci.2016.09.10. eCollection 2016.

No abstract available.

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Woolbright BL, Jaeschke H. Noncoding RNAs as therapeutics for acetaminophen-induced liver injury. Stem Cell Investig. 2016;3:54doi: 10.21037/sci.2016.09.10.
Woolbright, B. L., & Jaeschke, H. (2016). Noncoding RNAs as therapeutics for acetaminophen-induced liver injury. Stem cell investigation, 354. https://doi.org/10.21037/sci.2016.09.10
Woolbright, Benjamin L, and Jaeschke, Hartmut. "Noncoding RNAs as therapeutics for acetaminophen-induced liver injury." Stem cell investigation vol. 3 (2016): 54. doi: https://doi.org/10.21037/sci.2016.09.10
Woolbright BL, Jaeschke H. Noncoding RNAs as therapeutics for acetaminophen-induced liver injury. Stem Cell Investig. 2016 Oct 11;3:54. doi: 10.21037/sci.2016.09.10. eCollection 2016. PMID: 27777943; PMCID: PMC5067361.
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Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3.

Current chemical genomics

Gui C, Obaidat A, Chaguturu R, Hagenbuch B.
PMID: 20448812
Curr Chem Genomics. 2010 Mar 01;4:1-8. doi: 10.2174/1875397301004010001.

The two organic anion transporting polypeptides (OATPs) 1B1 and 1B3 are expressed at the sinusoidal membrane of hepatocytes. They have a broad and overlapping substrate specificity and transport many endobiotics and drugs. Specific inhibitors are required to determine the...

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Gui C, Obaidat A, Chaguturu R, et al. Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. Curr Chem Genomics. 2010;4:1-8doi: 10.2174/1875397301004010001.
Gui, C., Obaidat, A., Chaguturu, R., & Hagenbuch, B. (2010). Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. Current chemical genomics, 41-8. https://doi.org/10.2174/1875397301004010001
Gui, Chunshan, et al. "Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3." Current chemical genomics vol. 4 (2010): 1-8. doi: https://doi.org/10.2174/1875397301004010001
Gui C, Obaidat A, Chaguturu R, Hagenbuch B. Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. Curr Chem Genomics. 2010 Mar 01;4:1-8. doi: 10.2174/1875397301004010001. PMID: 20448812; PMCID: PMC2864424.
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MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury.

Journal of clinical medicine

McGill MR, Jaeschke H.
PMID: 26167291
J Clin Med. 2015 May 20;4(5):1063-78. doi: 10.3390/jcm4051063. eCollection 2015 May.

Drug-induced liver injury (DILI) is major problem for both the drug industry and for clinicians. There are two basic categories of DILI: intrinsic and idiosyncratic. The former is the chief cause of acute liver failure in several developed countries,...

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McGill MR, Jaeschke H. MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury. J Clin Med. 2015;4(5):1063-78doi: 10.3390/jcm4051063.
McGill, M. R., & Jaeschke, H. (2015). MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury. Journal of clinical medicine, 4(5), 1063-78. https://doi.org/10.3390/jcm4051063
McGill, Mitchell R, and Jaeschke, Hartmut. "MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury." Journal of clinical medicine vol. 4,5 (2015): 1063-78. doi: https://doi.org/10.3390/jcm4051063
McGill MR, Jaeschke H. MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury. J Clin Med. 2015 May 20;4(5):1063-78. doi: 10.3390/jcm4051063. eCollection 2015 May. PMID: 26167291; PMCID: PMC4470217.
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Alcoholic Hepatitis: Lost in Translation.

Journal of clinical and translational hepatology

Woolbright BL, Jaeschke H.
PMID: 29577035
J Clin Transl Hepatol. 2018 Mar 28;6(1):89-96. doi: 10.14218/JCTH.2017.00054. Epub 2017 Dec 17.

Alcoholic hepatitis is the most severe and acute form of alcoholic liver disease. The mortality rate associated with alcoholic hepatitis is high, largely due to the lack of suitable pharmacological interventions. While there has been substantial research in the...

