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[4 + 2] Cycloaddition of Vinylphosphine Oxides to α-Oxy- o-xylylene as a route to Phosphorylated Naphthyl and Biaryl Scaffolds.

The Journal of organic chemistry

Frynas S, Łastawiecka E, Kozioł AE, Flis A, Pietrusiewicz KM.
PMID: 30633521
J Org Chem. 2019 Feb 15;84(4):1818-1832. doi: 10.1021/acs.joc.8b02659. Epub 2019 Jan 25.

α-Oxy- o-xylylene, a highly reactive diene readily accessible from benzocyclobutenol, undergoes Diels-Alder reaction with vinylphosphine oxides, yielding the corresponding 2-phosphorylated 1-hydroxy-1,2,3,4-tetrahydronaphthalenes in excellent yields. Use of unsubstituted and trans-2-aryl-substituted vinylphosphine oxides leads to cycloadducts with complete regioselectivity and with...

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Frynas S, Łastawiecka E, Kozioł AE, et al. [4 + 2] Cycloaddition of Vinylphosphine Oxides to α-Oxy- o-xylylene as a route to Phosphorylated Naphthyl and Biaryl Scaffolds. J Org Chem. 2019;84(4):1818-1832doi: 10.1021/acs.joc.8b02659.
Frynas, S., Łastawiecka, E., Kozioł, A. E., Flis, A., & Pietrusiewicz, K. M. (2019). [4 + 2] Cycloaddition of Vinylphosphine Oxides to α-Oxy- o-xylylene as a route to Phosphorylated Naphthyl and Biaryl Scaffolds. The Journal of organic chemistry, 84(4), 1818-1832. https://doi.org/10.1021/acs.joc.8b02659
Frynas, Sławomir, et al. "[4 + 2] Cycloaddition of Vinylphosphine Oxides to α-Oxy- o-xylylene as a route to Phosphorylated Naphthyl and Biaryl Scaffolds." The Journal of organic chemistry vol. 84,4 (2019): 1818-1832. doi: https://doi.org/10.1021/acs.joc.8b02659
Frynas S, Łastawiecka E, Kozioł AE, Flis A, Pietrusiewicz KM. [4 + 2] Cycloaddition of Vinylphosphine Oxides to α-Oxy- o-xylylene as a route to Phosphorylated Naphthyl and Biaryl Scaffolds. J Org Chem. 2019 Feb 15;84(4):1818-1832. doi: 10.1021/acs.joc.8b02659. Epub 2019 Jan 25. PMID: 30633521.
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Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis.

European journal of medicinal chemistry

Sutherland HS, Lu GL, Tong AST, Conole D, Franzblau SG, Upton AM, Lotlikar MU, Cooper CB, Palmer BD, Choi PJ, Denny WA.
PMID: 34963068
Eur J Med Chem. 2021 Dec 21;229:114059. doi: 10.1016/j.ejmech.2021.114059. Epub 2021 Dec 21.

Drug resistant tuberculsosis (TB) is global health crisis that demands novel treatment strategies. Bacterial ATP synthase inhibitors such as bedaquiline and next-generation analogues (such as TBAJ-876) have shown promising efficacy in patient populations and preclinical studies, respectively, suggesting that...

Cite
Sutherland HS, Lu GL, Tong AST, et al. Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis. Eur J Med Chem. 2021;229:114059doi: 10.1016/j.ejmech.2021.114059.
Sutherland, H. S., Lu, G. L., Tong, A. S. T., Conole, D., Franzblau, S. G., Upton, A. M., Lotlikar, M. U., Cooper, C. B., Palmer, B. D., Choi, P. J., & Denny, W. A. (2021). Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis. European journal of medicinal chemistry, 229114059. https://doi.org/10.1016/j.ejmech.2021.114059
Sutherland, Hamish S, et al. "Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis." European journal of medicinal chemistry vol. 229 (2021): 114059. doi: https://doi.org/10.1016/j.ejmech.2021.114059
Sutherland HS, Lu GL, Tong AST, Conole D, Franzblau SG, Upton AM, Lotlikar MU, Cooper CB, Palmer BD, Choi PJ, Denny WA. Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis. Eur J Med Chem. 2021 Dec 21;229:114059. doi: 10.1016/j.ejmech.2021.114059. Epub 2021 Dec 21. PMID: 34963068.
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Hybrid Catalysis Enabling Room-Temperature Hydrogen Gas Release from N-Heterocycles and Tetrahydronaphthalenes.

