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Showing 1 to 12 of 19 entries
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An RNA-Based Fluorescent Biosensor for High-Throughput Analysis of the cGAS-cGAMP-STING Pathway.

Cell chemical biology

Bose D, Su Y, Marcus A, Raulet DH, Hammond MC.
PMID: 27889408
Cell Chem Biol. 2016 Dec 22;23(12):1539-1549. doi: 10.1016/j.chembiol.2016.10.014. Epub 2016 Nov 23.

In mammalian cells, the second messenger (2'-5',3'-5') cyclic guanosine monophosphate-adenosine monophosphate (2',3'-cGAMP), is produced by the cytosolic DNA sensor cGAMP synthase (cGAS), and subsequently bound by the stimulator of interferon genes (STING) to trigger interferon response. Thus, the cGAS-cGAMP-STING...

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Bose D, Su Y, Marcus A, et al. An RNA-Based Fluorescent Biosensor for High-Throughput Analysis of the cGAS-cGAMP-STING Pathway. Cell Chem Biol. 2016;23(12):1539-1549doi: 10.1016/j.chembiol.2016.10.014.
Bose, D., Su, Y., Marcus, A., Raulet, D. H., & Hammond, M. C. (2016). An RNA-Based Fluorescent Biosensor for High-Throughput Analysis of the cGAS-cGAMP-STING Pathway. Cell chemical biology, 23(12), 1539-1549. https://doi.org/10.1016/j.chembiol.2016.10.014
Bose, Debojit, et al. "An RNA-Based Fluorescent Biosensor for High-Throughput Analysis of the cGAS-cGAMP-STING Pathway." Cell chemical biology vol. 23,12 (2016): 1539-1549. doi: https://doi.org/10.1016/j.chembiol.2016.10.014
Bose D, Su Y, Marcus A, Raulet DH, Hammond MC. An RNA-Based Fluorescent Biosensor for High-Throughput Analysis of the cGAS-cGAMP-STING Pathway. Cell Chem Biol. 2016 Dec 22;23(12):1539-1549. doi: 10.1016/j.chembiol.2016.10.014. Epub 2016 Nov 23. PMID: 27889408; PMCID: PMC5397252.
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A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells.

Chemical science

Brewer TF, Burgos-Barragan G, Wit N, Patel KJ, Chang CJ.
PMID: 28580121
Chem Sci. 2017 May 01;8(5):4073-4081. doi: 10.1039/c7sc00748e. Epub 2017 Apr 07.

Formaldehyde (FA) is a major reactive carbonyl species (RCS) that is naturally produced in living systems through a diverse array of cellular pathways that span from epigenetic regulation to the metabolic processing of endogenous metabolites. At the same time,...

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Brewer TF, Burgos-Barragan G, Wit N, et al. A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells. Chem Sci. 2017;8(5):4073-4081doi: 10.1039/c7sc00748e.
Brewer, T. F., Burgos-Barragan, G., Wit, N., Patel, K. J., & Chang, C. J. (2017). A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells. Chemical science, 8(5), 4073-4081. https://doi.org/10.1039/c7sc00748e
Brewer, Thomas F, et al. "A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells." Chemical science vol. 8,5 (2017): 4073-4081. doi: https://doi.org/10.1039/c7sc00748e
Brewer TF, Burgos-Barragan G, Wit N, Patel KJ, Chang CJ. A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells. Chem Sci. 2017 May 01;8(5):4073-4081. doi: 10.1039/c7sc00748e. Epub 2017 Apr 07. PMID: 28580121; PMCID: PMC5434806.
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Ultrasensitive Antibody Detection by Agglutination-PCR (ADAP).

ACS central science

Tsai CT, Robinson PV, Spencer CA, Bertozzi CR.
PMID: 27064772
ACS Cent Sci. 2016 Mar 23;2(3):139-147. doi: 10.1021/acscentsci.5b00340. Epub 2016 Feb 16.

