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Druggable genome in attention deficit/hyperactivity disorder and its co-morbid conditions. New avenues for treatment.

Molecular psychiatry

Hegvik TA, Waløen K, Pandey SK, Faraone SV, Haavik J, Zayats T.
PMID: 31628418
Mol Psychiatry. 2021 Aug;26(8):4004-4015. doi: 10.1038/s41380-019-0540-z. Epub 2019 Oct 18.

Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder with only symptomatic care available. Genome-wide association (GWA) studies can provide a starting point in the search for novel drug targets and possibilities of drug repurposing. Here, we explored the druggable...

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Hegvik TA, Waløen K, Pandey SK, et al. Druggable genome in attention deficit/hyperactivity disorder and its co-morbid conditions. New avenues for treatment. Mol Psychiatry. 2019;26(8):4004-4015doi: 10.1038/s41380-019-0540-z.
Hegvik, T. A., Waløen, K., Pandey, S. K., Faraone, S. V., Haavik, J., & Zayats, T. (2021). Druggable genome in attention deficit/hyperactivity disorder and its co-morbid conditions. New avenues for treatment. Molecular psychiatry, 26(8), 4004-4015. https://doi.org/10.1038/s41380-019-0540-z
Hegvik, Tor-Arne, et al. "Druggable genome in attention deficit/hyperactivity disorder and its co-morbid conditions. New avenues for treatment." Molecular psychiatry vol. 26,8 (2021): 4004-4015. doi: https://doi.org/10.1038/s41380-019-0540-z
Hegvik TA, Waløen K, Pandey SK, Faraone SV, Haavik J, Zayats T. Druggable genome in attention deficit/hyperactivity disorder and its co-morbid conditions. New avenues for treatment. Mol Psychiatry. 2021 Aug;26(8):4004-4015. doi: 10.1038/s41380-019-0540-z. Epub 2019 Oct 18. PMID: 31628418; PMCID: PMC7165040.
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Erratum.

Biological psychiatry

[No authors listed]
PMID: 31558221
Biol Psychiatry. 2019 Oct 15;86(8):647. doi: 10.1016/j.biopsych.2019.07.025.

No abstract available.

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Erratum. Biol Psychiatry. 2019;86(8):647doi: 10.1016/j.biopsych.2019.07.025.
(2019). Erratum. Biological psychiatry, 86(8), 647. https://doi.org/10.1016/j.biopsych.2019.07.025
"Erratum." Biological psychiatry vol. 86,8 (2019): 647. doi: https://doi.org/10.1016/j.biopsych.2019.07.025
Erratum. Biol Psychiatry. 2019 Oct 15;86(8):647. doi: 10.1016/j.biopsych.2019.07.025. PMID: 31558221; PMCID: PMC7130456.
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Resource profile and user guide of the Polygenic Index Repository.

Nature human behaviour

Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linnér R, Ahlskog R, Kleinman A, Hinds DA, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger PD, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A.
PMID: 34140656
Nat Hum Behav. 2021 Dec;5(12):1744-1758. doi: 10.1038/s41562-021-01119-3. Epub 2021 Jun 17.

Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs for 47 phenotypes in 11 datasets. To maximize the...

Cite
Becker J, Burik CAP, Goldman G, et al. Resource profile and user guide of the Polygenic Index Repository. Nat Hum Behav. 2021;5(12):1744-1758doi: 10.1038/s41562-021-01119-3.
Becker, J., Burik, C. A. P., Goldman, G., Wang, N., Jayashankar, H., Bennett, M., Belsky, D. W., Karlsson Linnér, R., Ahlskog, R., Kleinman, A., Hinds, D. A., Caspi, A., Corcoran, D. L., Moffitt, T. E., Poulton, R., Sugden, K., Williams, B. S., Harris, K. M., Steptoe, A., Ajnakina, O., Milani, L., Esko, T., Iacono, W. G., McGue, M., Magnusson, P. K. E., Mallard, T. T., Harden, K. P., Tucker-Drob, E. M., Herd, P., Freese, J., Young, A., Beauchamp, J. P., Koellinger, P. D., Oskarsson, S., Johannesson, M., Visscher, P. M., Meyer, M. N., Laibson, D., Cesarini, D., Benjamin, D. J., Turley, P., & Okbay, A. (2021). Resource profile and user guide of the Polygenic Index Repository. Nature human behaviour, 5(12), 1744-1758. https://doi.org/10.1038/s41562-021-01119-3
Becker, Joel, et al. "Resource profile and user guide of the Polygenic Index Repository." Nature human behaviour vol. 5,12 (2021): 1744-1758. doi: https://doi.org/10.1038/s41562-021-01119-3
Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linnér R, Ahlskog R, Kleinman A, Hinds DA, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger PD, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A. Resource profile and user guide of the Polygenic Index Repository. Nat Hum Behav. 2021 Dec;5(12):1744-1758. doi: 10.1038/s41562-021-01119-3. Epub 2021 Jun 17. PMID: 34140656; PMCID: PMC8678380.
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Resource profile and user guide of the Polygenic Index Repository.

Nature human behaviour

Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linnér R, Ahlskog R, Kleinman A, Hinds DA, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger PD, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A.
PMID: 34140656
Nat Hum Behav. 2021 Dec;5(12):1744-1758. doi: 10.1038/s41562-021-01119-3. Epub 2021 Jun 17.

Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs for 47 phenotypes in 11 datasets. To maximize the...