Journal of the American Chemical Society

Kato S, Saga Y, Kojima M, Fuse H, Matsunaga S, Fukatsu A, Kondo M, Masaoka S, Kanai M.
PMID: 28139917
J Am Chem Soc. 2017 Feb 15;139(6):2204-2207. doi: 10.1021/jacs.7b00253. Epub 2017 Feb 06.

Hybrid catalyst systems to achieve acceptorless dehydrogenation of N-heterocycles and tetrahydronaphthalenes-model substrates for liquid organic hydrogen carriers-were developed. A binary hybrid catalysis comprising an acridinium photoredox catalyst and a Pd metal catalyst was effective for the dehydrogenation of N-heterocycles,...

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Kato S, Saga Y, Kojima M, et al. Hybrid Catalysis Enabling Room-Temperature Hydrogen Gas Release from N-Heterocycles and Tetrahydronaphthalenes. J Am Chem Soc. 2017;139(6):2204-2207doi: 10.1021/jacs.7b00253.
Kato, S., Saga, Y., Kojima, M., Fuse, H., Matsunaga, S., Fukatsu, A., Kondo, M., Masaoka, S., & Kanai, M. (2017). Hybrid Catalysis Enabling Room-Temperature Hydrogen Gas Release from N-Heterocycles and Tetrahydronaphthalenes. Journal of the American Chemical Society, 139(6), 2204-2207. https://doi.org/10.1021/jacs.7b00253
Kato, Shota, et al. "Hybrid Catalysis Enabling Room-Temperature Hydrogen Gas Release from N-Heterocycles and Tetrahydronaphthalenes." Journal of the American Chemical Society vol. 139,6 (2017): 2204-2207. doi: https://doi.org/10.1021/jacs.7b00253
Kato S, Saga Y, Kojima M, Fuse H, Matsunaga S, Fukatsu A, Kondo M, Masaoka S, Kanai M. Hybrid Catalysis Enabling Room-Temperature Hydrogen Gas Release from N-Heterocycles and Tetrahydronaphthalenes. J Am Chem Soc. 2017 Feb 15;139(6):2204-2207. doi: 10.1021/jacs.7b00253. Epub 2017 Feb 06. PMID: 28139917.
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Manganese(III)-mediated phosphinoyl radical reactions for stereoselective synthesis of phosphinoylated tetrahydronaphthalenes.

Chemical communications (Cambridge, England)

Pan XQ, Wang L, Zou JP, Zhang W.
PMID: 21633750
Chem Commun (Camb). 2011 Jul 21;47(27):7875-7. doi: 10.1039/c1cc12343b. Epub 2011 Jun 01.

Reactions of diphenylphosphinoyl radicals with 5-aryl-2-pentenoates or β-phenylethylene styrenes generate trans-substituted tetrahydronaphthalenes through a cascade reaction sequence.

