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Showing 1 to 12 of 12 entries
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Novel Marine Compounds: Anticancer or Genotoxic?.

Journal of biomedicine & biotechnology

Arif JM, Al-Hazzani AA, Kunhi M, Al-Khodairy F.
PMID: 15240919
J Biomed Biotechnol. 2004;2004(2):93-98. doi: 10.1155/S1110724304307060.

In the past several decades, marine organisms have generously gifted to the pharmaceutical industries numerous naturally bioactive compounds with antiviral, antibacterial, antimalarial, anti-inflammatory, antioxidant, and anticancer potentials. But till date only few anticancer drugs (cytarabine, vidarabine) have been commercially...

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Arif JM, Al-Hazzani AA, Kunhi M, et al. Novel Marine Compounds: Anticancer or Genotoxic?. J Biomed Biotechnol. 2004;2004(2):93-98doi: 10.1155/S1110724304307060.
Arif, J. M., Al-Hazzani, A. A., Kunhi, M., & Al-Khodairy, F. (2004). Novel Marine Compounds: Anticancer or Genotoxic?. Journal of biomedicine & biotechnology, 2004(2), 93-98. https://doi.org/10.1155/S1110724304307060
Arif, Jamal M., et al. "Novel Marine Compounds: Anticancer or Genotoxic?." Journal of biomedicine & biotechnology vol. 2004,2 (2004): 93-98. doi: https://doi.org/10.1155/S1110724304307060
Arif JM, Al-Hazzani AA, Kunhi M, Al-Khodairy F. Novel Marine Compounds: Anticancer or Genotoxic?. J Biomed Biotechnol. 2004;2004(2):93-98. doi: 10.1155/S1110724304307060. PMID: 15240919; PMCID: PMC548801.
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Screening for potential toxicity of antiviral therapies.

Current opinion in drug discovery & development

Szczech GM, Furman PA.
PMID: 19649838
Curr Opin Drug Discov Devel. 2000 Jan;3(1):56-62.

Preclinical screening for the toxicity of antiviral drugs has thus far proven quite successful. Twenty-three antivirals spanning a variety of chemical classes and including a combination product, have been safely developed and are listed in the 1999 Physician's Desk...

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Szczech GM, Furman PA. Screening for potential toxicity of antiviral therapies. Curr Opin Drug Discov Devel. 2000;3(1):56-62
Szczech, G. M., & Furman, P. A. (2000). Screening for potential toxicity of antiviral therapies. Current opinion in drug discovery & development, 3(1), 56-62.
Szczech, G M, and Furman, P A. "Screening for potential toxicity of antiviral therapies." Current opinion in drug discovery & development vol. 3,1 (2000): 56-62.
Szczech GM, Furman PA. Screening for potential toxicity of antiviral therapies. Curr Opin Drug Discov Devel. 2000 Jan;3(1):56-62. PMID: 19649838.
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Pentostatin (2prime prime or minute-Deoxycoformycin): Clinical Pharmacology, Role In Cancer Chemotherapy, and Future Prospects.

American journal of therapeutics

Spiers AS.
PMID: 11847552
Am J Ther. 1995 Mar;2(3):196-216.

Pentostatin (2prime prime or minute-deoxycoformycin, dCF) is a product of the fermentation of Streptomyces antibioticus. It is a tight-binding inhibitor of adenosine deaminase (ADA), an enzyme essential in cellular metabolism of purines. Children with congenital absence of ADA suffer...

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Spiers AS. Pentostatin (2prime prime or minute-Deoxycoformycin): Clinical Pharmacology, Role In Cancer Chemotherapy, and Future Prospects. Am J Ther. 1995;2(3):196-216
Spiers, A. S. (1995). Pentostatin (2prime prime or minute-Deoxycoformycin): Clinical Pharmacology, Role In Cancer Chemotherapy, and Future Prospects. American journal of therapeutics, 2(3), 196-216.
Spiers, Alexander S.D.. "Pentostatin (2prime prime or minute-Deoxycoformycin): Clinical Pharmacology, Role In Cancer Chemotherapy, and Future Prospects." American journal of therapeutics vol. 2,3 (1995): 196-216.
Spiers AS. Pentostatin (2prime prime or minute-Deoxycoformycin): Clinical Pharmacology, Role In Cancer Chemotherapy, and Future Prospects. Am J Ther. 1995 Mar;2(3):196-216. PMID: 11847552.
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Ganciclovir ophthalmic gel 0.15% for the treatment of acute herpetic keratitis: background, effectiveness, tolerability, safety, and future applications.

Therapeutics and clinical risk management

Chou TY, Hong BY.
PMID: 25187721
Ther Clin Risk Manag. 2014 Aug 20;10:665-81. doi: 10.2147/TCRM.S58242. eCollection 2014.

