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Showing 1 to 5 of 5 entries
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Retinal imaging demonstrates reduced capillary density in clinically unimpaired .

Alzheimer's & dementia (Amsterdam, Netherlands)

Elahi FM, Ashimatey SB, Bennett DJ, Walters SM, La Joie R, Jiang X, Wolf A, Cobigo Y, Staffaroni AM, Rosen HJ, Miller BL, Rabinovici GD, Kramer JH, Green AJ, Kashani AH.
PMID: 34013017
Alzheimers Dement (Amst). 2021 May 11;13(1):e12181. doi: 10.1002/dad2.12181. eCollection 2021.

INTRODUCTION: Apolipoprotein E (METHODS: We collected retinal optical coherence tomography angiography, cognitive testing, and brain imaging in research participants and built statistical models to test genotype-phenotype associations.RESULTS: Our analyses demonstrate lower retinal capillary densities in early disease, in cognitively...

Lower retinal capillary density in minimal cognitive impairment among older Latinx adults.

Alzheimer's & dementia (Amsterdam, Netherlands)

Ashimatey BS, D'Orazio LM, Ma SJ, Jann K, Jiang X, Lu H, Wang DJJ, Ringman JM, Kashani AH.
PMID: 32875053
Alzheimers Dement (Amst). 2020 Aug 25;12(1):e12071. doi: 10.1002/dad2.12071. eCollection 2020.

INTRODUCTION: We investigated the hypothesis that retinal capillary perfusion is a biomarker of early cognitive decline and cerebrovascular perfusion associated with small vessel disease in a pilot data set of Latinx adults at high risk for vascular cognitive impairment...

Abnormal retinal capillary blood flow in autosomal dominant Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)

Singer MB, Ringman JM, Chu Z, Zhou X, Jiang X, Shahidzadeh A, Wang RK, Kashani AH.
PMID: 33728371
Alzheimers Dement (Amst). 2021 Mar 04;13(1):e12162. doi: 10.1002/dad2.12162. eCollection 2021.

INTRODUCTION: This study characterizes retinal capillary blood flow in subjects with autosomal dominant Alzheimer's disease (ADAD)-causing mutations.METHODS: Carriers of RESULTS: ES carriers had significantly greater capillary blood flow than controls and LS carriers. ES and LS carriers had significantly...

Neurophysiological Basis of Multi-Scale Entropy of Brain Complexity and Its Relationship With Functional Connectivity.

Frontiers in neuroscience

Wang DJJ, Jann K, Fan C, Qiao Y, Zang YF, Lu H, Yang Y.
PMID: 29896081
Front Neurosci. 2018 May 29;12:352. doi: 10.3389/fnins.2018.00352. eCollection 2018.

Recently, non-linear statistical measures such as multi-scale entropy (MSE) have been introduced as indices of the complexity of electrophysiology and fMRI time-series across multiple time scales. In this work, we investigated the neurophysiological underpinnings of complexity (MSE) of electrophysiology...

Cerebral Hemodynamic and White Matter Changes of Type 2 Diabetes Revealed by Multi-TI Arterial Spin Labeling and Double Inversion Recovery Sequence.

Frontiers in neurology

Shen Y, Zhao B, Yan L, Jann K, Wang G, Wang J, Wang B, Pfeuffer J, Qian T, Wang DJJ.
PMID: 29312135
Front Neurol. 2017 Dec 22;8:717. doi: 10.3389/fneur.2017.00717. eCollection 2017.

Diabetes has been reported to affect the microvasculature and lead to cerebral small vessel disease (SVD). Past studies using arterial spin labeling (ASL) at single post-labeling delay reported reduced cerebral blood flow (CBF) in patients with type 2 diabetes....

Showing 1 to 5 of 5 entries