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Showing 1 to 12 of 30 entries
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Genome-Wide Association Study of Serum 25-Hydroxyvitamin D in US Women.

Frontiers in genetics

O'Brien KM, Sandler DP, Shi M, Harmon QE, Taylor JA, Weinberg CR.
PMID: 29545823
Front Genet. 2018 Mar 01;9:67. doi: 10.3389/fgene.2018.00067. eCollection 2018.

Genetic factors likely influence individuals' concentrations of 25-hydroxyvitamin D [25(OH)D], a biomarker of vitamin D exposure previously linked to reduced risk of several chronic diseases. We conducted a genome-wide association study of serum 25(OH)D (assessed using liquid chromatography-tandem mass...

Residential ultraviolet radiation and breast cancer risk in a large prospective cohort.

Environment international

Gregoire AM, VoPham T, Laden F, Yarosh R, O'Brien KM, Sandler DP, White AJ.
PMID: 34894486
Environ Int. 2022 Jan 15;159:107028. doi: 10.1016/j.envint.2021.107028. Epub 2021 Dec 08.

BACKGROUND: Ambient ultraviolet (UV) radiation has been increasing due to climate change. While this may result in adverse health consequences such as an increased incidence of skin cancer, UV radiation is also a source of vitamin D, which has...

Experiences With Everyday and Major Forms of Racial/Ethnic Discrimination and Type 2 Diabetes Risk Among White, Black, and Hispanic/Latina Women: Findings From the Sister Study.

American journal of epidemiology

Gaston SA, Atere-Roberts J, Ward J, Slopen NB, Forde AT, Sandler DP, Williams DR, Jackson CL.
PMID: 34215871
Am J Epidemiol. 2021 Dec 01;190(12):2552-2562. doi: 10.1093/aje/kwab189.

Racial/ethnic discrimination may contribute to the risk of type 2 diabetes mellitus (T2DM), but few studies have prospectively examined this relationship among racially/ethnically diverse populations. We analyzed prospective data from 33,833 eligible Sister Study participants enrolled from 2003 to...

Use of hair products in relation to ovarian cancer risk.

Carcinogenesis

White AJ, Sandler DP, Gaston SA, Jackson CL, O'Brien KM.
PMID: 34173819
Carcinogenesis. 2021 Oct 05;42(9):1189-1195. doi: 10.1093/carcin/bgab056.

We evaluated whether hair products, which may contain carcinogens and endocrine disruptors that can be absorbed into the bloodstream, are related to ovarian cancer incidence in a prospective cohort. After excluding women with a history of ovarian cancer or...

Germline Pathogenic Variants in Cancer Predisposition Genes Among Women With Invasive Lobular Carcinoma of the Breast.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Yadav S, Hu C, Nathanson KL, Weitzel JN, Goldgar DE, Kraft P, Gnanaolivu RD, Na J, Huang H, Boddicker NJ, Larson N, Gao C, Yao S, Weinberg C, Vachon CM, Trentham-Dietz A, Taylor JA, Sandler DR, Patel A, Palmer JR, Olson JE, Neuhausen S, Martinez E, Lindstrom S, Lacey JV, Kurian AW, John EM, Haiman C, Bernstein L, Auer PW, Anton-Culver H, Ambrosone CB, Karam R, Chao E, Yussuf A, Pesaran T, Dolinsky JS, Hart SN, LaDuca H, Polley EC, Domchek SM, Couch FJ.
PMID: 34672684
J Clin Oncol. 2021 Dec 10;39(35):3918-3926. doi: 10.1200/JCO.21.00640. Epub 2021 Oct 21.

PURPOSE: To determine the contribution of germline pathogenic variants (PVs) in hereditary cancer testing panel genes to invasive lobular carcinoma (ILC) of the breast.MATERIALS AND METHODS: The study included 2,999 women with ILC from a population-based cohort and 3,796...

Hazardous air pollutants and telomere length in the Sister Study.

Environmental epidemiology (Philadelphia, Pa.)

Niehoff NM, Gammon MD, Keil AP, Nichols HB, Engel LS, Taylor JA, White AJ, Sandler DP.
PMID: 32984752
Environ Epidemiol. 2019 Aug;3(4). doi: 10.1097/ee9.0000000000000053. Epub 2019 Jun 28.

BACKGROUND: Telomeres are vital for genomic integrity and telomere length has been linked to many adverse health outcomes. Some hazardous air pollutants, or air toxics, increase oxidative stress and inflammation, two possible determinants of shortened telomere length. No studies...

Multipollutant measurement error in air pollution epidemiology studies arising from predicting exposures with penalized regression splines.