Eye disease due to herpes simplex virus (HSV) is a leading cause of ocular morbidity and the number one infectious cause of unilateral corneal blindness in the developed parts of the globe. Recurrent keratitis can result in progressive corneal...

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Chou TY, Hong BY. Ganciclovir ophthalmic gel 0.15% for the treatment of acute herpetic keratitis: background, effectiveness, tolerability, safety, and future applications. Ther Clin Risk Manag. 2014;10:665-81doi: 10.2147/TCRM.S58242.
Chou, T. Y., & Hong, B. Y. (2014). Ganciclovir ophthalmic gel 0.15% for the treatment of acute herpetic keratitis: background, effectiveness, tolerability, safety, and future applications. Therapeutics and clinical risk management, 10665-81. https://doi.org/10.2147/TCRM.S58242
Chou, Timothy Y, and Hong, Bennett Y. "Ganciclovir ophthalmic gel 0.15% for the treatment of acute herpetic keratitis: background, effectiveness, tolerability, safety, and future applications." Therapeutics and clinical risk management vol. 10 (2014): 665-81. doi: https://doi.org/10.2147/TCRM.S58242
Chou TY, Hong BY. Ganciclovir ophthalmic gel 0.15% for the treatment of acute herpetic keratitis: background, effectiveness, tolerability, safety, and future applications. Ther Clin Risk Manag. 2014 Aug 20;10:665-81. doi: 10.2147/TCRM.S58242. eCollection 2014. PMID: 25187721; PMCID: PMC4149409.
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Synthesis and antiviral effect of phosphamide modified vidarabine for treating HSV 1 infections.

Bioorganic & medicinal chemistry letters

Wang Z, Zang R, Niu Z, Wang W, Wang X, Tang Y.
PMID: 34624489
Bioorg Med Chem Lett. 2021 Nov 15;52:128405. doi: 10.1016/j.bmcl.2021.128405. Epub 2021 Oct 06.

Vidarabine (ARA) was one of the earliest marine-related compounds to be used clinically for antiviral therapy, however, its fast metabolism is the main defect of this drug. To overcome this, we designed and synthesized a group of phosphamide-modified ARA...

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Wang Z, Zang R, Niu Z, et al. Synthesis and antiviral effect of phosphamide modified vidarabine for treating HSV 1 infections. Bioorg Med Chem Lett. 2021;52:128405doi: 10.1016/j.bmcl.2021.128405.
Wang, Z., Zang, R., Niu, Z., Wang, W., Wang, X., & Tang, Y. (2021). Synthesis and antiviral effect of phosphamide modified vidarabine for treating HSV 1 infections. Bioorganic & medicinal chemistry letters, 52128405. https://doi.org/10.1016/j.bmcl.2021.128405
Wang, Zhenhao, et al. "Synthesis and antiviral effect of phosphamide modified vidarabine for treating HSV 1 infections." Bioorganic & medicinal chemistry letters vol. 52 (2021): 128405. doi: https://doi.org/10.1016/j.bmcl.2021.128405
Wang Z, Zang R, Niu Z, Wang W, Wang X, Tang Y. Synthesis and antiviral effect of phosphamide modified vidarabine for treating HSV 1 infections. Bioorg Med Chem Lett. 2021 Nov 15;52:128405. doi: 10.1016/j.bmcl.2021.128405. Epub 2021 Oct 06. PMID: 34624489.
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Simultaneous herpes zoster rash in the upper extremity and interscapular region that resembles innervation zone of the dorsal ramus of the cervical nerve root: a case report.

AME case reports

Nomura H, Nomura S.
PMID: 34312604
AME Case Rep. 2021 Jul 25;5:25. doi: 10.21037/acr-21-1. eCollection 2021.

In daily medical practice, scapular pain associated with cervical radiculopathy is commonly seen prior to the onset of pain of the upper extremity; however, the cause of the scapular pain is uncertain. We report a case of herpes zoster...

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Nomura H, Nomura S. Simultaneous herpes zoster rash in the upper extremity and interscapular region that resembles innervation zone of the dorsal ramus of the cervical nerve root: a case report. AME Case Rep. 2021;5:25doi: 10.21037/acr-21-1.
Nomura, H., & Nomura, S. (2021). Simultaneous herpes zoster rash in the upper extremity and interscapular region that resembles innervation zone of the dorsal ramus of the cervical nerve root: a case report. AME case reports, 525. https://doi.org/10.21037/acr-21-1
Nomura, Hiroshi, and Nomura, Shigeharu. "Simultaneous herpes zoster rash in the upper extremity and interscapular region that resembles innervation zone of the dorsal ramus of the cervical nerve root: a case report." AME case reports vol. 5 (2021): 25. doi: https://doi.org/10.21037/acr-21-1
Nomura H, Nomura S. Simultaneous herpes zoster rash in the upper extremity and interscapular region that resembles innervation zone of the dorsal ramus of the cervical nerve root: a case report. AME Case Rep. 2021 Jul 25;5:25. doi: 10.21037/acr-21-1. eCollection 2021. PMID: 34312604; PMCID: PMC8256132.
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Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2.

