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Evolutionary forces in diabetes and hypertension pathogenesis in Africans.

Human molecular genetics

Meeks KAC, Bentley AR, Adeyemo AA, Rotimi CN.
PMID: 33734377
Hum Mol Genet. 2021 Apr 26;30:R110-R118. doi: 10.1093/hmg/ddaa238.

Rates of type 2 diabetes (T2D) and hypertension are increasing rapidly in urbanizing sub-Saharan Africa (SSA). While lifestyle factors drive the increases in T2D and hypertension prevalence, evidence across populations shows that genetic variation, which is driven by evolutionary...

Cite
Meeks KAC, Bentley AR, Adeyemo AA, et al. Evolutionary forces in diabetes and hypertension pathogenesis in Africans. Hum Mol Genet. 2021;30:R110-R118doi: 10.1093/hmg/ddaa238.
Meeks, K. A. C., Bentley, A. R., Adeyemo, A. A., & Rotimi, C. N. (2021). Evolutionary forces in diabetes and hypertension pathogenesis in Africans. Human molecular genetics, 30R110-R118. https://doi.org/10.1093/hmg/ddaa238
Meeks, Karlijn A C, et al. "Evolutionary forces in diabetes and hypertension pathogenesis in Africans." Human molecular genetics vol. 30 (2021): R110-R118. doi: https://doi.org/10.1093/hmg/ddaa238
Meeks KAC, Bentley AR, Adeyemo AA, Rotimi CN. Evolutionary forces in diabetes and hypertension pathogenesis in Africans. Hum Mol Genet. 2021 Apr 26;30:R110-R118. doi: 10.1093/hmg/ddaa238. PMID: 33734377; PMCID: PMC8117438.
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Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits.

Scientific reports

Gouveia MH, Bentley AR, Leonard H, Meeks KAC, Ekoru K, Chen G, Nalls MA, Simonsick EM, Tarazona-Santos E, Lima-Costa MF, Adeyemo A, Shriner D, Rotimi CN.
PMID: 33603002
Sci Rep. 2021 Feb 18;11(1):4075. doi: 10.1038/s41598-021-83450-3.

Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with cross-sectional blood pressure (BP) traits; however, GWAS based on longitudinal BP have been underexplored. We performed ethnic-specific and trans-ethnic GWAS meta-analysis using longitudinal and cross-sectional BP data...

Cite
Gouveia MH, Bentley AR, Leonard H, et al. Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits. Sci Rep. 2021;11(1):4075doi: 10.1038/s41598-021-83450-3.
Gouveia, M. H., Bentley, A. R., Leonard, H., Meeks, K. A. C., Ekoru, K., Chen, G., Nalls, M. A., Simonsick, E. M., Tarazona-Santos, E., Lima-Costa, M. F., Adeyemo, A., Shriner, D., & Rotimi, C. N. (2021). Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits. Scientific reports, 11(1), 4075. https://doi.org/10.1038/s41598-021-83450-3
Gouveia, Mateus H, et al. "Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits." Scientific reports vol. 11,1 (2021): 4075. doi: https://doi.org/10.1038/s41598-021-83450-3
Gouveia MH, Bentley AR, Leonard H, Meeks KAC, Ekoru K, Chen G, Nalls MA, Simonsick EM, Tarazona-Santos E, Lima-Costa MF, Adeyemo A, Shriner D, Rotimi CN. Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits. Sci Rep. 2021 Feb 18;11(1):4075. doi: 10.1038/s41598-021-83450-3. PMID: 33603002; PMCID: PMC7893038.
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Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits.

Genome medicine

Meeks KAC, Bentley AR, Gouveia MH, Chen G, Zhou J, Lei L, Adeyemo AA, Doumatey AP, Rotimi CN.
PMID: 34620218
Genome Med. 2021 Oct 07;13(1):156. doi: 10.1186/s13073-021-00971-2.

BACKGROUND: A complex set of perturbations occur in cytokines and hormones in the etiopathogenesis of obesity and related cardiometabolic conditions such as type 2 diabetes (T2D). Evidence for the genetic regulation of these cytokines and hormones is limited, particularly...