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Pan XQ, Wang L, Zou JP, et al. Manganese(III)-mediated phosphinoyl radical reactions for stereoselective synthesis of phosphinoylated tetrahydronaphthalenes. Chem Commun (Camb). 2011;47(27):7875-7doi: 10.1039/c1cc12343b.
Pan, X. Q., Wang, L., Zou, J. P., & Zhang, W. (2011). Manganese(III)-mediated phosphinoyl radical reactions for stereoselective synthesis of phosphinoylated tetrahydronaphthalenes. Chemical communications (Cambridge, England), 47(27), 7875-7. https://doi.org/10.1039/c1cc12343b
Pan, Xiang-Qiang, et al. "Manganese(III)-mediated phosphinoyl radical reactions for stereoselective synthesis of phosphinoylated tetrahydronaphthalenes." Chemical communications (Cambridge, England) vol. 47,27 (2011): 7875-7. doi: https://doi.org/10.1039/c1cc12343b
Pan XQ, Wang L, Zou JP, Zhang W. Manganese(III)-mediated phosphinoyl radical reactions for stereoselective synthesis of phosphinoylated tetrahydronaphthalenes. Chem Commun (Camb). 2011 Jul 21;47(27):7875-7. doi: 10.1039/c1cc12343b. Epub 2011 Jun 01. PMID: 21633750.
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Recent advances in the benzannulation of substituted 3-alkoxycarbonyl-3,5-hexadienoic acids and 3-alkoxycarbonylhex-3-en-5-ynoic acids to polysubstituted aromatics.

Chemistry (Weinheim an der Bergstrasse, Germany)

Serra S, Fuganti C, Brenna E.
PMID: 17639548
Chemistry. 2007;13(24):6782-91. doi: 10.1002/chem.200700735.

The benzannulation reactions of substituted 3-alkoxycarbonyl-3,5-hexadienoic and 3-alkoxycarbonylhex-3-en-5-ynoic acids offer a straightforward access to various polysubstituted aromatic compounds. The process is very flexible, and can be applied to the regiospecific preparation of oligoaryls, naphthalenes, ring-fused heterocycles, chiral tetrahydronaphthalenes, C-aryl-glycosides...

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Serra S, Fuganti C, Brenna E. Recent advances in the benzannulation of substituted 3-alkoxycarbonyl-3,5-hexadienoic acids and 3-alkoxycarbonylhex-3-en-5-ynoic acids to polysubstituted aromatics. Chemistry. 2007;13(24):6782-91doi: 10.1002/chem.200700735.
Serra, S., Fuganti, C., & Brenna, E. (2007). Recent advances in the benzannulation of substituted 3-alkoxycarbonyl-3,5-hexadienoic acids and 3-alkoxycarbonylhex-3-en-5-ynoic acids to polysubstituted aromatics. Chemistry (Weinheim an der Bergstrasse, Germany), 13(24), 6782-91. https://doi.org/10.1002/chem.200700735
Serra, Stefano, et al. "Recent advances in the benzannulation of substituted 3-alkoxycarbonyl-3,5-hexadienoic acids and 3-alkoxycarbonylhex-3-en-5-ynoic acids to polysubstituted aromatics." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 13,24 (2007): 6782-91. doi: https://doi.org/10.1002/chem.200700735
Serra S, Fuganti C, Brenna E. Recent advances in the benzannulation of substituted 3-alkoxycarbonyl-3,5-hexadienoic acids and 3-alkoxycarbonylhex-3-en-5-ynoic acids to polysubstituted aromatics. Chemistry. 2007;13(24):6782-91. doi: 10.1002/chem.200700735. PMID: 17639548.
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Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis.

European journal of medicinal chemistry

Sutherland HS, Lu GL, Tong AST, Conole D, Franzblau SG, Upton AM, Lotlikar MU, Cooper CB, Palmer BD, Choi PJ, Denny WA.
PMID: 34963068
Eur J Med Chem. 2021 Dec 21;229:114059. doi: 10.1016/j.ejmech.2021.114059. Epub 2021 Dec 21.

Drug resistant tuberculsosis (TB) is global health crisis that demands novel treatment strategies. Bacterial ATP synthase inhibitors such as bedaquiline and next-generation analogues (such as TBAJ-876) have shown promising efficacy in patient populations and preclinical studies, respectively, suggesting that...