Viruses

Sadowski LA, Upadhyay R, Greeley ZW, Margulies BJ.
PMID: 34202050
Viruses. 2021 Jun 25;13(7). doi: 10.3390/v13071228.

Herpes simplex viruses-1 and -2 (HSV-1 and -2) are two of the three human alphaherpesviruses that cause infections worldwide. Since both viruses can be acquired in the absence of visible signs and symptoms, yet still result in lifelong infection,...

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Sadowski LA, Upadhyay R, Greeley ZW, et al. Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2. Viruses. 2021;13(7)doi: 10.3390/v13071228.
Sadowski, L. A., Upadhyay, R., Greeley, Z. W., & Margulies, B. J. (2021). Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2. Viruses, 13(7), . https://doi.org/10.3390/v13071228
Sadowski, Lauren A, et al. "Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2." Viruses vol. 13,7 (2021). doi: https://doi.org/10.3390/v13071228
Sadowski LA, Upadhyay R, Greeley ZW, Margulies BJ. Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2. Viruses. 2021 Jun 25;13(7). doi: 10.3390/v13071228. PMID: 34202050; PMCID: PMC8310346.
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Orbital apex syndrome associated with herpes zoster ophthalmicus.

Clinical ophthalmology (Auckland, N.Z.)

Kurimoto T, Tonari M, Ishizaki N, Monta M, Hirata S, Oku H, Sugasawa J, Ikeda T.
PMID: 22140305
Clin Ophthalmol. 2011;5:1603-8. doi: 10.2147/OPTH.S25900. Epub 2011 Nov 09.

We report our findings for a patient with orbital apex syndrome associated with herpes zoster ophthalmicus. Our patient was initially admitted to a neighborhood hospital because of nausea and loss of appetite of 10 days' duration. The day after...

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Kurimoto T, Tonari M, Ishizaki N, et al. Orbital apex syndrome associated with herpes zoster ophthalmicus. Clin Ophthalmol. 2011;5:1603-8doi: 10.2147/OPTH.S25900.
Kurimoto, T., Tonari, M., Ishizaki, N., Monta, M., Hirata, S., Oku, H., Sugasawa, J., & Ikeda, T. (2011). Orbital apex syndrome associated with herpes zoster ophthalmicus. Clinical ophthalmology (Auckland, N.Z.), 51603-8. https://doi.org/10.2147/OPTH.S25900
Kurimoto, Takuji, et al. "Orbital apex syndrome associated with herpes zoster ophthalmicus." Clinical ophthalmology (Auckland, N.Z.) vol. 5 (2011): 1603-8. doi: https://doi.org/10.2147/OPTH.S25900
Kurimoto T, Tonari M, Ishizaki N, Monta M, Hirata S, Oku H, Sugasawa J, Ikeda T. Orbital apex syndrome associated with herpes zoster ophthalmicus. Clin Ophthalmol. 2011;5:1603-8. doi: 10.2147/OPTH.S25900. Epub 2011 Nov 09. PMID: 22140305; PMCID: PMC3225456.
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Marine Sponge is a Promising Natural Source of Anti-SARS-CoV-2 Scaffold.

Frontiers in pharmacology

Hamoda AM, Fayed B, Ashmawy NS, El-Shorbagi AA, Hamdy R, Soliman SSM.
PMID: 34079462
Front Pharmacol. 2021 May 13;12:666664. doi: 10.3389/fphar.2021.666664. eCollection 2021.

The current pandemic caused by SARS-CoV2 and named COVID-19 urgent the need for novel lead antiviral drugs. Recently, United States Food and Drug Administration (FDA) approved the use of remdesivir as anti-SARS-CoV-2. Remdesivir is a natural product-inspired nucleoside analogue...

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Hamoda AM, Fayed B, Ashmawy NS, et al. Marine Sponge is a Promising Natural Source of Anti-SARS-CoV-2 Scaffold. Front Pharmacol. 2021;12:666664doi: 10.3389/fphar.2021.666664.
Hamoda, A. M., Fayed, B., Ashmawy, N. S., El-Shorbagi, A. A., Hamdy, R., & Soliman, S. S. M. (2021). Marine Sponge is a Promising Natural Source of Anti-SARS-CoV-2 Scaffold. Frontiers in pharmacology, 12666664. https://doi.org/10.3389/fphar.2021.666664
Hamoda, Alshaimaa M, et al. "Marine Sponge is a Promising Natural Source of Anti-SARS-CoV-2 Scaffold." Frontiers in pharmacology vol. 12 (2021): 666664. doi: https://doi.org/10.3389/fphar.2021.666664
Hamoda AM, Fayed B, Ashmawy NS, El-Shorbagi AA, Hamdy R, Soliman SSM. Marine Sponge is a Promising Natural Source of Anti-SARS-CoV-2 Scaffold. Front Pharmacol. 2021 May 13;12:666664. doi: 10.3389/fphar.2021.666664. eCollection 2021. PMID: 34079462; PMCID: PMC8165660.
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Herpes simplex virus ocular infections.

