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Hydrogel containing adapalene- and dapsone-loaded lipid-core nanocapsules for cutaneous application: development, characterization, in vitro irritation and permeation studies.

Drug development and industrial pharmacy

Pereira RL, Leites FI, Paese K, Sponchiado RM, Michalowski CB, Guterres SS, Schapoval EE.
PMID: 27161601
Drug Dev Ind Pharm. 2016 Dec;42(12):2001-2008. doi: 10.1080/03639045.2016.1188110. Epub 2016 May 31.

Lipid-core polymeric nanocapsule suspensions containing adapalene and dapsone (AD-LCNC) were developed and incorporated in a Carbopol 940® hydrogel (AD-LCNC HG). A nanoemulsion (AD-NE), similarly prepared but omitting the polymer, was developed and also incorporated in a Carbopol 940

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Pereira RL, Leites FI, Paese K, et al. Hydrogel containing adapalene- and dapsone-loaded lipid-core nanocapsules for cutaneous application: development, characterization, in vitro irritation and permeation studies. Drug Dev Ind Pharm. 2016;42(12):2001-2008doi: 10.1080/03639045.2016.1188110.
Pereira, R. L., Leites, F. I., Paese, K., Sponchiado, R. M., Michalowski, C. B., Guterres, S. S., & Schapoval, E. E. (2016). Hydrogel containing adapalene- and dapsone-loaded lipid-core nanocapsules for cutaneous application: development, characterization, in vitro irritation and permeation studies. Drug development and industrial pharmacy, 42(12), 2001-2008. https://doi.org/10.1080/03639045.2016.1188110
Pereira, Rubia L, et al. "Hydrogel containing adapalene- and dapsone-loaded lipid-core nanocapsules for cutaneous application: development, characterization, in vitro irritation and permeation studies." Drug development and industrial pharmacy vol. 42,12 (2016): 2001-2008. doi: https://doi.org/10.1080/03639045.2016.1188110
Pereira RL, Leites FI, Paese K, Sponchiado RM, Michalowski CB, Guterres SS, Schapoval EE. Hydrogel containing adapalene- and dapsone-loaded lipid-core nanocapsules for cutaneous application: development, characterization, in vitro irritation and permeation studies. Drug Dev Ind Pharm. 2016 Dec;42(12):2001-2008. doi: 10.1080/03639045.2016.1188110. Epub 2016 May 31. PMID: 27161601.
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Transfersomes: a novel vesicular carrier for enhanced transdermal delivery of sertraline: development, characterization, and performance evaluation.

Scientia pharmaceutica

Gupta A, Aggarwal G, Singla S, Arora R.
PMID: 23264950
Sci Pharm. 2012 Oct-Dec;80(4):1061-80. doi: 10.3797/scipharm.1208-02. Epub 2012 Aug 31.

The aim of the present study was to investigate transfersomes as a transdermal delivery system for the poorly soluble drug, sertraline, in order to overcome the troubles associated with its oral delivery. Different transfersomal formulations were prepared with non-ionic...

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Gupta A, Aggarwal G, Singla S, et al. Transfersomes: a novel vesicular carrier for enhanced transdermal delivery of sertraline: development, characterization, and performance evaluation. Sci Pharm. 2012;80(4):1061-80doi: 10.3797/scipharm.1208-02.
Gupta, A., Aggarwal, G., Singla, S., & Arora, R. (2012). Transfersomes: a novel vesicular carrier for enhanced transdermal delivery of sertraline: development, characterization, and performance evaluation. Scientia pharmaceutica, 80(4), 1061-80. https://doi.org/10.3797/scipharm.1208-02
Gupta, Ankit, et al. "Transfersomes: a novel vesicular carrier for enhanced transdermal delivery of sertraline: development, characterization, and performance evaluation." Scientia pharmaceutica vol. 80,4 (2012): 1061-80. doi: https://doi.org/10.3797/scipharm.1208-02
Gupta A, Aggarwal G, Singla S, Arora R. Transfersomes: a novel vesicular carrier for enhanced transdermal delivery of sertraline: development, characterization, and performance evaluation. Sci Pharm. 2012 Oct-Dec;80(4):1061-80. doi: 10.3797/scipharm.1208-02. Epub 2012 Aug 31. PMID: 23264950; PMCID: PMC3528046.
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Novel nanoemulsion gel containing triple natural bio-actives combination of curcumin, thymoquinone, and resveratrol improves psoriasis therapy: in vitro and in vivo studies.

