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Showing 1 to 12 of 89 entries
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Dexamethasone Down-Regulates Expression of Triggering Receptor Expressed on Myeloid Cells-1: Evidence for a TNFα-Related Effect.

Frontiers in public health

Mihailidou I, Pelekanou A, Pistiki A, Spyridaki A, Tzepi IM, Damoraki G, Giamarellos-Bourboulis EJ.
PMID: 24350219
Front Public Health. 2013 Nov 14;1:50. doi: 10.3389/fpubh.2013.00050. eCollection 2013.

OBJECTIVES: To investigate the effect of dexamethasone on triggering receptor expressed on myeloid cells-1 (TREM-1).METHODS: Wild-type and tumor necrosis factor (TNF (-/-)) mice were pre-treated with saline, dexamethasone, or hydrocortisone and exposed to a lethal infection of Pseudomonas aeruginosa....

Correlation between triggering receptor expressed on myeloid cells-1 and clinical disease activity in Chinese patients with ulcerative colitis.

International journal of clinical and experimental medicine

Zhang S, Luo J, Shen B, Li L, Hu C, Li P, Deng C, Zhang F, Qian J, Li Y.
PMID: 25932145
Int J Clin Exp Med. 2015 Feb 15;8(2):2147-55. eCollection 2015.

The need for reliable biomarkers for monitoring disease activity in patients with ulcerative colitis (UC) is increasing. This study aimed at characterizing the correlation between serum sTREM-1 levels and diseases activity in Chinese patients with UC. Consecutive 76 patients...

TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier Dysfunction.

Gastroenterology research and practice

Dang S, Shen Y, Yin K, Zhang J.
PMID: 22611379
Gastroenterol Res Pract. 2012;2012:720865. doi: 10.1155/2012/720865. Epub 2012 May 07.

Severe acute pancreatitis (SAP) can cause intestinal barrier dysfunction (IBD), which significantly increases the disease severity and risk of mortality. We hypothesized that the innate immunity- and inflammatory-related protein-triggering receptor expressed on myeloid cells-1 (TREM-1) contributes to this complication...

Inhibition of Triggering Receptor Expressed on Myeloid Cells 1 Ameliorates Inflammation and Macrophage and Neutrophil Activation in Alcoholic Liver Disease in Mice.

Hepatology communications

Tornai D, Furi I, Shen ZT, Sigalov AB, Coban S, Szabo G.
PMID: 30619998
Hepatol Commun. 2018 Oct 29;3(1):99-115. doi: 10.1002/hep4.1269. eCollection 2019 Jan.

Alcoholic liver disease (ALD) is characterized by macrophage and neutrophil leukocyte recruitment and activation in the liver. Damage- and pathogen-associated molecular patterns contribute to a self-perpetuating proinflammatory state in ALD. Triggering receptor expressed on myeloid cells 1 (TREM-1) is...

PET Agents in Dementia: An Overview.

Seminars in nuclear medicine

van Waarde A, Marcolini S, de Deyn PP, Dierckx RAJO.
PMID: 33500121
Semin Nucl Med. 2021 May;51(3):196-229. doi: 10.1053/j.semnuclmed.2020.12.008. Epub 2021 Jan 23.

This article presents an overview of imaging agents for PET that have been applied for research and diagnostic purposes in patients affected by dementia. Classified by the target which the agents visualize, seven groups of tracers can be distinguished,...

Elevated Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 Level in Patients with Acute Coronary Syndrome (ACS): A Biomarker of Disease Severity and Outcome.

Mediators of inflammation

Shiber S, Kliminski V, Orvin K, Sagy I, Vaturi M, Kornowski R, Drescher M, Molad Y.
PMID: 33814983
Mediators Inflamm. 2021 Mar 15;2021:8872686. doi: 10.1155/2021/8872686. eCollection 2021.

BACKGROUND AND AIMS: Plasma levels of soluble triggering receptor expressed on myeloid cells (sTREM-1) reflect innate immune cell activation. We sought to evaluate sTREM-1 levels in patients with acute coronary syndrome (ACS) and their predictive value for disease severity...

Inhibition of The Interaction Of TREM-1 and eCIRP Attenuates Inflammation and Improves Survival In Hepatic Ischemia/Reperfusion.

Shock (Augusta, Ga.)

Borjas T, Jacob A, Yen H, Patel V, Coppa G, Aziz M, Wang P.
PMID: 34864782
Shock. 2021 Dec 03; doi: 10.1097/SHK.0000000000001894. Epub 2021 Dec 03.

