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Showing 1 to 12 of 36 entries
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Imbalance of angiogenesis in diabetic complications: the mechanisms.

International journal of preventive medicine

Tahergorabi Z, Khazaei M.
PMID: 23272281
Int J Prev Med. 2012 Dec;3(12):827-38. doi: 10.4103/2008-7802.104853.

Type 2 diabetes mellitus is a complex disease and a chronic health-care problem. Nowadays, because of alteration of lifestyle such as lack of exercise, intake of high fat diet subsequently obesity and aging population, the prevalence of diabetes mellitus...

A thrombospondin in the anthozoan Nematostella vectensis is associated with the nervous system and upregulated during regeneration.

Biology open

Tucker RP, Hess JF, Gong Q, Garvey K, Shibata B, Adams JC.
PMID: 23430283
Biol Open. 2013 Feb 15;2(2):217-26. doi: 10.1242/bio.20123103. Epub 2012 Dec 17.

Thrombospondins are multimeric extracellular matrix glycoproteins that play important roles in development, synaptogenesis and wound healing in mammals. We previously identified four putative thrombospondins in the genome of the starlet sea anemone Nematostella vectensis. This study presents the first...

Dataset for characterization of thrombospondin family in chum salmon (.

Data in brief

Lee SY, Kim YK.
PMID: 30766905
Data Brief. 2019 Jan 09;22:866-870. doi: 10.1016/j.dib.2019.01.008. eCollection 2019 Feb.

An extracellular matrix (ECM) is composed of multiprotein networks for stable interactions between cells. Thrombospondins (TSPs) are known to exert extracellular matrix interactions, synapse formation, angiogenesis and immune response in vertebrates. A five TSP gene family is divided into...

The Integrative Analysis of Thrombospondin Family Genes in Pan-Cancer Reveals that THBS2 Facilitates Gastrointestinal Cancer Metastasis.

Journal of oncology

Zhang C, Hu C, Su K, Wang K, Du X, Xing B, Liu X.
PMID: 34804159
J Oncol. 2021 Nov 10;2021:4405491. doi: 10.1155/2021/4405491. eCollection 2021.

Recent cancer studies have found that the thrombospondin (THBS) family, including THBS1, THBS2, THBS3, THBS4, and THBS5, play vital roles in the development and progression of human cancers. However, their relationships with tumor stage, prognosis, and tumor immunity in...

Functional role of periostin in development and wound repair: implications for connective tissue disease.

Journal of cell communication and signaling

Hamilton DW.
PMID: 18642132
J Cell Commun Signal. 2008 Jun;2(1):9-17. doi: 10.1007/s12079-008-0023-5. Epub 2008 Jul 20.

Integrity of the extracellular matrix (ECM) is essential for maintaining the normal structure and function of connective tissues. ECM is secreted locally by cells and organized into a complex meshwork providing physical support to cells, tissues, and organs. Initially...

Effects of cyanocobalamin and its combination with morphine on neuropathic rats and the relationship between these effects and thrombospondin-4 expression.

The Korean journal of pain

Düzenli N, Ülker S, Şengül G, Kayhan B, Önal A.
PMID: 34966013
Korean J Pain. 2022 Jan 01;35(1):66-77. doi: 10.3344/kjp.2022.35.1.66.

BACKGROUND: Thrombospondin-4 (TSP4) upregulates in the spinal cord following peripheral nerve injury and contributes to the development of neuropathic pain (NP). We investigated the effects of cyanocobalamin alone or in combination with morphine on pain and the relationship between...

Epicardial and endothelial cell activation concurs with extracellular matrix remodeling in atrial fibrillation.

Clinical and translational medicine

van den Berg NWE, Kawasaki M, Fabrizi B, Nariswari FA, Verduijn AC, Neefs J, Wesselink R, Al-Shama RFM, van der Wal AC, de Boer OJ, Aten J, Driessen AHG, Jongejan A, de Groot JR.
PMID: 34841686
Clin Transl Med. 2021 Nov;11(11):e558. doi: 10.1002/ctm2.558.

BACKGROUND: Improved understanding of the interconnectedness of structural remodeling processes in atrial fibrillation (AF) in patients could identify targets for future therapies.METHODS: We present transcriptome sequencing of atrial tissues of patients without AF, with paroxysmal AF, and persistent AF...

mRNA Expression of thrombospondin 1, 2 and 3 from proximal to distal in human abdominal aortic aneurysm - preliminary report.

Acta biochimica Polonica

Auguściak-Duma A, Lesiak M, Stępień K, Gutmajster E, Sieroń AL.
PMID: 34669362
Acta Biochim Pol. 2021 Oct 20;68(4):745-750. doi: 10.18388/abp.2020_5645.

Abdominal aortic aneurysm is a process involving the disruption and reconstruction of the extracellular matrix and the apoptosis of smooth muscle cells under the strong influence of the immune system. Thrombospondins are proteins that influence a wide range of...

Differential intolerance to loss of function and missense mutations in genes that encode human matricellular proteins.

Journal of cell communication and signaling

Kaur S, Roberts DD.
PMID: 33415696
J Cell Commun Signal. 2021 Mar;15(1):93-105. doi: 10.1007/s12079-020-00598-9. Epub 2021 Jan 07.

Targeted gene disruption in mice has provided valuable insights into the functions of matricellular proteins. Apart from missense and loss of function mutations that have been associated with inherited diseases, however, their functions in humans remain unclear. The availability...

Thrombospondins in the heart: potential functions in cardiac remodeling.

Journal of cell communication and signaling

Schellings MW, van Almen GC, Sage EH, Heymans S.
PMID: 19798592
J Cell Commun Signal. 2009 Dec;3(3):201-13. doi: 10.1007/s12079-009-0070-6. Epub 2009 Oct 02.

Cardiac remodeling after myocardial injury involves inflammation, angiogenesis, left ventricular hypertrophy and matrix remodeling. Thrombospondins (TSPs) belong to the group of matricellular proteins, which are non-structural extracellular matrix proteins that modulate cell-matrix interactions and cell function in injured tissues...

Thrombospondins function as regulators of angiogenesis.

Journal of cell communication and signaling

Bornstein P.
PMID: 19798599
J Cell Commun Signal. 2009 Dec;3(3):189-200. doi: 10.1007/s12079-009-0060-8. Epub 2009 Oct 02.

Thrombospondins (TSPs) -1 and -2 were among the first protein inhibitors of angiogenesis to be identified, a property that was subsequently attributed to the interactions of sequences in their type I repeats with endothelial cell-surface receptors. The interactions of...

Negative Regulators of Angiogenesis, Ocular Vascular Homeostasis, and Pathogenesis and Treatment of Exudative AMD.

Journal of ophthalmic & vision research

Farnoodian M, Sorenson CM, Sheibani N.
PMID: 30479719
J Ophthalmic Vis Res. 2018 Oct-Dec;13(4):470-486. doi: 10.4103/jovr.jovr_67_18.

Angiogenesis, the formation of new blood vessels from pre-existing capillaries, is very tightly regulated and normally does not occur except during developmental and reparative processes. This tight regulation is maintained by a balanced production of positive and negative regulators,...

Showing 1 to 12 of 36 entries