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Showing 1 to 12 of 50 entries
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Dopamine measurement during prolonged deep brain stimulation: a proof-of-principle study of paired pulse voltammetry.

Biomedical engineering letters

Paek SB, Knight EJ, Chang SY, Lujan JL, Jang DP, Bennet KE, Lee KH.
PMID: 24688801
Biomed Eng Lett. 2013 Mar 01;3(1):22-31. doi: 10.1007/s13534-013-0086-y.

PURPOSE: Deep Brain Stimulation (DBS) has been effective in treating various neurological and psychiatric disorders; however, its underlying mechanism hasn't been completely understood. Fast scan cyclic voltammetry (FSCV) is a valuable tool to elucidate underlying neurotransmitter mechanisms of DBS,...

The Pathogenesis of Lupus Nephritis.

Journal of clinical & cellular immunology

Sterner RM, Hartono SP, Grande JP.
PMID: 25133068
J Clin Cell Immunol. 2014 Apr;5(2). doi: 10.4172/2155-9899.1000205.

Lupus nephritis is a serious potential feature of systemic lupus erythematous (SLE). Though SLE typically cycles through periods of flares and remission, patients often eventually succumb to end-stage kidney or cardiovascular damage. This review of the pathogenesis of lupus...

Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics.

International journal of endocrinology

Her YF, Maher LJ.
PMID: 26294907
Int J Endocrinol. 2015;2015:296167. doi: 10.1155/2015/296167. Epub 2015 Jul 29.

It is counterintuitive that metabolic defects reducing ATP production can cause, rather than protect from, cancer. Yet this is precisely the case for familial paraganglioma, a form of neuroendocrine malignancy caused by loss of succinate dehydrogenase in the tricarboxylic...

Blocking Kallikrein 6 promotes developmental myelination.

Glia

Yoon H, Triplet EM, Simon WL, Choi CI, Kleppe LS, De Vita E, Miller AK, Scarisbrick IA.
PMID: 34626143
Glia. 2022 Mar;70(3):430-450. doi: 10.1002/glia.24100. Epub 2021 Oct 09.

Kallikrein related peptidase 6 (Klk6) is a secreted serine protease highly expressed in oligodendrocytes and implicated in demyelinating conditions. To gain insights into the significance of Klk6 to oligodendrocyte biology, we investigated the impact of global Klk6 gene knockout...

Manifold medicine: A schema that expands treatment dimensionality.

Drug discovery today

Ung CY, Weiskittel TM, Correia C, Kaufmann SH, Li H.
PMID: 34600126
Drug Discov Today. 2021 Sep 29; doi: 10.1016/j.drudis.2021.09.016. Epub 2021 Sep 29.

Drug discovery currently focuses on identifying new druggable targets and drug repurposing. Here, we illustrate a third domain of drug discovery: the dimensionality of treatment regimens. We formulate a new schema called 'Manifold Medicine', in which disease states are...

Platelet-rich plasma for the treatment of lichen sclerosus.

Plastic and aesthetic research

Villalpando BK, Wyles SP, Schaefer LA, Bodiford KJ, Bruce AJ.
PMID: 34950752
Plast Aesthet Res. 2021;8. doi: 10.20517/2347-9264.2021.86. Epub 2021 Dec 05.

AIM: Evaluate the clinical effectiveness of platelet-rich plasma as a treatment for lichen sclerosus.METHODS: A systematic review was performed. The electronic databases PubMed, Ovid MEDLINERESULTS: Platelet-rich plasma treatment was subjectively reported to improve quality of life, but objective measures...

Critical DNA damaging pathways in tumorigenesis.

Seminars in cancer biology

Kloeber JA, Lou Z.
PMID: 33905873
Semin Cancer Biol. 2021 Apr 24; doi: 10.1016/j.semcancer.2021.04.012. Epub 2021 Apr 24.

The acquisition of DNA damage is an early driving event in tumorigenesis. Premalignant lesions show activated DNA damage responses and inactivation of DNA damage checkpoints promotes malignant transformation. However, DNA damage is also a targetable vulnerability in cancer cells....

Manifold medicine: A schema that expands treatment dimensionality.

Drug discovery today

Ung CY, Weiskittel TM, Correia C, Kaufmann SH, Li H.
PMID: 34600126
Drug Discov Today. 2022 Jan;27(1):8-16. doi: 10.1016/j.drudis.2021.09.016. Epub 2021 Sep 29.

Drug discovery currently focuses on identifying new druggable targets and drug repurposing. Here, we illustrate a third domain of drug discovery: the dimensionality of treatment regimens. We formulate a new schema called 'Manifold Medicine', in which disease states are...

Manifold medicine: A schema that expands treatment dimensionality.

Drug discovery today

Ung CY, Weiskittel TM, Correia C, Kaufmann SH, Li H.
PMID: 34600126
Drug Discov Today. 2022 Jan;27(1):8-16. doi: 10.1016/j.drudis.2021.09.016. Epub 2021 Sep 29.

Drug discovery currently focuses on identifying new druggable targets and drug repurposing. Here, we illustrate a third domain of drug discovery: the dimensionality of treatment regimens. We formulate a new schema called 'Manifold Medicine', in which disease states are...

NKG7 Is a T-cell-Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy.

Cancer immunology research

Wen T, Barham W, Li Y, Zhang H, Gicobi JK, Hirdler JB, Liu X, Ham H, Peterson Martinez KE, Lucien F, Lavoie RR, Li H, Correia C, Monie DD, An Z, Harrington SM, Wu X, Guo R, Dronca RS, Mansfield AS, Yan Y, Markovic SN, Park SS, Sun J, Qin H, Liu MC, Vasmatzis G, Billadeau DD, Dong H.
PMID: 34911739
Cancer Immunol Res. 2021 Dec 15; doi: 10.1158/2326-6066.CIR-21-0539. Epub 2021 Dec 15.

Cytotoxic CD8

Emerging workforce readiness in regenerative healthcare.

Regenerative medicine

Wyles SP, Monie DD, Paradise CR, Meyer FB, Hayden RE, Terzic A.
PMID: 33622054
Regen Med. 2021 Mar;16(3):197-206. doi: 10.2217/rme-2020-0137. Epub 2021 Feb 24.

The biology of regenerative medicine has steadily matured, providing the foundation for randomized clinical trials and translation into validated applications. Today, the growing regenerative armamentarium is poised to impact disease management, yet a gap in training next-generation healthcare providers,...

Pretreatment imaging of peripheral vascular malformations.

Journal of vascular diagnostics

Johnson JB, Cogswell PM, McKusick MA, Binkovitz LA, Riederer SJ, Young PM.
PMID: 25625123
J Vasc Diagn. 2014;2014(2):121-126. doi: 10.2147/JVD.S66467.

Peripheral vascular malformations (VMs) are complex and diverse vascular lesions which require individualized pretreatment planning. Pretreatment imaging using various modalities, especially magnetic resonance imaging and time-resolved magnetic resonance angiography, is a valuable tool for classifying peripheral VMs to allow...

Showing 1 to 12 of 50 entries