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EloA promotes HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity.

Platelets

Hu L, Zhang W, Xiang Z, Wang Y, Zeng C, Wang X, Tan C, Zhang Y, Li F, Xiao Y, Zhou L, Li J, Wu C, Xiang Y, Xiang L, Zhang X, Wang X, Yang W, Chen M, Ran Q, Li Z, Chen L.
PMID: 34697988
Platelets. 2021 Oct 26;1-9. doi: 10.1080/09537104.2021.1988548. Epub 2021 Oct 26.

Megakaryocytes (MKs) are the unique non-pathological cells that undergo polyploidization in mammals. The polyploid formation is critical for understanding the MK biology, and transcriptional regulation is involved in the differentiation and maturation of MKs. However, little is known about...

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