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FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells.

F1000Research

Conrad W, Major MB, Cleary MA, Ferrer M, Roberts B, Marine S, Chung N, Arthur WT, Chien AJ, Berndt JD, Moon RT.
PMID: 24358901
F1000Res. 2013 May 31;2:134. doi: 10.12688/f1000research.2-134.v1. eCollection 2013.

The inability of targeted BRAF inhibitors to produce long-lasting improvement in the clinical outcome of melanoma highlights a need to identify additional approaches to inhibit melanoma growth. Recent studies have shown that activation of the Wnt/β-catenin pathway decreases tumor...

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Conrad W, Major MB, Cleary MA, et al. FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells. F1000Res. 2013;2:134doi: 10.12688/f1000research.2-134.v1.
Conrad, W., Major, M. B., Cleary, M. A., Ferrer, M., Roberts, B., Marine, S., Chung, N., Arthur, W. T., Chien, A. J., Berndt, J. D., & Moon, R. T. (2013). FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells. F1000Research, 2134. https://doi.org/10.12688/f1000research.2-134.v1
Conrad, Willliam, et al. "FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells." F1000Research vol. 2 (2013): 134. doi: https://doi.org/10.12688/f1000research.2-134.v1
Conrad W, Major MB, Cleary MA, Ferrer M, Roberts B, Marine S, Chung N, Arthur WT, Chien AJ, Berndt JD, Moon RT. FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells. F1000Res. 2013 May 31;2:134. doi: 10.12688/f1000research.2-134.v1. eCollection 2013. PMID: 24358901; PMCID: PMC3829391.1.
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Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors.

Frontiers in pharmacology

Evangelista EA, Cho CW, Aliwarga T, Totah RA.
PMID: 32581794
Front Pharmacol. 2020 Jun 09;11:828. doi: 10.3389/fphar.2020.00828. eCollection 2020.

Oxylipins derived from the oxidation of polyunsaturated fatty acids (PUFAs) act as important paracrine and autocrine signaling molecules. A subclass of oxylipins, the eicosanoids, have a broad range of physiological outcomes in inflammation, the immune response, cardiovascular homeostasis, and...

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Evangelista EA, Cho CW, Aliwarga T, et al. Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors. Front Pharmacol. 2020;11:828doi: 10.3389/fphar.2020.00828.
Evangelista, E. A., Cho, C. W., Aliwarga, T., & Totah, R. A. (2020). Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors. Frontiers in pharmacology, 11828. https://doi.org/10.3389/fphar.2020.00828
Evangelista, Eric A, et al. "Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors." Frontiers in pharmacology vol. 11 (2020): 828. doi: https://doi.org/10.3389/fphar.2020.00828
Evangelista EA, Cho CW, Aliwarga T, Totah RA. Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors. Front Pharmacol. 2020 Jun 09;11:828. doi: 10.3389/fphar.2020.00828. eCollection 2020. PMID: 32581794; PMCID: PMC7295938.
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Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril.

Scientific reports

Maldonato BJ, Russell DA, Totah RA.
PMID: 33649426
Sci Rep. 2021 Mar 01;11(1):4857. doi: 10.1038/s41598-021-84218-5.

Methylation of alkyl thiols is a biotransformation pathway designed to reduce thiol reactivity and potential toxicity, yet the gene and protein responsible for human alkyl thiol methyltransferase (TMT) activity remain unknown. Here we demonstrate with a range of experimental...

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Maldonato BJ, Russell DA, Totah RA. Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril. Sci Rep. 2021;11(1):4857doi: 10.1038/s41598-021-84218-5.
Maldonato, B. J., Russell, D. A., & Totah, R. A. (2021). Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril. Scientific reports, 11(1), 4857. https://doi.org/10.1038/s41598-021-84218-5
Maldonato, Benjamin J, et al. "Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril." Scientific reports vol. 11,1 (2021): 4857. doi: https://doi.org/10.1038/s41598-021-84218-5
Maldonato BJ, Russell DA, Totah RA. Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril. Sci Rep. 2021 Mar 01;11(1):4857. doi: 10.1038/s41598-021-84218-5. PMID: 33649426; PMCID: PMC7921093.
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TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules.

