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Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar.

Journal of the American College of Cardiology

Kim DS, Gloyn AL, Knowles JW.
PMID: 34325839
J Am Coll Cardiol. 2021 Aug 03;78(5):496-512. doi: 10.1016/j.jacc.2021.03.346.

Type 2 diabetes (T2D) is highly prevalent and is a strong contributor for cardiovascular disease. However, there is significant heterogeneity in disease pathogenesis and the risk of complications. Enormous progress has been made in our ability to catalog genetic...

Cite
Kim DS, Gloyn AL, Knowles JW. Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar. J Am Coll Cardiol. 2021;78(5):496-512doi: 10.1016/j.jacc.2021.03.346.
Kim, D. S., Gloyn, A. L., & Knowles, J. W. (2021). Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar. Journal of the American College of Cardiology, 78(5), 496-512. https://doi.org/10.1016/j.jacc.2021.03.346
Kim, Daniel Seung, et al. "Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar." Journal of the American College of Cardiology vol. 78,5 (2021): 496-512. doi: https://doi.org/10.1016/j.jacc.2021.03.346
Kim DS, Gloyn AL, Knowles JW. Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar. J Am Coll Cardiol. 2021 Aug 03;78(5):496-512. doi: 10.1016/j.jacc.2021.03.346. PMID: 34325839; PMCID: PMC8328195.
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A Global Overview of Precision Medicine in Type 2 Diabetes.

Diabetes

Fitipaldi H, McCarthy MI, Florez JC, Franks PW.
PMID: 30237159
Diabetes. 2018 Oct;67(10):1911-1922. doi: 10.2337/dbi17-0045.

The detailed characterization of human biology and behaviors is now possible at scale owing to innovations in biomarkers, bioimaging, and wearable technologies; "big data" from electronic medical records, health insurance databases, and other platforms becoming increasingly accessible; and rapidly...

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Fitipaldi H, McCarthy MI, Florez JC, et al. A Global Overview of Precision Medicine in Type 2 Diabetes. Diabetes. 2018;67(10):1911-1922doi: 10.2337/dbi17-0045.
Fitipaldi, H., McCarthy, M. I., Florez, J. C., & Franks, P. W. (2018). A Global Overview of Precision Medicine in Type 2 Diabetes. Diabetes, 67(10), 1911-1922. https://doi.org/10.2337/dbi17-0045
Fitipaldi, Hugo, et al. "A Global Overview of Precision Medicine in Type 2 Diabetes." Diabetes vol. 67,10 (2018): 1911-1922. doi: https://doi.org/10.2337/dbi17-0045
Fitipaldi H, McCarthy MI, Florez JC, Franks PW. A Global Overview of Precision Medicine in Type 2 Diabetes. Diabetes. 2018 Oct;67(10):1911-1922. doi: 10.2337/dbi17-0045. PMID: 30237159; PMCID: PMC6152339.
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Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar.

Journal of the American College of Cardiology

Kim DS, Gloyn AL, Knowles JW.
PMID: 34325839
J Am Coll Cardiol. 2021 Aug 03;78(5):496-512. doi: 10.1016/j.jacc.2021.03.346.

Type 2 diabetes (T2D) is highly prevalent and is a strong contributor for cardiovascular disease. However, there is significant heterogeneity in disease pathogenesis and the risk of complications. Enormous progress has been made in our ability to catalog genetic...

Cite
Kim DS, Gloyn AL, Knowles JW. Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar. J Am Coll Cardiol. 2021;78(5):496-512doi: 10.1016/j.jacc.2021.03.346.
Kim, D. S., Gloyn, A. L., & Knowles, J. W. (2021). Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar. Journal of the American College of Cardiology, 78(5), 496-512. https://doi.org/10.1016/j.jacc.2021.03.346
Kim, Daniel Seung, et al. "Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar." Journal of the American College of Cardiology vol. 78,5 (2021): 496-512. doi: https://doi.org/10.1016/j.jacc.2021.03.346
Kim DS, Gloyn AL, Knowles JW. Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar. J Am Coll Cardiol. 2021 Aug 03;78(5):496-512. doi: 10.1016/j.jacc.2021.03.346. PMID: 34325839; PMCID: PMC8328195.
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Analysis of overlapping genetic association in type 1 and type 2 diabetes.