Antibodies are widely used biomarkers for the diagnosis of many diseases. Assays based on solid-phase immobilization of antigens comprise the majority of clinical platforms for antibody detection, but can be undermined by antigen denaturation and epitope masking. These technological...

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Tsai CT, Robinson PV, Spencer CA, et al. Ultrasensitive Antibody Detection by Agglutination-PCR (ADAP). ACS Cent Sci. 2016;2(3):139-147doi: 10.1021/acscentsci.5b00340.
Tsai, C. T., Robinson, P. V., Spencer, C. A., & Bertozzi, C. R. (2016). Ultrasensitive Antibody Detection by Agglutination-PCR (ADAP). ACS central science, 2(3), 139-147. https://doi.org/10.1021/acscentsci.5b00340
Tsai, Cheng-Ting, et al. "Ultrasensitive Antibody Detection by Agglutination-PCR (ADAP)." ACS central science vol. 2,3 (2016): 139-147. doi: https://doi.org/10.1021/acscentsci.5b00340
Tsai CT, Robinson PV, Spencer CA, Bertozzi CR. Ultrasensitive Antibody Detection by Agglutination-PCR (ADAP). ACS Cent Sci. 2016 Mar 23;2(3):139-147. doi: 10.1021/acscentsci.5b00340. Epub 2016 Feb 16. PMID: 27064772; PMCID: PMC4819452.
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Synthesis of Cycloprodigiosin Identifies the Natural Isolate as a Scalemic Mixture.

Organic letters

Johnson RE, de Rond T, Lindsay VN, Keasling JD, Sarpong R.
PMID: 26114660
Org Lett. 2015 Jul 17;17(14):3474-7. doi: 10.1021/acs.orglett.5b01527. Epub 2015 Jun 26.

The enantiomers of the natural product cycloprodigiosin were prepared using an expedient five-step synthetic sequence that takes advantage of a Schöllkopf-Barton-Zard (SBZ) pyrrole annulation with a chiral isocyanoacetate and a nitrocyclohexene derivative. Using chiral HPLC and X-ray crystallographic analyses...

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Johnson RE, de Rond T, Lindsay VN, et al. Synthesis of Cycloprodigiosin Identifies the Natural Isolate as a Scalemic Mixture. Org Lett. 2015;17(14):3474-7doi: 10.1021/acs.orglett.5b01527.
Johnson, R. E., de Rond, T., Lindsay, V. N., Keasling, J. D., & Sarpong, R. (2015). Synthesis of Cycloprodigiosin Identifies the Natural Isolate as a Scalemic Mixture. Organic letters, 17(14), 3474-7. https://doi.org/10.1021/acs.orglett.5b01527
Johnson, Rebecca E, et al. "Synthesis of Cycloprodigiosin Identifies the Natural Isolate as a Scalemic Mixture." Organic letters vol. 17,14 (2015): 3474-7. doi: https://doi.org/10.1021/acs.orglett.5b01527
Johnson RE, de Rond T, Lindsay VN, Keasling JD, Sarpong R. Synthesis of Cycloprodigiosin Identifies the Natural Isolate as a Scalemic Mixture. Org Lett. 2015 Jul 17;17(14):3474-7. doi: 10.1021/acs.orglett.5b01527. Epub 2015 Jun 26. PMID: 26114660; PMCID: PMC4509414.
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A modular platform to develop peptoid-based selective fluorescent metal sensors.

Chemical communications (Cambridge, England)

Knight AS, Kulkarni RU, Zhou EY, Franke JM, Miller EW, Francis MB.
PMID: 28272633
Chem Commun (Camb). 2017 Mar 25;53(24):3477-3480. doi: 10.1039/c7cc00931c. Epub 2017 Mar 08.

Despite the reduction in industrial use of toxic heavy metals, there remain contaminated natural water sources across the world. Herein we present a modular platform for developing selective sensors for toxic metal ions using N-substituted glycine, or peptoid, oligomers...