Developmental cell

Nourbakhsh K, Ferreccio AA, Bernard MJ, Yadav S.
PMID: 34879262
Dev Cell. 2021 Dec 20;56(24):3321-3333.e5. doi: 10.1016/j.devcel.2021.11.015. Epub 2021 Dec 07.

The endoplasmic reticulum (ER) depends on extensive association with the microtubule (MT) cytoskeleton for its structure and mitotic inheritance. However, mechanisms that underlie coupling of ER membranes to MTs are poorly understood. We have identified thousand and one amino...

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Nourbakhsh K, Ferreccio AA, Bernard MJ, et al. TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules. Dev Cell. 2021;56(24):3321-3333.e5doi: 10.1016/j.devcel.2021.11.015.
Nourbakhsh, K., Ferreccio, A. A., Bernard, M. J., & Yadav, S. (2021). TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules. Developmental cell, 56(24), 3321-3333.e5. https://doi.org/10.1016/j.devcel.2021.11.015
Nourbakhsh, Kimya, et al. "TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules." Developmental cell vol. 56,24 (2021): 3321-3333.e5. doi: https://doi.org/10.1016/j.devcel.2021.11.015
Nourbakhsh K, Ferreccio AA, Bernard MJ, Yadav S. TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules. Dev Cell. 2021 Dec 20;56(24):3321-3333.e5. doi: 10.1016/j.devcel.2021.11.015. Epub 2021 Dec 07. PMID: 34879262; PMCID: PMC8699727.
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Identification of α,β-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells.

Frontiers in molecular neuroscience

van Esbroeck ACM, Kantae V, Di X, van der Wel T, den Dulk H, Stevens AF, Singh S, Bakker AT, Florea BI, Stella N, Overkleeft HS, Hankemeier T, van der Stelt M.
PMID: 31849602
Front Mol Neurosci. 2019 Nov 26;12:286. doi: 10.3389/fnmol.2019.00286. eCollection 2019.

The endocannabinoid 2-arachidonoylglycerol (2-AG) is involved in neuronal differentiation. This study aimed to identify the biosynthetic enzymes responsible for 2-AG production during retinoic acid (RA)-induced neurite outgrowth of Neuro-2a cells. First, we confirmed that RA stimulation of Neuro-2a cells...

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van Esbroeck ACM, Kantae V, Di X, et al. Identification of α,β-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells. Front Mol Neurosci. 2019;12:286doi: 10.3389/fnmol.2019.00286.
van Esbroeck, A. C. M., Kantae, V., Di, X., van der Wel, T., den Dulk, H., Stevens, A. F., Singh, S., Bakker, A. T., Florea, B. I., Stella, N., Overkleeft, H. S., Hankemeier, T., & van der Stelt, M. (2019). Identification of α,β-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells. Frontiers in molecular neuroscience, 12286. https://doi.org/10.3389/fnmol.2019.00286
van Esbroeck, Annelot C M, et al. "Identification of α,β-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells." Frontiers in molecular neuroscience vol. 12 (2019): 286. doi: https://doi.org/10.3389/fnmol.2019.00286
van Esbroeck ACM, Kantae V, Di X, van der Wel T, den Dulk H, Stevens AF, Singh S, Bakker AT, Florea BI, Stella N, Overkleeft HS, Hankemeier T, van der Stelt M. Identification of α,β-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells. Front Mol Neurosci. 2019 Nov 26;12:286. doi: 10.3389/fnmol.2019.00286. eCollection 2019. PMID: 31849602; PMCID: PMC6901982.
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Multi-omics investigation reveals benzalkonium chloride disinfectants alter sterol and lipid homeostasis in the mouse neonatal brain.

