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Showing 1 to 12 of 148 entries
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ATTRIBUTES OF FORM IN THE BUILT ENVIRONMENT THAT INFLUENCE PERCEIVED WALKABILITY.

Journal of architectural and planning research

Oreskovic NM, Charles PR, Shepherd DT, Nelson KP, Bar M.
PMID: 25554719
J Archit Plann Res. 2014;31(3):218-232.

A recent focus of design and building regulations, including form-based codes and the Leadership in Energy and Environmental Design for Neighborhood Development rating system, has been on promoting pedestrian activity. This study assessed perceptions of walkability for residential and...

The Case for Addressing Operator Fatigue.

Review of human factors and ergonomics

Duffy JF, Zitting KM, Czeisler CA.
PMID: 26056516
Rev Hum Factors Ergon. 2015 Jun;10(1):29-78. doi: 10.1177/1557234X15573949.

Sleep deficiency, which can be caused by acute sleep deprivation, chronic insufficient sleep, untreated sleep disorders, disruption of circadian timing, and other factors, is endemic in the U.S., including among professional and non-professional drivers and operators. Vigilance and attention...

Admission vitamin D status is associated with discharge destination in critically ill surgical patients.

Annals of intensive care

Brook K, Camargo CA, Christopher KB, Quraishi SA.
PMID: 26380991
Ann Intensive Care. 2015 Dec;5(1):23. doi: 10.1186/s13613-015-0065-9. Epub 2015 Sep 17.

BACKGROUND: Discharge destination after critical illness is increasingly recognized as a valuable patient-centered outcome. Recently, vitamin D status has been shown to be associated with important outcomes such as length of stay (LOS) and mortality in intensive care unit...

Randomized phase 2 trial of NP001-a novel immune regulator: Safety and early efficacy in ALS.

Neurology(R) neuroimmunology & neuroinflammation

Miller RG, Block G, Katz JS, Barohn RJ, Gopalakrishnan V, Cudkowicz M, Zhang JR, McGrath MS, Ludington E, Appel SH, Azhir A.
PMID: 25884010
Neurol Neuroimmunol Neuroinflamm. 2015 Apr 09;2(3):e100. doi: 10.1212/NXI.0000000000000100. eCollection 2015 Jun.

OBJECTIVE: To assess the safety, tolerability, and preliminary efficacy of NP001, a novel immune regulator of inflammatory monocytes/macrophages, for slowing progression of amyotrophic lateral sclerosis (ALS).METHODS: This was a phase 2 randomized, double-blind, placebo-controlled trial of NP001 in 136...

Addition of 25-hydroxyvitamin D levels to the Deyo-Charlson Comorbidity Index improves 90-day mortality prediction in critically ill patients.

Journal of intensive care

Mahato B, Otero TM, Holland CA, Giguere PT, Bajwa EK, Camargo CA, Quraishi SA.
PMID: 27330812
J Intensive Care. 2016 Jun 17;4:40. doi: 10.1186/s40560-016-0165-0. eCollection 2016.

BACKGROUND: The Deyo-Charlson Comorbidity Index (DCCI) has low predictive value in the intensive care unit (ICU). Our goal was to determine whether addition of 25-hydroxyvitamin D (25OHD) levels to the DCCI improved 90-day mortality prediction in critically ill patients.METHODS:...

Differential effects of motor cortical excitability and plasticity in young and old individuals: a Transcranial Magnetic Stimulation (TMS) study.

Frontiers in aging neuroscience

Bashir S, Perez JM, Horvath JC, Pena-Gomez C, Vernet M, Capia A, Alonso-Alonso M, Pascual-Leone A.
PMID: 24959141
Front Aging Neurosci. 2014 Jun 10;6:111. doi: 10.3389/fnagi.2014.00111. eCollection 2014.

Aging is associated with changes in the motor system that, over time, can lead to functional impairments and contribute negatively to the ability to recover after brain damage. Unfortunately, there are still many questions surrounding the physiological mechanisms underlying...

