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Current and emerging radiotherapy strategies for pancreatic adenocarcinoma: stereotactic, intensity modulated and particle radiotherapy.

Annals of pancreatic cancer

Ng SP, Koay EJ.
PMID: 30198024
Ann Pancreat Cancer. 2018 Aug;1. doi: 10.21037/apc.2018.07.03. Epub 2018 Aug 13.

The role of radiotherapy for locally advanced pancreatic cancer (LAPC) is unclear based on studies that used conventional doses and fractionation schedules. Modern radiotherapy techniques have not been studied in depth, however. We reviewed the literature on emerging methods...

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Ng SP, Koay EJ. Current and emerging radiotherapy strategies for pancreatic adenocarcinoma: stereotactic, intensity modulated and particle radiotherapy. Ann Pancreat Cancer. 2018;1doi: 10.21037/apc.2018.07.03.
Ng, S. P., & Koay, E. J. (2018). Current and emerging radiotherapy strategies for pancreatic adenocarcinoma: stereotactic, intensity modulated and particle radiotherapy. Annals of pancreatic cancer, 1. https://doi.org/10.21037/apc.2018.07.03
Ng, Sweet Ping, and Koay, Eugene J. "Current and emerging radiotherapy strategies for pancreatic adenocarcinoma: stereotactic, intensity modulated and particle radiotherapy." Annals of pancreatic cancer vol. 1 (2018). doi: https://doi.org/10.21037/apc.2018.07.03
Ng SP, Koay EJ. Current and emerging radiotherapy strategies for pancreatic adenocarcinoma: stereotactic, intensity modulated and particle radiotherapy. Ann Pancreat Cancer. 2018 Aug;1. doi: 10.21037/apc.2018.07.03. Epub 2018 Aug 13. PMID: 30198024; PMCID: PMC6124686.
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Education and Outreach in Physical Sciences in Oncology.

Trends in cancer

Walker SA, Pham A, Nizzero S, Kim M, Riter B, Bletz J, Judge S, Phillips B, Noble D, Murray D, Wetzel E, Samson S, McMahon M, Flink C, Couch J, Tomlin C, Swanson K, Anderson ARA, Odde D, Shen H, Hughes S, Zahir N, Enderling H, Wolfram J.
PMID: 33168416
Trends Cancer. 2021 Jan;7(1):3-9. doi: 10.1016/j.trecan.2020.10.007. Epub 2020 Nov 07.

Physical sciences are often overlooked in the field of cancer research. The Physical Sciences in Oncology Initiative was launched to integrate physics, mathematics, chemistry, and engineering with cancer research and clinical oncology through education, outreach, and collaboration. Here, we...

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Walker SA, Pham A, Nizzero S, et al. Education and Outreach in Physical Sciences in Oncology. Trends Cancer. 2020;7(1):3-9doi: 10.1016/j.trecan.2020.10.007.
Walker, S. A., Pham, A., Nizzero, S., Kim, M., Riter, B., Bletz, J., Judge, S., Phillips, B., Noble, D., Murray, D., Wetzel, E., Samson, S., McMahon, M., Flink, C., Couch, J., Tomlin, C., Swanson, K., Anderson, A. R. A., Odde, D., Shen, H., Hughes, S., Zahir, N., Enderling, H., & Wolfram, J. (2021). Education and Outreach in Physical Sciences in Oncology. Trends in cancer, 7(1), 3-9. https://doi.org/10.1016/j.trecan.2020.10.007
Walker, Sierra A, et al. "Education and Outreach in Physical Sciences in Oncology." Trends in cancer vol. 7,1 (2021): 3-9. doi: https://doi.org/10.1016/j.trecan.2020.10.007
Walker SA, Pham A, Nizzero S, Kim M, Riter B, Bletz J, Judge S, Phillips B, Noble D, Murray D, Wetzel E, Samson S, McMahon M, Flink C, Couch J, Tomlin C, Swanson K, Anderson ARA, Odde D, Shen H, Hughes S, Zahir N, Enderling H, Wolfram J. Education and Outreach in Physical Sciences in Oncology. Trends Cancer. 2021 Jan;7(1):3-9. doi: 10.1016/j.trecan.2020.10.007. Epub 2020 Nov 07. PMID: 33168416; PMCID: PMC7895467.
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DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis.