Toxicological sciences : an official journal of the Society of Toxicology

Herron JM, Hines KM, Tomita H, Seguin RP, Cui JY, Xu L.
PMID: 31199489
Toxicol Sci. 2019 Jun 14; doi: 10.1093/toxsci/kfz139. Epub 2019 Jun 14.

Lipids are critical for neurodevelopment; therefore, disruption of lipid homeostasis by environmental chemicals is expected to have detrimental effects on this process. Previously, we demonstrated that the benzalkonium chlorides (BACs), a class of commonly used disinfectants, alter cholesterol biosynthesis...

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Herron JM, Hines KM, Tomita H, et al. Multi-omics investigation reveals benzalkonium chloride disinfectants alter sterol and lipid homeostasis in the mouse neonatal brain. Toxicol Sci. 2019;doi: 10.1093/toxsci/kfz139.
Herron, J. M., Hines, K. M., Tomita, H., Seguin, R. P., Cui, J. Y., & Xu, L. (2019). Multi-omics investigation reveals benzalkonium chloride disinfectants alter sterol and lipid homeostasis in the mouse neonatal brain. Toxicological sciences : an official journal of the Society of Toxicology, . https://doi.org/10.1093/toxsci/kfz139
Herron, Josi M, et al. "Multi-omics investigation reveals benzalkonium chloride disinfectants alter sterol and lipid homeostasis in the mouse neonatal brain." Toxicological sciences : an official journal of the Society of Toxicology vol. (2019). doi: https://doi.org/10.1093/toxsci/kfz139
Herron JM, Hines KM, Tomita H, Seguin RP, Cui JY, Xu L. Multi-omics investigation reveals benzalkonium chloride disinfectants alter sterol and lipid homeostasis in the mouse neonatal brain. Toxicol Sci. 2019 Jun 14; doi: 10.1093/toxsci/kfz139. Epub 2019 Jun 14. PMID: 31199489; PMCID: PMC6736422.
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FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells.

F1000Research

Conrad W, Major MB, Cleary MA, Ferrer M, Roberts B, Marine S, Chung N, Arthur WT, Moon RT, Berndt JD, Chien AJ.
PMID: 24358901
F1000Res. 2013 May 31;2:134. doi: 10.12688/f1000research.2-134.v2. eCollection 2013.

The inability of targeted BRAF inhibitors to produce long-lasting improvement in the clinical outcome of melanoma highlights a need to identify additional approaches to inhibit melanoma growth. Recent studies have shown that activation of the Wnt/β-catenin pathway decreases tumor...

Cite
Conrad W, Major MB, Cleary MA, et al. FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells. F1000Res. 2013;2:134doi: 10.12688/f1000research.2-134.v2.
Conrad, W., Major, M. B., Cleary, M. A., Ferrer, M., Roberts, B., Marine, S., Chung, N., Arthur, W. T., Moon, R. T., Berndt, J. D., & Chien, A. J. (2013). FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells. F1000Research, 2134. https://doi.org/10.12688/f1000research.2-134.v2
Conrad, Willliam, et al. "FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells." F1000Research vol. 2 (2013): 134. doi: https://doi.org/10.12688/f1000research.2-134.v2
Conrad W, Major MB, Cleary MA, Ferrer M, Roberts B, Marine S, Chung N, Arthur WT, Moon RT, Berndt JD, Chien AJ. FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells. F1000Res. 2013 May 31;2:134. doi: 10.12688/f1000research.2-134.v2. eCollection 2013. PMID: 24358901; PMCID: PMC3829391.
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Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems.

Chemical reviews

James EI, Murphree TA, Vorauer C, Engen JR, Guttman M.
PMID: 34493042
Chem Rev. 2021 Sep 07; doi: 10.1021/acs.chemrev.1c00279. Epub 2021 Sep 07.

Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is a widespread tool for structural analysis across academia and the biopharmaceutical industry. By monitoring the exchangeability of backbone amide protons, HDX-MS can reveal information about higher-order structure and dynamics...

