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Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition.

Hepatology communications

Männistö V, Kaminska D, Käkelä P, Neuvonen M, Niemi M, Alvarez M, Pajukanta P, Romeo S, Nieuwdorp M, Groen AK, Pihlajamäki J.
PMID: 33553972
Hepatol Commun. 2020 Nov 25;5(2):244-257. doi: 10.1002/hep4.1630. eCollection 2021 Feb.

The protein phosphatase 1 regulatory subunit 3B (

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Männistö V, Kaminska D, Käkelä P, et al. Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition. Hepatol Commun. 2020;5(2):244-257doi: 10.1002/hep4.1630.
Männistö, V., Kaminska, D., Käkelä, P., Neuvonen, M., Niemi, M., Alvarez, M., Pajukanta, P., Romeo, S., Nieuwdorp, M., Groen, A. K., & Pihlajamäki, J. (2021). Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition. Hepatology communications, 5(2), 244-257. https://doi.org/10.1002/hep4.1630
Männistö, Ville, et al. "Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition." Hepatology communications vol. 5,2 (2021): 244-257. doi: https://doi.org/10.1002/hep4.1630
Männistö V, Kaminska D, Käkelä P, Neuvonen M, Niemi M, Alvarez M, Pajukanta P, Romeo S, Nieuwdorp M, Groen AK, Pihlajamäki J. Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition. Hepatol Commun. 2020 Nov 25;5(2):244-257. doi: 10.1002/hep4.1630. eCollection 2021 Feb. PMID: 33553972; PMCID: PMC7850313.
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Super Enhancers in Cancers, Complex Disease, and Developmental Disorders.

Genes

Niederriter AR, Varshney A, Parker SC, Martin DM.
PMID: 26569311
Genes (Basel). 2015 Nov 09;6(4):1183-200. doi: 10.3390/genes6041183.

Recently, unique areas of transcriptional regulation termed super-enhancers have been identified and implicated in human disease. Defined by their magnitude of size, transcription factor density, and binding of transcriptional machinery, super-enhancers have been associated with genes driving cell differentiation....

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Niederriter AR, Varshney A, Parker SC, et al. Super Enhancers in Cancers, Complex Disease, and Developmental Disorders. Genes (Basel). 2015;6(4):1183-200doi: 10.3390/genes6041183.
Niederriter, A. R., Varshney, A., Parker, S. C., & Martin, D. M. (2015). Super Enhancers in Cancers, Complex Disease, and Developmental Disorders. Genes, 6(4), 1183-200. https://doi.org/10.3390/genes6041183
Niederriter, Adrienne R, et al. "Super Enhancers in Cancers, Complex Disease, and Developmental Disorders." Genes vol. 6,4 (2015): 1183-200. doi: https://doi.org/10.3390/genes6041183
Niederriter AR, Varshney A, Parker SC, Martin DM. Super Enhancers in Cancers, Complex Disease, and Developmental Disorders. Genes (Basel). 2015 Nov 09;6(4):1183-200. doi: 10.3390/genes6041183. PMID: 26569311; PMCID: PMC4690034.
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Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI.

Cell reports. Medicine

van der Kolk BW, Saari S, Lovric A, Arif M, Alvarez M, Ko A, Miao Z, Sahebekhtiari N, Muniandy M, Heinonen S, Oghabian A, Jokinen R, Jukarainen S, Hakkarainen A, Lundbom J, Kuula J, Groop PH, Tukiainen T, Lundbom N, Rissanen A, Kaprio J, Williams EG, Zamboni N, Mardinoglu A, Pajukanta P, Pietiläinen KH.
PMID: 33948567
Cell Rep Med. 2021 Mar 30;2(4):100226. doi: 10.1016/j.xcrm.2021.100226. eCollection 2021 Apr 20.

Tissue-specific mechanisms prompting obesity-related development complications in humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and skeletal muscle to examine the effects of acquired obesity among 49 BMI-discordant monozygotic twin pairs. Overall, adipose tissue appears to...

