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Nursing careers for veterans

pipeline programs

Kuehn BM.
GSID: EawzWmDArfUJ
BM Kuehn - JAMA, 2013 - jamanetwork.com

Women who are pregnant should not take valproate sodium, valproic acid, or divalproex sodium to prevent migraine headaches, warned the US Food and Drug Administration …

Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid.

Translational psychiatry

Servadio M, Melancia F, Manduca A, di Masi A, Schiavi S, Cartocci V, Pallottini V, Campolongo P, Ascenzi P, Trezza V.
PMID: 27676443
Transl Psychiatry. 2016 Sep 27;6(9):e902. doi: 10.1038/tp.2016.182.

Autism spectrum disorders (ASD) are characterized by altered sociability, compromised communication and stereotyped/repetitive behaviors, for which no specific treatments are currently available. Prenatal exposure to valproic acid (VPA) is a known, although still underestimated, environmental risk factor for ASD....

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Servadio M, Melancia F, Manduca A, et al. Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid. Transl Psychiatry. 2016;6(9):e902doi: 10.1038/tp.2016.182.
Servadio, M., Melancia, F., Manduca, A., di Masi, A., Schiavi, S., Cartocci, V., Pallottini, V., Campolongo, P., Ascenzi, P., & Trezza, V. (2016). Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid. Translational psychiatry, 6(9), e902. https://doi.org/10.1038/tp.2016.182
Servadio, M, et al. "Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid." Translational psychiatry vol. 6,9 (2016): e902. doi: https://doi.org/10.1038/tp.2016.182
Servadio M, Melancia F, Manduca A, di Masi A, Schiavi S, Cartocci V, Pallottini V, Campolongo P, Ascenzi P, Trezza V. Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid. Transl Psychiatry. 2016 Sep 27;6(9):e902. doi: 10.1038/tp.2016.182. PMID: 27676443; PMCID: PMC5048215.
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Post-stroke emotional incontinence or bipolar disorder?.

Neuropsychiatric disease and treatment

Mnif L, Sellami R, Masmoudi J.
PMID: 27536109
Neuropsychiatr Dis Treat. 2016 Jul 29;12:1883-5. doi: 10.2147/NDT.S102273. eCollection 2016.

INTRODUCTION: Post-stroke emotional incontinence and bipolar disorder are two disorders that involve the dysfunction of brain structures responsible for emotional regulation. The objective of this work is to study the links between these disorders through a clinical case.CASE REPORT:...

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Mnif L, Sellami R, Masmoudi J. Post-stroke emotional incontinence or bipolar disorder?. Neuropsychiatr Dis Treat. 2016;12:1883-5doi: 10.2147/NDT.S102273.
Mnif, L., Sellami, R., & Masmoudi, J. (2016). Post-stroke emotional incontinence or bipolar disorder?. Neuropsychiatric disease and treatment, 121883-5. https://doi.org/10.2147/NDT.S102273
Mnif, Leila, et al. "Post-stroke emotional incontinence or bipolar disorder?." Neuropsychiatric disease and treatment vol. 12 (2016): 1883-5. doi: https://doi.org/10.2147/NDT.S102273
Mnif L, Sellami R, Masmoudi J. Post-stroke emotional incontinence or bipolar disorder?. Neuropsychiatr Dis Treat. 2016 Jul 29;12:1883-5. doi: 10.2147/NDT.S102273. eCollection 2016. PMID: 27536109; PMCID: PMC4973722.
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Predictable enriched environment prevents development of hyper-emotionality in the VPA rat model of autism.

Frontiers in neuroscience

Favre MR, La Mendola D, Meystre J, Christodoulou D, Cochrane MJ, Markram H, Markram K.
PMID: 26089770
Front Neurosci. 2015 Jun 02;9:127. doi: 10.3389/fnins.2015.00127. eCollection 2015.

Understanding the effects of environmental stimulation in autism can improve therapeutic interventions against debilitating sensory overload, social withdrawal, fear and anxiety. Here, we evaluate the role of environmental predictability on behavior and protein expression, and inter-individual differences, in the...