Safety and Immunogenicity of a Recombinant Adenovirus Serotype 35-Vectored HIV-1 Vaccine in Adenovirus Serotype 5 Seronegative and Seropositive Individuals.

Journal of AIDS & clinical research

Fuchs JD, Bart PA, Frahm N, Morgan C, Gilbert PB, Kochar N, DeRosa SC, Tomaras GD, Wagner TM, Baden LR, Koblin BA, Rouphael NG, Kalams SA, Keefer MC, Goepfert PA, Sobieszczyk ME, Mayer KH, Swann E, Liao HX, Haynes BF, Graham BS, McElrath MJ.
PMID: 26587311
J AIDS Clin Res. 2015 May;6(5). doi: 10.4172/2155-6113.1000461. Epub 2015 May 23.

BACKGROUND: Recombinant adenovirus serotype 5 (rAd5)-vectored HIV-1 vaccines have not prevented HIV-1 infection or disease and pre-existing Ad5 neutralizing antibodies may limit the clinical utility of Ad5 vectors globally. Using a rare Ad serotype vector, such as Ad35, may...

Prediction of Happy-Sad mood from daily behaviors and previous sleep history.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Sano A, Yu AZ, McHill AW, Phillips AJ, Taylor S, Jaques N, Klerman EB, Picard RW.
PMID: 26737854
Annu Int Conf IEEE Eng Med Biol Soc. 2015;2015:6796-9. doi: 10.1109/EMBC.2015.7319954.

We collected and analyzed subjective and objective data using surveys and wearable sensors worn day and night from 68 participants for ~30 days each, to address questions related to the relationships among sleep duration, sleep irregularity, self-reported Happy-Sad mood...

Beta-2-Adrenergic Receptor Methylation Influences Asthma Phenotype in The School Inner City Asthma Study.

Receptors & clinical investigation

Gaffin JM, Phipatanakul W.
PMID: 25590045
Receptors Clin Investig. 2014;1(1). doi: 10.14800/rci.15.

Asthma is the most common chronic illness of childhood and inner city residents suffer a disproportionately high rate of asthma diagnosis and asthma morbidity. The School Inner City Asthma Study investigates the school classroom based environmental exposures that may...

Mesh-based Monte Carlo method using fast ray-tracing in Plücker coordinates.

Biomedical optics express

Fang Q.
PMID: 21170299
Biomed Opt Express. 2010 Aug 02;1(1):165-75. doi: 10.1364/BOE.1.000165. Epub 2010 Jul 15.

We describe a fast mesh-based Monte Carlo (MC) photon migration algorithm for static and time-resolved imaging in 3D complex media. Compared with previous works using voxel-based media discretization, a mesh-based approach can be more accurate in modeling targets with...

Back to the future: studying cholera pathogenesis using infant rabbits.

mBio

Ritchie JM, Rui H, Bronson RT, Waldor MK.
PMID: 20689747
mBio. 2010 May 18;1(1). doi: 10.1128/mBio.00047-10.

Cholera is a severe diarrheal disease, caused by Vibrio cholerae, for which there has been no reproducible, nonsurgical animal model. Here, we report that orogastric inoculation of V. cholerae into 3-day-old rabbits pretreated with cimetidine led to lethal, watery...

Impact of biofluid viscosity on size and sedimentation efficiency of the isolated microvesicles.

Frontiers in physiology

Momen-Heravi F, Balaj L, Alian S, Trachtenberg AJ, Hochberg FH, Skog J, Kuo WP.
PMID: 22661955
Front Physiol. 2012 May 28;3:162. doi: 10.3389/fphys.2012.00162. eCollection 2012.

Microvesicles are nano-sized lipid vesicles released by all cells in vivo and in vitro. They are released physiologically under normal conditions but their rate of release is higher under pathological conditions such as tumors. Once released they end up...

Showing 1 to 12 of 148 entries