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The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy.

Epilepsy research and treatment

Lucchese G, Spinosa JP, Kanduc D.
PMID: 24982805
Epilepsy Res Treat. 2014;2014:236309. doi: 10.1155/2014/236309. Epub 2014 Jun 01.

Sequence matching analyses show that Clostridium tetani neurotoxin shares numerous pentapeptides (68, including multiple occurrences) with 42 human proteins that, when altered, have been associated with epilepsy. Such a peptide sharing is higher than expected, nonstochastic, and involves tetanus...

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Lucchese G, Spinosa JP, Kanduc D. The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy. Epilepsy Res Treat. 2014;2014:236309doi: 10.1155/2014/236309.
Lucchese, G., Spinosa, J. P., & Kanduc, D. (2014). The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy. Epilepsy research and treatment, 2014236309. https://doi.org/10.1155/2014/236309
Lucchese, Guglielmo, et al. "The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy." Epilepsy research and treatment vol. 2014 (2014): 236309. doi: https://doi.org/10.1155/2014/236309
Lucchese G, Spinosa JP, Kanduc D. The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy. Epilepsy Res Treat. 2014;2014:236309. doi: 10.1155/2014/236309. Epub 2014 Jun 01. PMID: 24982805; PMCID: PMC4058587.
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Chronic epileptic foci in neocortex: in vivo and in vitro effects of tetanus toxin.

The European journal of neuroscience

Brener K, Amitai Y, Jefferys JG, Gutnick MJ.
PMID: 12106268
Eur J Neurosci. 1991;3(1):47-54. doi: 10.1111/j.1460-9568.1991.tb00810.x.

Injection of 0.2 - 3.0 ng of tetanus toxin into rat parietal neocortex resulted in permanent (> 7 months) changes in the local circuit properties of this tissue. It caused excessive synchronization of neuronal activity. This was seen as...

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Brener K, Amitai Y, Jefferys JG, et al. Chronic epileptic foci in neocortex: in vivo and in vitro effects of tetanus toxin. Eur J Neurosci. 1991;3(1):47-54doi: 10.1111/j.1460-9568.1991.tb00810.x.
Brener, K., Amitai, Y., Jefferys, J. G., & Gutnick, M. J. (1991). Chronic epileptic foci in neocortex: in vivo and in vitro effects of tetanus toxin. The European journal of neuroscience, 3(1), 47-54. https://doi.org/10.1111/j.1460-9568.1991.tb00810.x
Brener, K, et al. "Chronic epileptic foci in neocortex: in vivo and in vitro effects of tetanus toxin." The European journal of neuroscience vol. 3,1 (1991): 47-54. doi: https://doi.org/10.1111/j.1460-9568.1991.tb00810.x
Brener K, Amitai Y, Jefferys JG, Gutnick MJ. Chronic epileptic foci in neocortex: in vivo and in vitro effects of tetanus toxin. Eur J Neurosci. 1991;3(1):47-54. doi: 10.1111/j.1460-9568.1991.tb00810.x. PMID: 12106268.
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Factors Influencing the Production of Tetanus Toxin: Gaseous Products of Growth.

Journal of bacteriology

Mueller JH, Miller PA, Lerner EM.
PMID: 16561553
J Bacteriol. 1948 Jul;56(1):97-8.

No abstract available.

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Mueller JH, Miller PA, Lerner EM. Factors Influencing the Production of Tetanus Toxin: Gaseous Products of Growth. J Bacteriol. 1948;56(1):97-8
Mueller, J. H., Miller, P. A., & Lerner, E. M. (1948). Factors Influencing the Production of Tetanus Toxin: Gaseous Products of Growth. Journal of bacteriology, 56(1), 97-8.
Mueller, J H, et al. "Factors Influencing the Production of Tetanus Toxin: Gaseous Products of Growth." Journal of bacteriology vol. 56,1 (1948): 97-8.
Mueller JH, Miller PA, Lerner EM. Factors Influencing the Production of Tetanus Toxin: Gaseous Products of Growth. J Bacteriol. 1948 Jul;56(1):97-8. PMID: 16561553; PMCID: PMC518549.
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Amino Acid analysis and molecular weight determination of tetanus toxin.

Infection and immunity

Holmes MJ, Ryan WL.
PMID: 16557929
Infect Immun. 1971 Jan;3(1):133-40. doi: 10.1128/iai.3.1.133-140.1971.

A procedure for the isolation of tetanus toxin was developed. The toxin was precipitated with ammonium sulfate and further purified by use of molecular sieve chromatography and preparative disc gel electrophoresis. The degree of purification resulting from these fractionation...

