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Showing 1 to 12 of 45 entries
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A survey of practices for the use of electronic health records to support research recruitment.

Journal of clinical and translational science

Obeid JS, Beskow LM, Rape M, Gouripeddi R, Black RA, Cimino JJ, Embi PJ, Weng C, Marnocha R, Buse JB.
PMID: 29657859
J Clin Transl Sci. 2017 Aug;1(4):246-252. doi: 10.1017/cts.2017.301.

Electronic health records (EHRs) provide great promise for identifying cohorts and enhancing research recruitment. Such approaches are sorely needed, but there are few descriptions in the literature of prevailing practices to guide their use. A multidisciplinary workgroup was formed...

ADPedKD: A Global Online Platform on the Management of Children With ADPKD.

Kidney international reports

De Rechter S, Bockenhauer D, Guay-Woodford LM, Liu I, Mallett AJ, Soliman NA, Sylvestre LC, Schaefer F, Liebau MC, Mekahli D.
PMID: 31517146
Kidney Int Rep. 2019 May 29;4(9):1271-1284. doi: 10.1016/j.ekir.2019.05.015. eCollection 2019 Sep.

BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of renal failure. For several decades, ADPKD was regarded as an adult-onset disease. In the past decade, it has become more widely appreciated that the disease...

Predicting Future Care Requirements Using Machine Learning for Pediatric Intensive and Routine Care Inpatients.

Critical care explorations

Trujillo Rivera EA, Chamberlain JM, Patel AK, Zeng-Treitler Q, Bost JE, Heneghan JA, Morizono H, Pollack MM.
PMID: 34396143
Crit Care Explor. 2021 Aug 10;3(8):e0505. doi: 10.1097/CCE.0000000000000505. eCollection 2021 Aug.

Develop and compare separate prediction models for ICU and non-ICU care for hospitalized children in four future time periods (6-12, 12-18, 18-24, and 24-30 hr) and assess these models in an independent cohort and simulated children's hospital.DESIGN: Predictive modeling...

Association Between COVID-19 and Mortality in Hip Fracture Surgery in the National COVID Cohort Collaborative (N3C): A Retrospective Cohort Study.

Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews

Levitt EB, Patch DA, Mabry S, Terrero A, Jaeger B, Haendel MA, Chute CG, Quade JH, Ponce B, Theiss S, Spitler CA, Johnson JP.
PMID: 34982060
J Am Acad Orthop Surg Glob Res Rev. 2022 Jan 04;6(1). doi: 10.5435/JAAOSGlobal-D-21-00282.

BACKGROUND: This study investigated the outcomes of coronavirus disease (COVID-19)-positive patients undergoing hip fracture surgery using a national database.METHODS: This is a retrospective cohort study comparing hip fracture surgery outcomes between COVID-19 positive and negative matched cohorts from 46...

Inflammation in children with cystic fibrosis: contribution of bacterial production of long-chain fatty acids.

Pediatric research

Felton E, Burrell A, Chaney H, Sami I, Koumbourlis AC, Freishtat RJ, Crandall KA, Hahn A.
PMID: 33654282
Pediatr Res. 2021 Jul;90(1):99-108. doi: 10.1038/s41390-021-01419-4. Epub 2021 Mar 02.

BACKGROUND: Cystic fibrosis (CF) affects >70,000 people worldwide, yet the microbiologic trigger for pulmonary exacerbations (PExs) remains unknown. The objective of this study was to identify changes in bacterial metabolic pathways associated with clinical status.METHODS: Respiratory samples were collected...

Multi-Omics Identifies Circulating miRNA and Protein Biomarkers for Facioscapulohumeral Dystrophy.

Journal of personalized medicine

Heier CR, Zhang A, Nguyen NY, Tully CB, Panigrahi A, Gordish-Dressman H, Pandey SN, Guglieri M, Ryan MM, Clemens PR, Thangarajh M, Webster R, Smith EC, Connolly AM, McDonald CM, Karachunski P, Tulinius M, Harper A, Mah JK, Fiorillo AA, Chen YW, Cooperative International Neuromuscular Research Group Cinrg Investigators.
PMID: 33228131
J Pers Med. 2020 Nov 19;10(4). doi: 10.3390/jpm10040236.

The development of therapeutics for muscle diseases such as facioscapulohumeral dystrophy (FSHD) is impeded by a lack of objective, minimally invasive biomarkers. Here we identify circulating miRNAs and proteins that are dysregulated in early-onset FSHD patients to develop blood-based...

