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High-Throughput Minigenome System for Identifying Small-Molecule Inhibitors of Ebola Virus Replication.

ACS infectious diseases

Edwards MR, Pietzsch C, Vausselin T, Shaw ML, Bukreyev A, Basler CF.
PMID: 26284260
ACS Infect Dis. 2015 Aug 14;1(8):380-7. doi: 10.1021/acsinfecdis.5b00053. Epub 2015 Jun 24.

Ebola virus (EBOV), a member of the family Filoviridae, is a nonsegmented negative-sense RNA virus that causes severe, often lethal, disease in humans. EBOV RNA synthesis is carried out by a complex that includes several viral proteins. The function...

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Edwards MR, Pietzsch C, Vausselin T, et al. High-Throughput Minigenome System for Identifying Small-Molecule Inhibitors of Ebola Virus Replication. ACS Infect Dis. 2015;1(8):380-7doi: 10.1021/acsinfecdis.5b00053.
Edwards, M. R., Pietzsch, C., Vausselin, T., Shaw, M. L., Bukreyev, A., & Basler, C. F. (2015). High-Throughput Minigenome System for Identifying Small-Molecule Inhibitors of Ebola Virus Replication. ACS infectious diseases, 1(8), 380-7. https://doi.org/10.1021/acsinfecdis.5b00053
Edwards, Megan R, et al. "High-Throughput Minigenome System for Identifying Small-Molecule Inhibitors of Ebola Virus Replication." ACS infectious diseases vol. 1,8 (2015): 380-7. doi: https://doi.org/10.1021/acsinfecdis.5b00053
Edwards MR, Pietzsch C, Vausselin T, Shaw ML, Bukreyev A, Basler CF. High-Throughput Minigenome System for Identifying Small-Molecule Inhibitors of Ebola Virus Replication. ACS Infect Dis. 2015 Aug 14;1(8):380-7. doi: 10.1021/acsinfecdis.5b00053. Epub 2015 Jun 24. PMID: 26284260; PMCID: PMC4537067.
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Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction.

Frontiers in microbiology

Pleet ML, Mathiesen A, DeMarino C, Akpamagbo YA, Barclay RA, Schwab A, Iordanskiy S, Sampey GC, Lepene B, Nekhai S, Aman MJ, Kashanchi F.
PMID: 27872619
Front Microbiol. 2016 Nov 07;7:1765. doi: 10.3389/fmicb.2016.01765. eCollection 2016.

Ebola virus (EBOV) is an enveloped, ssRNA virus from the family

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Pleet ML, Mathiesen A, DeMarino C, et al. Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction. Front Microbiol. 2016;7:1765doi: 10.3389/fmicb.2016.01765.
Pleet, M. L., Mathiesen, A., DeMarino, C., Akpamagbo, Y. A., Barclay, R. A., Schwab, A., Iordanskiy, S., Sampey, G. C., Lepene, B., Nekhai, S., Aman, M. J., & Kashanchi, F. (2016). Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction. Frontiers in microbiology, 71765. https://doi.org/10.3389/fmicb.2016.01765
Pleet, Michelle L, et al. "Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction." Frontiers in microbiology vol. 7 (2016): 1765. doi: https://doi.org/10.3389/fmicb.2016.01765
Pleet ML, Mathiesen A, DeMarino C, Akpamagbo YA, Barclay RA, Schwab A, Iordanskiy S, Sampey GC, Lepene B, Nekhai S, Aman MJ, Kashanchi F. Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction. Front Microbiol. 2016 Nov 07;7:1765. doi: 10.3389/fmicb.2016.01765. eCollection 2016. PMID: 27872619; PMCID: PMC5098130.
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Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound.

Scientia pharmaceutica

Smith KA, Lin X, Bolshakov O, Griffin J, Niu X, Kovalskyy D, Ivanov A, Jerebtsova M, Taylor RE, Akala E, Nekhai S.
PMID: 26839837
Sci Pharm. 2015 Jun 22;83(3):535-48. doi: 10.3797/scipharm.1502-01. Print 2015.