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Favre MR, La Mendola D, Meystre J, et al. Predictable enriched environment prevents development of hyper-emotionality in the VPA rat model of autism. Front Neurosci. 2015;9:127doi: 10.3389/fnins.2015.00127.
Favre, M. R., La Mendola, D., Meystre, J., Christodoulou, D., Cochrane, M. J., Markram, H., & Markram, K. (2015). Predictable enriched environment prevents development of hyper-emotionality in the VPA rat model of autism. Frontiers in neuroscience, 9127. https://doi.org/10.3389/fnins.2015.00127
Favre, Mônica R, et al. "Predictable enriched environment prevents development of hyper-emotionality in the VPA rat model of autism." Frontiers in neuroscience vol. 9 (2015): 127. doi: https://doi.org/10.3389/fnins.2015.00127
Favre MR, La Mendola D, Meystre J, Christodoulou D, Cochrane MJ, Markram H, Markram K. Predictable enriched environment prevents development of hyper-emotionality in the VPA rat model of autism. Front Neurosci. 2015 Jun 02;9:127. doi: 10.3389/fnins.2015.00127. eCollection 2015. PMID: 26089770; PMCID: PMC4452729.
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Corrigendum to “Long-term valproic acid exposure increases the number of neocortical neurons in the developing rat brain" [Neurosci.Lett. 580 (2014) 12–16] A possible new animal model of autism.

Neuroscience letters

Sabers A, Bertelsen FC, Scheel-Krüger J, Nyengaard JR, Møller A.
PMID: 26060869
Neurosci Lett. 2015 Feb 19;588:203-7. doi: 10.1016/j.neulet.2014.12.014.

The aim of this study was to test the hypothesis that long-term fetal valproic acid (VPA) exposure at doses relevant to the human clinic interferes with normal brain development. Pregnant rats were given intraperitoneal injections of VPA (20 mg/kg...

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Sabers A, Bertelsen FC, Scheel-Krüger J, et al. Corrigendum to “Long-term valproic acid exposure increases the number of neocortical neurons in the developing rat brain" [Neurosci.Lett. 580 (2014) 12–16] A possible new animal model of autism. Neurosci Lett. 2015;588:203-7doi: 10.1016/j.neulet.2014.12.014.
Sabers, A., Bertelsen, F. C., Scheel-Krüger, J., Nyengaard, J. R., & Møller, A. (2015). Corrigendum to “Long-term valproic acid exposure increases the number of neocortical neurons in the developing rat brain" [Neurosci.Lett. 580 (2014) 12–16] A possible new animal model of autism. Neuroscience letters, 588203-7. https://doi.org/10.1016/j.neulet.2014.12.014
Sabers, Anne, et al. "Corrigendum to “Long-term valproic acid exposure increases the number of neocortical neurons in the developing rat brain" [Neurosci.Lett. 580 (2014) 12–16] A possible new animal model of autism." Neuroscience letters vol. 588 (2015): 203-7. doi: https://doi.org/10.1016/j.neulet.2014.12.014
Sabers A, Bertelsen FC, Scheel-Krüger J, Nyengaard JR, Møller A. Corrigendum to “Long-term valproic acid exposure increases the number of neocortical neurons in the developing rat brain" [Neurosci.Lett. 580 (2014) 12–16] A possible new animal model of autism. Neurosci Lett. 2015 Feb 19;588:203-7. doi: 10.1016/j.neulet.2014.12.014. PMID: 26060869.
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Three patients needing high doses of valproic Acid to get therapeutic concentrations.

Case reports in psychiatry

Jackson J, McCollum B, Ognibene J, Diaz FJ, de Leon J.
PMID: 26000191
Case Rep Psychiatry. 2015;2015:542862. doi: 10.1155/2015/542862. Epub 2015 Apr 27.

Valproic acid (VPA) can autoinduce its own metabolism. Cases requiring VPA doses >4000 mg/day to obtain therapeutic plasma concentrations, such as these 3 cases, have never been published. Case 1 received VPA for seizures and schizophrenia and had >50...

