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Showing 1 to 12 of 36 entries
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Auto-antibodies to p53 and the Subsequent Development of Colorectal Cancer in a U.S. Prospective Cohort Consortium.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Butt J, Blot WJ, Visvanathan K, Le Marchand L, Wilkens LR, Chen Y, Sesso HD, Teras L, Ryser MD, Hyslop T, Wassertheil-Smoller S, Tinker LF, Potter JD, Song M, Berndt SI, Waterboer T, Pawlita M, Epplein M.
PMID: 32972968
Cancer Epidemiol Biomarkers Prev. 2020 Dec;29(12):2729-2734. doi: 10.1158/1055-9965.EPI-20-0780. Epub 2020 Sep 24.

BACKGROUND: Auto-antibodies to tumor suppressor p53 are found in a subset of patients with colorectal cancer. A recent prospective study in the United States has reported a significant 1.8-fold increased odds for colorectal cancer development with prediagnostic seropositivity to...

Replication and Genetic Risk Score Analysis for Pancreatic Cancer in a Diverse Multiethnic Population.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Bogumil D, Conti DV, Sheng X, Xia L, Shu XO, Pandol SJ, Blot WJ, Zheng W, Le Marchand L, Haiman CA, Setiawan VW.
PMID: 32958499
Cancer Epidemiol Biomarkers Prev. 2020 Dec;29(12):2686-2692. doi: 10.1158/1055-9965.EPI-20-0963. Epub 2020 Sep 21.

BACKGROUND: Genome-wide association studies (GWAS) have identified several SNPs associated with pancreatic cancer. No studies yet have attempted to replicate these SNPs in US minority populations. We aimed to replicate the associations of 31 GWAS-identified SNPs with pancreatic cancer...

Racial/ethnic disparities in weight or BMI change in adulthood and pancreatic cancer incidence: The multiethnic cohort.

Cancer medicine

Farias AJ, Streicher SA, Stram DO, Wang S, Pandol SJ, Le Marchand L, Setiawan VW.
PMID: 33998145
Cancer Med. 2021 Jun;10(12):4097-4106. doi: 10.1002/cam4.3958. Epub 2021 May 16.

INTRODUCTION: Compared to non-Hispanic Whites, Japanese Americans, Native Hawaiians, and African Americans have higher incidences of pancreatic cancer (PCa) that are not entirely explained by rates of obesity but may be explained by weight changes throughout adulthood.METHODS: The multiethnic...

Diet and Liver Adiposity in Older Adults: The Multiethnic Cohort Adiposity Phenotype Study.

The Journal of nutrition

Kaenkumchorn TK, Merritt MA, Lim U, Le Marchand L, Boushey CJ, Shepherd JA, Wilkens LR, Ernst T, Lampe JW.
PMID: 34590125
J Nutr. 2021 Nov 02;151(11):3579-3587. doi: 10.1093/jn/nxab300.

BACKGROUND: Diet plays a key role in the pathogenesis of nonalcoholic fatty liver disease. Limited data exist regarding specific nutrients and food groups and liver fat continuously, particularly among different ethnicities.OBJECTIVES: We aimed to determine the relationship between usual...

Germline Pathogenic Variants in Cancer Predisposition Genes Among Women With Invasive Lobular Carcinoma of the Breast.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Yadav S, Hu C, Nathanson KL, Weitzel JN, Goldgar DE, Kraft P, Gnanaolivu RD, Na J, Huang H, Boddicker NJ, Larson N, Gao C, Yao S, Weinberg C, Vachon CM, Trentham-Dietz A, Taylor JA, Sandler DR, Patel A, Palmer JR, Olson JE, Neuhausen S, Martinez E, Lindstrom S, Lacey JV, Kurian AW, John EM, Haiman C, Bernstein L, Auer PW, Anton-Culver H, Ambrosone CB, Karam R, Chao E, Yussuf A, Pesaran T, Dolinsky JS, Hart SN, LaDuca H, Polley EC, Domchek SM, Couch FJ.
PMID: 34672684
J Clin Oncol. 2021 Dec 10;39(35):3918-3926. doi: 10.1200/JCO.21.00640. Epub 2021 Oct 21.

PURPOSE: To determine the contribution of germline pathogenic variants (PVs) in hereditary cancer testing panel genes to invasive lobular carcinoma (ILC) of the breast.MATERIALS AND METHODS: The study included 2,999 women with ILC from a population-based cohort and 3,796...

Association of change in the neighborhood obesogenic environment with colorectal cancer risk: The Multiethnic Cohort Study.

SSM - population health

Shvetsov YB, Shariff-Marco S, Yang J, Conroy SM, Canchola AJ, Albright CL, Park SY, Monroe KR, Le Marchand L, Gomez SL, Wilkens LR, Cheng I.
PMID: 31909167
SSM Popul Health. 2019 Dec 24;10:100532. doi: 10.1016/j.ssmph.2019.100532. eCollection 2020 Apr.