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Holmes MJ, Ryan WL. Amino Acid analysis and molecular weight determination of tetanus toxin. Infect Immun. 1971;3(1):133-40doi: 10.1128/iai.3.1.133-140.1971.
Holmes, M. J., & Ryan, W. L. (1971). Amino Acid analysis and molecular weight determination of tetanus toxin. Infection and immunity, 3(1), 133-40. https://doi.org/10.1128/iai.3.1.133-140.1971
Holmes, M J, and Ryan, W L. "Amino Acid analysis and molecular weight determination of tetanus toxin." Infection and immunity vol. 3,1 (1971): 133-40. doi: https://doi.org/10.1128/iai.3.1.133-140.1971
Holmes MJ, Ryan WL. Amino Acid analysis and molecular weight determination of tetanus toxin. Infect Immun. 1971 Jan;3(1):133-40. doi: 10.1128/iai.3.1.133-140.1971. PMID: 16557929; PMCID: PMC416118.
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Organization and regulation of the neurotoxin genes in Clostridium botulinum and Clostridium tetani.

Anaerobe

Raffestin S, Marvaud JC, Cerrato R, Dupuy B, Popoff MR.
PMID: 16701505
Anaerobe. 2004 Apr;10(2):93-100. doi: 10.1016/j.anaerobe.2004.01.001.

Botulinum and tetanus neurotoxins are structurally and functionally related 150 kDa proteins that are potent inhibitors of neuroexocytosis. Botulinum neurotoxin associates with non-toxic proteins to form complexes of various sizes. The botulinum neurotoxin and non-toxic protein genes are clustered...

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Raffestin S, Marvaud JC, Cerrato R, et al. Organization and regulation of the neurotoxin genes in Clostridium botulinum and Clostridium tetani. Anaerobe. 2004;10(2):93-100doi: 10.1016/j.anaerobe.2004.01.001.
Raffestin, S., Marvaud, J. C., Cerrato, R., Dupuy, B., & Popoff, M. R. (2004). Organization and regulation of the neurotoxin genes in Clostridium botulinum and Clostridium tetani. Anaerobe, 10(2), 93-100. https://doi.org/10.1016/j.anaerobe.2004.01.001
Raffestin, Stéphanie, et al. "Organization and regulation of the neurotoxin genes in Clostridium botulinum and Clostridium tetani." Anaerobe vol. 10,2 (2004): 93-100. doi: https://doi.org/10.1016/j.anaerobe.2004.01.001
Raffestin S, Marvaud JC, Cerrato R, Dupuy B, Popoff MR. Organization and regulation of the neurotoxin genes in Clostridium botulinum and Clostridium tetani. Anaerobe. 2004 Apr;10(2):93-100. doi: 10.1016/j.anaerobe.2004.01.001. PMID: 16701505.
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Clostridial neurotoxins: new tools for dissecting exocytosis.

Trends in cell biology

Niemann H, Blasi J, Jahn R.
PMID: 14731646
Trends Cell Biol. 1994 May;4(5):179-85. doi: 10.1016/0962-8924(94)90203-8.

Tetanus toxin and botulinal toxins are potent inhibitors of neuronal exocytosis. Within the past five years the protein sequences of all eight neurotoxins have been determined, their mode of action as metalloproteases has been established, and their intraneuronal targets...

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Niemann H, Blasi J, Jahn R. Clostridial neurotoxins: new tools for dissecting exocytosis. Trends Cell Biol. 1994;4(5):179-85doi: 10.1016/0962-8924(94)90203-8.
Niemann, H., Blasi, J., & Jahn, R. (1994). Clostridial neurotoxins: new tools for dissecting exocytosis. Trends in cell biology, 4(5), 179-85. https://doi.org/10.1016/0962-8924(94)90203-8
Niemann, H, et al. "Clostridial neurotoxins: new tools for dissecting exocytosis." Trends in cell biology vol. 4,5 (1994): 179-85. doi: https://doi.org/10.1016/0962-8924(94)90203-8
Niemann H, Blasi J, Jahn R. Clostridial neurotoxins: new tools for dissecting exocytosis. Trends Cell Biol. 1994 May;4(5):179-85. doi: 10.1016/0962-8924(94)90203-8. PMID: 14731646.
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PRODUCTION OF TETANUS TOXIN ON PEPTONE-FREE MEDIA.

The Journal of clinical investigation

Mueller JH, Schoenbach EB, Jezukawicz JJ, Miller PA.
PMID: 16695008
J Clin Invest. 1943 Mar;22(2):315-8. doi: 10.1172/JCI101397.