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Woolbright BL, Jaeschke H. Alcoholic Hepatitis: Lost in Translation. J Clin Transl Hepatol. 2017;6(1):89-96doi: 10.14218/JCTH.2017.00054.
Woolbright, B. L., & Jaeschke, H. (2018). Alcoholic Hepatitis: Lost in Translation. Journal of clinical and translational hepatology, 6(1), 89-96. https://doi.org/10.14218/JCTH.2017.00054
Woolbright, Benjamin L, and Jaeschke, Hartmut. "Alcoholic Hepatitis: Lost in Translation." Journal of clinical and translational hepatology vol. 6,1 (2018): 89-96. doi: https://doi.org/10.14218/JCTH.2017.00054
Woolbright BL, Jaeschke H. Alcoholic Hepatitis: Lost in Translation. J Clin Transl Hepatol. 2018 Mar 28;6(1):89-96. doi: 10.14218/JCTH.2017.00054. Epub 2017 Dec 17. PMID: 29577035; PMCID: PMC5863004.
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Acute Immunotoxic Effects of Perfluorononanoic Acid (PFNA) in C57BL/6 Mice.

Clinical & experimental pharmacology

Rockwell CE, Turley AE, Cheng X, Fields PE, Klaassen CD.
PMID: 25568816
Clin Exp Pharmacol. 2013; doi: 10.4172/2161-1459.S4-002.

otrganic perfluorochemicals (PFCs) have become an environmental concern due to widespread detection in human blood and experimental evidence for immune, developmental, and liver toxicity. Whereas the blood concentrations of many PFCs are declining, blood levels of Perfluorononanoic Acid (PFNA)...

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Rockwell CE, Turley AE, Cheng X, et al. Acute Immunotoxic Effects of Perfluorononanoic Acid (PFNA) in C57BL/6 Mice. Clin Exp Pharmacol. 2013;doi: 10.4172/2161-1459.S4-002.
Rockwell, C. E., Turley, A. E., Cheng, X., Fields, P. E., & Klaassen, C. D. (2013). Acute Immunotoxic Effects of Perfluorononanoic Acid (PFNA) in C57BL/6 Mice. Clinical & experimental pharmacology, . https://doi.org/10.4172/2161-1459.S4-002
Rockwell, Cheryl E, et al. "Acute Immunotoxic Effects of Perfluorononanoic Acid (PFNA) in C57BL/6 Mice." Clinical & experimental pharmacology vol. (2013). doi: https://doi.org/10.4172/2161-1459.S4-002
Rockwell CE, Turley AE, Cheng X, Fields PE, Klaassen CD. Acute Immunotoxic Effects of Perfluorononanoic Acid (PFNA) in C57BL/6 Mice. Clin Exp Pharmacol. 2013; doi: 10.4172/2161-1459.S4-002. PMID: 25568816; PMCID: PMC4283221.
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Role of early growth response 1 in liver metabolism and liver cancer.

Hepatoma research

Magee N, Zhang Y.
PMID: 29607419
Hepatoma Res. 2017;3:268-277. doi: 10.20517/2394-5079.2017.36. Epub 2017 Nov 20.

The liver is an essential organ for nutrient and drug metabolism - possessing the remarkable ability to sense environmental and metabolic stimuli and provide an optimally adaptive response. Early growth response 1 (Egr1), an immediate early transcriptional factor which...

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Magee N, Zhang Y. Role of early growth response 1 in liver metabolism and liver cancer. Hepatoma Res. 2017;3:268-277doi: 10.20517/2394-5079.2017.36.
Magee, N., & Zhang, Y. (2017). Role of early growth response 1 in liver metabolism and liver cancer. Hepatoma research, 3268-277. https://doi.org/10.20517/2394-5079.2017.36
Magee, Nancy, and Zhang, Yuxia. "Role of early growth response 1 in liver metabolism and liver cancer." Hepatoma research vol. 3 (2017): 268-277. doi: https://doi.org/10.20517/2394-5079.2017.36
Magee N, Zhang Y. Role of early growth response 1 in liver metabolism and liver cancer. Hepatoma Res. 2017;3:268-277. doi: 10.20517/2394-5079.2017.36. Epub 2017 Nov 20. PMID: 29607419; PMCID: PMC5877465.
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Decoding the Role of Extracellular Vesicles in Liver Diseases.

Liver research

Deng F, Magee N, Zhang Y.
PMID: 29552373
Liver Res. 2017 Sep;1(3):147-155. doi: 10.1016/j.livres.2017.11.003. Epub 2017 Dec 07.