Drugs of today (Barcelona, Spain : 1998)

Lee SY.
PMID: 15094853
Drugs Today (Barc). 1998 Mar;34(3):241-9. doi: 10.1358/dot.1998.34.3.485179.

Herpes simplex ocular infection is the leading cause of infectious corneal blindness in the United States and presents a frequent challenge to ophthalmologists. The epithelial infections are usually readily controlled with trifluridine or vidarabine, but clinical resistance may be...

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Lee SY. Herpes simplex virus ocular infections. Drugs Today (Barc). 1998;34(3):241-9doi: 10.1358/dot.1998.34.3.485179.
Lee, S. Y. (1998). Herpes simplex virus ocular infections. Drugs of today (Barcelona, Spain : 1998), 34(3), 241-9. https://doi.org/10.1358/dot.1998.34.3.485179
Lee, S Y. "Herpes simplex virus ocular infections." Drugs of today (Barcelona, Spain : 1998) vol. 34,3 (1998): 241-9. doi: https://doi.org/10.1358/dot.1998.34.3.485179
Lee SY. Herpes simplex virus ocular infections. Drugs Today (Barc). 1998 Mar;34(3):241-9. doi: 10.1358/dot.1998.34.3.485179. PMID: 15094853.
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A Cell-Based Reporter Assay for Screening Inhibitors of MERS Coronavirus RNA-Dependent RNA Polymerase Activity.

Journal of clinical medicine

Min JS, Kim GW, Kwon S, Jin YH.
PMID: 32727069
J Clin Med. 2020 Jul 27;9(8). doi: 10.3390/jcm9082399.

Severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19) are emerging zoonotic diseases caused by coronavirus (CoV) infections. The viral RNA-dependent RNA polymerase (RdRp) has been suggested as a valuable target for antiviral...

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Min JS, Kim GW, Kwon S, et al. A Cell-Based Reporter Assay for Screening Inhibitors of MERS Coronavirus RNA-Dependent RNA Polymerase Activity. J Clin Med. 2020;9(8)doi: 10.3390/jcm9082399.
Min, J. S., Kim, G. W., Kwon, S., & Jin, Y. H. (2020). A Cell-Based Reporter Assay for Screening Inhibitors of MERS Coronavirus RNA-Dependent RNA Polymerase Activity. Journal of clinical medicine, 9(8), . https://doi.org/10.3390/jcm9082399
Min, Jung Sun, et al. "A Cell-Based Reporter Assay for Screening Inhibitors of MERS Coronavirus RNA-Dependent RNA Polymerase Activity." Journal of clinical medicine vol. 9,8 (2020). doi: https://doi.org/10.3390/jcm9082399
Min JS, Kim GW, Kwon S, Jin YH. A Cell-Based Reporter Assay for Screening Inhibitors of MERS Coronavirus RNA-Dependent RNA Polymerase Activity. J Clin Med. 2020 Jul 27;9(8). doi: 10.3390/jcm9082399. PMID: 32727069; PMCID: PMC7465106.
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Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2.

Viruses

Sadowski LA, Upadhyay R, Greeley ZW, Margulies BJ.
PMID: 34202050
Viruses. 2021 Jun 25;13(7). doi: 10.3390/v13071228.

Herpes simplex viruses-1 and -2 (HSV-1 and -2) are two of the three human alphaherpesviruses that cause infections worldwide. Since both viruses can be acquired in the absence of visible signs and symptoms, yet still result in lifelong infection,...

Cite
Sadowski LA, Upadhyay R, Greeley ZW, et al. Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2. Viruses. 2021;13(7)doi: 10.3390/v13071228.
Sadowski, L. A., Upadhyay, R., Greeley, Z. W., & Margulies, B. J. (2021). Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2. Viruses, 13(7), . https://doi.org/10.3390/v13071228
Sadowski, Lauren A, et al. "Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2." Viruses vol. 13,7 (2021). doi: https://doi.org/10.3390/v13071228
Sadowski LA, Upadhyay R, Greeley ZW, Margulies BJ. Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2. Viruses. 2021 Jun 25;13(7). doi: 10.3390/v13071228. PMID: 34202050; PMCID: PMC8310346.
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Showing 1 to 12 of 12 entries