Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 7 of 7 entries
Sorted by: Best Match Show Resources per page
Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics.

Frontiers in genetics

Holland D, Wang Y, Thompson WK, Schork A, Chen CH, Lo MT, Witoelar A, Werge T, O'Donovan M, Andreassen OA, Dale AM.
PMID: 26909100
Front Genet. 2016 Feb 16;7:15. doi: 10.3389/fgene.2016.00015. eCollection 2016.

Genome-wide Association Studies (GWAS) result in millions of summary statistics ("z-scores") for single nucleotide polymorphism (SNP) associations with phenotypes. These rich datasets afford deep insights into the nature and extent of genetic contributions to complex phenotypes such as psychiatric...

Cite
Holland D, Wang Y, Thompson WK, et al. Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics. Front Genet. 2016;7:15doi: 10.3389/fgene.2016.00015.
Holland, D., Wang, Y., Thompson, W. K., Schork, A., Chen, C. H., Lo, M. T., Witoelar, A., Werge, T., O'Donovan, M., Andreassen, O. A., & Dale, A. M. (2016). Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics. Frontiers in genetics, 715. https://doi.org/10.3389/fgene.2016.00015
Holland, Dominic, et al. "Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics." Frontiers in genetics vol. 7 (2016): 15. doi: https://doi.org/10.3389/fgene.2016.00015
Holland D, Wang Y, Thompson WK, Schork A, Chen CH, Lo MT, Witoelar A, Werge T, O'Donovan M, Andreassen OA, Dale AM. Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics. Front Genet. 2016 Feb 16;7:15. doi: 10.3389/fgene.2016.00015. eCollection 2016. PMID: 26909100; PMCID: PMC4754432.
Copy Download .nbib Format: NLM
Risk Factors, Clinical Features, and Polygenic Risk Scores in Schizophrenia and Schizoaffective Disorder Depressive-Type.

Schizophrenia bulletin

Dennison CA, Legge SE, Hubbard L, Lynham AJ, Zammit S, Holmans P, Cardno AG, Owen MJ, O'Donovan MC, Walters JTR.
PMID: 33837784
Schizophr Bull. 2021 Aug 21;47(5):1375-1384. doi: 10.1093/schbul/sbab036.

There is controversy about the status of schizoaffective disorder depressive-type (SA-D), particularly whether it should be considered a form of schizophrenia or a distinct disorder. We aimed to determine whether individuals with SA-D differ from individuals with schizophrenia in...

Cite
Dennison CA, Legge SE, Hubbard L, et al. Risk Factors, Clinical Features, and Polygenic Risk Scores in Schizophrenia and Schizoaffective Disorder Depressive-Type. Schizophr Bull. 2021;47(5):1375-1384doi: 10.1093/schbul/sbab036.
Dennison, C. A., Legge, S. E., Hubbard, L., Lynham, A. J., Zammit, S., Holmans, P., Cardno, A. G., Owen, M. J., O'Donovan, M. C., & Walters, J. T. R. (2021). Risk Factors, Clinical Features, and Polygenic Risk Scores in Schizophrenia and Schizoaffective Disorder Depressive-Type. Schizophrenia bulletin, 47(5), 1375-1384. https://doi.org/10.1093/schbul/sbab036
Dennison, Charlotte A, et al. "Risk Factors, Clinical Features, and Polygenic Risk Scores in Schizophrenia and Schizoaffective Disorder Depressive-Type." Schizophrenia bulletin vol. 47,5 (2021): 1375-1384. doi: https://doi.org/10.1093/schbul/sbab036
Dennison CA, Legge SE, Hubbard L, Lynham AJ, Zammit S, Holmans P, Cardno AG, Owen MJ, O'Donovan MC, Walters JTR. Risk Factors, Clinical Features, and Polygenic Risk Scores in Schizophrenia and Schizoaffective Disorder Depressive-Type. Schizophr Bull. 2021 Aug 21;47(5):1375-1384. doi: 10.1093/schbul/sbab036. PMID: 33837784; PMCID: PMC8379553.
Copy Download .nbib Format: NLM
Discordant associations of educational attainment with ASD and ADHD implicate a polygenic form of pleiotropy.

