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Showing 1 to 8 of 8 entries
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Bioassay of tolazamide for possible carcinogenicity.

National Cancer Institute carcinogenesis technical report series

[No authors listed]
PMID: 12830246
Natl Cancer Inst Carcinog Tech Rep Ser. 1978;51:1-111.

A bioassay of the hypoglycemic drug tolazamide for possible carcinogenicity was conducted by administering the test chemical in feed to Fischer 344 rats and B6C3F1 mice. Groups of 35 rats and 35 mice of each sex were administered tolazamide...

Completing the picture of tolazamide polymorphism under extreme conditions: a low-temperature study.

Acta crystallographica. Section C, Structural chemistry

Fedorov AY, Rychkov DA, Losev EA, Drebushchak TN, Boldyreva EV.
PMID: 31062718
Acta Crystallogr C Struct Chem. 2019 May 01;75:598-608. doi: 10.1107/S2053229619005217. Epub 2019 Apr 29.

We present the results of an experimental and computational study of structural changes in two polymorphs of tolazamide {systematic name: 1-[(azepan-1-ylamino)carbonyl]-4-methylbenzenesulfonamide}, C

Tolazamide and tolbutamide in the control of diabetes.

Canadian Medical Association journal

McKendry JB.
PMID: 20328905
Can Med Assoc J. 1967 May 06;96(18):1286.

No abstract available.

Effect of sulfonylureas administered centrally on the blood glucose level in immobilization stress model.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Sharma N, Sim YB, Park SH, Lim SM, Kim SS, Jung JS, Hong JS, Suh HW.
PMID: 25954123
Korean J Physiol Pharmacol. 2015 May;19(3):197-202. doi: 10.4196/kjpp.2015.19.3.197. Epub 2015 Apr 30.

Sulfonylureas are widely used as an antidiabetic drug. In the present study, the effects of sulfonylurea administered supraspinally on immobilization stress-induced blood glucose level were studied in ICR mice. Mice were once enforced into immobilization stress for 30 min...

Isoenergetic Polymorphism: The Puzzle of Tolazamide as a Case Study.

Chemistry (Weinheim an der Bergstrasse, Germany)

Boldyreva EV, Arkhipov SG, Drebushchak TN, Drebushchak VA, Losev EA, Matvienko AA, Minkov VS, Rychkov DA, Seryotkin YV, Stare J, Zakharov BA.
PMID: 26337712
Chemistry. 2015 Oct 19;21(43):15395-404. doi: 10.1002/chem.201501541. Epub 2015 Sep 04.

In the present case study of tolazamide we illustrate how many seemingly contradictory results that have been obtained from experimental observations and theoretical calculations can finally start forming a consistent picture: a "puzzle put together". For many years, tolazamide...

Insulin monotherapy compared with the addition of oral glucose-lowering agents to insulin for people with type 2 diabetes already on insulin therapy and inadequate glycaemic control.

The Cochrane database of systematic reviews

Vos RC, van Avendonk MJ, Jansen H, Goudswaard AN, van den Donk M, Gorter K, Kerssen A, Rutten GE.
PMID: 27640062
Cochrane Database Syst Rev. 2016 Sep 18;9:CD006992. doi: 10.1002/14651858.CD006992.pub2.

BACKGROUND: It is unclear whether people with type 2 diabetes mellitus on insulin monotherapy who do not achieve adequate glycaemic control should continue insulin as monotherapy or can benefit from adding oral glucose-lowering agents to the insulin therapy.OBJECTIVES: To...

Tolazamide and tolbutamide in the control of diabetes.

Canadian Medical Association journal

Rennie CS, Anderson DO.
PMID: 20328904
Can Med Assoc J. 1967 May 06;96(18):1285-6.

No abstract available.

Virtual Screening of Natural and Synthetic Ligands Against Diabetic Retinopathy by Molecular Interaction With Angiopoietin-2.

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)

Srivastava P, Tiwari A, Trivedi AC, Thakur V, Pant AB, Saxena S.
PMID: 26107766
Asia Pac J Ophthalmol (Phila). 2014 Jul-Aug;3(4):257-9. doi: 10.1097/APO.0000000000000071.

PURPOSE: Diabetic retinopathy (DR) is the most common diabetic eye disease and a leading cause of blindness. The role of angiopoietin-2 a tyrosine kinase receptor is well-reported in angiogenesis during the onset of the disease. The purpose of this...

Showing 1 to 8 of 8 entries