Cite
Becker J, Burik CAP, Goldman G, et al. Resource profile and user guide of the Polygenic Index Repository. Nat Hum Behav. 2021;5(12):1744-1758doi: 10.1038/s41562-021-01119-3.
Becker, J., Burik, C. A. P., Goldman, G., Wang, N., Jayashankar, H., Bennett, M., Belsky, D. W., Karlsson Linnér, R., Ahlskog, R., Kleinman, A., Hinds, D. A., Caspi, A., Corcoran, D. L., Moffitt, T. E., Poulton, R., Sugden, K., Williams, B. S., Harris, K. M., Steptoe, A., Ajnakina, O., Milani, L., Esko, T., Iacono, W. G., McGue, M., Magnusson, P. K. E., Mallard, T. T., Harden, K. P., Tucker-Drob, E. M., Herd, P., Freese, J., Young, A., Beauchamp, J. P., Koellinger, P. D., Oskarsson, S., Johannesson, M., Visscher, P. M., Meyer, M. N., Laibson, D., Cesarini, D., Benjamin, D. J., Turley, P., & Okbay, A. (2021). Resource profile and user guide of the Polygenic Index Repository. Nature human behaviour, 5(12), 1744-1758. https://doi.org/10.1038/s41562-021-01119-3
Becker, Joel, et al. "Resource profile and user guide of the Polygenic Index Repository." Nature human behaviour vol. 5,12 (2021): 1744-1758. doi: https://doi.org/10.1038/s41562-021-01119-3
Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linnér R, Ahlskog R, Kleinman A, Hinds DA, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger PD, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A. Resource profile and user guide of the Polygenic Index Repository. Nat Hum Behav. 2021 Dec;5(12):1744-1758. doi: 10.1038/s41562-021-01119-3. Epub 2021 Jun 17. PMID: 34140656; PMCID: PMC8678380.
Copy Download .nbib Format: NLM
Resource profile and user guide of the Polygenic Index Repository.

Nature human behaviour

Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linnér R, Ahlskog R, Kleinman A, Hinds DA, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger PD, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A.
PMID: 34140656
Nat Hum Behav. 2021 Dec;5(12):1744-1758. doi: 10.1038/s41562-021-01119-3. Epub 2021 Jun 17.

Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs for 47 phenotypes in 11 datasets. To maximize the...

Cite
Becker J, Burik CAP, Goldman G, et al. Resource profile and user guide of the Polygenic Index Repository. Nat Hum Behav. 2021;5(12):1744-1758doi: 10.1038/s41562-021-01119-3.
Becker, J., Burik, C. A. P., Goldman, G., Wang, N., Jayashankar, H., Bennett, M., Belsky, D. W., Karlsson Linnér, R., Ahlskog, R., Kleinman, A., Hinds, D. A., Caspi, A., Corcoran, D. L., Moffitt, T. E., Poulton, R., Sugden, K., Williams, B. S., Harris, K. M., Steptoe, A., Ajnakina, O., Milani, L., Esko, T., Iacono, W. G., McGue, M., Magnusson, P. K. E., Mallard, T. T., Harden, K. P., Tucker-Drob, E. M., Herd, P., Freese, J., Young, A., Beauchamp, J. P., Koellinger, P. D., Oskarsson, S., Johannesson, M., Visscher, P. M., Meyer, M. N., Laibson, D., Cesarini, D., Benjamin, D. J., Turley, P., & Okbay, A. (2021). Resource profile and user guide of the Polygenic Index Repository. Nature human behaviour, 5(12), 1744-1758. https://doi.org/10.1038/s41562-021-01119-3
Becker, Joel, et al. "Resource profile and user guide of the Polygenic Index Repository." Nature human behaviour vol. 5,12 (2021): 1744-1758. doi: https://doi.org/10.1038/s41562-021-01119-3
Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linnér R, Ahlskog R, Kleinman A, Hinds DA, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger PD, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A. Resource profile and user guide of the Polygenic Index Repository. Nat Hum Behav. 2021 Dec;5(12):1744-1758. doi: 10.1038/s41562-021-01119-3. Epub 2021 Jun 17. PMID: 34140656; PMCID: PMC8678380.
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Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders.

Cell

[No authors listed]
PMID: 31835028
Cell. 2019 Dec 12;179(7):1469-1482.e11. doi: 10.1016/j.cell.2019.11.020.

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia...

Cite
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell. 2019;179(7):1469-1482.e11doi: 10.1016/j.cell.2019.11.020.
(2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell, 179(7), 1469-1482.e11. https://doi.org/10.1016/j.cell.2019.11.020
"Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders." Cell vol. 179,7 (2019): 1469-1482.e11. doi: https://doi.org/10.1016/j.cell.2019.11.020
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell. 2019 Dec 12;179(7):1469-1482.e11. doi: 10.1016/j.cell.2019.11.020. PMID: 31835028; PMCID: PMC7077032.
Copy Download .nbib Format: NLM
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders.

Cell

[No authors listed]
PMID: 31835028
Cell. 2019 Dec 12;179(7):1469-1482.e11. doi: 10.1016/j.cell.2019.11.020.

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia...

Cite
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell. 2019;179(7):1469-1482.e11doi: 10.1016/j.cell.2019.11.020.
(2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell, 179(7), 1469-1482.e11. https://doi.org/10.1016/j.cell.2019.11.020
"Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders." Cell vol. 179,7 (2019): 1469-1482.e11. doi: https://doi.org/10.1016/j.cell.2019.11.020
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell. 2019 Dec 12;179(7):1469-1482.e11. doi: 10.1016/j.cell.2019.11.020. PMID: 31835028; PMCID: PMC7077032.
Copy Download .nbib Format: NLM
Showing 1 to 7 of 7 entries