Diabetologia

Inshaw JRJ, Sidore C, Cucca F, Stefana MI, Crouch DJM, McCarthy MI, Mahajan A, Todd JA.
PMID: 33830302
Diabetologia. 2021 Jun;64(6):1342-1347. doi: 10.1007/s00125-021-05428-0. Epub 2021 Apr 08.

AIMS/HYPOTHESIS: Given the potential shared aetiology between type 1 and type 2 diabetes, we aimed to identify any genetic regions associated with both diseases. For associations where there is a shared signal and the allele that increases risk to...

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Inshaw JRJ, Sidore C, Cucca F, et al. Analysis of overlapping genetic association in type 1 and type 2 diabetes. Diabetologia. 2021;64(6):1342-1347doi: 10.1007/s00125-021-05428-0.
Inshaw, J. R. J., Sidore, C., Cucca, F., Stefana, M. I., Crouch, D. J. M., McCarthy, M. I., Mahajan, A., & Todd, J. A. (2021). Analysis of overlapping genetic association in type 1 and type 2 diabetes. Diabetologia, 64(6), 1342-1347. https://doi.org/10.1007/s00125-021-05428-0
Inshaw, Jamie R J, et al. "Analysis of overlapping genetic association in type 1 and type 2 diabetes." Diabetologia vol. 64,6 (2021): 1342-1347. doi: https://doi.org/10.1007/s00125-021-05428-0
Inshaw JRJ, Sidore C, Cucca F, Stefana MI, Crouch DJM, McCarthy MI, Mahajan A, Todd JA. Analysis of overlapping genetic association in type 1 and type 2 diabetes. Diabetologia. 2021 Jun;64(6):1342-1347. doi: 10.1007/s00125-021-05428-0. Epub 2021 Apr 08. PMID: 33830302; PMCID: PMC8099827.
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Human Genetics of Obesity and Type 2 Diabetes Mellitus: Past, Present, and Future.

Circulation. Genomic and precision medicine

Ingelsson E, McCarthy MI.
PMID: 29899044
Circ Genom Precis Med. 2018 Jun;11(6):e002090. doi: 10.1161/CIRCGEN.118.002090.

Type 2 diabetes mellitus (T2D) and obesity already represent 2 of the most prominent risk factors for cardiovascular disease, and are destined to increase in importance given the global changes in lifestyle. Ten years have passed since the first...

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Ingelsson E, McCarthy MI. Human Genetics of Obesity and Type 2 Diabetes Mellitus: Past, Present, and Future. Circ Genom Precis Med. 2018;11(6):e002090doi: 10.1161/CIRCGEN.118.002090.
Ingelsson, E., & McCarthy, M. I. (2018). Human Genetics of Obesity and Type 2 Diabetes Mellitus: Past, Present, and Future. Circulation. Genomic and precision medicine, 11(6), e002090. https://doi.org/10.1161/CIRCGEN.118.002090
Ingelsson, Erik, and McCarthy, Mark I. "Human Genetics of Obesity and Type 2 Diabetes Mellitus: Past, Present, and Future." Circulation. Genomic and precision medicine vol. 11,6 (2018): e002090. doi: https://doi.org/10.1161/CIRCGEN.118.002090
Ingelsson E, McCarthy MI. Human Genetics of Obesity and Type 2 Diabetes Mellitus: Past, Present, and Future. Circ Genom Precis Med. 2018 Jun;11(6):e002090. doi: 10.1161/CIRCGEN.118.002090. PMID: 29899044; PMCID: PMC6405228.
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A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function.

Wellcome open research

Grotz AK, Abaitua F, Navarro-Guerrero E, Hastoy B, Ebner D, Gloyn AL.
PMID: 31976379
Wellcome Open Res. 2020 Apr 29;4:150. doi: 10.12688/wellcomeopenres.15447.2. eCollection 2019.

Type 2 diabetes (T2D) is a global pandemic with a strong genetic component, but most causal genes influencing the disease risk remain unknown. It is clear, however, that the pancreatic beta cell is central to T2D pathogenesis.