Cite
Sutherland HS, Lu GL, Tong AST, et al. Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis. Eur J Med Chem. 2021;229:114059doi: 10.1016/j.ejmech.2021.114059.
Sutherland, H. S., Lu, G. L., Tong, A. S. T., Conole, D., Franzblau, S. G., Upton, A. M., Lotlikar, M. U., Cooper, C. B., Palmer, B. D., Choi, P. J., & Denny, W. A. (2021). Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis. European journal of medicinal chemistry, 229114059. https://doi.org/10.1016/j.ejmech.2021.114059
Sutherland, Hamish S, et al. "Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis." European journal of medicinal chemistry vol. 229 (2021): 114059. doi: https://doi.org/10.1016/j.ejmech.2021.114059
Sutherland HS, Lu GL, Tong AST, Conole D, Franzblau SG, Upton AM, Lotlikar MU, Cooper CB, Palmer BD, Choi PJ, Denny WA. Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis. Eur J Med Chem. 2021 Dec 21;229:114059. doi: 10.1016/j.ejmech.2021.114059. Epub 2021 Dec 21. PMID: 34963068.
Copy Download .nbib Format: NLM
Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis.

European journal of medicinal chemistry

Sutherland HS, Lu GL, Tong AST, Conole D, Franzblau SG, Upton AM, Lotlikar MU, Cooper CB, Palmer BD, Choi PJ, Denny WA.
PMID: 34963068
Eur J Med Chem. 2021 Dec 21;229:114059. doi: 10.1016/j.ejmech.2021.114059. Epub 2021 Dec 21.

Drug resistant tuberculsosis (TB) is global health crisis that demands novel treatment strategies. Bacterial ATP synthase inhibitors such as bedaquiline and next-generation analogues (such as TBAJ-876) have shown promising efficacy in patient populations and preclinical studies, respectively, suggesting that...

Cite
Sutherland HS, Lu GL, Tong AST, et al. Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis. Eur J Med Chem. 2021;229:114059doi: 10.1016/j.ejmech.2021.114059.
Sutherland, H. S., Lu, G. L., Tong, A. S. T., Conole, D., Franzblau, S. G., Upton, A. M., Lotlikar, M. U., Cooper, C. B., Palmer, B. D., Choi, P. J., & Denny, W. A. (2021). Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis. European journal of medicinal chemistry, 229114059. https://doi.org/10.1016/j.ejmech.2021.114059
Sutherland, Hamish S, et al. "Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis." European journal of medicinal chemistry vol. 229 (2021): 114059. doi: https://doi.org/10.1016/j.ejmech.2021.114059
Sutherland HS, Lu GL, Tong AST, Conole D, Franzblau SG, Upton AM, Lotlikar MU, Cooper CB, Palmer BD, Choi PJ, Denny WA. Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis. Eur J Med Chem. 2021 Dec 21;229:114059. doi: 10.1016/j.ejmech.2021.114059. Epub 2021 Dec 21. PMID: 34963068.
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Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis.

European journal of medicinal chemistry

Sutherland HS, Lu GL, Tong AST, Conole D, Franzblau SG, Upton AM, Lotlikar MU, Cooper CB, Palmer BD, Choi PJ, Denny WA.
PMID: 34963068
Eur J Med Chem. 2021 Dec 21;229:114059. doi: 10.1016/j.ejmech.2021.114059. Epub 2021 Dec 21.

Drug resistant tuberculsosis (TB) is global health crisis that demands novel treatment strategies. Bacterial ATP synthase inhibitors such as bedaquiline and next-generation analogues (such as TBAJ-876) have shown promising efficacy in patient populations and preclinical studies, respectively, suggesting that...