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Jackson J, McCollum B, Ognibene J, et al. Three patients needing high doses of valproic Acid to get therapeutic concentrations. Case Rep Psychiatry. 2015;2015:542862doi: 10.1155/2015/542862.
Jackson, J., McCollum, B., Ognibene, J., Diaz, F. J., & de Leon, J. (2015). Three patients needing high doses of valproic Acid to get therapeutic concentrations. Case reports in psychiatry, 2015542862. https://doi.org/10.1155/2015/542862
Jackson, James, et al. "Three patients needing high doses of valproic Acid to get therapeutic concentrations." Case reports in psychiatry vol. 2015 (2015): 542862. doi: https://doi.org/10.1155/2015/542862
Jackson J, McCollum B, Ognibene J, Diaz FJ, de Leon J. Three patients needing high doses of valproic Acid to get therapeutic concentrations. Case Rep Psychiatry. 2015;2015:542862. doi: 10.1155/2015/542862. Epub 2015 Apr 27. PMID: 26000191; PMCID: PMC4427013.
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Valproic Acid as a potentiator of metabolic syndrome in institutionalized residents on concomitant antipsychotics: fat chance, or slim to none?.

P & T : a peer-reviewed journal for formulary management

Zuo S, Fries BE, Szafara K, Regal R.
PMID: 25673963
P T. 2015 Feb;40(2):126-32.

BACKGROUND: Valproic acid (VPA) is one of the most commonly used antiepileptic medications worldwide; it is also a popular mood stabilizer for use in bipolar disorder and dementia. This study assessed whether VPA may potentiate metabolic side effects in...

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Zuo S, Fries BE, Szafara K, et al. Valproic Acid as a potentiator of metabolic syndrome in institutionalized residents on concomitant antipsychotics: fat chance, or slim to none?. P T. 2015;40(2):126-32
Zuo, S., Fries, B. E., Szafara, K., & Regal, R. (2015). Valproic Acid as a potentiator of metabolic syndrome in institutionalized residents on concomitant antipsychotics: fat chance, or slim to none?. P & T : a peer-reviewed journal for formulary management, 40(2), 126-32.
Zuo, Silu, et al. "Valproic Acid as a potentiator of metabolic syndrome in institutionalized residents on concomitant antipsychotics: fat chance, or slim to none?." P & T : a peer-reviewed journal for formulary management vol. 40,2 (2015): 126-32.
Zuo S, Fries BE, Szafara K, Regal R. Valproic Acid as a potentiator of metabolic syndrome in institutionalized residents on concomitant antipsychotics: fat chance, or slim to none?. P T. 2015 Feb;40(2):126-32. PMID: 25673963; PMCID: PMC4315115.
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Psychiatric disturbances as a first clinical symptom of Wilson's disease - case report.

Psychiatria polska

Litwin T, Dzieżyc K, Karliński M, Szafrański T, Członkowska A.
PMID: 27288679
Psychiatr Pol. 2016;50(2):337-344. doi: 10.12740/PP/45218.

OBJECTIVES: Wilson's disease (WD) is an inherited disorder of copper metabolism with wide spectrum of clinical symptoms, mainly hepatic or neurological. Psychiatric disorders occur less frequently and are not pathognomonic for WD. However, in almost 20% of cases they...

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Litwin T, Dzieżyc K, Karliński M, et al. Zaburzenia psychiatryczne jako pierwszy objaw choroby Wilsona - opis przypadku. Psychiatric disturbances as a first clinical symptom of Wilson's disease - case report. Psychiatr Pol. 2016;50(2):337-344doi: 10.12740/PP/45218.
Litwin, T., Dzieżyc, K., Karliński, M., Szafrański, T., & Członkowska, A. (2016). Zaburzenia psychiatryczne jako pierwszy objaw choroby Wilsona - opis przypadku. Psychiatric disturbances as a first clinical symptom of Wilson's disease - case report. Psychiatria polska, 50(2), 337-344. https://doi.org/10.12740/PP/45218
Litwin, Tomasz, et al. "Zaburzenia psychiatryczne jako pierwszy objaw choroby Wilsona - opis przypadku." Psychiatric disturbances as a first clinical symptom of Wilson's disease - case report. Psychiatria polska vol. 50,2 (2016): 337-344. doi: https://doi.org/10.12740/PP/45218
Litwin T, Dzieżyc K, Karliński M, Szafrański T, Członkowska A. Zaburzenia psychiatryczne jako pierwszy objaw choroby Wilsona - opis przypadku. Psychiatric disturbances as a first clinical symptom of Wilson's disease - case report. Psychiatr Pol. 2016;50(2):337-344. doi: 10.12740/PP/45218. Polish. PMID: 27288679.
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Characteristics of Adult T-Cell Leukemia/Lymphoma Patients with Long Survival: Prognostic Significance of Skin Lesions and Possible Beneficial Role of Valproic Acid.