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James EI, Murphree TA, Vorauer C, et al. Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems. Chem Rev. 2021;doi: 10.1021/acs.chemrev.1c00279.
James, E. I., Murphree, T. A., Vorauer, C., Engen, J. R., & Guttman, M. (2021). Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems. Chemical reviews, . https://doi.org/10.1021/acs.chemrev.1c00279
James, Ellie I, et al. "Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems." Chemical reviews vol. (2021). doi: https://doi.org/10.1021/acs.chemrev.1c00279
James EI, Murphree TA, Vorauer C, Engen JR, Guttman M. Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems. Chem Rev. 2021 Sep 07; doi: 10.1021/acs.chemrev.1c00279. Epub 2021 Sep 07. PMID: 34493042.
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Development and validation of a LC-MS/MS method for in vivo quantification of meta-iodobenzylguanidine (mIBG).

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

López Quiñones AJ, Shireman LM, Wang J.
PMID: 34530306
J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Sep 01;1181:122927. doi: 10.1016/j.jchromb.2021.122927. Epub 2021 Sep 03.

meta-iodobenzylguanidine (mIBG) is a radiopharmaceutical used for the diagnosis and treatment of neuroendocrine cancers. Previous quantification of mIBG in biodistribution and pharmacokinetic studies mainly relied on the use of radiolabeled mIBG, which involves the handling of highly radioactive materials....

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López Quiñones AJ, Shireman LM, Wang J. Development and validation of a LC-MS/MS method for in vivo quantification of meta-iodobenzylguanidine (mIBG). J Chromatogr B Analyt Technol Biomed Life Sci. 2021;1181:122927doi: 10.1016/j.jchromb.2021.122927.
López Quiñones, A. J., Shireman, L. M., & Wang, J. (2021). Development and validation of a LC-MS/MS method for in vivo quantification of meta-iodobenzylguanidine (mIBG). Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1181122927. https://doi.org/10.1016/j.jchromb.2021.122927
López Quiñones, Antonio J, et al. "Development and validation of a LC-MS/MS method for in vivo quantification of meta-iodobenzylguanidine (mIBG)." Journal of chromatography. B, Analytical technologies in the biomedical and life sciences vol. 1181 (2021): 122927. doi: https://doi.org/10.1016/j.jchromb.2021.122927
López Quiñones AJ, Shireman LM, Wang J. Development and validation of a LC-MS/MS method for in vivo quantification of meta-iodobenzylguanidine (mIBG). J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Sep 01;1181:122927. doi: 10.1016/j.jchromb.2021.122927. Epub 2021 Sep 03. PMID: 34530306; PMCID: PMC8545618.
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Pregnancy Has No Clinically Significant Effect on the Pharmacokinetics of Bupropion or Its Metabolites.

Therapeutic drug monitoring

Fay EE, Czuba LC, Sager JE, Shum S, Stephenson-Famy A, Isoherranen N.
PMID: 33814540
Ther Drug Monit. 2021 Dec 01;43(6):780-788. doi: 10.1097/FTD.0000000000000885.

BACKGROUND: Bupropion (BUP) is a chiral antidepressant and smoking cessation aide with benefits and side effects correlated with parent and active metabolite concentrations. BUP is metabolized by CYP2B6, CYP2C19, and CYP3A4 to hydroxy-BUP (OH-BUP) as well as by 11β-hydroxysteroid...