Cite
Sutherland HS, Lu GL, Tong AST, et al. Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis. Eur J Med Chem. 2021;229:114059doi: 10.1016/j.ejmech.2021.114059.
Sutherland, H. S., Lu, G. L., Tong, A. S. T., Conole, D., Franzblau, S. G., Upton, A. M., Lotlikar, M. U., Cooper, C. B., Palmer, B. D., Choi, P. J., & Denny, W. A. (2021). Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis. European journal of medicinal chemistry, 229114059. https://doi.org/10.1016/j.ejmech.2021.114059
Sutherland, Hamish S, et al. "Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis." European journal of medicinal chemistry vol. 229 (2021): 114059. doi: https://doi.org/10.1016/j.ejmech.2021.114059
Sutherland HS, Lu GL, Tong AST, Conole D, Franzblau SG, Upton AM, Lotlikar MU, Cooper CB, Palmer BD, Choi PJ, Denny WA. Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis. Eur J Med Chem. 2021 Dec 21;229:114059. doi: 10.1016/j.ejmech.2021.114059. Epub 2021 Dec 21. PMID: 34963068.
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Formation of aromatic rings through enamine annulation.

Organic letters

Wang C, Kohn H.
PMID: 10880223
Org Lett. 2000 Jun 15;2(12):1773-5. doi: 10.1021/ol000093p.

Condensation of pyrrolidine enamine of ketones with 1, 4-diacetoxy-2-butanone provides a new, concise synthetic route to substituted benzenes, dihydroindenes, tetrahydronaphthalenes, and di- and octahydrophenanthrenes. The reaction produced modest yields with regiocontrol of the secondary amine substituent.

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Wang C, Kohn H. Formation of aromatic rings through enamine annulation. Org Lett. 2000;2(12):1773-5doi: 10.1021/ol000093p.
Wang, C., & Kohn, H. (2000). Formation of aromatic rings through enamine annulation. Organic letters, 2(12), 1773-5. https://doi.org/10.1021/ol000093p
Wang, and Kohn. "Formation of aromatic rings through enamine annulation." Organic letters vol. 2,12 (2000): 1773-5. doi: https://doi.org/10.1021/ol000093p
Wang C, Kohn H. Formation of aromatic rings through enamine annulation. Org Lett. 2000 Jun 15;2(12):1773-5. doi: 10.1021/ol000093p. PMID: 10880223.
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Directed, DDQ-Promoted Benzylic Oxygenations of Tetrahydronaphthalenes.

The Journal of organic chemistry

Ramdayal FD, Kiemle DJ, LaLonde RT.
PMID: 11674529
J Org Chem. 1999 Jun 25;64(13):4607-4609. doi: 10.1021/jo981950u.

Positional preferences for para benzylic oxygenation of tetrahydronaphthalenes by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-aqueous dioxane were investigated by comparing the tetralone products from 6-hydroxy-7-methoxy- and 6-acetoxy-7-methoxy-1,2,3,4-tetrahydronaphthalene. The directing influence by an aromatic substituent on para benzylic oxygenation was in the order OH...

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Ramdayal FD, Kiemle DJ, LaLonde RT. Directed, DDQ-Promoted Benzylic Oxygenations of Tetrahydronaphthalenes. J Org Chem. 1999;64(13):4607-4609doi: 10.1021/jo981950u.
Ramdayal, F. D., Kiemle, D. J., & LaLonde, R. T. (1999). Directed, DDQ-Promoted Benzylic Oxygenations of Tetrahydronaphthalenes. The Journal of organic chemistry, 64(13), 4607-4609. https://doi.org/10.1021/jo981950u
Ramdayal, Frank D., et al. "Directed, DDQ-Promoted Benzylic Oxygenations of Tetrahydronaphthalenes." The Journal of organic chemistry vol. 64,13 (1999): 4607-4609. doi: https://doi.org/10.1021/jo981950u
Ramdayal FD, Kiemle DJ, LaLonde RT. Directed, DDQ-Promoted Benzylic Oxygenations of Tetrahydronaphthalenes. J Org Chem. 1999 Jun 25;64(13):4607-4609. doi: 10.1021/jo981950u. PMID: 11674529.
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[4 + 2] cycloaromatization of 4-bis(methylthio)-3-buten-2-one with active methylene ketones: a simple and facile phenol annulation.

