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Showing 1 to 6 of 6 entries
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Epigenetic markers of renal function in african americans.

Nursing research and practice

Bomotti SM, Smith JA, Zagel AL, Taylor JY, Turner ST, Kardia SL.
PMID: 24396594
Nurs Res Pract. 2013;2013:687519. doi: 10.1155/2013/687519. Epub 2013 Dec 12.

Chronic kidney disease (CKD) is an increasing concern in the United States due to its rapidly rising prevalence, particularly among African Americans. Epigenetic DNA methylation markers are becoming important biomarkers of chronic diseases such as CKD. To better understand...

Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans.

Epigenetics

Ammous F, Zhao W, Ratliff SM, Kho M, Shang L, Jones AC, Chaudhary NS, Tiwari HK, Irvin MR, Arnett DK, Mosley TH, Bielak LF, Kardia SLR, Zhou X, Smith J.
PMID: 33100131
Epigenetics. 2021 Aug;16(8):862-875. doi: 10.1080/15592294.2020.1827717. Epub 2020 Oct 26.

Target organ damage (TOD) manifests as vascular injuries in the body organ systems associated with long-standing hypertension. DNA methylation in peripheral blood leukocytes can capture inflammatory processes and gene expression changes underlying TOD. We investigated the association between epigenome-wide...

Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans.

Epigenetics

Ammous F, Zhao W, Ratliff SM, Kho M, Shang L, Jones AC, Chaudhary NS, Tiwari HK, Irvin MR, Arnett DK, Mosley TH, Bielak LF, Kardia SLR, Zhou X, Smith J.
PMID: 33100131
Epigenetics. 2021 Aug;16(8):862-875. doi: 10.1080/15592294.2020.1827717. Epub 2020 Oct 26.

Target organ damage (TOD) manifests as vascular injuries in the body organ systems associated with long-standing hypertension. DNA methylation in peripheral blood leukocytes can capture inflammatory processes and gene expression changes underlying TOD. We investigated the association between epigenome-wide...

An evaluation of the metabolic syndrome in a large multi-ethnic study: the Family Blood Pressure Program.

Nutrition & metabolism

Kraja AT, Rao DC, Weder AB, Mosley TH, Turner ST, Hsiung CA, Quertermous T, Cooper R, Curb JD, Province MA.
PMID: 16076393
Nutr Metab (Lond). 2005 Aug 02;2:17. doi: 10.1186/1743-7075-2-17.

BACKGROUND: The Family Blood Pressure Program is an ongoing, NHLBI-sponsored, multi-center program to study the genetic determinants of high blood pressure. The goal of this particular study was to study patterns of metabolic syndrome (MetS) in four ethnic groups:...

Epigenomic Indicators of Age in African Americans.

Hereditary genetics : current research

Smith JA, Zagel AL, Sun YV, Dolinoy DC, Bielak LF, Peyser PA, Turner ST, Mosley TH, Kardia SL.
PMID: 26807331
Hereditary Genet. 2014 Dec;3(3). doi: 10.4172/2161-1041.1000137. Epub 2014 Oct 01.

Age is a well-established risk factor for chronic diseases. However, the cellular and molecular changes associated with aging processes that are related to chronic disease initiation and progression are not well-understood. Thus, there is an increased need to identify...

Investigating the complex genetic architecture of ankle-brachial index, a measure of peripheral arterial disease, in non-Hispanic whites.

BMC medical genomics

Kardia SL, Greene MT, Boerwinkle E, Turner ST, Kullo IJ.
PMID: 18482449
BMC Med Genomics. 2008 May 15;1:16. doi: 10.1186/1755-8794-1-16.

BACKGROUND: Atherosclerotic peripheral arterial disease (PAD) affects 8-10 million people in the United States and is associated with a marked impairment in quality of life and an increased risk of cardiovascular events. Noninvasive assessment of PAD is performed by...

Showing 1 to 6 of 6 entries