Cell-to-cell communication is a fascinating process that is essential for maintaining tissue and whole-body homeostasis. Extracellular vesicles (EVs) are cell-derived membrane-bound nanoparticles that are a means of communication between cells. Accumulating evidence indicates that EVs can render either beneficial...

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Deng F, Magee N, Zhang Y. Decoding the Role of Extracellular Vesicles in Liver Diseases. Liver Res. 2017;1(3):147-155doi: 10.1016/j.livres.2017.11.003.
Deng, F., Magee, N., & Zhang, Y. (2017). Decoding the Role of Extracellular Vesicles in Liver Diseases. Liver research, 1(3), 147-155. https://doi.org/10.1016/j.livres.2017.11.003
Deng, Fengyan, et al. "Decoding the Role of Extracellular Vesicles in Liver Diseases." Liver research vol. 1,3 (2017): 147-155. doi: https://doi.org/10.1016/j.livres.2017.11.003
Deng F, Magee N, Zhang Y. Decoding the Role of Extracellular Vesicles in Liver Diseases. Liver Res. 2017 Sep;1(3):147-155. doi: 10.1016/j.livres.2017.11.003. Epub 2017 Dec 07. PMID: 29552373; PMCID: PMC5851463.
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Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers.

Drug metabolism and disposition: the biological fate of chemicals

Liu J, Cui JY, Lu YF, Corton JC, Klaassen CD.
PMID: 33162398
Drug Metab Dispos. 2021 Jan;49(1):111-119. doi: 10.1124/dmd.120.000181. Epub 2020 Nov 08.

Individual variations in xenobiotic metabolism affect the sensitivity to diseases. In this study, the impacts of sex, age, and race/ethnicity on drug-processing genes and nuclear factor erythroid 2-related factor 2 (NRF2) genes in human livers were examined via QuantiGene...

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Liu J, Cui JY, Lu YF, et al. Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers. Drug Metab Dispos. 2020;49(1):111-119doi: 10.1124/dmd.120.000181.
Liu, J., Cui, J. Y., Lu, Y. F., Corton, J. C., & Klaassen, C. D. (2021). Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers. Drug metabolism and disposition: the biological fate of chemicals, 49(1), 111-119. https://doi.org/10.1124/dmd.120.000181
Liu, Jie, et al. "Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers." Drug metabolism and disposition: the biological fate of chemicals vol. 49,1 (2021): 111-119. doi: https://doi.org/10.1124/dmd.120.000181
Liu J, Cui JY, Lu YF, Corton JC, Klaassen CD. Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers. Drug Metab Dispos. 2021 Jan;49(1):111-119. doi: 10.1124/dmd.120.000181. Epub 2020 Nov 08. PMID: 33162398; PMCID: PMC7804821.
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Acetaminophen-induced Liver Injury: from Animal Models to Humans.

Journal of clinical and translational hepatology

Jaeschke H, Xie Y, McGill MR.
PMID: 26355817
J Clin Transl Hepatol. 2014 Sep;2(3):153-61. doi: 10.14218/JCTH.2014.00014. Epub 2014 Sep 15.

Drug-induced liver injury is an important clinical problem and a challenge for drug development. Whereas progress in understanding rare and unpredictable (idiosyncratic) drug hepatotoxicity is severely hampered by the lack of relevant animal models, enormous insight has been gained...

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Jaeschke H, Xie Y, McGill MR. Acetaminophen-induced Liver Injury: from Animal Models to Humans. J Clin Transl Hepatol. 2014;2(3):153-61doi: 10.14218/JCTH.2014.00014.
Jaeschke, H., Xie, Y., & McGill, M. R. (2014). Acetaminophen-induced Liver Injury: from Animal Models to Humans. Journal of clinical and translational hepatology, 2(3), 153-61. https://doi.org/10.14218/JCTH.2014.00014
Jaeschke, Hartmut, et al. "Acetaminophen-induced Liver Injury: from Animal Models to Humans." Journal of clinical and translational hepatology vol. 2,3 (2014): 153-61. doi: https://doi.org/10.14218/JCTH.2014.00014
Jaeschke H, Xie Y, McGill MR. Acetaminophen-induced Liver Injury: from Animal Models to Humans. J Clin Transl Hepatol. 2014 Sep;2(3):153-61. doi: 10.14218/JCTH.2014.00014. Epub 2014 Sep 15. PMID: 26355817; PMCID: PMC4521247.
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Showing 1 to 12 of 14 entries