Complete eradication of HIV-1 infection is impeded by the existence of latent HIV-1 reservoirs in which the integrated HIV-1 provirus is transcriptionally inactive. Activation of HIV-1 transcription requires the viral Tat protein and host cell factors, including protein phosphatase-1...

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Smith KA, Lin X, Bolshakov O, et al. Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound. Sci Pharm. 2015;83(3):535-48doi: 10.3797/scipharm.1502-01.
Smith, K. A., Lin, X., Bolshakov, O., Griffin, J., Niu, X., Kovalskyy, D., Ivanov, A., Jerebtsova, M., Taylor, R. E., Akala, E., & Nekhai, S. (2015). Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound. Scientia pharmaceutica, 83(3), 535-48. https://doi.org/10.3797/scipharm.1502-01
Smith, Kahli A, et al. "Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound." Scientia pharmaceutica vol. 83,3 (2015): 535-48. doi: https://doi.org/10.3797/scipharm.1502-01
Smith KA, Lin X, Bolshakov O, Griffin J, Niu X, Kovalskyy D, Ivanov A, Jerebtsova M, Taylor RE, Akala E, Nekhai S. Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound. Sci Pharm. 2015 Jun 22;83(3):535-48. doi: 10.3797/scipharm.1502-01. Print 2015. PMID: 26839837; PMCID: PMC4727795.
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Applications of Parametrized NMR Spin Systems of Small Molecules.

Analytical chemistry

Dashti H, Wedell JR, Westler WM, Tonelli M, Aceti D, Amarasinghe GK, Markley JL, Eghbalnia HR.
PMID: 30125102
Anal Chem. 2018 Sep 18;90(18):10646-10649. doi: 10.1021/acs.analchem.8b02660. Epub 2018 Aug 24.

We have developed technology for producing accurate spectral fingerprints of small molecules through modeling of NMR spin system matrices to encapsulate their chemical shifts and scalar couplings. We describe here how libraries of these spin systems utilizing unique and...

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Dashti H, Wedell JR, Westler WM, et al. Applications of Parametrized NMR Spin Systems of Small Molecules. Anal Chem. 2018;90(18):10646-10649doi: 10.1021/acs.analchem.8b02660.
Dashti, H., Wedell, J. R., Westler, W. M., Tonelli, M., Aceti, D., Amarasinghe, G. K., Markley, J. L., & Eghbalnia, H. R. (2018). Applications of Parametrized NMR Spin Systems of Small Molecules. Analytical chemistry, 90(18), 10646-10649. https://doi.org/10.1021/acs.analchem.8b02660
Dashti, Hesam, et al. "Applications of Parametrized NMR Spin Systems of Small Molecules." Analytical chemistry vol. 90,18 (2018): 10646-10649. doi: https://doi.org/10.1021/acs.analchem.8b02660
Dashti H, Wedell JR, Westler WM, Tonelli M, Aceti D, Amarasinghe GK, Markley JL, Eghbalnia HR. Applications of Parametrized NMR Spin Systems of Small Molecules. Anal Chem. 2018 Sep 18;90(18):10646-10649. doi: 10.1021/acs.analchem.8b02660. Epub 2018 Aug 24. PMID: 30125102; PMCID: PMC6201686.
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Therapeutics for postexposure treatment of Ebola virus infection.

Future virology

Jerebtsova M, Nekhai S.
PMID: 26213559
Future Virol. 2015 Mar;10(3):221-232. doi: 10.2217/fvl.14.109.

The current Ebola virus disease (EVD) outbreak in West Africa is the largest with over 5100 deaths in four West African countries as of 14 November 2014. EVD has high case-fatality rates but no licensed treatment or vaccine is...

