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Comparison of bottom-up proteomic approaches for LC-MS analysis of complex proteomes.

Analytical methods : advancing methods and applications

Weston LA, Bauer KM, Hummon AB.
PMID: 24288579
Anal Methods. 2013 Sep 21;5(18). doi: 10.1039/C3AY40853A.

Discovery-based proteomic studies aim to answer important biological questions by identifying as many proteins as possible. In order to accomplish this lofty goal, an effort must be placed on determining an optimal workflow that maximizes protein identifications. In this...

Influence of Oral Progesterone Administration on Drug-Induced QT Interval Lengthening: A Randomized, Double-Blind, Placebo-Controlled Crossover Study.

JACC. Clinical electrophysiology

Tisdale JE, Jaynes HA, Overholser BR, Sowinski KM, Flockhart DA, Kovacs RJ.
PMID: 28451647
JACC Clin Electrophysiol. 2016 Dec;2(7):765-774. doi: 10.1016/j.jacep.2016.02.015.

OBJECTIVES: We tested the hypothesis that oral progesterone administration attenuates drug-induced QT interval lengthening.BACKGROUND: Evidence from preclinical and human investigations suggests that higher serum progesterone concentrations may be protective against drug-induced QT interval lengthening.METHODS: In this prospective, double-blind, crossover...

Characterization of the Cellular Output of a Point-of-Care Device and the Implications for Addressing Critical Limb Ischemia.

BioResearch open access

Woodell-May JE, Tan ML, King WJ, Swift MJ, Welch ZR, Murphy MP, McKale JM.
PMID: 26634187
Biores Open Access. 2015 Nov 01;4(1):417-24. doi: 10.1089/biores.2015.0006. eCollection 2015.

Critical limb ischemia (CLI) is a terminal disease with high morbidity and healthcare costs due to limb loss. There are no effective medical therapies for patients with CLI to prevent amputation. Cell-based therapies are currently being investigated to address...

Mesenchymal stem cells: new players in retinopathy therapy.

Frontiers in endocrinology

Rajashekhar G.
PMID: 24795699
Front Endocrinol (Lausanne). 2014 Apr 24;5:59. doi: 10.3389/fendo.2014.00059. eCollection 2014.

Retinopathies in human and animal models have shown to occur through loss of pericytes resulting in edema formation, excessive immature retinal angiogenesis, and neuronal apoptosis eventually leading to blindness. In recent years, the concept of regenerating terminally differentiated organs...

Emerging Adults with Type 1 Diabetes during the First Year Post-High School: Perceptions of Parental Behaviors.

Emerging adulthood (Print)

Hanna KM, Weaver MT, Stump TE, Guthrie D, Oruche UM.
PMID: 25019036
Emerg Adulthood. 2014 Jun 01;2(2):128-137. doi: 10.1177/2167696813512621.

Among 182 emerging adults with type 1 diabetes (93% White and 57% female), changes during the year post-high school were examined in perceptions of diabetes-specific conflict with parents, parent-youth shared responsibility, parental tangible aid, and parental autonomy support, as...

Implications of genomic signatures in the differential vulnerability to fetal alcohol exposure in C57BL/6 and DBA/2 mice.

Frontiers in genetics

Lossie AC, Muir WM, Lo CL, Timm F, Liu Y, Gray W, Zhou FC.
PMID: 24966868
Front Genet. 2014 Jun 11;5:173. doi: 10.3389/fgene.2014.00173. eCollection 2014.

Maternal alcohol consumption inflicts a multitude of phenotypic consequences that range from undetectable changes to severe dysmorphology. Using tightly controlled murine studies that deliver precise amounts of alcohol at discrete developmental stages, our group and other labs demonstrated in...

Experience Developing a Community Pharmacy Practice-based Research Network.

Innovations in pharmacy

Snyder ME, Frail CK, Seel LV, Hultgren KE.
PMID: 25018893
Innov Pharm. 2012;3(2). doi: 10.24926/iip.v3i2.261.

