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Showing 1 to 12 of 16 entries
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Evaluation of the diagnostic value of alpha-l-fucosidase, alpha-fetoprotein and thymidine kinase 1 with ROC and logistic regression for hepatocellular carcinoma.

FEBS open bio

Zhang SY, Lin BD, Li BR.
PMID: 25870783
FEBS Open Bio. 2015 Mar 26;5:240-4. doi: 10.1016/j.fob.2015.03.010. eCollection 2015.

The purpose of this study was to evaluate the diagnostic efficiency for hepatocellular carcinoma (HCC) with the combined analysis of alpha-l-fucosidase (AFU), alpha-fetoprotein (AFP) and thymidine kinase 1 (TK1). Serum levels of AFU, AFP and TK1 were measured in:...

The Value of Preoperative Alpha-L-Fucosidase Levels in Evaluation of Malignancy and Differential Diagnosis of Urothelial Neoplasms.

Journal of oncology

Chen D, Xing N, Cui Z, Zhang C, Zhang Z, Li D, Yan L.
PMID: 32774371
J Oncol. 2020 Jul 25;2020:6723616. doi: 10.1155/2020/6723616. eCollection 2020.

PURPOSE: To evaluate the role of Alpha-L-fucosidase (AFU) in diagnosis and differential diagnosis of pure urothelial carcinoma (UC), urothelial carcinoma with squamous differentiation (UCSD), and squamous cell carcinoma (SqCC).METHODS: A retrospective study was performed for 599 patients who were...

A predictive model for the diagnosis of non-alcoholic fatty liver disease based on an integrated machine learning method.

American journal of translational research

Ma X, Yang C, Liang K, Sun B, Jin W, Chen L, Dong M, Liu S, Xin Y, Zhuang L.
PMID: 34956485
Am J Transl Res. 2021 Nov 15;13(11):12704-12713. eCollection 2021.

Diagnostic markers for non-alcoholic fatty liver disease (NAFLD) are still needed for screening individuals at risk. In recent years, the machine learning method was used to search for the diagnostic markers of multiple diseases. In this study, we developed...

Hydrolysis of fucoidan by abalone liver alpha-L-fucosidase.

FEBS letters

Tanaka K, Sorai S.
PMID: 11947625
FEBS Lett. 1970 Jul 15;9(1):45-48. doi: 10.1016/0014-5793(70)80307-6.

No abstract available.

Diagnosis and Supportive Management of Fucosidosis: A Case Report.

Cureus

Kaur A, Dhaliwal AS, Raynes H, Naidich TP, Kaufman DM.
PMID: 31886074
Cureus. 2019 Nov 12;11(11):e6139. doi: 10.7759/cureus.6139.

Fucosidosis is a lysosomal storage disease, resulting from a deficiency of the enzyme alpha-L-fucosidase. We present the case of an affected female with numerous manifestations, clinically and radiographically. In fucosidosis, advanced interventions are not always necessary to have rewarding...

Effect of immobilization on stability and kinetic properties of alpha-L-fucosidase from Turbo cornutus.

Biotechnology and bioengineering

Cohenford MA, Urbanowski JC, Dain JA.
PMID: 18551437
Biotechnol Bioeng. 1983 Jun;25(6):1501-8. doi: 10.1002/bit.260250607.

An amount of alpha-L-fucosidase from T. cornutus liver was copolymerized with glutaraldehyde using bovine serum albumin as the carrier protein. The properties of the native, the soluble enzyme polymer complex, and the insoluble enzyme polymer complex were studied and...

Metataxonomic profiling and prediction of functional behaviour of wheat straw degrading microbial consortia.

Biotechnology for biofuels

Jiménez DJ, Dini-Andreote F, van Elsas JD.
PMID: 24955113
Biotechnol Biofuels. 2014 Jun 12;7:92. doi: 10.1186/1754-6834-7-92. eCollection 2014.

BACKGROUND: Mixed microbial cultures, in which bacteria and fungi interact, have been proposed as an efficient way to deconstruct plant waste. The characterization of specific microbial consortia could be the starting point for novel biotechnological applications related to the...

Fucosidosis in Tunisian patients: mutational analysis and homology-based modeling of FUCA1 enzyme.

BMC medical genomics

Chkioua L, Amri Y, Chaima S, Fenni F, Boudabous H, Ben Turkia H, Messaoud T, Tebib N, Laradi S.
PMID: 34425818
BMC Med Genomics. 2021 Aug 23;14(1):208. doi: 10.1186/s12920-021-01061-3.

BACKGROUND: Fucosidosis is an autosomal recessive lysosomal storage disease caused by defective alpha-L-fucosidase (FUCA1) activity, leading to the accumulation of fucose-containing glycolipids and glycoproteins in various tissues. Clinical features include angiokeratoma, progressive psychomotor retardation, neurologic signs, coarse facial features,...

A predictive model for the diagnosis of non-alcoholic fatty liver disease based on an integrated machine learning method.

American journal of translational research

Ma X, Yang C, Liang K, Sun B, Jin W, Chen L, Dong M, Liu S, Xin Y, Zhuang L.
PMID: 34956485
Am J Transl Res. 2021 Nov 15;13(11):12704-12713. eCollection 2021.

Diagnostic markers for non-alcoholic fatty liver disease (NAFLD) are still needed for screening individuals at risk. In recent years, the machine learning method was used to search for the diagnostic markers of multiple diseases. In this study, we developed...

Low levels of alpha-L-fucosidase activity in colorectal cancer are due to decreased amounts of the enzymatic protein and are related with Dukes' stage.

International journal of oncology

Delacadena M, Fernandez J, Decarlos A, Martinezzorzano V, Gilmartin E, Rodriguezberrocal F.
PMID: 21541579
Int J Oncol. 1996 Oct;9(4):747-54. doi: 10.3892/ijo.9.4.747.

Colorectal cancer remains a major medical problem and survival of the patients is directly correlated to the possibility of metastases occurrence. We searched for biochemical differences between colorectal adenocarcinomas and their precursor normal cells with the aim of complementing...

Alpha-l-fucosidase: a novel serum biomarker to predict prognosis in early stage esophageal squamous cell carcinoma.

Journal of thoracic disease

Yu X, Zhang R, Yang T, Zhang M, Xi K, Lin Y, Wen Y, Wang G, Huang Z, Zhang X, Zhang L.
PMID: 31656672
J Thorac Dis. 2019 Sep;11(9):3980-3990. doi: 10.21037/jtd.2019.08.92.

BACKGROUND: Alpha-l-fucosidase (AFU) not only detects hepatocellular carcinoma (HCC) early but also is used as a clinical prognostic indicator of several malignant tumors. However, no study has investigated the prognostic significance of AFU in a cohort of patients with...

Glycoconjugate stability in human milk: glycosidase activities and sugar release.

The Journal of nutritional biochemistry

Wiederschain GY, Newburg DS.
PMID: 12031261
J Nutr Biochem. 2001 Oct;12(10):559-564. doi: 10.1016/s0955-2863(01)00174-7.

Many human milk glycoconjugates (glycolipids, glycoproteins, mucins, glycosaminoglycans) and oligosaccharides are biologically active, and their activity depends on the precise structure of the glycan. The sugars on the terminus of the glycan are vulnerable to cleavage by glycosidases. Because...

Showing 1 to 12 of 16 entries