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Knight AS, Kulkarni RU, Zhou EY, et al. A modular platform to develop peptoid-based selective fluorescent metal sensors. Chem Commun (Camb). 2017;53(24):3477-3480doi: 10.1039/c7cc00931c.
Knight, A. S., Kulkarni, R. U., Zhou, E. Y., Franke, J. M., Miller, E. W., & Francis, M. B. (2017). A modular platform to develop peptoid-based selective fluorescent metal sensors. Chemical communications (Cambridge, England), 53(24), 3477-3480. https://doi.org/10.1039/c7cc00931c
Knight, Abigail S, et al. "A modular platform to develop peptoid-based selective fluorescent metal sensors." Chemical communications (Cambridge, England) vol. 53,24 (2017): 3477-3480. doi: https://doi.org/10.1039/c7cc00931c
Knight AS, Kulkarni RU, Zhou EY, Franke JM, Miller EW, Francis MB. A modular platform to develop peptoid-based selective fluorescent metal sensors. Chem Commun (Camb). 2017 Mar 25;53(24):3477-3480. doi: 10.1039/c7cc00931c. Epub 2017 Mar 08. PMID: 28272633; PMCID: PMC5697149.
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Development of Peptoid-Based Ligands for the Removal of Cadmium from Biological Media.

Chemical science

Knight AS, Zhou EY, Francis MB.
PMID: 26918113
Chem Sci. 2015 Jul 01;7(6):4042-4048. doi: 10.1039/C5SC00676G. Epub 2015 May 14.

Cadmium poisoning poses a serious health concern due to cadmium's increasing industrial use, yet there is currently no recommended treatment. The selective coordination of cadmium in a biological environment-i.e. in the presence of serum ions, small molecules, and proteins-is...

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Knight AS, Zhou EY, Francis MB. Development of Peptoid-Based Ligands for the Removal of Cadmium from Biological Media. Chem Sci. 2015;7(6):4042-4048doi: 10.1039/C5SC00676G.
Knight, A. S., Zhou, E. Y., & Francis, M. B. (2015). Development of Peptoid-Based Ligands for the Removal of Cadmium from Biological Media. Chemical science, 7(6), 4042-4048. https://doi.org/10.1039/C5SC00676G
Knight, Abigail S, et al. "Development of Peptoid-Based Ligands for the Removal of Cadmium from Biological Media." Chemical science vol. 7,6 (2015): 4042-4048. doi: https://doi.org/10.1039/C5SC00676G
Knight AS, Zhou EY, Francis MB. Development of Peptoid-Based Ligands for the Removal of Cadmium from Biological Media. Chem Sci. 2015 Jul 01;7(6):4042-4048. doi: 10.1039/C5SC00676G. Epub 2015 May 14. PMID: 26918113; PMCID: PMC4762606.
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Enzyme Activated Gold Nanoparticles for Versatile Site-Selective Bioconjugation.

Journal of the American Chemical Society

Ramsey AV, Bischoff AJ, Francis MB.
PMID: 33939917
J Am Chem Soc. 2021 May 19;143(19):7342-7350. doi: 10.1021/jacs.0c11678. Epub 2021 May 03.

A new enzymatic method is reported for constructing protein- and DNA-AuNP conjugates. The strategy relies on the initial functionalization of AuNPs with phenols, followed by activation with the enzyme tyrosinase. Using an oxidative coupling reaction, the activated phenols are...

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Ramsey AV, Bischoff AJ, Francis MB. Enzyme Activated Gold Nanoparticles for Versatile Site-Selective Bioconjugation. J Am Chem Soc. 2021;143(19):7342-7350doi: 10.1021/jacs.0c11678.
Ramsey, A. V., Bischoff, A. J., & Francis, M. B. (2021). Enzyme Activated Gold Nanoparticles for Versatile Site-Selective Bioconjugation. Journal of the American Chemical Society, 143(19), 7342-7350. https://doi.org/10.1021/jacs.0c11678
Ramsey, Alexandra V, et al. "Enzyme Activated Gold Nanoparticles for Versatile Site-Selective Bioconjugation." Journal of the American Chemical Society vol. 143,19 (2021): 7342-7350. doi: https://doi.org/10.1021/jacs.0c11678
Ramsey AV, Bischoff AJ, Francis MB. Enzyme Activated Gold Nanoparticles for Versatile Site-Selective Bioconjugation. J Am Chem Soc. 2021 May 19;143(19):7342-7350. doi: 10.1021/jacs.0c11678. Epub 2021 May 03. PMID: 33939917.
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Overcoming inefficient cellobiose fermentation by cellobiose phosphorylase in the presence of xylose.