The Journal of organic chemistry

Barun O, Nandi S, Panda K, Ila H, Junjappa H.
PMID: 12126437
J Org Chem. 2002 Jul 26;67(15):5398-401. doi: 10.1021/jo020219r.

A new method for beta-phenol annulation involving base-induced [4C + 2C] cycloaromatization of readily available 4-bis(methylthio)-3-buten-2-one with a variety of cyclic and acyclic active methylene ketones has been reported. Appropriate choice of ketones allows synthesis of diverse frameworks such...

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Barun O, Nandi S, Panda K, et al. [4 + 2] cycloaromatization of 4-bis(methylthio)-3-buten-2-one with active methylene ketones: a simple and facile phenol annulation. J Org Chem. 2002;67(15):5398-401doi: 10.1021/jo020219r.
Barun, O., Nandi, S., Panda, K., Ila, H., & Junjappa, H. (2002). [4 + 2] cycloaromatization of 4-bis(methylthio)-3-buten-2-one with active methylene ketones: a simple and facile phenol annulation. The Journal of organic chemistry, 67(15), 5398-401. https://doi.org/10.1021/jo020219r
Barun, Okram, et al. "[4 + 2] cycloaromatization of 4-bis(methylthio)-3-buten-2-one with active methylene ketones: a simple and facile phenol annulation." The Journal of organic chemistry vol. 67,15 (2002): 5398-401. doi: https://doi.org/10.1021/jo020219r
Barun O, Nandi S, Panda K, Ila H, Junjappa H. [4 + 2] cycloaromatization of 4-bis(methylthio)-3-buten-2-one with active methylene ketones: a simple and facile phenol annulation. J Org Chem. 2002 Jul 26;67(15):5398-401. doi: 10.1021/jo020219r. PMID: 12126437.
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Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis.

European journal of medicinal chemistry

Sutherland HS, Lu GL, Tong AST, Conole D, Franzblau SG, Upton AM, Lotlikar MU, Cooper CB, Palmer BD, Choi PJ, Denny WA.
PMID: 34963068
Eur J Med Chem. 2021 Dec 21;229:114059. doi: 10.1016/j.ejmech.2021.114059. Epub 2021 Dec 21.

Drug resistant tuberculsosis (TB) is global health crisis that demands novel treatment strategies. Bacterial ATP synthase inhibitors such as bedaquiline and next-generation analogues (such as TBAJ-876) have shown promising efficacy in patient populations and preclinical studies, respectively, suggesting that...

Cite
Sutherland HS, Lu GL, Tong AST, et al. Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis. Eur J Med Chem. 2021;229:114059doi: 10.1016/j.ejmech.2021.114059.
Sutherland, H. S., Lu, G. L., Tong, A. S. T., Conole, D., Franzblau, S. G., Upton, A. M., Lotlikar, M. U., Cooper, C. B., Palmer, B. D., Choi, P. J., & Denny, W. A. (2021). Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis. European journal of medicinal chemistry, 229114059. https://doi.org/10.1016/j.ejmech.2021.114059
Sutherland, Hamish S, et al. "Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis." European journal of medicinal chemistry vol. 229 (2021): 114059. doi: https://doi.org/10.1016/j.ejmech.2021.114059
Sutherland HS, Lu GL, Tong AST, Conole D, Franzblau SG, Upton AM, Lotlikar MU, Cooper CB, Palmer BD, Choi PJ, Denny WA. Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis. Eur J Med Chem. 2021 Dec 21;229:114059. doi: 10.1016/j.ejmech.2021.114059. Epub 2021 Dec 21. PMID: 34963068.
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Showing 1 to 12 of 15 entries