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Showing 1 to 12 of 137 entries
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Marginal methods for clustered longitudinal binary data with incomplete covariates.

Journal of statistical planning and inference

Chen B, Yi GY, Cook RJ, Zhou XH.
PMID: 23805025
J Stat Plan Inference. 2012 Oct;142(10):2819-2831. doi: 10.1016/j.jspi.2012.04.006.

Many analyses for incomplete longitudinal data are directed to examining the impact of covariates on the marginal mean responses. We consider the setting in which longitudinal responses are collected from individuals nested within clusters. We discuss methods for assessing...

Trace Ratio Linear Discriminant Analysis for Medical Diagnosis: A Case Study of Dementia.

IEEE signal processing letters

Zhao M, Chan RH, Tang P, Chow TW, Wong SW.
PMID: 24077217
IEEE Signal Process Lett. 2013 Mar 07;20(5):431-434. doi: 10.1109/LSP.2013.2250281.

Dementia is one of the most common neurological disorders among the elderly. Identifying those who are of high risk suffering dementia is important to the administration of early treatment in order to slow down the progression of dementia symptoms....

Neuropathologic correlates of trial-related instruments for Alzheimer's disease.

American journal of neurodegenerative disease

Cummings JL, Ringman J, Vinters HV.
PMID: 24754002
Am J Neurodegener Dis. 2014 Mar 28;3(1):45-9. eCollection 2014.

To advance disease-modifying therapies, it is critical to understand the relationship between the neuropathological changes of Alzheimer's Disease (AD) and the clinical measures used in therapeutic trials. We reviewed neuropathologically proven cases of AD from the National Alzheimer's Coordinating...

Rates of lobar atrophy in asymptomatic .

Alzheimer's & dementia (New York, N. Y.)

Chen Q, Boeve BF, Senjem M, Tosakulwong N, Lesnick TG, Brushaber D, Dheel C, Fields J, Forsberg L, Gavrilova R, Gearhart D, Graff-Radford J, Graff-Radford NR, Jack CR, Jones DT, Knopman DS, Kremers WK, Lapid M, Rademakers R, Syrjanen J, Boxer AL, Rosen H, Wszolek ZK, Kantarci K.
PMID: 31388560
Alzheimers Dement (N Y). 2019 Jul 30;5:338-346. doi: 10.1016/j.trci.2019.05.010. eCollection 2019.

RESULTS: The rate of temporal lobe atrophy in asymptomatic DISCUSSION: Accelerated decline in temporal lobe volume occurs in asymptomatic

Detecting galaxy-filament alignments in the Sloan Digital Sky Survey III.

Monthly notices of the Royal Astronomical Society

Chen YC, Ho S, Blazek J, He S, Mandelbaum R, Melchior P, Singh S.
PMID: 30880842
Mon Not R Astron Soc. 2019 May;485(2):2492-2504. doi: 10.1093/mnras/stz539. Epub 2019 Feb 26.

Previous studies have shown the filamentary structures in the cosmic web influence the alignments of nearby galaxies. We study this effect in the LOWZ sample of the Sloan Digital Sky Survey using the 'Cosmic Web Reconstruction' filament catalogue. We...

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations.

Annals of neurology

Shinohara M, Kanekiyo T, Yang L, Linthicum D, Shinohara M, Fu Y, Price L, Frisch-Daiello JL, Han X, Fryer JD, Bu G.
PMID: 26933942
Ann Neurol. 2016 May;79(5):758-774. doi: 10.1002/ana.24628. Epub 2016 Mar 29.

OBJECTIVE: Apolipoprotein E (apoE), a major cholesterol carrier in the brain, is associated with a strong risk for Alzheimer disease. Compared to the risky APOE4 gene allele, the effects of the protective APOE2 gene allele are vastly understudied, and...

Polypharmacy in an Elderly Population: Enhancing Medication Management Through the Use of Clinical Decision Support Software Platforms.

Neurology and therapy

Keine D, Zelek M, Walker JQ, Sabbagh MN.
PMID: 30900186
Neurol Ther. 2019 Jun;8(1):79-94. doi: 10.1007/s40120-019-0131-6. Epub 2019 Mar 21.

INTRODUCTION: Polypharmacy is a growing problem in the United States. The use of multiple medications increases the likelihood that a patient will experience potential drug interactions and adverse drug reactions (ADRs). Those individuals with dementia or Alzheimer's disease (AD)...

Identification and estimation of causal effects with outcomes truncated by death.

Biometrika

Wang L, Zhou XH, Richardson TS.
PMID: 29430035
Biometrika. 2017 Sep;104(3):597-612. doi: 10.1093/biomet/asx034. Epub 2017 Jul 11.

It is common in medical studies that the outcome of interest is truncated by death, meaning that a subject has died before the outcome could be measured. In this case, restricted analysis among survivors may be subject to selection...

Reliability of Medical History Reporting in Older Adults With and Without Cognitive Impairment.

Journal of central nervous system disease

Curcio N, Wilmoth K, LoBue C, Cullum CM.
PMID: 31040738
J Cent Nerv Syst Dis. 2019 Apr 22;11:1179573519843874. doi: 10.1177/1179573519843874. eCollection 2019.

BACKGROUND: Clinical diagnosis of cognitive disorders depends on accurate reporting of medical history, yet little is known about the reliability and the validity of such reports, particularly in older patients with and without cognitive impairment.METHODS: In 2 studies, we...

Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease.

Annals of clinical and translational neurology

Raghavan NS, Brickman AM, Andrews H, Manly JJ, Schupf N, Lantigua R, Wolock CJ, Kamalakaran S, Petrovski S, Tosto G, Vardarajan BN, Goldstein DB, Mayeux R.
PMID: 30009200
Ann Clin Transl Neurol. 2018 May 24;5(7):832-842. doi: 10.1002/acn3.582. eCollection 2018 Jul.

OBJECTIVE: The genetic bases of Alzheimer's disease remain uncertain. An international effort to fully articulate genetic risks and protective factors is underway with the hope of identifying potential therapeutic targets and preventive strategies. The goal here was to identify...

Sex as a Risk Factor for Developing Cognitive Impairments in National Alzheimer's Coordinating Center Participants.

Journal of Alzheimer's disease reports

Wang G, Li W.
PMID: 33681711
J Alzheimers Dis Rep. 2021 Jan 11;5(1):1-6. doi: 10.3233/ADR-200275.

BACKGROUND: It is inconclusive on how sex affects the risk of developing mild cognitive impairment (MCI) or dementia.OBJECTIVE: To investigate how sex affects the risk of developing MCI or dementia.METHODS: A secondary data analysis was performed on data collected...

Comprehensive Evaluation of the Functional Activities Questionnaire (FAQ) and Its Reliability and Validity.

Assessment

González DA, Gonzales MM, Resch ZJ, Sullivan AC, Soble JR.
PMID: 33543638
Assessment. 2021 Feb 05;1073191121991215. doi: 10.1177/1073191121991215. Epub 2021 Feb 05.

The Functional Activities Questionnaire (FAQ) is a collateral-report measure of difficulties in activities of daily living. Despite its widespread use, psychometric analyses have been limited in scope, piecemeal across samples, and limited primarily to classical test theory. This article...

Showing 1 to 12 of 137 entries