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Showing 1 to 12 of 24 entries
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Mild Cognitive Impairment and Dementia Prevalence: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS).

Alzheimer's & dementia (Amsterdam, Netherlands)

Knopman DS, Gottesman RF, Sharrett AR, Wruck LM, Windham BG, Coker L, Schneider AL, Hengrui S, Alonso A, Coresh J, Albert MS, Mosley TH.
PMID: 26949733
Alzheimers Dement (Amst). 2016;2:1-11. doi: 10.1016/j.dadm.2015.12.002.

INTRODUCTION: We examined prevalence of mild cognitive impairment (MCI) and dementia in the Atherosclerosis Risk in Communities (ARIC) Neurocognitive Study.METHODS: Beginning in June, 2011, we invited all surviving ARIC participants to undergo cognitive, neurological and brain imaging assessments to...

Pre-Statistical Considerations for Harmonization of Cognitive Instruments: Harmonization of ARIC, CARDIA, CHS, FHS, MESA, and NOMAS.

Journal of Alzheimer's disease : JAD

Briceño EM, Gross AL, Giordani BJ, Manly JJ, Gottesman RF, Elkind MSV, Sidney S, Hingtgen S, Sacco RL, Wright CB, Fitzpatrick A, Fohner AE, Mosley TH, Yaffe K, Levine DA.
PMID: 34459397
J Alzheimers Dis. 2021;83(4):1803-1813. doi: 10.3233/JAD-210459.

BACKGROUND: Meta-analyses of individuals' cognitive data are increasing to investigate the biomedical, lifestyle, and sociocultural factors that influence cognitive decline and dementia risk. Pre-statistical harmonization of cognitive instruments is a critical methodological step for accurate cognitive data harmonization, yet...

Prestroke Physical Activity and Adverse Health Outcomes After Stroke in the Atherosclerosis Risk in Communities Study.

Stroke

Mediano MFF, Mok Y, Coresh J, Kucharska-Newton A, Palta P, Lakshminarayan K, Rosamond WD, Matsushita K, Koton S.
PMID: 33784831
Stroke. 2021 Jun;52(6):2086-2095. doi: 10.1161/STROKEAHA.120.032695. Epub 2021 Mar 31.

BACKGROUND AND PURPOSE: The association of physical activity (PA) before stroke (prestroke PA) with long-term prognosis after stroke is still unclear. We examined the association of prestroke PA with adverse health outcomes in the ARIC study (Atherosclerosis Risk in...

Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases.

Journal of the American Society of Nephrology : JASN

Yu Z, Jin J, Tin A, Köttgen A, Yu B, Chen J, Surapaneni A, Zhou L, Ballantyne CM, Hoogeveen RC, Arking DE, Chatterjee N, Grams ME, Coresh J.
PMID: 34548389
J Am Soc Nephrol. 2021 Sep 21; doi: 10.1681/ASN.2020111599. Epub 2021 Sep 21.

BACKGROUND: Genome-wide association studies (GWAS) have revealed numerous loci for kidney function (eGFR). The relationship between polygenic predictors of eGFR, risk of incident adverse kidney outcomes, and the plasma proteome is not known.METHODS: We developed a genome-wide polygenic risk...

Liver Enzymes and Risk of Stroke: The Atherosclerosis Risk in Communities (ARIC) Study.

Journal of stroke

Ruban A, Daya N, Schneider ALC, Gottesman R, Selvin E, Coresh J, Lazo M, Koton S.
PMID: 33053951
J Stroke. 2020 Sep;22(3):357-368. doi: 10.5853/jos.2020.00290. Epub 2020 Sep 29.

BACKGROUND AND PURPOSE: Liver enzymes (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and gamma-glutamyl transpeptidase [GGT]) are glutamate-regulatory enzymes, and higher glutamate levels correlated with worse prognosis of patients with neurotrauma. However, less is known about the association between liver...

Assessing Bias in Cognitive Testing for Older Adults with Sensory Impairment: An Analysis of Differential Item Functioning in the Baltimore Longitudinal Study on Aging (BLSA) and the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS).

Journal of the International Neuropsychological Society : JINS

Nichols E, Deal JA, Swenor BK, Abraham AG, Armstrong NM, Carlson MC, Griswold M, Lin FR, Mosley TH, Ramulu PY, Reed NS, Resnick SM, Sharrett AR, Gross AL.
PMID: 33896441
J Int Neuropsychol Soc. 2021 Apr 26;1-12. doi: 10.1017/S1355617721000400. Epub 2021 Apr 26.

