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Further Insights into the Oxidative Pathway of Thiocarbonyl-Type Antitubercular Prodrugs: Ethionamide, Thioacetazone, and Isoxyl.

Chemical research in toxicology

de Freitas Paulo T, Duhayon C, de França Lopes LG, Silva Sousa EH, Chauvin R, Bernardes-Génisson V.
PMID: 34319702
Chem Res Toxicol. 2021 Aug 16;34(8):1879-1889. doi: 10.1021/acs.chemrestox.1c00164. Epub 2021 Jul 28.

A chemical activation study of the thiocarbonyl-type antitubercular prodrugs, ethionamide (ETH), thioacetazone (TAZ), and isoxyl (ISO), was performed. Biomimetic oxidation of ethionamide using H

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de Freitas Paulo T, Duhayon C, de França Lopes LG, et al. Further Insights into the Oxidative Pathway of Thiocarbonyl-Type Antitubercular Prodrugs: Ethionamide, Thioacetazone, and Isoxyl. Chem Res Toxicol. 2021;34(8):1879-1889doi: 10.1021/acs.chemrestox.1c00164.
de Freitas Paulo, T., Duhayon, C., de França Lopes, L. G., Silva Sousa, E. H., Chauvin, R., & Bernardes-Génisson, V. (2021). Further Insights into the Oxidative Pathway of Thiocarbonyl-Type Antitubercular Prodrugs: Ethionamide, Thioacetazone, and Isoxyl. Chemical research in toxicology, 34(8), 1879-1889. https://doi.org/10.1021/acs.chemrestox.1c00164
de Freitas Paulo, Tércio, et al. "Further Insights into the Oxidative Pathway of Thiocarbonyl-Type Antitubercular Prodrugs: Ethionamide, Thioacetazone, and Isoxyl." Chemical research in toxicology vol. 34,8 (2021): 1879-1889. doi: https://doi.org/10.1021/acs.chemrestox.1c00164
de Freitas Paulo T, Duhayon C, de França Lopes LG, Silva Sousa EH, Chauvin R, Bernardes-Génisson V. Further Insights into the Oxidative Pathway of Thiocarbonyl-Type Antitubercular Prodrugs: Ethionamide, Thioacetazone, and Isoxyl. Chem Res Toxicol. 2021 Aug 16;34(8):1879-1889. doi: 10.1021/acs.chemrestox.1c00164. Epub 2021 Jul 28. PMID: 34319702.
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Isoniazid and thioacetazone may exhibit antitubercular activity by binding directly with the active site of mycolic acid cyclopropane synthase: Hypothesis based on computational analysis.

Bioinformation

Banerjee D, Bhattacharyya R.
PMID: 23055630
Bioinformation. 2012;8(16):787-9. doi: 10.6026/97320630008787. Epub 2012 Aug 24.

Isoniazid and thioacetazone are the two important antitubercular drugs. In case of thioacetazone it is established that it inhibits mycolic acid cyclopropane synthase but the exact binding site accounting for such inhibition is presently unknown. In case of isoniazid...

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Banerjee D, Bhattacharyya R. Isoniazid and thioacetazone may exhibit antitubercular activity by binding directly with the active site of mycolic acid cyclopropane synthase: Hypothesis based on computational analysis. Bioinformation. 2012;8(16):787-9doi: 10.6026/97320630008787.
Banerjee, D., & Bhattacharyya, R. (2012). Isoniazid and thioacetazone may exhibit antitubercular activity by binding directly with the active site of mycolic acid cyclopropane synthase: Hypothesis based on computational analysis. Bioinformation, 8(16), 787-9. https://doi.org/10.6026/97320630008787
Banerjee, Dibyajyoti, and Bhattacharyya, Rajasri. "Isoniazid and thioacetazone may exhibit antitubercular activity by binding directly with the active site of mycolic acid cyclopropane synthase: Hypothesis based on computational analysis." Bioinformation vol. 8,16 (2012): 787-9. doi: https://doi.org/10.6026/97320630008787
Banerjee D, Bhattacharyya R. Isoniazid and thioacetazone may exhibit antitubercular activity by binding directly with the active site of mycolic acid cyclopropane synthase: Hypothesis based on computational analysis. Bioinformation. 2012;8(16):787-9. doi: 10.6026/97320630008787. Epub 2012 Aug 24. PMID: 23055630; PMCID: PMC3449388.
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Synthesis and evaluation of new fluorinated anti-tubercular compounds.

Iranian journal of pharmaceutical research : IJPR

Esfahanizadeh M, Omidi K, Kauffman J, Gudarzi A, Shahraki Zahedani S, Amidi S, Kobarfard F.
PMID: 24734062
Iran J Pharm Res. 2014;13(1):115-26.

Treatment of tuberculosis (TB) and the discovery of effective new anti-tubercular drugs are among the most urgent priorities in health organizations all over the world. In the present study, fluorinated analogs of some of the most important anti-TB agents...

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Esfahanizadeh M, Omidi K, Kauffman J, et al. Synthesis and evaluation of new fluorinated anti-tubercular compounds. Iran J Pharm Res. 2014;13(1):115-26
Esfahanizadeh, M., Omidi, K., Kauffman, J., Gudarzi, A., Shahraki Zahedani, S., Amidi, S., & Kobarfard, F. (2014). Synthesis and evaluation of new fluorinated anti-tubercular compounds. Iranian journal of pharmaceutical research : IJPR, 13(1), 115-26.
Esfahanizadeh, Marjan, et al. "Synthesis and evaluation of new fluorinated anti-tubercular compounds." Iranian journal of pharmaceutical research : IJPR vol. 13,1 (2014): 115-26.
Esfahanizadeh M, Omidi K, Kauffman J, Gudarzi A, Shahraki Zahedani S, Amidi S, Kobarfard F. Synthesis and evaluation of new fluorinated anti-tubercular compounds. Iran J Pharm Res. 2014;13(1):115-26. PMID: 24734062; PMCID: PMC3985232.
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Showing 1 to 3 of 3 entries