Journal of the Royal Statistical Society. Series C, Applied statistics

Bergen S, Sheppard L, Kaufman JD, Szpiro AA.
PMID: 27789915
J R Stat Soc Ser C Appl Stat. 2016 Nov;65(5):731-753. doi: 10.1111/rssc.12144. Epub 2016 Mar 01.

Air pollution epidemiology studies are trending towards a multi-pollutant approach. In these studies, exposures at subject locations are unobserved and must be predicted using observed exposures at misaligned monitoring locations. This induces measurement error, which can bias the estimated...

Ovarian Cancer Risk Factor Associations by Primary Anatomic Site: The Ovarian Cancer Cohort Consortium.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Fortner RT, Rice MS, Knutsen SF, Orlich MJ, Visvanathan K, Patel AV, Gaudet MM, Tjønneland A, Kvaskoff M, Kaaks R, Trichopolou A, Pala V, Onland-Moret NC, Gram IT, Amiano P, Idahl A, Allen NE, Weiderpass E, Poynter JN, Robien K, Giles GG, Milne RL, Setiawan VW, Merritt MA, van den Brandt PA, Zeleniuch-Jacquotte A, Arslan AA, O'Brien KM, Sandler DP, Wolk A, Håkansson N, Harris HR, Trabert B, Wentzensen N, Tworoger SS, Schouten LJ.
PMID: 32732252
Cancer Epidemiol Biomarkers Prev. 2020 Oct;29(10):2010-2018. doi: 10.1158/1055-9965.EPI-20-0354. Epub 2020 Jul 30.

BACKGROUND: Epithelial ovarian, fallopian tube, and primary peritoneal cancers have shared developmental pathways. Few studies have prospectively examined heterogeneity in risk factor associations across these three anatomic sites.METHODS: We identified 3,738 ovarian, 337 peritoneal, and 176 fallopian tube incident...

Selecting a Scale for Spatial Confounding Adjustment.

Journal of the Royal Statistical Society. Series A, (Statistics in Society)

Keller JP, Szpiro AA.
PMID: 33132544
J R Stat Soc Ser A Stat Soc. 2020 Jun;183(3):1121-1143. doi: 10.1111/rssa.12556. Epub 2020 Mar 11.

Unmeasured, spatially-structured factors can confound associations between spatial environmental exposures and health outcomes. Adding flexible splines to a regression model is a simple approach for spatial confounding adjustment, but the spline degrees of freedom do not provide an easily...

The establishment of the Household Air Pollution Consortium (HAPCO).

Atmosphere

Hosgood HD, Klugman M, Matsuo K, White AJ, Sadakane A, Shu XO, Lopez-Ridaura R, Shin A, Tsuji I, Malekzadeh R, Noisel N, Bhatti P, Yang G, Saito E, Rahman S, Hu W, Bassig B, Downward G, Vermeulen R, Xue X, Rohan T, Abe SK, Broët P, Grant EJ, Dummer TJB, Rothman N, Inoue M, Lajous M, Yoo KY, Ito H, Sandler DP, Ashan H, Zheng W, Boffetta P, Lan Q.
PMID: 32064123
Atmosphere (Basel). 2019 Jul;10(7). doi: 10.3390/atmos10070422. Epub 2019 Jul 23.

Household air pollution (HAP) is of public health concern with ~3 billion people worldwide (including >15 million in the US) exposed. HAP from coal use is a human lung carcinogen, yet the epidemiological evidence on carcinogenicity of HAP from...

Reliability of DNA methylation measures using Illumina methylation BeadChip.

Epigenetics

Xu Z, Taylor JA.
PMID: 32749174
Epigenetics. 2021 May;16(5):495-502. doi: 10.1080/15592294.2020.1805692. Epub 2020 Aug 15.

Illumina BeadChips are widely utilized in epigenome-wide association studies (EWAS). Several studies have reported that many probes on these arrays have poor reliability. Here, we compare different pre-processing methods to improve intra-class correlation coefficients (ICC). We describe the characteristics...

ipDMR: identification of differentially methylated regions with interval P-values.

Bioinformatics (Oxford, England)

Xu Z, Xie C, Taylor JA, Niu L.
PMID: 32805005
Bioinformatics. 2021 May 05;37(5):711-713. doi: 10.1093/bioinformatics/btaa732.

SUMMARY: ipDMR is an R software tool for identification of differentially methylated regions (DMRs) using auto-correlated P-values for individual CpGs from epigenome-wide association analysis using array or bisulfite sequencing data. It summarizes P-values for adjacent CpGs, identifies association peaks...

Showing 1 to 12 of 30 entries