OBJECTIVES: Vision and hearing impairments affect 55% of people aged 60+ years and are associated with lower cognitive test performance; however, tests rely on vision, hearing, or both. We hypothesized that scores on tests that depend on vision or...

Brain White Matter Structure and Amyloid Deposition in Black and White Older Adults: The ARIC-PET Study.

Journal of the American Heart Association

Walker KA, Silverstein N, Zhou Y, Hughes TM, Jack CR, Knopman DS, Sharrett AR, Wong DF, Mosley TH, Gottesman RF.
PMID: 34431373
J Am Heart Assoc. 2021 Sep 07;10(17):e022087. doi: 10.1161/JAHA.121.022087. Epub 2021 Aug 25.

Background White matter abnormalities are a common feature of aging and Alzheimer disease, and tend to be more severe among Black individuals. However, the extent to which white matter abnormalities relate to amyloid deposition, a marker of Alzheimer pathology,...

The Alzheimer's Disease Sequencing Project: Study design and sample selection.

Neurology. Genetics

Beecham GW, Bis JC, Martin ER, Choi SH, DeStefano AL, van Duijn CM, Fornage M, Gabriel SB, Koboldt DC, Larson DE, Naj AC, Psaty BM, Salerno W, Bush WS, Foroud TM, Wijsman E, Farrer LA, Goate A, Haines JL, Pericak-Vance MA, Boerwinkle E, Mayeux R, Seshadri S, Schellenberg G.
PMID: 29184913
Neurol Genet. 2017 Oct 13;3(5):e194. doi: 10.1212/NXG.0000000000000194. eCollection 2017 Oct.

No abstract available.

Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences.

PLoS genetics

Zhan L, Li J, Jew B, Sul JH.
PMID: 34516545
PLoS Genet. 2021 Sep 13;17(9):e1009772. doi: 10.1371/journal.pgen.1009772. eCollection 2021 Sep.

Late-onset Alzheimer's disease (LOAD) is the most common type of dementia causing irreversible brain damage to the elderly and presents a major public health challenge. Clinical research and genome-wide association studies have suggested a potential contribution of the endocytic...

Visual Function, Physical Function, and Activities of Daily Living in Two Aging Communities.

Translational vision science & technology

Guo X, Arsiwala LT, Dong Y, Mihailovic A, Ramulu PY, Sharrett AR, Mosley T, Abraham AG.
PMID: 34913953
Transl Vis Sci Technol. 2021 Dec 01;10(14):15. doi: 10.1167/tvst.10.14.15.

PURPOSE: We report the distribution of visual acuity impairment (VAI), contrast sensitivity impairment (CSI) and their associations with physical health in an aging population.METHODS: In this cross-sectional analysis, VAI was categorized as mild (20/40-20/60) and moderate or greater (

Prestroke Physical Activity and Adverse Health Outcomes After Stroke in the Atherosclerosis Risk in Communities Study.

Stroke

Mediano MFF, Mok Y, Coresh J, Kucharska-Newton A, Palta P, Lakshminarayan K, Rosamond WD, Matsushita K, Koton S.
PMID: 33784831
Stroke. 2021 Jun;52(6):2086-2095. doi: 10.1161/STROKEAHA.120.032695. Epub 2021 Mar 31.

BACKGROUND AND PURPOSE: The association of physical activity (PA) before stroke (prestroke PA) with long-term prognosis after stroke is still unclear. We examined the association of prestroke PA with adverse health outcomes in the ARIC study (Atherosclerosis Risk in...

Plasma clusterin levels and risk of dementia, Alzheimer's disease, and stroke.

Alzheimer's & dementia (Amsterdam, Netherlands)

Weinstein G, Beiser AS, Preis SR, Courchesne P, Chouraki V, Levy D, Seshadri S.
PMID: 27453932
Alzheimers Dement (Amst). 2016 Jul 09;3:103-9. doi: 10.1016/j.dadm.2016.06.005. eCollection 2016.

INTRODUCTION: Genetic variation in the clusterin gene has been associated with Alzheimer Disease (AD), and the clusterin protein is thought to play a mechanistic role. We explored the associations of clusterin plasma levels with incident dementia, AD, and stroke.METHODS:...

Showing 1 to 12 of 24 entries