BACKGROUND: Neighborhood environment has been associated with health behaviors. Despite the evidence of the influence of neighborhood social and physical factors on cancer risk, no research has evaluated whether changes in the neighborhood obesogenic environment, either by physical moves...

Association of Genetic Risk Score With NAFLD in An Ethnically Diverse Cohort.

Hepatology communications

Wang J, Conti DV, Bogumil D, Sheng X, Noureddin M, Wilkens LR, Le Marchand L, Rosen HR, Haiman CA, Setiawan VW.
PMID: 34558842
Hepatol Commun. 2021 Oct;5(10):1689-1703. doi: 10.1002/hep4.1751. Epub 2021 Jun 18.

Most genetic studies of nonalcoholic fatty liver disease (NAFLD) have been conducted in Whites. In this large and ethnically diverse cohort, we assessed the transportability of previously identified genetic variants for NAFLD, built a genetic risk score (GRS), and...

Diet quality and all-cause and cancer-specific mortality in cancer survivors and non-cancer individuals: the Multiethnic Cohort Study.

European journal of nutrition

Park SY, Kang M, Shvetsov YB, Setiawan VW, Boushey CJ, Haiman CA, Wilkens LR, Le Marchand L.
PMID: 34657186
Eur J Nutr. 2021 Oct 17; doi: 10.1007/s00394-021-02700-2. Epub 2021 Oct 17.

PURPOSE: We examined post-diagnostic diet quality in relation to all-cause and cancer-specific mortality among adults diagnosed with invasive cancer between cohort entry (45-75 years) and their 10-year follow-up, in comparison with those without invasive cancer during that period, in...

Risk of Alzheimer's disease and related dementia by sex and race/ethnicity: The Multiethnic Cohort Study.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Lim U, Wang S, Park SY, Bogumil D, Wu AH, Cheng I, Haiman CA, Le Marchand L, Wilkens LR, White L, Setiawan VW.
PMID: 34882963
Alzheimers Dement. 2021 Dec 09; doi: 10.1002/alz.12528. Epub 2021 Dec 09.

INTRODUCTION: Data are limited for comparison of sex- and race/ethnicity-specific risks of Alzheimer's disease and related dementia (ADRD).METHODS: In the population-based Multiethnic Cohort, we estimated the age-standardized diagnostic incidence rate (ASDIR) and relative risk of late-onset ADRD (n =...

Prediagnostic Antibody Responses to .

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Lo CH, Blot WJ, Teras LR, Visvanathan K, Le Marchand L, Haiman CA, Chen Y, Sesso HD, Wassertheil-Smoller S, Tinker LF, Peek RM, Potter JD, Cover TL, Zeleniuch-Jacquotte A, Berndt SI, Waterboer T, Epplein M, Butt J, Song M.
PMID: 33737297
Cancer Epidemiol Biomarkers Prev. 2021 Jun;30(6):1279-1282. doi: 10.1158/1055-9965.EPI-20-1471. Epub 2021 Mar 18.

BACKGROUND: The association between prediagnostic antibody responses to METHODS: We conducted a nested case-control study of 8,126 participants in a consortium of 10 prospective cohorts in the United States.RESULTS: Higher seroprevalence of any CONCLUSIONS: Prediagnostic antibody responses to IMPACT:...

Multiethnic Prediction of Nicotine Biomarkers and Association With Nicotine Dependence.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Bergen AW, McMahan CS, McGee S, Ervin CM, Tindle HA, Le Marchand L, Murphy SE, Stram DO, Patel YM, Park SL, Baurley JW.
PMID: 34313775
Nicotine Tob Res. 2021 Nov 05;23(12):2162-2169. doi: 10.1093/ntr/ntab124.

INTRODUCTION: The nicotine metabolite ratio and nicotine equivalents are measures of metabolism rate and intake. Genome-wide prediction of these nicotine biomarkers in multiethnic samples will enable tobacco-related biomarker, behavioral, and exposure research in studies without measured biomarkers.AIMS AND METHODS:...

Type 2 Diabetes Among Filipino American Adults in the Multiethnic Cohort.

Preventing chronic disease

Raquinio PASH, Maskarinec G, Dela Cruz R, Setiawan VW, Kristal BS, Wilkens LR, Le Marchand L.
PMID: 34818147
Prev Chronic Dis. 2021 Nov 24;18:E98. doi: 10.5888/pcd18.210240.

INTRODUCTION: Several Asian racial and ethnic groups, including individuals of Filipino ancestry, are at higher risk of developing type 2 diabetes than White individuals, despite their lower body mass index (BMI). This study examined determinants of type 2 diabetes...

Showing 1 to 12 of 36 entries