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Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D.

Journal of medicinal chemistry

Shaik AB, Boateng CA, Battiti FO, Bonifazi A, Cao J, Chen L, Chitsazi R, Ravi S, Lee KH, Shi L, Newman AH.
PMID: 34636551
J Med Chem. 2021 Oct 28;64(20):15313-15333. doi: 10.1021/acs.jmedchem.1c01353. Epub 2021 Oct 12.

The crystal structure of the dopamine D

Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D.

ACS medicinal chemistry letters

Battiti FO, Newman AH, Bonifazi A.
PMID: 33062179
ACS Med Chem Lett. 2020 Feb 28;11(10):1956-1964. doi: 10.1021/acsmedchemlett.9b00660. eCollection 2020 Oct 08.

In this study, starting from our selective D

Chiral Cyclic Aliphatic Linkers as Building Blocks for Selective Dopamine D.

Journal of medicinal chemistry

Battiti FO, Zaidi SA, Katritch V, Newman AH, Bonifazi A.
PMID: 34699207
J Med Chem. 2021 Nov 11;64(21):16088-16105. doi: 10.1021/acs.jmedchem.1c01433. Epub 2021 Oct 26.

Linkers are emerging as a key component in regulating the pharmacology of bitopic ligands directed toward G-protein coupled receptors (GPCRs). In this study, the role of regio- and stereochemistry in cyclic aliphatic linkers tethering well-characterized primary and secondary pharmacophores...

Showing 1 to 3 of 3 entries