Biotechnology for biofuels

Chomvong K, Kordić V, Li X, Bauer S, Gillespie AE, Ha SJ, Oh EJ, Galazka JM, Jin YS, Cate JH.
PMID: 24944578
Biotechnol Biofuels. 2014 Jun 07;7:85. doi: 10.1186/1754-6834-7-85. eCollection 2014.

BACKGROUND: Cellobiose and xylose co-fermentation holds promise for efficiently producing biofuels from plant biomass. Cellobiose phosphorylase (CBP), an intracellular enzyme generally found in anaerobic bacteria, cleaves cellobiose to glucose and glucose-1-phosphate, providing energetic advantages under the anaerobic conditions required...

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Chomvong K, Kordić V, Li X, et al. Overcoming inefficient cellobiose fermentation by cellobiose phosphorylase in the presence of xylose. Biotechnol Biofuels. 2014;7:85doi: 10.1186/1754-6834-7-85.
Chomvong, K., Kordić, V., Li, X., Bauer, S., Gillespie, A. E., Ha, S. J., Oh, E. J., Galazka, J. M., Jin, Y. S., & Cate, J. H. (2014). Overcoming inefficient cellobiose fermentation by cellobiose phosphorylase in the presence of xylose. Biotechnology for biofuels, 785. https://doi.org/10.1186/1754-6834-7-85
Chomvong, Kulika, et al. "Overcoming inefficient cellobiose fermentation by cellobiose phosphorylase in the presence of xylose." Biotechnology for biofuels vol. 7 (2014): 85. doi: https://doi.org/10.1186/1754-6834-7-85
Chomvong K, Kordić V, Li X, Bauer S, Gillespie AE, Ha SJ, Oh EJ, Galazka JM, Jin YS, Cate JH. Overcoming inefficient cellobiose fermentation by cellobiose phosphorylase in the presence of xylose. Biotechnol Biofuels. 2014 Jun 07;7:85. doi: 10.1186/1754-6834-7-85. eCollection 2014. PMID: 24944578; PMCID: PMC4061319.
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Origins of Ca.

Biochemistry

Zhou X, Belavek KJ, Miller EW.
PMID: 34251789
Biochemistry. 2021 Nov 23;60(46):3547-3554. doi: 10.1021/acs.biochem.1c00350. Epub 2021 Jul 12.

In 1980, Roger Tsien published a paper, in this journal [Tsien, R. Y. (1980)

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Zhou X, Belavek KJ, Miller EW. Origins of Ca. Biochemistry. 2021;60(46):3547-3554doi: 10.1021/acs.biochem.1c00350.
Zhou, X., Belavek, K. J., & Miller, E. W. (2021). Origins of Ca. Biochemistry, 60(46), 3547-3554. https://doi.org/10.1021/acs.biochem.1c00350
Zhou, Xinqi, et al. "Origins of Ca." Biochemistry vol. 60,46 (2021): 3547-3554. doi: https://doi.org/10.1021/acs.biochem.1c00350
Zhou X, Belavek KJ, Miller EW. Origins of Ca. Biochemistry. 2021 Nov 23;60(46):3547-3554. doi: 10.1021/acs.biochem.1c00350. Epub 2021 Jul 12. PMID: 34251789; PMCID: PMC8612960.
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Chemical strategies for the covalent modification of filamentous phage.

Frontiers in microbiology

Bernard JM, Francis MB.
PMID: 25566240
Front Microbiol. 2014 Dec 23;5:734. doi: 10.3389/fmicb.2014.00734. eCollection 2014.