Nature communications

Verhoef E, Grove J, Shapland CY, Demontis D, Burgess S, Rai D, Børglum AD, St Pourcain B.
PMID: 34764245
Nat Commun. 2021 Nov 11;12(1):6534. doi: 10.1038/s41467-021-26755-1.

Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are complex co-occurring neurodevelopmental conditions. Their genetic architectures reveal striking similarities but also differences, including strong, discordant polygenic associations with educational attainment (EA). To study genetic mechanisms that present as ASD-related...

Cite
Verhoef E, Grove J, Shapland CY, et al. Discordant associations of educational attainment with ASD and ADHD implicate a polygenic form of pleiotropy. Nat Commun. 2021;12(1):6534doi: 10.1038/s41467-021-26755-1.
Verhoef, E., Grove, J., Shapland, C. Y., Demontis, D., Burgess, S., Rai, D., Børglum, A. D., & St Pourcain, B. (2021). Discordant associations of educational attainment with ASD and ADHD implicate a polygenic form of pleiotropy. Nature communications, 12(1), 6534. https://doi.org/10.1038/s41467-021-26755-1
Verhoef, Ellen, et al. "Discordant associations of educational attainment with ASD and ADHD implicate a polygenic form of pleiotropy." Nature communications vol. 12,1 (2021): 6534. doi: https://doi.org/10.1038/s41467-021-26755-1
Verhoef E, Grove J, Shapland CY, Demontis D, Burgess S, Rai D, Børglum AD, St Pourcain B. Discordant associations of educational attainment with ASD and ADHD implicate a polygenic form of pleiotropy. Nat Commun. 2021 Nov 11;12(1):6534. doi: 10.1038/s41467-021-26755-1. PMID: 34764245; PMCID: PMC8586371.
Copy Download .nbib Format: NLM
Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status.

JAMA psychiatry

Agerbo E, Trabjerg BB, Børglum AD, Schork AJ, Vilhjálmsson BJ, Pedersen CB, Hakulinen C, Albiñana C, Hougaard DM, Grove J, McGrath JJ, Bybjerg-Grauholm J, Mors O, Plana-Ripoll O, Werge T, Wray NR, Mortensen PB, Musliner KL.
PMID: 33439215
JAMA Psychiatry. 2021 Apr 01;78(4):387-397. doi: 10.1001/jamapsychiatry.2020.4172.

IMPORTANCE: Combining information on polygenic risk scores (PRSs) with other known risk factors could potentially improve the identification of risk of depression in the general population. However, to our knowledge, no study has estimated the association of PRS with...

Cite
Agerbo E, Trabjerg BB, Børglum AD, et al. Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status. JAMA Psychiatry. 2021;78(4):387-397doi: 10.1001/jamapsychiatry.2020.4172.
Agerbo, E., Trabjerg, B. B., Børglum, A. D., Schork, A. J., Vilhjálmsson, B. J., Pedersen, C. B., Hakulinen, C., Albiñana, C., Hougaard, D. M., Grove, J., McGrath, J. J., Bybjerg-Grauholm, J., Mors, O., Plana-Ripoll, O., Werge, T., Wray, N. R., Mortensen, P. B., & Musliner, K. L. (2021). Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status. JAMA psychiatry, 78(4), 387-397. https://doi.org/10.1001/jamapsychiatry.2020.4172
Agerbo, Esben, et al. "Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status." JAMA psychiatry vol. 78,4 (2021): 387-397. doi: https://doi.org/10.1001/jamapsychiatry.2020.4172
Agerbo E, Trabjerg BB, Børglum AD, Schork AJ, Vilhjálmsson BJ, Pedersen CB, Hakulinen C, Albiñana C, Hougaard DM, Grove J, McGrath JJ, Bybjerg-Grauholm J, Mors O, Plana-Ripoll O, Werge T, Wray NR, Mortensen PB, Musliner KL. Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status. JAMA Psychiatry. 2021 Apr 01;78(4):387-397. doi: 10.1001/jamapsychiatry.2020.4172. PMID: 33439215; PMCID: PMC7807393.
Copy Download .nbib Format: NLM
Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status.