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Grotz AK, Abaitua F, Navarro-Guerrero E, et al. A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function. Wellcome Open Res. 2020;4:150doi: 10.12688/wellcomeopenres.15447.2.
Grotz, A. K., Abaitua, F., Navarro-Guerrero, E., Hastoy, B., Ebner, D., & Gloyn, A. L. (2019). A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function. Wellcome open research, 4150. https://doi.org/10.12688/wellcomeopenres.15447.2
Grotz, Antje K, et al. "A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function." Wellcome open research vol. 4 (2019): 150. doi: https://doi.org/10.12688/wellcomeopenres.15447.2
Grotz AK, Abaitua F, Navarro-Guerrero E, Hastoy B, Ebner D, Gloyn AL. A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function. Wellcome Open Res. 2020 Apr 29;4:150. doi: 10.12688/wellcomeopenres.15447.2. eCollection 2019. PMID: 31976379; PMCID: PMC6961417.
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Genome-Wide Association Study of Peripheral Artery Disease.

Circulation. Genomic and precision medicine

van Zuydam NR, Stiby A, Abdalla M, Austin E, Dahlström EH, McLachlan S, Vlachopoulou E, Ahlqvist E, Di Liao C, Sandholm N, Forsblom C, Mahajan A, Robertson NR, Rayner NW, Lindholm E, Sinisalo J, Perola M, Kallio M, Weiss E, Price J, Paterson A, Klein B, Salomaa V, Palmer CNA, Groop PH, Groop L, McCarthy MI, de Andrade M, Morris AP, Hopewell JC, Colhoun HM, Kullo IJ.
PMID: 34601942
Circ Genom Precis Med. 2021 Oct;14(5):e002862. doi: 10.1161/CIRCGEN.119.002862. Epub 2021 Oct 04.

BACKGROUND: Peripheral artery disease (PAD) affects >200 million people worldwide and is associated with high mortality and morbidity. We sought to identify genomic variants associated with PAD overall and in the contexts of diabetes and smoking status.METHODS: We identified...

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van Zuydam NR, Stiby A, Abdalla M, et al. Genome-Wide Association Study of Peripheral Artery Disease. Circ Genom Precis Med. 2021;14(5):e002862doi: 10.1161/CIRCGEN.119.002862.
van Zuydam, N. R., Stiby, A., Abdalla, M., Austin, E., Dahlström, E. H., McLachlan, S., Vlachopoulou, E., Ahlqvist, E., Di Liao, C., Sandholm, N., Forsblom, C., Mahajan, A., Robertson, N. R., Rayner, N. W., Lindholm, E., Sinisalo, J., Perola, M., Kallio, M., Weiss, E., Price, J., Paterson, A., Klein, B., Salomaa, V., Palmer, C. N. A., Groop, P. H., Groop, L., McCarthy, M. I., de Andrade, M., Morris, A. P., Hopewell, J. C., Colhoun, H. M., Kullo, I. J. (2021). Genome-Wide Association Study of Peripheral Artery Disease. Circulation. Genomic and precision medicine, 14(5), e002862. https://doi.org/10.1161/CIRCGEN.119.002862
van Zuydam, Natalie R, et al. "Genome-Wide Association Study of Peripheral Artery Disease." Circulation. Genomic and precision medicine vol. 14,5 (2021): e002862. doi: https://doi.org/10.1161/CIRCGEN.119.002862
van Zuydam NR, Stiby A, Abdalla M, Austin E, Dahlström EH, McLachlan S, Vlachopoulou E, Ahlqvist E, Di Liao C, Sandholm N, Forsblom C, Mahajan A, Robertson NR, Rayner NW, Lindholm E, Sinisalo J, Perola M, Kallio M, Weiss E, Price J, Paterson A, Klein B, Salomaa V, Palmer CNA, Groop PH, Groop L, McCarthy MI, de Andrade M, Morris AP, Hopewell JC, Colhoun HM, Kullo IJ. Genome-Wide Association Study of Peripheral Artery Disease. Circ Genom Precis Med. 2021 Oct;14(5):e002862. doi: 10.1161/CIRCGEN.119.002862. Epub 2021 Oct 04. PMID: 34601942; PMCID: PMC8542067.
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Showing 1 to 7 of 7 entries