JCI insight

Deng J, Kang Y, Cheng CC, Li X, Dai B, Katz MH, Men T, Kim MP, Koay EA, Huang H, Brekken RA, Fleming JB.
PMID: 34237033
JCI Insight. 2021 Sep 08;6(17). doi: 10.1172/jci.insight.146133.

Pancreatic ductal adenocarcinoma (PDAC) tumors are characterized by a desmoplastic reaction resulting in dense deposition of collagen that is known to promote cancer progression. A central mediator of protumorigenic collagen signaling is the receptor tyrosine kinase discoid domain receptor...

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Deng J, Kang Y, Cheng CC, et al. DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis. JCI Insight. 2021;6(17)doi: 10.1172/jci.insight.146133.
Deng, J., Kang, Y., Cheng, C. C., Li, X., Dai, B., Katz, M. H., Men, T., Kim, M. P., Koay, E. A., Huang, H., Brekken, R. A., & Fleming, J. B. (2021). DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis. JCI insight, 6(17), . https://doi.org/10.1172/jci.insight.146133
Deng, Jenying, et al. "DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis." JCI insight vol. 6,17 (2021). doi: https://doi.org/10.1172/jci.insight.146133
Deng J, Kang Y, Cheng CC, Li X, Dai B, Katz MH, Men T, Kim MP, Koay EA, Huang H, Brekken RA, Fleming JB. DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis. JCI Insight. 2021 Sep 08;6(17). doi: 10.1172/jci.insight.146133. PMID: 34237033; PMCID: PMC8492346.
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A composite smeared finite element for mass transport in capillary systems and biological tissue.

Computer methods in applied mechanics and engineering

Kojic M, Milosevic M, Simic V, Koay EJ, Fleming JB, Nizzero S, Kojic N, Ziemys A, Ferrari M.
PMID: 29200531
Comput Methods Appl Mech Eng. 2017 Sep 01;324:413-437. doi: 10.1016/j.cma.2017.06.019. Epub 2017 Jun 29.

One of the key processes in living organisms is mass transport occurring from blood vessels to tissues for supplying tissues with oxygen, nutrients, drugs, immune cells, and - in the reverse direction - transport of waste products of cell...

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Kojic M, Milosevic M, Simic V, et al. A composite smeared finite element for mass transport in capillary systems and biological tissue. Comput Methods Appl Mech Eng. 2017;324:413-437doi: 10.1016/j.cma.2017.06.019.
Kojic, M., Milosevic, M., Simic, V., Koay, E. J., Fleming, J. B., Nizzero, S., Kojic, N., Ziemys, A., & Ferrari, M. (2017). A composite smeared finite element for mass transport in capillary systems and biological tissue. Computer methods in applied mechanics and engineering, 324413-437. https://doi.org/10.1016/j.cma.2017.06.019
Kojic, M, et al. "A composite smeared finite element for mass transport in capillary systems and biological tissue." Computer methods in applied mechanics and engineering vol. 324 (2017): 413-437. doi: https://doi.org/10.1016/j.cma.2017.06.019
Kojic M, Milosevic M, Simic V, Koay EJ, Fleming JB, Nizzero S, Kojic N, Ziemys A, Ferrari M. A composite smeared finite element for mass transport in capillary systems and biological tissue. Comput Methods Appl Mech Eng. 2017 Sep 01;324:413-437. doi: 10.1016/j.cma.2017.06.019. Epub 2017 Jun 29. PMID: 29200531; PMCID: PMC5703437.
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Taking the vehicle out of drug delivery.

Materials today (Kidlington, England)

Shen J, Wolfram J, Ferrari M, Shen H.
PMID: 28522922
Mater Today (Kidlington). 2017 Apr;20(3):95-97. doi: 10.1016/j.mattod.2017.01.013.

No abstract available.