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Fay EE, Czuba LC, Sager JE, et al. Pregnancy Has No Clinically Significant Effect on the Pharmacokinetics of Bupropion or Its Metabolites. Ther Drug Monit. 2021;43(6):780-788doi: 10.1097/FTD.0000000000000885.
Fay, E. E., Czuba, L. C., Sager, J. E., Shum, S., Stephenson-Famy, A., & Isoherranen, N. (2021). Pregnancy Has No Clinically Significant Effect on the Pharmacokinetics of Bupropion or Its Metabolites. Therapeutic drug monitoring, 43(6), 780-788. https://doi.org/10.1097/FTD.0000000000000885
Fay, Emily E, et al. "Pregnancy Has No Clinically Significant Effect on the Pharmacokinetics of Bupropion or Its Metabolites." Therapeutic drug monitoring vol. 43,6 (2021): 780-788. doi: https://doi.org/10.1097/FTD.0000000000000885
Fay EE, Czuba LC, Sager JE, Shum S, Stephenson-Famy A, Isoherranen N. Pregnancy Has No Clinically Significant Effect on the Pharmacokinetics of Bupropion or Its Metabolites. Ther Drug Monit. 2021 Dec 01;43(6):780-788. doi: 10.1097/FTD.0000000000000885. PMID: 33814540; PMCID: PMC8426418.
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Analytical and functional aspects of protein-ligand interactions: Beyond induced fit and conformational selection.

Archives of biochemistry and biophysics

Redhair M, Atkins WM.
PMID: 34715072
Arch Biochem Biophys. 2021 Dec 15;714:109064. doi: 10.1016/j.abb.2021.109064. Epub 2021 Oct 26.

Ligand-dependent changes in protein conformation are foundational to biology. Historical mechanistic models for substrate-specific proteins are induced fit (IF) and conformational selection (CS), which invoke a change in protein conformation after ligand binds or before ligand binds, respectively. These...

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Redhair M, Atkins WM. Analytical and functional aspects of protein-ligand interactions: Beyond induced fit and conformational selection. Arch Biochem Biophys. 2021;714:109064doi: 10.1016/j.abb.2021.109064.
Redhair, M., & Atkins, W. M. (2021). Analytical and functional aspects of protein-ligand interactions: Beyond induced fit and conformational selection. Archives of biochemistry and biophysics, 714109064. https://doi.org/10.1016/j.abb.2021.109064
Redhair, Michelle, and Atkins, William M. "Analytical and functional aspects of protein-ligand interactions: Beyond induced fit and conformational selection." Archives of biochemistry and biophysics vol. 714 (2021): 109064. doi: https://doi.org/10.1016/j.abb.2021.109064
Redhair M, Atkins WM. Analytical and functional aspects of protein-ligand interactions: Beyond induced fit and conformational selection. Arch Biochem Biophys. 2021 Dec 15;714:109064. doi: 10.1016/j.abb.2021.109064. Epub 2021 Oct 26. PMID: 34715072; PMCID: PMC8629920.
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TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules.

Developmental cell

Nourbakhsh K, Ferreccio AA, Bernard MJ, Yadav S.
PMID: 34879262
Dev Cell. 2021 Dec 20;56(24):3321-3333.e5. doi: 10.1016/j.devcel.2021.11.015. Epub 2021 Dec 07.

The endoplasmic reticulum (ER) depends on extensive association with the microtubule (MT) cytoskeleton for its structure and mitotic inheritance. However, mechanisms that underlie coupling of ER membranes to MTs are poorly understood. We have identified thousand and one amino...

Cite
Nourbakhsh K, Ferreccio AA, Bernard MJ, et al. TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules. Dev Cell. 2021;56(24):3321-3333.e5doi: 10.1016/j.devcel.2021.11.015.
Nourbakhsh, K., Ferreccio, A. A., Bernard, M. J., & Yadav, S. (2021). TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules. Developmental cell, 56(24), 3321-3333.e5. https://doi.org/10.1016/j.devcel.2021.11.015
Nourbakhsh, Kimya, et al. "TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules." Developmental cell vol. 56,24 (2021): 3321-3333.e5. doi: https://doi.org/10.1016/j.devcel.2021.11.015
Nourbakhsh K, Ferreccio AA, Bernard MJ, Yadav S. TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules. Dev Cell. 2021 Dec 20;56(24):3321-3333.e5. doi: 10.1016/j.devcel.2021.11.015. Epub 2021 Dec 07. PMID: 34879262; PMCID: PMC8699727.
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Showing 1 to 12 of 25 entries