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Showing 1 to 12 of 21 entries
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Conservation of the "Outside-in" Germination Pathway in .

Frontiers in microbiology

Bhattacharjee D, Sorg JA.
PMID: 30386321
Front Microbiol. 2018 Oct 17;9:2487. doi: 10.3389/fmicb.2018.02487. eCollection 2018.

No abstract available.

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Bhattacharjee D, Sorg JA. Conservation of the "Outside-in" Germination Pathway in . Front Microbiol. 2018;9:2487doi: 10.3389/fmicb.2018.02487.
Bhattacharjee, D., & Sorg, J. A. (2018). Conservation of the "Outside-in" Germination Pathway in . Frontiers in microbiology, 92487. https://doi.org/10.3389/fmicb.2018.02487
Bhattacharjee, Disha, and Sorg, Joseph A. "Conservation of the "Outside-in" Germination Pathway in ." Frontiers in microbiology vol. 9 (2018): 2487. doi: https://doi.org/10.3389/fmicb.2018.02487
Bhattacharjee D, Sorg JA. Conservation of the "Outside-in" Germination Pathway in . Front Microbiol. 2018 Oct 17;9:2487. doi: 10.3389/fmicb.2018.02487. eCollection 2018. PMID: 30386321; PMCID: PMC6199464.
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AMiGA: Software for Automated Analysis of Microbial Growth Assays.

mSystems

Midani FS, Collins J, Britton RA.
PMID: 34254821
mSystems. 2021 Aug 31;6(4):e0050821. doi: 10.1128/mSystems.00508-21. Epub 2021 Jul 13.

The analysis of microbial growth is one of the central methods in the field of microbiology. Microbial growth dynamics can be characterized by meaningful parameters, including carrying capacity, exponential growth rate, and growth lag. However, microbial assays with clinical...

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Midani FS, Collins J, Britton RA. AMiGA: Software for Automated Analysis of Microbial Growth Assays. mSystems. 2021;6(4):e0050821doi: 10.1128/mSystems.00508-21.
Midani, F. S., Collins, J., & Britton, R. A. (2021). AMiGA: Software for Automated Analysis of Microbial Growth Assays. mSystems, 6(4), e0050821. https://doi.org/10.1128/mSystems.00508-21
Midani, Firas S, et al. "AMiGA: Software for Automated Analysis of Microbial Growth Assays." mSystems vol. 6,4 (2021): e0050821. doi: https://doi.org/10.1128/mSystems.00508-21
Midani FS, Collins J, Britton RA. AMiGA: Software for Automated Analysis of Microbial Growth Assays. mSystems. 2021 Aug 31;6(4):e0050821. doi: 10.1128/mSystems.00508-21. Epub 2021 Jul 13. PMID: 34254821; PMCID: PMC8409736.
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Fecal Microbiota Transplantation Commonly Failed in Children with Co-Morbidities.

Journal of pediatric gastroenterology and nutrition

Kellermayer R, Wu Q, Nagy-Szakal D, Queliza K, Ihekweazu FD, Bocchini CE, Magee AR, Oezguen N, Spinler JK, Hollister EB, Shulman RJ, Versalovic J, Luna RA, Savidge TC.
PMID: 34724447
J Pediatr Gastroenterol Nutr. 2021 Oct 28; doi: 10.1097/MPG.0000000000003336. Epub 2021 Oct 28.

OBJECTIVES: Fecal microbiota transplantation (FMT) is arguably the most effective treatment for recurrent Clostridioides difficile infection (rCDI). Clinical reports on pediatric FMT have not systematically evaluated microbiome restoration in patients with co-morbidities. Here we determined whether FMT recipient age...

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Kellermayer R, Wu Q, Nagy-Szakal D, et al. Fecal Microbiota Transplantation Commonly Failed in Children with Co-Morbidities. J Pediatr Gastroenterol Nutr. 2021;doi: 10.1097/MPG.0000000000003336.
Kellermayer, R., Wu, Q., Nagy-Szakal, D., Queliza, K., Ihekweazu, F. D., Bocchini, C. E., Magee, A. R., Oezguen, N., Spinler, J. K., Hollister, E. B., Shulman, R. J., Versalovic, J., Luna, R. A., & Savidge, T. C. (2021). Fecal Microbiota Transplantation Commonly Failed in Children with Co-Morbidities. Journal of pediatric gastroenterology and nutrition, . https://doi.org/10.1097/MPG.0000000000003336
Kellermayer, Richard, et al. "Fecal Microbiota Transplantation Commonly Failed in Children with Co-Morbidities." Journal of pediatric gastroenterology and nutrition vol. (2021). doi: https://doi.org/10.1097/MPG.0000000000003336
Kellermayer R, Wu Q, Nagy-Szakal D, Queliza K, Ihekweazu FD, Bocchini CE, Magee AR, Oezguen N, Spinler JK, Hollister EB, Shulman RJ, Versalovic J, Luna RA, Savidge TC. Fecal Microbiota Transplantation Commonly Failed in Children with Co-Morbidities. J Pediatr Gastroenterol Nutr. 2021 Oct 28; doi: 10.1097/MPG.0000000000003336. Epub 2021 Oct 28. PMID: 34724447.
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The metabolic profile of Bifidobacterium dentium reflects its status as a human gut commensal.