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Meeks KAC, Bentley AR, Gouveia MH, et al. Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits. Genome Med. 2021;13(1):156doi: 10.1186/s13073-021-00971-2.
Meeks, K. A. C., Bentley, A. R., Gouveia, M. H., Chen, G., Zhou, J., Lei, L., Adeyemo, A. A., Doumatey, A. P., & Rotimi, C. N. (2021). Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits. Genome medicine, 13(1), 156. https://doi.org/10.1186/s13073-021-00971-2
Meeks, Karlijn A C, et al. "Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits." Genome medicine vol. 13,1 (2021): 156. doi: https://doi.org/10.1186/s13073-021-00971-2
Meeks KAC, Bentley AR, Gouveia MH, Chen G, Zhou J, Lei L, Adeyemo AA, Doumatey AP, Rotimi CN. Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits. Genome Med. 2021 Oct 07;13(1):156. doi: 10.1186/s13073-021-00971-2. PMID: 34620218; PMCID: PMC8499470.
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Evolutionary forces in diabetes and hypertension pathogenesis in Africans.

Human molecular genetics

Meeks KAC, Bentley AR, Adeyemo AA, Rotimi CN.
PMID: 33734377
Hum Mol Genet. 2021 Apr 26;30:R110-R118. doi: 10.1093/hmg/ddaa238.

Rates of type 2 diabetes (T2D) and hypertension are increasing rapidly in urbanizing sub-Saharan Africa (SSA). While lifestyle factors drive the increases in T2D and hypertension prevalence, evidence across populations shows that genetic variation, which is driven by evolutionary...

Cite
Meeks KAC, Bentley AR, Adeyemo AA, et al. Evolutionary forces in diabetes and hypertension pathogenesis in Africans. Hum Mol Genet. 2021;30:R110-R118doi: 10.1093/hmg/ddaa238.
Meeks, K. A. C., Bentley, A. R., Adeyemo, A. A., & Rotimi, C. N. (2021). Evolutionary forces in diabetes and hypertension pathogenesis in Africans. Human molecular genetics, 30R110-R118. https://doi.org/10.1093/hmg/ddaa238
Meeks, Karlijn A C, et al. "Evolutionary forces in diabetes and hypertension pathogenesis in Africans." Human molecular genetics vol. 30 (2021): R110-R118. doi: https://doi.org/10.1093/hmg/ddaa238
Meeks KAC, Bentley AR, Adeyemo AA, Rotimi CN. Evolutionary forces in diabetes and hypertension pathogenesis in Africans. Hum Mol Genet. 2021 Apr 26;30:R110-R118. doi: 10.1093/hmg/ddaa238. PMID: 33734377; PMCID: PMC8117438.
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GWAS in Africans identifies novel lipids loci and demonstrates heterogenous association within Africa.

Human molecular genetics

Bentley AR, Chen G, Doumatey AP, Shriner D, Meeks KAC, Gouveia MH, Ekoru K, Zhou J, Adeyemo A, Rotimi CN.
PMID: 34196372
Hum Mol Genet. 2021 Nov 01;30(22):2205-2214. doi: 10.1093/hmg/ddab174.

Serum lipids are biomarkers of cardiometabolic disease risk, and understanding genomic factors contributing to their distribution is of interest. Studies of lipids in Africans are rare, though it is expected that such studies could identify novel loci. We conducted...

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Bentley AR, Chen G, Doumatey AP, et al. GWAS in Africans identifies novel lipids loci and demonstrates heterogenous association within Africa. Hum Mol Genet. 2021;30(22):2205-2214doi: 10.1093/hmg/ddab174.
Bentley, A. R., Chen, G., Doumatey, A. P., Shriner, D., Meeks, K. A. C., Gouveia, M. H., Ekoru, K., Zhou, J., Adeyemo, A., & Rotimi, C. N. (2021). GWAS in Africans identifies novel lipids loci and demonstrates heterogenous association within Africa. Human molecular genetics, 30(22), 2205-2214. https://doi.org/10.1093/hmg/ddab174
Bentley, Amy R, et al. "GWAS in Africans identifies novel lipids loci and demonstrates heterogenous association within Africa." Human molecular genetics vol. 30,22 (2021): 2205-2214. doi: https://doi.org/10.1093/hmg/ddab174
Bentley AR, Chen G, Doumatey AP, Shriner D, Meeks KAC, Gouveia MH, Ekoru K, Zhou J, Adeyemo A, Rotimi CN. GWAS in Africans identifies novel lipids loci and demonstrates heterogenous association within Africa. Hum Mol Genet. 2021 Nov 01;30(22):2205-2214. doi: 10.1093/hmg/ddab174. PMID: 34196372; PMCID: PMC8561421.
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Showing 1 to 5 of 5 entries