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The Secretory Granule Protein 7B2 is Secreted in Parallel with Proopiomelanocortin and its End-Products by the Mouse Corticotroph Tumour Cells AtT-20.

Journal of neuroendocrinology

Vieau D, Tougard C, Rosenbaum E, Lenne F, Bertagna X.
PMID: 19215457
J Neuroendocrinol. 1991 Jun 01;3(3):229-31. doi: 10.1111/j.1365-2826.1991.tb00268.x.

First isolated in porcine pituitary glands the protein 7B2 subsequently proved to be a specific biochemical marker of the secretory granules. Likewise 7B2 was detected in almost all normal and tumoral endocrine tissues. Unexpectedly, several authors failed to demonstrate...

Effects of pentobarbital on proopiomelanocortin opioid products of neonatal piglets during normoxia and hypoxia.

Journal of neuroendocrinology

Moss IR, Inman JD.
PMID: 19215492
J Neuroendocrinol. 1991 Aug 01;3(4):455-60. doi: 10.1111/j.1365-2826.1991.tb00303.x.

Abstract Endogenous opioids have been shown to suppress physiological functions in the neonate. It has been suggested that anesthesia with barbiturates might enhance this suppression by influencing opioid systems directly. To explore this possibility, naive piglets, 2.2+/-0.8 (X+/-SD) days...

Conversion of lipotropic peptides by purified cathepsin D of human pituitary: release of gamma-endorphin by cleavage of the Leu(77)-PHE(78) bond.

Neuroscience letters

Benuck M, Grynbaum A, Cooper TB, Marks N.
PMID: 19605248
Neurosci Lett. 1978 Nov;10(1):3-9. doi: 10.1016/0304-3940(78)90003-4.

Cathepsin D (EC 3.4.3.23) purified from human putuitary by affinity chromatography on pepstatin-Sepharose cleaved human beta-endorphin (LPH 61-91) at the Leu(77)-Phe(78) bond after incubation at pH 3.2 for 1-3. Incubation with smaller lipotropic fragments (enkephalin, alpha-endorphin, gamma-endorphin) did not...

Isolation and structure of pro-methionine-enkephalin: Potential enkephalin precursor from porcine hypothalamus.

Proceedings of the National Academy of Sciences of the United States of America

Huang WY, Chang RC, Kastin AJ, Coy DH, Schally AV.
PMID: 16592735
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6177-80. doi: 10.1073/pnas.76.12.6177.

A hexapeptide that we have named pro-methionine-enkephalin has been isolated from acid extracts of porcine hypothalami and found to have the amino acid sequence H-Tyr-Gly-Gly-Phe-Met(O)-Arg-OH. This peptide is not a fragment of either porcine beta-lipotropin or beta-endorphin, which suggests...

Silent corticotroph adenoma: case report and literature review.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Braithwaite SS, Clasen RA, D'Angelo CM.
PMID: 15251785
Endocr Pract. 1997 Sep-Oct;3(5):297-301. doi: 10.4158/EP.3.5.297.

OBJECTIVE: To review the initial clinical manifestations and diagnosis of silent corticotroph adenoma.METHODS: We report a case and summarize the relevant literature.RESULTS: A 52-year-old patient with hypopituitarism underwent resection of a silent corticotroph adenoma. A circulating species was detected...

Showing 1 to 5 of 5 entries