No abstract available.

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Mueller JH, Schoenbach EB, Jezukawicz JJ, et al. PRODUCTION OF TETANUS TOXIN ON PEPTONE-FREE MEDIA. J Clin Invest. 1943;22(2):315-8doi: 10.1172/JCI101397.
Mueller, J. H., Schoenbach, E. B., Jezukawicz, J. J., & Miller, P. A. (1943). PRODUCTION OF TETANUS TOXIN ON PEPTONE-FREE MEDIA. The Journal of clinical investigation, 22(2), 315-8. https://doi.org/10.1172/JCI101397
Mueller, J H, et al. "PRODUCTION OF TETANUS TOXIN ON PEPTONE-FREE MEDIA." The Journal of clinical investigation vol. 22,2 (1943): 315-8. doi: https://doi.org/10.1172/JCI101397
Mueller JH, Schoenbach EB, Jezukawicz JJ, Miller PA. PRODUCTION OF TETANUS TOXIN ON PEPTONE-FREE MEDIA. J Clin Invest. 1943 Mar;22(2):315-8. doi: 10.1172/JCI101397. PMID: 16695008; PMCID: PMC435241.
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The effect of tetanus toxin on the choline esterase activity of the muscles of rats.

The Journal of physiology

Martini E, Torda C, Zironi A.
PMID: 16995125
J Physiol. 1939 Jul 14;96(2):168-71. doi: 10.1113/jphysiol.1939.sp003767.

No abstract available.

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Martini E, Torda C, Zironi A. The effect of tetanus toxin on the choline esterase activity of the muscles of rats. J Physiol. 1939;96(2):168-71doi: 10.1113/jphysiol.1939.sp003767.
Martini, E., Torda, C., & Zironi, A. (1939). The effect of tetanus toxin on the choline esterase activity of the muscles of rats. The Journal of physiology, 96(2), 168-71. https://doi.org/10.1113/jphysiol.1939.sp003767
Martini, E, et al. "The effect of tetanus toxin on the choline esterase activity of the muscles of rats." The Journal of physiology vol. 96,2 (1939): 168-71. doi: https://doi.org/10.1113/jphysiol.1939.sp003767
Martini E, Torda C, Zironi A. The effect of tetanus toxin on the choline esterase activity of the muscles of rats. J Physiol. 1939 Jul 14;96(2):168-71. doi: 10.1113/jphysiol.1939.sp003767. PMID: 16995125; PMCID: PMC1393853.
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Pre-emptive treatment for Clostridium tetani: importance of early recognition and treatment in the community.

BMJ case reports

Laverse E, Dhamija K, Meyers M, Grant K.
PMID: 21686979
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.03.2009.1649. Epub 2009 Jun 11.

The case of a 79-year-old woman with neurotoxin producing Clostridium tetani identified in a lower limb laceration that was promptly treated is presented; the patient developed no symptoms of tetanus. Her antibody levels were measured as 0.01 U/ml (protective...

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Laverse E, Dhamija K, Meyers M, et al. Pre-emptive treatment for Clostridium tetani: importance of early recognition and treatment in the community. BMJ Case Rep. 2009;2009doi: 10.1136/bcr.03.2009.1649.
Laverse, E., Dhamija, K., Meyers, M., & Grant, K. (2009). Pre-emptive treatment for Clostridium tetani: importance of early recognition and treatment in the community. BMJ case reports, 2009. https://doi.org/10.1136/bcr.03.2009.1649
Laverse, Etienne, et al. "Pre-emptive treatment for Clostridium tetani: importance of early recognition and treatment in the community." BMJ case reports vol. 2009 (2009). doi: https://doi.org/10.1136/bcr.03.2009.1649
Laverse E, Dhamija K, Meyers M, Grant K. Pre-emptive treatment for Clostridium tetani: importance of early recognition and treatment in the community. BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.03.2009.1649. Epub 2009 Jun 11. PMID: 21686979; PMCID: PMC3028174.
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The Stability of Tetanus Toxin in 50% Glycerine and of Tetanus Antitoxin in Saturated Salt Solution.

The Journal of hygiene

Macconkey AT.
PMID: 20474825
J Hyg (Lond). 1924 Jul;22(4):473-6. doi: 10.1017/s0022172400008408.

No abstract available.