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Shen J, Wolfram J, Ferrari M, et al. Taking the vehicle out of drug delivery. Mater Today (Kidlington). 2017;20(3):95-97doi: 10.1016/j.mattod.2017.01.013.
Shen, J., Wolfram, J., Ferrari, M., & Shen, H. (2017). Taking the vehicle out of drug delivery. Materials today (Kidlington, England), 20(3), 95-97. https://doi.org/10.1016/j.mattod.2017.01.013
Shen, Jianliang, et al. "Taking the vehicle out of drug delivery." Materials today (Kidlington, England) vol. 20,3 (2017): 95-97. doi: https://doi.org/10.1016/j.mattod.2017.01.013
Shen J, Wolfram J, Ferrari M, Shen H. Taking the vehicle out of drug delivery. Mater Today (Kidlington). 2017 Apr;20(3):95-97. doi: 10.1016/j.mattod.2017.01.013. PMID: 28522922; PMCID: PMC5431297.
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Attenuated Microcirculation in Small Metastatic Tumors in Murine Liver.

Pharmaceutics

Ziemys A, Simic V, Milosevic M, Kojic M, Liu YT, Yokoi K.
PMID: 34065867
Pharmaceutics. 2021 May 12;13(5). doi: 10.3390/pharmaceutics13050703.

Metastatic cancer disease is the major cause of death in cancer patients. Because those small secondary tumors are clinically hardly detectable in their early stages, little is known about drug biodistribution and permeation into those metastatic tumors potentially contributing...

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Ziemys A, Simic V, Milosevic M, et al. Attenuated Microcirculation in Small Metastatic Tumors in Murine Liver. Pharmaceutics. 2021;13(5)doi: 10.3390/pharmaceutics13050703.
Ziemys, A., Simic, V., Milosevic, M., Kojic, M., Liu, Y. T., & Yokoi, K. (2021). Attenuated Microcirculation in Small Metastatic Tumors in Murine Liver. Pharmaceutics, 13(5), . https://doi.org/10.3390/pharmaceutics13050703
Ziemys, Arturas, et al. "Attenuated Microcirculation in Small Metastatic Tumors in Murine Liver." Pharmaceutics vol. 13,5 (2021). doi: https://doi.org/10.3390/pharmaceutics13050703
Ziemys A, Simic V, Milosevic M, Kojic M, Liu YT, Yokoi K. Attenuated Microcirculation in Small Metastatic Tumors in Murine Liver. Pharmaceutics. 2021 May 12;13(5). doi: 10.3390/pharmaceutics13050703. PMID: 34065867; PMCID: PMC8150276.
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Behind the Wheel of Epithelial Plasticity in KRAS-Driven Cancers.

Frontiers in oncology

Arner EN, Du W, Brekken RA.
PMID: 31681587
Front Oncol. 2019 Oct 11;9:1049. doi: 10.3389/fonc.2019.01049. eCollection 2019.

Cellular plasticity, a feature associated with epithelial-to-mesenchymal transition (EMT), contributes to tumor cell survival, migration, invasion, and therapy resistance. Phenotypic plasticity of the epithelium is a critical feature in multiple phases of human cancer in an oncogene- and tissue-specific...

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Arner EN, Du W, Brekken RA. Behind the Wheel of Epithelial Plasticity in KRAS-Driven Cancers. Front Oncol. 2019;9:1049doi: 10.3389/fonc.2019.01049.
Arner, E. N., Du, W., & Brekken, R. A. (2019). Behind the Wheel of Epithelial Plasticity in KRAS-Driven Cancers. Frontiers in oncology, 91049. https://doi.org/10.3389/fonc.2019.01049
Arner, Emily N, et al. "Behind the Wheel of Epithelial Plasticity in KRAS-Driven Cancers." Frontiers in oncology vol. 9 (2019): 1049. doi: https://doi.org/10.3389/fonc.2019.01049
Arner EN, Du W, Brekken RA. Behind the Wheel of Epithelial Plasticity in KRAS-Driven Cancers. Front Oncol. 2019 Oct 11;9:1049. doi: 10.3389/fonc.2019.01049. eCollection 2019. PMID: 31681587; PMCID: PMC6798880.
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Mathematical prediction of clinical outcomes in advanced cancer patients treated with checkpoint inhibitor immunotherapy.

Science advances

Butner JD, Elganainy D, Wang CX, Wang Z, Chen SH, Esnaola NF, Pasqualini R, Arap W, Hong DS, Welsh J, Koay EJ, Cristini V.
PMID: 32426472
Sci Adv. 2020 Apr 29;6(18):eaay6298. doi: 10.1126/sciadv.aay6298. eCollection 2020 May.

We present a mechanistic mathematical model of immune checkpoint inhibitor therapy to address the oncological need for early, broadly applicable readouts (biomarkers) of patient response to immunotherapy. The model is built upon the complex biological and physical interactions between...