Historically filamentous bacteriophage have been known to be the workhorse of phage display due to their ability to link genotype to phenotype. More recently, the filamentous phage scaffold has proven to be powerful outside the realm of phage display...

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Bernard JM, Francis MB. Chemical strategies for the covalent modification of filamentous phage. Front Microbiol. 2014;5:734doi: 10.3389/fmicb.2014.00734.
Bernard, J. M., & Francis, M. B. (2014). Chemical strategies for the covalent modification of filamentous phage. Frontiers in microbiology, 5734. https://doi.org/10.3389/fmicb.2014.00734
Bernard, Jenna M L, and Francis, Matthew B. "Chemical strategies for the covalent modification of filamentous phage." Frontiers in microbiology vol. 5 (2014): 734. doi: https://doi.org/10.3389/fmicb.2014.00734
Bernard JM, Francis MB. Chemical strategies for the covalent modification of filamentous phage. Front Microbiol. 2014 Dec 23;5:734. doi: 10.3389/fmicb.2014.00734. eCollection 2014. PMID: 25566240; PMCID: PMC4274979.
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Thioether Coordination Chemistry for Molecular Imaging of Copper in Biological Systems.

Israel journal of chemistry

Ramos-Torres KM, Kolemen S, Chang CJ.
PMID: 31263315
Isr J Chem. 2016 Oct 01;56(9):724-737. doi: 10.1002/ijch.201600023. Epub 2016 Jul 25.

Copper is an essential element in biological systems. Its potent redox activity renders it necessary for life, but at the same time, misregulation of its cellular pools can lead to oxidative stress implicated in aging and various disease states....

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Ramos-Torres KM, Kolemen S, Chang CJ. Thioether Coordination Chemistry for Molecular Imaging of Copper in Biological Systems. Isr J Chem. 2016;56(9):724-737doi: 10.1002/ijch.201600023.
Ramos-Torres, K. M., Kolemen, S., & Chang, C. J. (2016). Thioether Coordination Chemistry for Molecular Imaging of Copper in Biological Systems. Israel journal of chemistry, 56(9), 724-737. https://doi.org/10.1002/ijch.201600023
Ramos-Torres, Karla M, et al. "Thioether Coordination Chemistry for Molecular Imaging of Copper in Biological Systems." Israel journal of chemistry vol. 56,9 (2016): 724-737. doi: https://doi.org/10.1002/ijch.201600023
Ramos-Torres KM, Kolemen S, Chang CJ. Thioether Coordination Chemistry for Molecular Imaging of Copper in Biological Systems. Isr J Chem. 2016 Oct 01;56(9):724-737. doi: 10.1002/ijch.201600023. Epub 2016 Jul 25. PMID: 31263315; PMCID: PMC6602089.
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A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells.

Chemical science

Wang Z, Detomasi TC, Chang CJ.
PMID: 34163931
Chem Sci. 2020 Dec 15;12(5):1720-1729. doi: 10.1039/d0sc03844j.

Potassium is the most abundant intracellular metal in the body, playing vital roles in regulating intracellular fluid volume, nutrient transport, and cell-to-cell communication through nerve and muscle contraction. On the other hand, aberrant alterations in K

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Wang Z, Detomasi TC, Chang CJ. A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells. Chem Sci. 2020;12(5):1720-1729doi: 10.1039/d0sc03844j.
Wang, Z., Detomasi, T. C., & Chang, C. J. (2020). A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells. Chemical science, 12(5), 1720-1729. https://doi.org/10.1039/d0sc03844j
Wang, Zeming, et al. "A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells." Chemical science vol. 12,5 (2020): 1720-1729. doi: https://doi.org/10.1039/d0sc03844j
Wang Z, Detomasi TC, Chang CJ. A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells. Chem Sci. 2020 Dec 15;12(5):1720-1729. doi: 10.1039/d0sc03844j. PMID: 34163931; PMCID: PMC8179100.
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Showing 1 to 12 of 19 entries