Leukemia research and treatment

Yves P, Stephane M, Rishika B, Christine D, Gérard P.
PMID: 26199759
Leuk Res Treatment. 2015;2015:476805. doi: 10.1155/2015/476805. Epub 2015 Jun 14.

We describe the clinical and biological features of ten patients with a survival superior to ten years (long survival), out of 175 patients diagnosed with Adult T-cell Leukemia/Lymphoma (ATL) in Martinique (1983-2013). There were 5 lymphoma and 5 chronic...

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Yves P, Stephane M, Rishika B, et al. Characteristics of Adult T-Cell Leukemia/Lymphoma Patients with Long Survival: Prognostic Significance of Skin Lesions and Possible Beneficial Role of Valproic Acid. Leuk Res Treatment. 2015;2015:476805doi: 10.1155/2015/476805.
Yves, P., Stephane, M., Rishika, B., Christine, D., & Gérard, P. (2015). Characteristics of Adult T-Cell Leukemia/Lymphoma Patients with Long Survival: Prognostic Significance of Skin Lesions and Possible Beneficial Role of Valproic Acid. Leukemia research and treatment, 2015476805. https://doi.org/10.1155/2015/476805
Yves, Plumelle, et al. "Characteristics of Adult T-Cell Leukemia/Lymphoma Patients with Long Survival: Prognostic Significance of Skin Lesions and Possible Beneficial Role of Valproic Acid." Leukemia research and treatment vol. 2015 (2015): 476805. doi: https://doi.org/10.1155/2015/476805
Yves P, Stephane M, Rishika B, Christine D, Gérard P. Characteristics of Adult T-Cell Leukemia/Lymphoma Patients with Long Survival: Prognostic Significance of Skin Lesions and Possible Beneficial Role of Valproic Acid. Leuk Res Treatment. 2015;2015:476805. doi: 10.1155/2015/476805. Epub 2015 Jun 14. PMID: 26199759; PMCID: PMC4496652.
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Intermittent activation of notch signaling promotes bone formation.

American journal of translational research

Ji Y, Ke Y, Gao S.
PMID: 28670381
Am J Transl Res. 2017 Jun 15;9(6):2933-2944. eCollection 2017.

Stimulatory and inhibitory effects of Notch signaling pathway on osteogenesis were both widely reported, questioning the effectiveness of small molecules targeting the Notch pathway for prevention or treatment of bone loss diseases. Here we showed that Notch signaling is...

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Ji Y, Ke Y, Gao S. Intermittent activation of notch signaling promotes bone formation. Am J Transl Res. 2017;9(6):2933-2944
Ji, Y., Ke, Y., & Gao, S. (2017). Intermittent activation of notch signaling promotes bone formation. American journal of translational research, 9(6), 2933-2944.
Ji, Yaoting, et al. "Intermittent activation of notch signaling promotes bone formation." American journal of translational research vol. 9,6 (2017): 2933-2944.
Ji Y, Ke Y, Gao S. Intermittent activation of notch signaling promotes bone formation. Am J Transl Res. 2017 Jun 15;9(6):2933-2944. eCollection 2017. PMID: 28670381; PMCID: PMC5489893.
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Valproic Acid, a Histone Deacetylase Inhibitor, in Combination with Paclitaxel for Anaplastic Thyroid Cancer: Results of a Multicenter Randomized Controlled Phase II/III Trial.