Fecal Transplant in Children With .

Open forum infectious diseases

Hourigan SK, Ahn M, Gibson KM, Pérez-Losada M, Felix G, Weidner M, Leibowitz I, Niederhuber JE, Sears CL, Crandall KA, Oliva-Hemker M.
PMID: 31660343
Open Forum Infect Dis. 2019 Aug 26;6(10):ofz379. doi: 10.1093/ofid/ofz379. eCollection 2019 Oct.

BACKGROUND: Fecal microbiota transplantation (FMT) treats METHODS: Nine children with recurrent CDI underwent FMT. Stool was collected from donor and recipient pre-FMT and longitudinally post-FMT for up to 24 weeks. Shotgun metagenomic sequencing was performed. Reads were analyzed using...

Airway microbial diversity is decreased in young children with cystic fibrosis compared to healthy controls but improved with CFTR modulation.

Heliyon

Hahn A, Burrell A, Ansusinha E, Peng D, Chaney H, Sami I, Perez GF, Koumbourlis AC, McCarter R, Freishtat RJ, Crandall KA, Zemanick ET.
PMID: 32514485
Heliyon. 2020 Jun 01;6(6):e04104. doi: 10.1016/j.heliyon.2020.e04104. eCollection 2020 Jun.

BACKGROUND: Culture-independent next generation sequencing has identified diverse microbial communities within the cystic fibrosis (CF) airway. The study objective was to test for differences in the upper airway microbiome of children with CF and healthy controls and age-related differences...

Phenotypical Sub-setting of the First Episode of Severe Viral Respiratory Infection Based on Clinical Assessment and Underlying Airway Disease: A Pilot Study.

Frontiers in pediatrics

Arroyo M, Salka K, Perez GF, Rodríguez-Martínez CE, Castro-Rodriguez JA, Gutierrez MJ, Nino G.
PMID: 32300576
Front Pediatr. 2020 Apr 02;8:121. doi: 10.3389/fped.2020.00121. eCollection 2020.

No abstract available.

Cyclooxygenase inhibitor use is associated with increased COVID-19 severity.

medRxiv : the preprint server for health sciences

Reese JT, Coleman B, Chan L, Blau H, Callahan TJ, Cappelletti L, Fontana T, Bradwell KR, Harris NL, Casiraghi E, Valentini G, Karlebach G, Deer R, McMurry JA, Haendel MA, Chute CG, Pfaff E, Moffitt R, Spratt H, Singh J, Mungall CJ, Williams AE, Robinson PN.
PMID: 33907758
medRxiv. 2021 Apr 20; doi: 10.1101/2021.04.13.21255438.

BACKGROUND: Cyclooxygenase (COX) inhibitors including non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to reduce pain, fever, and inflammation but have been associated with complications in community acquired pneumonia and other respiratory tract infections (RTIs). Conclusive data are not available...

The National COVID Cohort Collaborative: Analyses of Original and Computationally Derived Electronic Health Record Data.

Journal of medical Internet research

Foraker R, Guo A, Thomas J, Zamstein N, Payne PR, Wilcox A.
PMID: 34559671
J Med Internet Res. 2021 Oct 04;23(10):e30697. doi: 10.2196/30697.

BACKGROUND: Computationally derived ("synthetic") data can enable the creation and analysis of clinical, laboratory, and diagnostic data as if they were the original electronic health record data. Synthetic data can support data sharing to answer critical research questions to...

Scientific Review Committees as part of institutional review of human participant research: Initial implementation at institutions with Clinical and Translational Science Awards.

Journal of clinical and translational science

Selker HP, Welch LC, Patchen-Fowler E, Breeze JL, Terrin N, Parajulee A, LeClair A, Naeim A, Marnocha R, Morelli Novak J, Caldwell CS, Cola PA, Croker JA, Cifu DX, Williams KM, Snyder DC, Kitterman D.
PMID: 32313701
J Clin Transl Sci. 2020 Jan 27;4(2):115-124. doi: 10.1017/cts.2019.439. eCollection 2020 Apr.

INTRODUCTION: Scientific quality and feasibility are part of ethics review by Institutional Review Boards (IRBs). Scientific Review Committees (SRCs) were proposed to facilitate this assessment by the Clinical and Translational Science Award (CTSA) SRC Consensus Group. This study assessed...

Showing 1 to 12 of 45 entries