BMC microbiology

Engevik MA, Danhof HA, Hall A, Engevik KA, Horvath TD, Haidacher SJ, Hoch KM, Endres BT, Bajaj M, Garey KW, Britton RA, Spinler JK, Haag AM, Versalovic J.
PMID: 34030655
BMC Microbiol. 2021 May 24;21(1):154. doi: 10.1186/s12866-021-02166-6.

BACKGROUND: Bifidobacteria are commensal microbes of the mammalian gastrointestinal tract. In this study, we aimed to identify the intestinal colonization mechanisms and key metabolic pathways implemented by Bifidobacterium dentium.RESULTS: B. dentium displayed acid resistance, with high viability over a...

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Engevik MA, Danhof HA, Hall A, et al. The metabolic profile of Bifidobacterium dentium reflects its status as a human gut commensal. BMC Microbiol. 2021;21(1):154doi: 10.1186/s12866-021-02166-6.
Engevik, M. A., Danhof, H. A., Hall, A., Engevik, K. A., Horvath, T. D., Haidacher, S. J., Hoch, K. M., Endres, B. T., Bajaj, M., Garey, K. W., Britton, R. A., Spinler, J. K., Haag, A. M., & Versalovic, J. (2021). The metabolic profile of Bifidobacterium dentium reflects its status as a human gut commensal. BMC microbiology, 21(1), 154. https://doi.org/10.1186/s12866-021-02166-6
Engevik, Melinda A, et al. "The metabolic profile of Bifidobacterium dentium reflects its status as a human gut commensal." BMC microbiology vol. 21,1 (2021): 154. doi: https://doi.org/10.1186/s12866-021-02166-6
Engevik MA, Danhof HA, Hall A, Engevik KA, Horvath TD, Haidacher SJ, Hoch KM, Endres BT, Bajaj M, Garey KW, Britton RA, Spinler JK, Haag AM, Versalovic J. The metabolic profile of Bifidobacterium dentium reflects its status as a human gut commensal. BMC Microbiol. 2021 May 24;21(1):154. doi: 10.1186/s12866-021-02166-6. PMID: 34030655; PMCID: PMC8145834.
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Systems biology evaluation of refractory Clostridioides difficile infection including multiple failures of fecal microbiota transplantation.

Anaerobe

Gonzales-Luna AJ, Spinler JK, Oezguen N, Khan MAW, Danhof HA, Endres BT, Alam MJ, Begum K, Lancaster C, Costa GP, Savidge TC, Hurdle JG, Britton R, Garey KW.
PMID: 34044101
Anaerobe. 2021 Aug;70:102387. doi: 10.1016/j.anaerobe.2021.102387. Epub 2021 May 24.

BACKGROUND: Fecal microbiota transplantation (FMT) aims to cure Clostridioides difficile infection (CDI) through reestablishing a healthy microbiome and restoring colonization resistance. Although often effective after one infusion, patients with continued microbiome disruptions may require multiple FMTs. In this N-of-1...