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Macconkey AT. The Stability of Tetanus Toxin in 50% Glycerine and of Tetanus Antitoxin in Saturated Salt Solution. J Hyg (Lond). 1924;22(4):473-6doi: 10.1017/s0022172400008408.
Macconkey, A. T. (1924). The Stability of Tetanus Toxin in 50% Glycerine and of Tetanus Antitoxin in Saturated Salt Solution. The Journal of hygiene, 22(4), 473-6. https://doi.org/10.1017/s0022172400008408
Macconkey, A T. "The Stability of Tetanus Toxin in 50% Glycerine and of Tetanus Antitoxin in Saturated Salt Solution." The Journal of hygiene vol. 22,4 (1924): 473-6. doi: https://doi.org/10.1017/s0022172400008408
Macconkey AT. The Stability of Tetanus Toxin in 50% Glycerine and of Tetanus Antitoxin in Saturated Salt Solution. J Hyg (Lond). 1924 Jul;22(4):473-6. doi: 10.1017/s0022172400008408. PMID: 20474825; PMCID: PMC2167544.
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Ex vivo release of GABA from tetanus toxin-induced chronic epileptic foci decreased during the active seizure phase.

Neurochemistry international

Jefferys JG, Mitchell P, O'Hara L, Tiley C, Hardy J, Jordan SJ, Lynch M, Wadsworth J.
PMID: 20504714
Neurochem Int. 1991;18(3):373-9. doi: 10.1016/0197-0186(91)90169-e.

Injecting a few mouse LD(50) of tetanus toxin into rat hippocampus has been shown to induce a remarkably persistent sequence of functional changes which provide a chronic model of limbic epilepsy. Here we have measured the release of amino...

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Jefferys JG, Mitchell P, O'Hara L, et al. Ex vivo release of GABA from tetanus toxin-induced chronic epileptic foci decreased during the active seizure phase. Neurochem Int. 1991;18(3):373-9doi: 10.1016/0197-0186(91)90169-e.
Jefferys, J. G., Mitchell, P., O'Hara, L., Tiley, C., Hardy, J., Jordan, S. J., Lynch, M., & Wadsworth, J. (1991). Ex vivo release of GABA from tetanus toxin-induced chronic epileptic foci decreased during the active seizure phase. Neurochemistry international, 18(3), 373-9. https://doi.org/10.1016/0197-0186(91)90169-e
Jefferys, J G, et al. "Ex vivo release of GABA from tetanus toxin-induced chronic epileptic foci decreased during the active seizure phase." Neurochemistry international vol. 18,3 (1991): 373-9. doi: https://doi.org/10.1016/0197-0186(91)90169-e
Jefferys JG, Mitchell P, O'Hara L, Tiley C, Hardy J, Jordan SJ, Lynch M, Wadsworth J. Ex vivo release of GABA from tetanus toxin-induced chronic epileptic foci decreased during the active seizure phase. Neurochem Int. 1991;18(3):373-9. doi: 10.1016/0197-0186(91)90169-e. PMID: 20504714.
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THE ROLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : V. PHENOMENA OF PASSIVE IMMUNITY IN BLOCKED AND SPLENECTOMIZED MICE.

The Journal of experimental medicine

Jungeblut CW.
PMID: 19869412
J Exp Med. 1928 Jan 31;47(2):261-72. doi: 10.1084/jem.47.2.261.

1. Blockade of the reticulo-endothelial system by means of one intravenous injection of India ink as well as splenectomy did not alter the course of either Pneumococcus Type I infection or tetanus intoxication in mice. 2. The protective action...

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Jungeblut CW. THE ROLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : V. PHENOMENA OF PASSIVE IMMUNITY IN BLOCKED AND SPLENECTOMIZED MICE. J Exp Med. 1928;47(2):261-72doi: 10.1084/jem.47.2.261.
Jungeblut, C. W. (1928). THE ROLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : V. PHENOMENA OF PASSIVE IMMUNITY IN BLOCKED AND SPLENECTOMIZED MICE. The Journal of experimental medicine, 47(2), 261-72. https://doi.org/10.1084/jem.47.2.261
Jungeblut, C W. "THE ROLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : V. PHENOMENA OF PASSIVE IMMUNITY IN BLOCKED AND SPLENECTOMIZED MICE." The Journal of experimental medicine vol. 47,2 (1928): 261-72. doi: https://doi.org/10.1084/jem.47.2.261
Jungeblut CW. THE ROLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : V. PHENOMENA OF PASSIVE IMMUNITY IN BLOCKED AND SPLENECTOMIZED MICE. J Exp Med. 1928 Jan 31;47(2):261-72. doi: 10.1084/jem.47.2.261. PMID: 19869412; PMCID: PMC2131355.
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Showing 1 to 12 of 112 entries