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van der Kolk BW, Saari S, Lovric A, et al. Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI. Cell Rep Med. 2021;2(4):100226doi: 10.1016/j.xcrm.2021.100226.
van der Kolk, B. W., Saari, S., Lovric, A., Arif, M., Alvarez, M., Ko, A., Miao, Z., Sahebekhtiari, N., Muniandy, M., Heinonen, S., Oghabian, A., Jokinen, R., Jukarainen, S., Hakkarainen, A., Lundbom, J., Kuula, J., Groop, P. H., Tukiainen, T., Lundbom, N., Rissanen, A., Kaprio, J., Williams, E. G., Zamboni, N., Mardinoglu, A., Pajukanta, P., & Pietiläinen, K. H. (2021). Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI. Cell reports. Medicine, 2(4), 100226. https://doi.org/10.1016/j.xcrm.2021.100226
van der Kolk, Birgitta W, et al. "Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI." Cell reports. Medicine vol. 2,4 (2021): 100226. doi: https://doi.org/10.1016/j.xcrm.2021.100226
van der Kolk BW, Saari S, Lovric A, Arif M, Alvarez M, Ko A, Miao Z, Sahebekhtiari N, Muniandy M, Heinonen S, Oghabian A, Jokinen R, Jukarainen S, Hakkarainen A, Lundbom J, Kuula J, Groop PH, Tukiainen T, Lundbom N, Rissanen A, Kaprio J, Williams EG, Zamboni N, Mardinoglu A, Pajukanta P, Pietiläinen KH. Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI. Cell Rep Med. 2021 Mar 30;2(4):100226. doi: 10.1016/j.xcrm.2021.100226. eCollection 2021 Apr 20. PMID: 33948567; PMCID: PMC8080113.
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Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes.

Genome medicine

Pan DZ, Miao Z, Comenho C, Rajkumar S, Koka A, Lee SHT, Alvarez M, Kaminska D, Ko A, Sinsheimer JS, Mohlke KL, Mancuso N, Muñoz-Hernandez LL, Herrera-Hernandez M, Tusié-Luna MT, Aguilar-Salinas C, Pietiläinen KH, Pihlajamäki J, Laakso M, Garske KM, Pajukanta P.
PMID: 34340684
Genome Med. 2021 Aug 02;13(1):123. doi: 10.1186/s13073-021-00939-2.

BACKGROUND: Obesity predisposes individuals to multiple cardiometabolic disorders, including type 2 diabetes (T2D). As body mass index (BMI) cannot reliably differentiate fat from lean mass, the metabolically detrimental abdominal obesity has been estimated using waist-hip ratio (WHR). Waist-hip ratio...

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Pan DZ, Miao Z, Comenho C, et al. Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes. Genome Med. 2021;13(1):123doi: 10.1186/s13073-021-00939-2.
Pan, D. Z., Miao, Z., Comenho, C., Rajkumar, S., Koka, A., Lee, S. H. T., Alvarez, M., Kaminska, D., Ko, A., Sinsheimer, J. S., Mohlke, K. L., Mancuso, N., Muñoz-Hernandez, L. L., Herrera-Hernandez, M., Tusié-Luna, M. T., Aguilar-Salinas, C., Pietiläinen, K. H., Pihlajamäki, J., Laakso, M., Garske, K. M., & Pajukanta, P. (2021). Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes. Genome medicine, 13(1), 123. https://doi.org/10.1186/s13073-021-00939-2
Pan, David Z, et al. "Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes." Genome medicine vol. 13,1 (2021): 123. doi: https://doi.org/10.1186/s13073-021-00939-2
Pan DZ, Miao Z, Comenho C, Rajkumar S, Koka A, Lee SHT, Alvarez M, Kaminska D, Ko A, Sinsheimer JS, Mohlke KL, Mancuso N, Muñoz-Hernandez LL, Herrera-Hernandez M, Tusié-Luna MT, Aguilar-Salinas C, Pietiläinen KH, Pihlajamäki J, Laakso M, Garske KM, Pajukanta P. Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes. Genome Med. 2021 Aug 02;13(1):123. doi: 10.1186/s13073-021-00939-2. PMID: 34340684; PMCID: PMC8327600.
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Showing 1 to 4 of 4 entries