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Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates.

Pharmaceutics

Kovar L, Schräpel C, Selzer D, Kohl Y, Bals R, Schwab M, Lehr T.
PMID: 32585880
Pharmaceutics. 2020 Jun 23;12(6). doi: 10.3390/pharmaceutics12060578.

Buprenorphine plays a crucial role in the therapeutic management of pain in adults, adolescents and pediatric subpopulations. However, only few pharmacokinetic studies of buprenorphine in children, particularly neonates, are available as conducting clinical trials in this population is especially...

Showing 1 to 1 of 1 entries