In 2010, the Purdue University College of Pharmacy established the Medication Safety Research Network of Indiana (Rx-SafeNet), the first practice-based research network (PBRN) in Indiana comprised solely of community pharmacies. In the development of Rx-SafeNet and through our early...

Invasive cervical cancers from women living in the United States or Botswana: differences in human papillomavirus type distribution.

Infectious agents and cancer

Ermel A, Ramogola-Masire D, Zetola N, Tong Y, Qadadri B, Azar MM, Brown DR.
PMID: 25053972
Infect Agent Cancer. 2014 Jul 08;9:22. doi: 10.1186/1750-9378-9-22. eCollection 2014.

BACKGROUND: Cervical cancer is the primary cause of cancer-related deaths in women living in Botswana.METHODS: Paraffin-embedded blocks of formalin-fixed invasive cervical cancer specimens were identified from women living in the U.S. (n = 50) or Botswana (n = 171)...

Novel recruitment strategy to enrich for LRRK2 mutation carriers.

Molecular genetics & genomic medicine

Foroud T, Smith D, Jackson J, Verbrugge J, Halter C, Wetherill L, Sims K, Xin W, Arnedo V, Lasch S, Marek K.
PMID: 26436106
Mol Genet Genomic Med. 2015 Sep;3(5):404-12. doi: 10.1002/mgg3.151. Epub 2015 May 06.

The LRRK2 G2019S mutation is found at higher frequency among Parkinson disease (PD) patients of Ashkenazi Jewish (AJ) ancestry. This study was designed to test whether an internet-based approach could be an effective approach to screen and identify mutation...

[(11)C]PiB PET in Gerstmann-Sträussler-Scheinker disease.

American journal of nuclear medicine and molecular imaging

Deters KD, Risacher SL, Yoder KK, Oblak AL, Unverzagt FW, Murrell JR, Epperson F, Tallman EF, Quaid KA, Farlow MR, Saykin AJ, Ghetti B.
PMID: 27069768
Am J Nucl Med Mol Imaging. 2016 Jan 28;6(1):84-93. eCollection 2016.

Gerstmann-Sträussler-Scheinker Disease (GSS) is a familial neurodegenerative disorder characterized clinically by ataxia, parkinsonism, and dementia, and neuropathologically by deposition of diffuse and amyloid plaques composed of prion protein (PrP). The purpose of this study was to evaluate if [(11)C]Pittsburgh...

NETWORK-BASED GENOME WIDE STUDY OF HIPPOCAMPAL IMAGING PHENOTYPE IN ALZHEIMER'S DISEASE TO IDENTIFY FUNCTIONAL INTERACTION MODULES.

Proceedings of the ... IEEE International Conference on Acoustics, Speech, and Signal Processing. ICASSP (Conference)

Yao X, Yan J, Risacher S, Moore J, Saykin A, Shen L.
PMID: 28989328
Proc IEEE Int Conf Acoust Speech Signal Process. 2017;2017:6170-6174. doi: 10.1109/ICASSP.2017.7953342. Epub 2017 Jun 19.

Identification of functional modules from biological network is a promising approach to enhance the statistical power of genome-wide association study (GWAS) and improve biological interpretation for complex diseases. The precise functions of genes are highly relevant to tissue context,...

Automatic car driving detection using raw accelerometry data.

Physiological measurement

Strączkiewicz M, Urbanek JK, Fadel WF, Crainiceanu CM, Harezlak J.
PMID: 27653528
Physiol Meas. 2016 Oct;37(10):1757-1769. doi: 10.1088/0967-3334/37/10/1757. Epub 2016 Sep 21.

Measuring physical activity using wearable devices has become increasingly popular. Raw data collected from such devices is usually summarized as 'activity counts', which combine information of human activity with environmental vibrations. Driving is a major sedentary activity that artificially...

Showing 1 to 12 of 241 entries