International journal of endocrinology

Catalano MG, Pugliese M, Gallo M, Brignardello E, Milla P, Orlandi F, Limone PP, Arvat E, Boccuzzi G, Piovesan A.
PMID: 27766105
Int J Endocrinol. 2016;2016:2930414. doi: 10.1155/2016/2930414. Epub 2016 Sep 27.

Anaplastic thyroid cancer (ATC) has a median survival less than 5 months and, to date, no effective therapy exists. Taxanes have recently been stated as the main drug treatment for ATC, and the histone deacetylase inhibitor valproic acid efficiently...

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Catalano MG, Pugliese M, Gallo M, et al. Valproic Acid, a Histone Deacetylase Inhibitor, in Combination with Paclitaxel for Anaplastic Thyroid Cancer: Results of a Multicenter Randomized Controlled Phase II/III Trial. Int J Endocrinol. 2016;2016:2930414doi: 10.1155/2016/2930414.
Catalano, M. G., Pugliese, M., Gallo, M., Brignardello, E., Milla, P., Orlandi, F., Limone, P. P., Arvat, E., Boccuzzi, G., & Piovesan, A. (2016). Valproic Acid, a Histone Deacetylase Inhibitor, in Combination with Paclitaxel for Anaplastic Thyroid Cancer: Results of a Multicenter Randomized Controlled Phase II/III Trial. International journal of endocrinology, 20162930414. https://doi.org/10.1155/2016/2930414
Catalano, Maria Graziella, et al. "Valproic Acid, a Histone Deacetylase Inhibitor, in Combination with Paclitaxel for Anaplastic Thyroid Cancer: Results of a Multicenter Randomized Controlled Phase II/III Trial." International journal of endocrinology vol. 2016 (2016): 2930414. doi: https://doi.org/10.1155/2016/2930414
Catalano MG, Pugliese M, Gallo M, Brignardello E, Milla P, Orlandi F, Limone PP, Arvat E, Boccuzzi G, Piovesan A. Valproic Acid, a Histone Deacetylase Inhibitor, in Combination with Paclitaxel for Anaplastic Thyroid Cancer: Results of a Multicenter Randomized Controlled Phase II/III Trial. Int J Endocrinol. 2016;2016:2930414. doi: 10.1155/2016/2930414. Epub 2016 Sep 27. PMID: 27766105; PMCID: PMC5059567.
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A Case of Mania Presenting with Hypersexual Behavior and Gender Dysphoria that Resolved with Valproic Acid.

Mental illness

Heare MR, Barsky M, Faziola LR.
PMID: 27994833
Ment Illn. 2016 Nov 23;8(2):6546. doi: 10.4081/mi.2016.6546. eCollection 2016 Nov 23.

Hypersexuality and gender dysphoria have both been described in the literature as symptoms of mania. Hypersexuality is listed in the

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Heare MR, Barsky M, Faziola LR. A Case of Mania Presenting with Hypersexual Behavior and Gender Dysphoria that Resolved with Valproic Acid. Ment Illn. 2016;8(2):6546doi: 10.4081/mi.2016.6546.
Heare, M. R., Barsky, M., & Faziola, L. R. (2016). A Case of Mania Presenting with Hypersexual Behavior and Gender Dysphoria that Resolved with Valproic Acid. Mental illness, 8(2), 6546. https://doi.org/10.4081/mi.2016.6546
Heare, Michelle R, et al. "A Case of Mania Presenting with Hypersexual Behavior and Gender Dysphoria that Resolved with Valproic Acid." Mental illness vol. 8,2 (2016): 6546. doi: https://doi.org/10.4081/mi.2016.6546
Heare MR, Barsky M, Faziola LR. A Case of Mania Presenting with Hypersexual Behavior and Gender Dysphoria that Resolved with Valproic Acid. Ment Illn. 2016 Nov 23;8(2):6546. doi: 10.4081/mi.2016.6546. eCollection 2016 Nov 23. PMID: 27994833; PMCID: PMC5136748.
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