JAMA psychiatry

Agerbo E, Trabjerg BB, Børglum AD, Schork AJ, Vilhjálmsson BJ, Pedersen CB, Hakulinen C, Albiñana C, Hougaard DM, Grove J, McGrath JJ, Bybjerg-Grauholm J, Mors O, Plana-Ripoll O, Werge T, Wray NR, Mortensen PB, Musliner KL.
PMID: 33439215
JAMA Psychiatry. 2021 Apr 01;78(4):387-397. doi: 10.1001/jamapsychiatry.2020.4172.

IMPORTANCE: Combining information on polygenic risk scores (PRSs) with other known risk factors could potentially improve the identification of risk of depression in the general population. However, to our knowledge, no study has estimated the association of PRS with...

Cite
Agerbo E, Trabjerg BB, Børglum AD, et al. Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status. JAMA Psychiatry. 2021;78(4):387-397doi: 10.1001/jamapsychiatry.2020.4172.
Agerbo, E., Trabjerg, B. B., Børglum, A. D., Schork, A. J., Vilhjálmsson, B. J., Pedersen, C. B., Hakulinen, C., Albiñana, C., Hougaard, D. M., Grove, J., McGrath, J. J., Bybjerg-Grauholm, J., Mors, O., Plana-Ripoll, O., Werge, T., Wray, N. R., Mortensen, P. B., & Musliner, K. L. (2021). Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status. JAMA psychiatry, 78(4), 387-397. https://doi.org/10.1001/jamapsychiatry.2020.4172
Agerbo, Esben, et al. "Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status." JAMA psychiatry vol. 78,4 (2021): 387-397. doi: https://doi.org/10.1001/jamapsychiatry.2020.4172
Agerbo E, Trabjerg BB, Børglum AD, Schork AJ, Vilhjálmsson BJ, Pedersen CB, Hakulinen C, Albiñana C, Hougaard DM, Grove J, McGrath JJ, Bybjerg-Grauholm J, Mors O, Plana-Ripoll O, Werge T, Wray NR, Mortensen PB, Musliner KL. Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status. JAMA Psychiatry. 2021 Apr 01;78(4):387-397. doi: 10.1001/jamapsychiatry.2020.4172. PMID: 33439215; PMCID: PMC7807393.
Copy Download .nbib Format: NLM
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders.

Cell

[No authors listed]
PMID: 31835028
Cell. 2019 Dec 12;179(7):1469-1482.e11. doi: 10.1016/j.cell.2019.11.020.

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia...

Cite
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell. 2019;179(7):1469-1482.e11doi: 10.1016/j.cell.2019.11.020.
(2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell, 179(7), 1469-1482.e11. https://doi.org/10.1016/j.cell.2019.11.020
"Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders." Cell vol. 179,7 (2019): 1469-1482.e11. doi: https://doi.org/10.1016/j.cell.2019.11.020
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell. 2019 Dec 12;179(7):1469-1482.e11. doi: 10.1016/j.cell.2019.11.020. PMID: 31835028; PMCID: PMC7077032.
Copy Download .nbib Format: NLM
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders.

Cell

[No authors listed]
PMID: 31835028
Cell. 2019 Dec 12;179(7):1469-1482.e11. doi: 10.1016/j.cell.2019.11.020.

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia...

Cite
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell. 2019;179(7):1469-1482.e11doi: 10.1016/j.cell.2019.11.020.
(2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell, 179(7), 1469-1482.e11. https://doi.org/10.1016/j.cell.2019.11.020
"Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders." Cell vol. 179,7 (2019): 1469-1482.e11. doi: https://doi.org/10.1016/j.cell.2019.11.020
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell. 2019 Dec 12;179(7):1469-1482.e11. doi: 10.1016/j.cell.2019.11.020. PMID: 31835028; PMCID: PMC7077032.
Copy Download .nbib Format: NLM
Showing 1 to 7 of 7 entries