INTRODUCTION: Triggering receptor expressed on myeloid cells-1 (TREM-1) has important implications in sepsis and inflammation and is a novel receptor for extracellular cold-inducible RNA-binding protein (eCIRP). We hypothesize that the inhibition of TREM-1 via its interaction with eCIRP by...

Inhibition of the Interaction of TREM-1 and eCIRP Attenuates Inflammation and Improves Survival in Hepatic Ischemia/Reperfusion.

Shock (Augusta, Ga.)

Borjas T, Jacob A, Yen H, Patel V, Coppa GF, Aziz M, Wang P.
PMID: 34864782
Shock. 2022 Feb 01;57(2):246-255. doi: 10.1097/SHK.0000000000001894.

INTRODUCTION: Triggering receptor expressed on myeloid cells-1 (TREM-1) has important implications in sepsis and inflammation and is a novel receptor for extracellular cold-inducible RNA-binding protein (eCIRP). We hypothesize that the inhibition of TREM-1 via its interaction with eCIRP by...

Transcriptomic Profiling Reveals a Role for TREM-1 Activation in Enterovirus D68 Infection-Induced Proinflammatory Responses.

Frontiers in immunology

Li J, Yang S, Liu S, Chen Y, Liu H, Su Y, Liu R, Cui Y, Song Y, Teng Y, Wang T.
PMID: 34887856
Front Immunol. 2021 Nov 23;12:749618. doi: 10.3389/fimmu.2021.749618. eCollection 2021.

Increasing cases related to the pathogenicity of Enterovirus D68 (EV-D68) have made it a growing worldwide public health concern, especially due to increased severe respiratory illness and acute flaccid myelitis (AFM) in children. There are currently no vaccines or...

sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity.

Viruses

da Silva-Neto PV, de Carvalho JCS, Pimentel VE, Pérez MM, Toro DM, Fraga-Silva TFC, Fuzo CA, Oliveira CNS, Rodrigues LC, Argolo JGM, Carmona-Garcia I, Neto NT, Souza COS, Fernandes TM, Bastos VAF, Degiovani AM, Constant LF, Ostini FM, Feitosa MR, Parra RS, Vilar FC, Gaspar GG, da Rocha JJR, Feres O, Frantz FG, Gerlach RF, Maruyama SR, Russo EMS, Viana AL, Fernandes APM, Santos IKFM, Bonato VLD, Boechat AL, Malheiro A, Sadikot RT, Dias-Baruffi M, Cardoso CRB, Faccioli LH, Sorgi CA, On Behalf Of The Imunocovid Study Group.
PMID: 34960790
Viruses. 2021 Dec 15;13(12). doi: 10.3390/v13122521.

Uncontrolled inflammatory responses play a critical role in coronavirus disease (COVID-19). In this context, because the triggering-receptor expressed on myeloid cells-1 (TREM-1) is considered an intrinsic amplifier of inflammatory signals, this study investigated the role of soluble TREM-1 (sTREM-1)...

Soluble triggering receptor expressed on myeloid cells-1 as a serum biomarker of early neurologic deterioration and prognosis in acute supratentorial intracerebral hemorrhage.

Clinica chimica acta; international journal of clinical chemistry

Gu Y, Deng X, Liang C, Chen Y, Lei H, Zhang Q.
PMID: 34655609
Clin Chim Acta. 2021 Dec;523:290-296. doi: 10.1016/j.cca.2021.10.010. Epub 2021 Oct 13.

BACKGROUND: Triggering receptor expressed on myeloid cells-1 (TREM-1) participates in neuroinflammation. We intended to ascertain whether serum soluble TREM-1 (sTREM-1) could be utilized as a biomarker of inflammation, severity, early neurologic deterioration (END) and outcome after primary intracerebral hemorrhage...

Evaluation of "soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), interleukin-1β, and matrix metalloproteinase-8" as a short panel of salivary biomarkers in patients with and without stage III/IV periodontitis and type 2 diabetes mellitus.

Journal of oral biology and craniofacial research

Balaji S, Cholan PK, Victor DJ.
PMID: 34745862
J Oral Biol Craniofac Res. 2022 Jan-Feb;12(1):33-37. doi: 10.1016/j.jobcr.2021.10.003. Epub 2021 Oct 08.

BACKGROUND AND AIM: Periodontitis involves a dynamic disease process, demanding the identification of biomarkers to diagnose the current state of disease activity. Therefore this study assessed the potential of "sTREM-1, IL-1β, and MMP-8" as a short panel of biomarkers...

Showing 1 to 12 of 89 entries