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Butner JD, Elganainy D, Wang CX, et al. Mathematical prediction of clinical outcomes in advanced cancer patients treated with checkpoint inhibitor immunotherapy. Sci Adv. 2020;6(18):eaay6298doi: 10.1126/sciadv.aay6298.
Butner, J. D., Elganainy, D., Wang, C. X., Wang, Z., Chen, S. H., Esnaola, N. F., Pasqualini, R., Arap, W., Hong, D. S., Welsh, J., Koay, E. J., & Cristini, V. (2020). Mathematical prediction of clinical outcomes in advanced cancer patients treated with checkpoint inhibitor immunotherapy. Science advances, 6(18), eaay6298. https://doi.org/10.1126/sciadv.aay6298
Butner, Joseph D, et al. "Mathematical prediction of clinical outcomes in advanced cancer patients treated with checkpoint inhibitor immunotherapy." Science advances vol. 6,18 (2020): eaay6298. doi: https://doi.org/10.1126/sciadv.aay6298
Butner JD, Elganainy D, Wang CX, Wang Z, Chen SH, Esnaola NF, Pasqualini R, Arap W, Hong DS, Welsh J, Koay EJ, Cristini V. Mathematical prediction of clinical outcomes in advanced cancer patients treated with checkpoint inhibitor immunotherapy. Sci Adv. 2020 Apr 29;6(18):eaay6298. doi: 10.1126/sciadv.aay6298. eCollection 2020 May. PMID: 32426472; PMCID: PMC7190324.
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Innate immunity plays a key role in controlling viral load in COVID-19: mechanistic insights from a whole-body infection dynamics model.

medRxiv : the preprint server for health sciences

Dogra P, Ruiz-Ramírez J, Sinha K, Butner JD, Peláez MJ, Rawat M, Yellepeddi VK, Pasqualini R, Arap W, Sostman HD, Cristini V, Wang Z.
PMID: 33173913
medRxiv. 2020 Nov 05; doi: 10.1101/2020.10.30.20215335.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a pathogen of immense public health concern. Efforts to control the disease have only proven mildly successful, and the disease will likely continue to cause excessive fatalities until effective preventative measures...

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Dogra P, Ruiz-Ramírez J, Sinha K, et al. Innate immunity plays a key role in controlling viral load in COVID-19: mechanistic insights from a whole-body infection dynamics model. medRxiv. 2020;doi: 10.1101/2020.10.30.20215335.
Dogra, P., Ruiz-Ramírez, J., Sinha, K., Butner, J. D., Peláez, M. J., Rawat, M., Yellepeddi, V. K., Pasqualini, R., Arap, W., Sostman, H. D., Cristini, V., & Wang, Z. (2020). Innate immunity plays a key role in controlling viral load in COVID-19: mechanistic insights from a whole-body infection dynamics model. medRxiv : the preprint server for health sciences, . https://doi.org/10.1101/2020.10.30.20215335
Dogra, Prashant, et al. "Innate immunity plays a key role in controlling viral load in COVID-19: mechanistic insights from a whole-body infection dynamics model." medRxiv : the preprint server for health sciences vol. (2020). doi: https://doi.org/10.1101/2020.10.30.20215335
Dogra P, Ruiz-Ramírez J, Sinha K, Butner JD, Peláez MJ, Rawat M, Yellepeddi VK, Pasqualini R, Arap W, Sostman HD, Cristini V, Wang Z. Innate immunity plays a key role in controlling viral load in COVID-19: mechanistic insights from a whole-body infection dynamics model. medRxiv. 2020 Nov 05; doi: 10.1101/2020.10.30.20215335. PMID: 33173913; PMCID: PMC7654909.
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VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironment.

JCI insight

Zhang Y, Huang H, Coleman M, Ziemys A, Gopal P, Kazmi SM, Brekken RA.
PMID: 34673569
JCI Insight. 2021 Dec 08;6(23). doi: 10.1172/jci.insight.150735.

Angiogenesis, a hallmark of cancer, is induced by vascular endothelial growth factor-A (hereafter VEGF). As a result, anti-VEGF therapy is commonly used for cancer treatment. Recent studies have found that VEGF expression is also associated with immune suppression in...