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Gonzales-Luna AJ, Spinler JK, Oezguen N, et al. Systems biology evaluation of refractory Clostridioides difficile infection including multiple failures of fecal microbiota transplantation. Anaerobe. 2021;70:102387doi: 10.1016/j.anaerobe.2021.102387.
Gonzales-Luna, A. J., Spinler, J. K., Oezguen, N., Khan, M. A. W., Danhof, H. A., Endres, B. T., Alam, M. J., Begum, K., Lancaster, C., Costa, G. P., Savidge, T. C., Hurdle, J. G., Britton, R., & Garey, K. W. (2021). Systems biology evaluation of refractory Clostridioides difficile infection including multiple failures of fecal microbiota transplantation. Anaerobe, 70102387. https://doi.org/10.1016/j.anaerobe.2021.102387
Gonzales-Luna, Anne J, et al. "Systems biology evaluation of refractory Clostridioides difficile infection including multiple failures of fecal microbiota transplantation." Anaerobe vol. 70 (2021): 102387. doi: https://doi.org/10.1016/j.anaerobe.2021.102387
Gonzales-Luna AJ, Spinler JK, Oezguen N, Khan MAW, Danhof HA, Endres BT, Alam MJ, Begum K, Lancaster C, Costa GP, Savidge TC, Hurdle JG, Britton R, Garey KW. Systems biology evaluation of refractory Clostridioides difficile infection including multiple failures of fecal microbiota transplantation. Anaerobe. 2021 Aug;70:102387. doi: 10.1016/j.anaerobe.2021.102387. Epub 2021 May 24. PMID: 34044101; PMCID: PMC8384661.
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Clostridioides difficile SpoVAD and SpoVAE Interact and Are Required for Dipicolinic Acid Uptake into Spores.

Journal of bacteriology

Baloh M, Sorg JA.
PMID: 34424035
J Bacteriol. 2021 Oct 12;203(21):e0039421. doi: 10.1128/JB.00394-21. Epub 2021 Aug 23.

Clostridioides difficile spores, like the spores from most endospore-forming organisms, are a metabolically dormant stage of development with a complex structure that conveys considerable resistance to environmental conditions, e.g., wet heat. This resistance is due to the large amount...

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Baloh M, Sorg JA. Clostridioides difficile SpoVAD and SpoVAE Interact and Are Required for Dipicolinic Acid Uptake into Spores. J Bacteriol. 2021;203(21):e0039421doi: 10.1128/JB.00394-21.
Baloh, M., & Sorg, J. A. (2021). Clostridioides difficile SpoVAD and SpoVAE Interact and Are Required for Dipicolinic Acid Uptake into Spores. Journal of bacteriology, 203(21), e0039421. https://doi.org/10.1128/JB.00394-21
Baloh, Marko, and Sorg, Joseph A. "Clostridioides difficile SpoVAD and SpoVAE Interact and Are Required for Dipicolinic Acid Uptake into Spores." Journal of bacteriology vol. 203,21 (2021): e0039421. doi: https://doi.org/10.1128/JB.00394-21
Baloh M, Sorg JA. Clostridioides difficile SpoVAD and SpoVAE Interact and Are Required for Dipicolinic Acid Uptake into Spores. J Bacteriol. 2021 Oct 12;203(21):e0039421. doi: 10.1128/JB.00394-21. Epub 2021 Aug 23. PMID: 34424035; PMCID: PMC8508128.
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Complete Genome Sequence of Clostridioides difficile Ribotype 255 Strain Mta-79, Assembled Using Oxford Nanopore and Illumina Sequencing.

Microbiology resource announcements

Spinler JK, Gonzales-Luna AJ, Raza S, Runge JK, Luna RA, Savidge TC, Garey KW.
PMID: 31624167
Microbiol Resour Announc. 2019 Oct 17;8(42). doi: 10.1128/MRA.00935-19.

Hybrid

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Spinler JK, Gonzales-Luna AJ, Raza S, et al. Complete Genome Sequence of Clostridioides difficile Ribotype 255 Strain Mta-79, Assembled Using Oxford Nanopore and Illumina Sequencing. Microbiol Resour Announc. 2019;8(42)doi: 10.1128/MRA.00935-19.
Spinler, J. K., Gonzales-Luna, A. J., Raza, S., Runge, J. K., Luna, R. A., Savidge, T. C., & Garey, K. W. (2019). Complete Genome Sequence of Clostridioides difficile Ribotype 255 Strain Mta-79, Assembled Using Oxford Nanopore and Illumina Sequencing. Microbiology resource announcements, 8(42), . https://doi.org/10.1128/MRA.00935-19
Spinler, Jennifer K, et al. "Complete Genome Sequence of Clostridioides difficile Ribotype 255 Strain Mta-79, Assembled Using Oxford Nanopore and Illumina Sequencing." Microbiology resource announcements vol. 8,42 (2019). doi: https://doi.org/10.1128/MRA.00935-19
Spinler JK, Gonzales-Luna AJ, Raza S, Runge JK, Luna RA, Savidge TC, Garey KW. Complete Genome Sequence of Clostridioides difficile Ribotype 255 Strain Mta-79, Assembled Using Oxford Nanopore and Illumina Sequencing. Microbiol Resour Announc. 2019 Oct 17;8(42). doi: 10.1128/MRA.00935-19. PMID: 31624167; PMCID: PMC6797532.
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Epidemic .

