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Showing 1 to 12 of 85 entries
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Periodontitis and bone metabolism in patients with advanced heart failure and after heart transplantation.

ESC heart failure

Schulze-Späte U, Mizani I, Salaverry KR, Chang J, Wu C, Jones M, Kennel PJ, Brunjes DL, Choo TH, Kato TS, Mancini D, Grbic J, Schulze PC.
PMID: 28451454
ESC Heart Fail. 2017 May;4(2):169-177. doi: 10.1002/ehf2.12126. Epub 2017 Mar 01.

AIMS: Heart failure (HF) is a multi-organ, pro-inflammatory syndrome that impairs bone metabolism. Pro-inflammatory cytokines and bone catabolism enhance periodontal disease, a local inflammatory, bacteria-induced disease that causes bone loss and periodontal soft tissue destruction.METHODS AND RESULTS: Medical and...

Anhedonia in the psychosis risk syndrome: associations with social impairment and basal orbitofrontal cortical activity.

NPJ schizophrenia

Cressman VL, Schobel SA, Steinfeld S, Ben-David S, Thompson JL, Small SA, Moore H, Corcoran CM.
PMID: 27336033
NPJ Schizophr. 2015 Jul 15;1:15020. doi: 10.1038/npjschz.2015.20. eCollection 2015.

BACKGROUND/OBJECTIVES: Anhedonia is associated with poor social function in schizophrenia. Here, we examined this association in individuals at clinical high risk (CHR) for schizophrenia and related psychotic disorders, taking into account social anxiety. We then explored correlations between anhedonia...

User-composable Electronic Health Record Improves Efficiency of Clinician Data Viewing for Patient Case Appraisal: A Mixed-Methods Study.

EGEMS (Washington, DC)

Senathirajah Y, Kaufman D, Bakken S.
PMID: 27195306
EGEMS (Wash DC). 2016 May 02;4(1):1176. doi: 10.13063/2327-9214.1176. eCollection 2016.

BACKGROUND: Challenges in the design of electronic health records (EHRs) include designing usable systems that must meet the complex, rapidly changing, and high-stakes information needs of clinicians. The ability to move and assemble elements together on the same page...

Adolescent Female Text Messaging Preferences to Prevent Pregnancy After an Emergency Department Visit: A Qualitative Analysis.

Journal of medical Internet research

Chernick LS, Schnall R, Stockwell MS, Castaño PM, Higgins T, Westhoff C, Santelli J, Dayan PS.
PMID: 27687855
J Med Internet Res. 2016 Sep 29;18(9):e261. doi: 10.2196/jmir.6324.

BACKGROUND: Over 15 million adolescents use the emergency department (ED) each year in the United States. Adolescent females who use the ED for medical care have been found to be at high risk for unintended pregnancy. Given that adolescents...

Self-reported race and ethnicity of US biobank participants compared to the US Census.

Journal of community genetics

Cohn EG, Hamilton N, Larson EL, Williams JK.
PMID: 28623623
J Community Genet. 2017 Jul;8(3):229-238. doi: 10.1007/s12687-017-0308-6. Epub 2017 Jun 16.

Precision medicine envisions a future of effective diagnosis, treatment, and prevention grounded in precise understandings of the genetic and environmental determinants of disease. Given that the original genome-wide association studies represented a predominately European White population, and that diversity...

Identifying and aligning expectations in a mentoring relationship.

Clinical and translational science

Huskins WC, Silet K, Weber-Main AM, Begg MD, Fowler VG, Hamilton J, Fleming M.
PMID: 22212226
Clin Transl Sci. 2011 Dec;4(6):439-47. doi: 10.1111/j.1752-8062.2011.00356.x. Epub 2011 Nov 18.

The mentoring relationship between a scholar and their primary mentor is a core feature of research training. Anecdotal evidence suggests this relationship is adversely affected when scholar and mentor expectations are not aligned. We examined three questions: (1) What...

Meta-analysis of perceived stress and its association with incident coronary heart disease.

The American journal of cardiology

Richardson S, Shaffer JA, Falzon L, Krupka D, Davidson KW, Edmondson D.
PMID: 22975465
Am J Cardiol. 2012 Dec 15;110(12):1711-6. doi: 10.1016/j.amjcard.2012.08.004. Epub 2012 Sep 10.

Most studies examining potential associations between psychological factors and cardiovascular outcomes have focused on depression or anxiety. The effect of perceived stress on incident coronary heart disease (CHD) has yet to be reviewed systematically. We conducted a systematic review...

EliXR-TIME: A Temporal Knowledge Representation for Clinical Research Eligibility Criteria.

AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science

Boland MR, Tu SW, Carini S, Sim I, Weng C.
PMID: 22779055
AMIA Jt Summits Transl Sci Proc. 2012;2012:71-80. Epub 2012 Mar 19.

Effective clinical text processing requires accurate extraction and representation of temporal expressions. Multiple temporal information extraction models were developed but a similar need for extracting temporal expressions in eligibility criteria (e.g., for eligibility determination) remains. We identified the temporal...

How Should We Treat Depression in Patients with Cardiovascular Disease?.

Dialogues in cardiovascular medicine : DCM

Kronish IM, Krupka DJ, Davidson KW.
PMID: 24039506
Dialog Cardiovasc Med. 2012;17(2):126-133.

Among patients with cardiovascular disease (CVD), depression is highly prevalent and is associated with worse cardiovascular prognosis and lower quality of life. Treatments for depression in CVD patients produce modest, but clinically significant reductions in depressive symptoms and show...

Safety, Feasibility, and Biomarker Effects of High-Dose Vitamin D Supplementation Among Women at High Risk for Breast Cancer.

International journal of food science, nutrition and dietetics

Crew KD, Xiao T, Thomas PS, Terry MB, Maurer M, Kalinsky K, Feldman S, Brafman L, Refice SR, Hershman DL.
PMID: 28480224
Int J Food Sci Nutr Diet. 2015;2015:1-16. doi: 10.19070/2326-3350-SI01001. Epub 2015 Feb 23.

Vitamin D deficiency is a potentially modifiable risk factor that may be targeted for breast cancer prevention. We examined the safety, feasibility, and biomarker effects of high-dose vitamin D among women at high risk for breast cancer. Forty high-risk...

Double genomic control is not effective to correct for population stratification in meta-analysis for genome-wide association studies.

Frontiers in genetics

Wang S, Chen W, Chen X, Hu F, Archer KJ, Liu HN, Sun S, Gao G.
PMID: 23269928
Front Genet. 2012 Dec 24;3:300. doi: 10.3389/fgene.2012.00300. eCollection 2012.

Meta-analysis of genome-wide association studies (GWAS) has become a useful tool to identify genetic variants that are associated with complex human diseases. To control spurious associations between genetic variants and disease that are caused by population stratification, double genomic...

Clinical providers' experiences with returning results from genomic sequencing: an interview study.

BMC medical genomics

Wynn J, Lewis K, Amendola LM, Bernhardt BA, Biswas S, Joshi M, McMullen C, Scollon S.
PMID: 29739461
BMC Med Genomics. 2018 May 08;11(1):45. doi: 10.1186/s12920-018-0360-z.

BACKGROUND: Current medical practice includes the application of genomic sequencing (GS) in clinical and research settings. Despite expanded use of this technology, the process of disclosure of genomic results to patients and research participants has not been thoroughly examined...

Showing 1 to 12 of 85 entries