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Zhang Y, Huang H, Coleman M, et al. VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironment. JCI Insight. 2021;6(23)doi: 10.1172/jci.insight.150735.
Zhang, Y., Huang, H., Coleman, M., Ziemys, A., Gopal, P., Kazmi, S. M., & Brekken, R. A. (2021). VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironment. JCI insight, 6(23), . https://doi.org/10.1172/jci.insight.150735
Zhang, Yuqing, et al. "VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironment." JCI insight vol. 6,23 (2021). doi: https://doi.org/10.1172/jci.insight.150735
Zhang Y, Huang H, Coleman M, Ziemys A, Gopal P, Kazmi SM, Brekken RA. VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironment. JCI Insight. 2021 Dec 08;6(23). doi: 10.1172/jci.insight.150735. PMID: 34673569; PMCID: PMC8675197.
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Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling.

eLife

Butner JD, Martin GV, Wang Z, Corradetti B, Ferrari M, Esnaola N, Chung C, Hong DS, Welsh JW, Hasegawa N, Mittendorf EA, Curley SA, Chen SH, Pan PY, Libutti SK, Ganesan S, Sidman RL, Pasqualini R, Arap W, Koay EJ, Cristini V.
PMID: 34749885
Elife. 2021 Nov 09;10. doi: 10.7554/eLife.70130.

BACKGROUND: Checkpoint inhibitor therapy of cancer has led to markedly improved survival of a subset of patients in multiple solid malignant tumor types, yet the factors driving these clinical responses or lack thereof are not known. We have developed...

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Butner JD, Martin GV, Wang Z, et al. Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling. Elife. 2021;10doi: 10.7554/eLife.70130.
Butner, J. D., Martin, G. V., Wang, Z., Corradetti, B., Ferrari, M., Esnaola, N., Chung, C., Hong, D. S., Welsh, J. W., Hasegawa, N., Mittendorf, E. A., Curley, S. A., Chen, S. H., Pan, P. Y., Libutti, S. K., Ganesan, S., Sidman, R. L., Pasqualini, R., Arap, W., Koay, E. J., & Cristini, V. (2021). Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling. eLife, 10. https://doi.org/10.7554/eLife.70130
Butner, Joseph D, et al. "Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.70130
Butner JD, Martin GV, Wang Z, Corradetti B, Ferrari M, Esnaola N, Chung C, Hong DS, Welsh JW, Hasegawa N, Mittendorf EA, Curley SA, Chen SH, Pan PY, Libutti SK, Ganesan S, Sidman RL, Pasqualini R, Arap W, Koay EJ, Cristini V. Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling. Elife. 2021 Nov 09;10. doi: 10.7554/eLife.70130. PMID: 34749885; PMCID: PMC8629426.
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DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis.

JCI insight

Deng J, Kang Y, Cheng CC, Li X, Dai B, Katz MH, Men T, Kim MP, Koay EA, Huang H, Brekken RA, Fleming JB.
PMID: 34237033
JCI Insight. 2021 Sep 08;6(17). doi: 10.1172/jci.insight.146133.

Pancreatic ductal adenocarcinoma (PDAC) tumors are characterized by a desmoplastic reaction resulting in dense deposition of collagen that is known to promote cancer progression. A central mediator of protumorigenic collagen signaling is the receptor tyrosine kinase discoid domain receptor...

Cite
Deng J, Kang Y, Cheng CC, et al. DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis. JCI Insight. 2021;6(17)doi: 10.1172/jci.insight.146133.
Deng, J., Kang, Y., Cheng, C. C., Li, X., Dai, B., Katz, M. H., Men, T., Kim, M. P., Koay, E. A., Huang, H., Brekken, R. A., & Fleming, J. B. (2021). DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis. JCI insight, 6(17), . https://doi.org/10.1172/jci.insight.146133
Deng, Jenying, et al. "DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis." JCI insight vol. 6,17 (2021). doi: https://doi.org/10.1172/jci.insight.146133
Deng J, Kang Y, Cheng CC, Li X, Dai B, Katz MH, Men T, Kim MP, Koay EA, Huang H, Brekken RA, Fleming JB. DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis. JCI Insight. 2021 Sep 08;6(17). doi: 10.1172/jci.insight.146133. PMID: 34237033; PMCID: PMC8492346.
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Showing 1 to 12 of 42 entries