Open forum infectious diseases

Endres BT, Begum K, Sun H, Walk ST, Memariani A, Lancaster C, Gonzales-Luna AJ, Dotson KM, Bassères E, Offiong C, Tupy S, Kuper K, Septimus E, Arafat R, Alam MJ, Zhao Z, Hurdle JG, Savidge TC, Garey KW.
PMID: 30793006
Open Forum Infect Dis. 2019 Feb 09;6(2):ofz013. doi: 10.1093/ofid/ofz013. eCollection 2019 Feb.

No abstract available.

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Endres BT, Begum K, Sun H, et al. Epidemic . Open Forum Infect Dis. 2019;6(2):ofz013doi: 10.1093/ofid/ofz013.
Endres, B. T., Begum, K., Sun, H., Walk, S. T., Memariani, A., Lancaster, C., Gonzales-Luna, A. J., Dotson, K. M., Bassères, E., Offiong, C., Tupy, S., Kuper, K., Septimus, E., Arafat, R., Alam, M. J., Zhao, Z., Hurdle, J. G., Savidge, T. C., & Garey, K. W. (2019). Epidemic . Open forum infectious diseases, 6(2), ofz013. https://doi.org/10.1093/ofid/ofz013
Endres, Bradley T, et al. "Epidemic ." Open forum infectious diseases vol. 6,2 (2019): ofz013. doi: https://doi.org/10.1093/ofid/ofz013
Endres BT, Begum K, Sun H, Walk ST, Memariani A, Lancaster C, Gonzales-Luna AJ, Dotson KM, Bassères E, Offiong C, Tupy S, Kuper K, Septimus E, Arafat R, Alam MJ, Zhao Z, Hurdle JG, Savidge TC, Garey KW. Epidemic . Open Forum Infect Dis. 2019 Feb 09;6(2):ofz013. doi: 10.1093/ofid/ofz013. eCollection 2019 Feb. PMID: 30793006; PMCID: PMC6368847.
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A multisite genomic epidemiology study of .

Microbial genomics

Miles-Jay A, Young VB, Pamer EG, Savidge TC, Kamboj M, Garey KW, Snitkin ES.
PMID: 34180789
Microb Genom. 2021 Jun;7(6). doi: 10.1099/mgen.0.000590.

No abstract available.

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Miles-Jay A, Young VB, Pamer EG, et al. A multisite genomic epidemiology study of . Microb Genom. 2021;7(6)doi: 10.1099/mgen.0.000590.
Miles-Jay, A., Young, V. B., Pamer, E. G., Savidge, T. C., Kamboj, M., Garey, K. W., & Snitkin, E. S. (2021). A multisite genomic epidemiology study of . Microbial genomics, 7(6), . https://doi.org/10.1099/mgen.0.000590
Miles-Jay, Arianna, et al. "A multisite genomic epidemiology study of ." Microbial genomics vol. 7,6 (2021). doi: https://doi.org/10.1099/mgen.0.000590
Miles-Jay A, Young VB, Pamer EG, Savidge TC, Kamboj M, Garey KW, Snitkin ES. A multisite genomic epidemiology study of . Microb Genom. 2021 Jun;7(6). doi: 10.1099/mgen.0.000590. PMID: 34180789; PMCID: PMC8461479.
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AMiGA: Software for Automated Analysis of Microbial Growth Assays.

mSystems

Midani FS, Collins J, Britton RA.
PMID: 34254821
mSystems. 2021 Aug 31;6(4):e0050821. doi: 10.1128/mSystems.00508-21. Epub 2021 Jul 13.

The analysis of microbial growth is one of the central methods in the field of microbiology. Microbial growth dynamics can be characterized by meaningful parameters, including carrying capacity, exponential growth rate, and growth lag. However, microbial assays with clinical...