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Jerebtsova M, Nekhai S. Therapeutics for postexposure treatment of Ebola virus infection. Future Virol. 2015;10(3):221-232doi: 10.2217/fvl.14.109.
Jerebtsova, M., & Nekhai, S. (2015). Therapeutics for postexposure treatment of Ebola virus infection. Future virology, 10(3), 221-232. https://doi.org/10.2217/fvl.14.109
Jerebtsova, Marina, and Nekhai, Sergei. "Therapeutics for postexposure treatment of Ebola virus infection." Future virology vol. 10,3 (2015): 221-232. doi: https://doi.org/10.2217/fvl.14.109
Jerebtsova M, Nekhai S. Therapeutics for postexposure treatment of Ebola virus infection. Future Virol. 2015 Mar;10(3):221-232. doi: 10.2217/fvl.14.109. PMID: 26213559; PMCID: PMC4508675.
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Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition.

Frontiers in microbiology

Lin X, Ammosova T, Choy MS, Pietzsch CA, Ivanov A, Ahmad A, Saygideğer Y, Kumari N, Kovalskyy D, Üren A, Peti W, Bukreyev A, Nekhai S.
PMID: 31572348
Front Microbiol. 2019 Sep 13;10:2145. doi: 10.3389/fmicb.2019.02145. eCollection 2019.

Ebola virus (EBOV) is a non-segmented negative-sense RNA virus that causes a severe human disease. The ongoing EBOV outbreak in the Eastern part of Democratic Republic of the Congo has resulted to date in over 2500 confirmed cases including...

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Lin X, Ammosova T, Choy MS, et al. Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition. Front Microbiol. 2019;10:2145doi: 10.3389/fmicb.2019.02145.
Lin, X., Ammosova, T., Choy, M. S., Pietzsch, C. A., Ivanov, A., Ahmad, A., Saygideğer, Y., Kumari, N., Kovalskyy, D., Üren, A., Peti, W., Bukreyev, A., & Nekhai, S. (2019). Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition. Frontiers in microbiology, 102145. https://doi.org/10.3389/fmicb.2019.02145
Lin, Xionghao, et al. "Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition." Frontiers in microbiology vol. 10 (2019): 2145. doi: https://doi.org/10.3389/fmicb.2019.02145
Lin X, Ammosova T, Choy MS, Pietzsch CA, Ivanov A, Ahmad A, Saygideğer Y, Kumari N, Kovalskyy D, Üren A, Peti W, Bukreyev A, Nekhai S. Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition. Front Microbiol. 2019 Sep 13;10:2145. doi: 10.3389/fmicb.2019.02145. eCollection 2019. PMID: 31572348; PMCID: PMC6753193.
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Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03.

Oncotarget

Lin X, Kumari N, DeMarino C, Kont YS, Ammosova T, Kulkarni A, Jerebtsova M, Vazquez-Meves G, Ivanov A, Dmytro K, Üren A, Kashanchi F, Nekhai S.
PMID: 29100346
Oncotarget. 2017 Aug 07;8(44):76749-76769. doi: 10.18632/oncotarget.19999. eCollection 2017 Sep 29.

We recently identified the protein phosphatase-1 - targeting compound, 1E7-03 which inhibited HIV-1

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Lin X, Kumari N, DeMarino C, et al. Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03. Oncotarget. 2017;8(44):76749-76769doi: 10.18632/oncotarget.19999.
Lin, X., Kumari, N., DeMarino, C., Kont, Y. S., Ammosova, T., Kulkarni, A., Jerebtsova, M., Vazquez-Meves, G., Ivanov, A., Dmytro, K., Üren, A., Kashanchi, F., & Nekhai, S. (2017). Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03. Oncotarget, 8(44), 76749-76769. https://doi.org/10.18632/oncotarget.19999
Lin, Xionghao, et al. "Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03." Oncotarget vol. 8,44 (2017): 76749-76769. doi: https://doi.org/10.18632/oncotarget.19999
Lin X, Kumari N, DeMarino C, Kont YS, Ammosova T, Kulkarni A, Jerebtsova M, Vazquez-Meves G, Ivanov A, Dmytro K, Üren A, Kashanchi F, Nekhai S. Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03. Oncotarget. 2017 Aug 07;8(44):76749-76769. doi: 10.18632/oncotarget.19999. eCollection 2017 Sep 29. PMID: 29100346; PMCID: PMC5652740.
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Showing 1 to 7 of 7 entries