Cite
Midani FS, Collins J, Britton RA. AMiGA: Software for Automated Analysis of Microbial Growth Assays. mSystems. 2021;6(4):e0050821doi: 10.1128/mSystems.00508-21.
Midani, F. S., Collins, J., & Britton, R. A. (2021). AMiGA: Software for Automated Analysis of Microbial Growth Assays. mSystems, 6(4), e0050821. https://doi.org/10.1128/mSystems.00508-21
Midani, Firas S, et al. "AMiGA: Software for Automated Analysis of Microbial Growth Assays." mSystems vol. 6,4 (2021): e0050821. doi: https://doi.org/10.1128/mSystems.00508-21
Midani FS, Collins J, Britton RA. AMiGA: Software for Automated Analysis of Microbial Growth Assays. mSystems. 2021 Aug 31;6(4):e0050821. doi: 10.1128/mSystems.00508-21. Epub 2021 Jul 13. PMID: 34254821; PMCID: PMC8409736.
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Comparative clinical outcomes evaluation of hospitalized patients infected with Clostridioides difficile ribotype 106 vs. other toxigenic strains.

Anaerobe

Almutairi MS, Gonzales-Luna AJ, Alnezary FS, Fallatah SB, Alam MJ, Begum K, Garey KW.
PMID: 34461273
Anaerobe. 2021 Aug 27;72:102440. doi: 10.1016/j.anaerobe.2021.102440. Epub 2021 Aug 27.

BACKGROUND: Although Clostridioides difficile surveillance often identifies emerging strains, clinical outcome evaluations are rarely performed. Ribotype (RT) 106 is a commonly isolated C. difficile strain worldwide; however, studies investigating RT 106 clinical outcomes are limited. The purpose of this...

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Almutairi MS, Gonzales-Luna AJ, Alnezary FS, et al. Comparative clinical outcomes evaluation of hospitalized patients infected with Clostridioides difficile ribotype 106 vs. other toxigenic strains. Anaerobe. 2021;72:102440doi: 10.1016/j.anaerobe.2021.102440.
Almutairi, M. S., Gonzales-Luna, A. J., Alnezary, F. S., Fallatah, S. B., Alam, M. J., Begum, K., & Garey, K. W. (2021). Comparative clinical outcomes evaluation of hospitalized patients infected with Clostridioides difficile ribotype 106 vs. other toxigenic strains. Anaerobe, 72102440. https://doi.org/10.1016/j.anaerobe.2021.102440
Almutairi, Masaad Saeed, et al. "Comparative clinical outcomes evaluation of hospitalized patients infected with Clostridioides difficile ribotype 106 vs. other toxigenic strains." Anaerobe vol. 72 (2021): 102440. doi: https://doi.org/10.1016/j.anaerobe.2021.102440
Almutairi MS, Gonzales-Luna AJ, Alnezary FS, Fallatah SB, Alam MJ, Begum K, Garey KW. Comparative clinical outcomes evaluation of hospitalized patients infected with Clostridioides difficile ribotype 106 vs. other toxigenic strains. Anaerobe. 2021 Aug 27;72:102440. doi: 10.1016/j.anaerobe.2021.102440. Epub 2021 Aug 27. PMID: 34461273.
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Protease-stable DARPins as promising oral therapeutics.

Protein engineering, design & selection : PEDS

Simeon RA, Zeng Y, Chonira V, Aguirre AM, Lasagna M, Baloh M, Sorg JA, Tommos C, Chen Z.
PMID: 34882774
Protein Eng Des Sel. 2021 Feb 15;34. doi: 10.1093/protein/gzab028.

Clostridioides difficile is an enteric bacterium whose exotoxins, TcdA and TcdB, inactivate small GTPases within the host cells, leading to bloody diarrhea. In prior work, our group engineered a panel of potent TcdB-neutralizing designed ankyrin repeat proteins (DARPin) as...

Cite
Simeon RA, Zeng Y, Chonira V, et al. Protease-stable DARPins as promising oral therapeutics. Protein Eng Des Sel. 2021;34doi: 10.1093/protein/gzab028.
Simeon, R. A., Zeng, Y., Chonira, V., Aguirre, A. M., Lasagna, M., Baloh, M., Sorg, J. A., Tommos, C., & Chen, Z. (2021). Protease-stable DARPins as promising oral therapeutics. Protein engineering, design & selection : PEDS, 34. https://doi.org/10.1093/protein/gzab028
Simeon, Rudo A, et al. "Protease-stable DARPins as promising oral therapeutics." Protein engineering, design & selection : PEDS vol. 34 (2021). doi: https://doi.org/10.1093/protein/gzab028
Simeon RA, Zeng Y, Chonira V, Aguirre AM, Lasagna M, Baloh M, Sorg JA, Tommos C, Chen Z. Protease-stable DARPins as promising oral therapeutics. Protein Eng Des Sel. 2021 Feb 15;34. doi: 10.1093/protein/gzab028. PMID: 34882774.
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Showing 1 to 12 of 21 entries