Drug delivery and translational research

Khatoon K, Ali A, Ahmad FJ, Hafeez Z, Rizvi MMA, Akhter S, Beg S.
PMID: 32965640
Drug Deliv Transl Res. 2021 Jun;11(3):1245-1260. doi: 10.1007/s13346-020-00852-y. Epub 2020 Sep 23.

Curcumin, resveratrol, and thymoquinone are the potential natural bio-actives reported with good anti-psoriatic activity. However, poor aqueous solubility and limited skin permeation of these natural bio-actives hinder their effective delivery and potential therapeutic outcome. In this regard, current research...

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Khatoon K, Ali A, Ahmad FJ, et al. Novel nanoemulsion gel containing triple natural bio-actives combination of curcumin, thymoquinone, and resveratrol improves psoriasis therapy: in vitro and in vivo studies. Drug Deliv Transl Res. 2020;11(3):1245-1260doi: 10.1007/s13346-020-00852-y.
Khatoon, K., Ali, A., Ahmad, F. J., Hafeez, Z., Rizvi, M. M. A., Akhter, S., & Beg, S. (2021). Novel nanoemulsion gel containing triple natural bio-actives combination of curcumin, thymoquinone, and resveratrol improves psoriasis therapy: in vitro and in vivo studies. Drug delivery and translational research, 11(3), 1245-1260. https://doi.org/10.1007/s13346-020-00852-y
Khatoon, Karishma, et al. "Novel nanoemulsion gel containing triple natural bio-actives combination of curcumin, thymoquinone, and resveratrol improves psoriasis therapy: in vitro and in vivo studies." Drug delivery and translational research vol. 11,3 (2021): 1245-1260. doi: https://doi.org/10.1007/s13346-020-00852-y
Khatoon K, Ali A, Ahmad FJ, Hafeez Z, Rizvi MMA, Akhter S, Beg S. Novel nanoemulsion gel containing triple natural bio-actives combination of curcumin, thymoquinone, and resveratrol improves psoriasis therapy: in vitro and in vivo studies. Drug Deliv Transl Res. 2021 Jun;11(3):1245-1260. doi: 10.1007/s13346-020-00852-y. Epub 2020 Sep 23. PMID: 32965640.
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Stability, permeation, and cytotoxicity reduction of capsicum extract nanoparticles loaded hydrogel containing wax gourd extract.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Chittasupho C, Thongnopkoon T, Burapapisut S, Charoensukkho C, Shuwisitkul D, Samee W.
PMID: 33424247
Saudi Pharm J. 2020 Dec;28(12):1538-1547. doi: 10.1016/j.jsps.2020.10.001. Epub 2020 Oct 15.

The aim of this study was to develop hydrogel loaded with capsicum extract nanoparticles and wax gourd extract for transdermal delivery of capsaicin. The addition of wax gourd extract was supposed to reduce cytotoxicity of capsaicin in capsicum extract...

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Chittasupho C, Thongnopkoon T, Burapapisut S, et al. Stability, permeation, and cytotoxicity reduction of capsicum extract nanoparticles loaded hydrogel containing wax gourd extract. Saudi Pharm J. 2020;28(12):1538-1547doi: 10.1016/j.jsps.2020.10.001.
Chittasupho, C., Thongnopkoon, T., Burapapisut, S., Charoensukkho, C., Shuwisitkul, D., & Samee, W. (2020). Stability, permeation, and cytotoxicity reduction of capsicum extract nanoparticles loaded hydrogel containing wax gourd extract. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 28(12), 1538-1547. https://doi.org/10.1016/j.jsps.2020.10.001
Chittasupho, Chuda, et al. "Stability, permeation, and cytotoxicity reduction of capsicum extract nanoparticles loaded hydrogel containing wax gourd extract." Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society vol. 28,12 (2020): 1538-1547. doi: https://doi.org/10.1016/j.jsps.2020.10.001
Chittasupho C, Thongnopkoon T, Burapapisut S, Charoensukkho C, Shuwisitkul D, Samee W. Stability, permeation, and cytotoxicity reduction of capsicum extract nanoparticles loaded hydrogel containing wax gourd extract. Saudi Pharm J. 2020 Dec;28(12):1538-1547. doi: 10.1016/j.jsps.2020.10.001. Epub 2020 Oct 15. PMID: 33424247; PMCID: PMC7783228.
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Carbopol emulgel loaded with ebastine for urticaria: development, characterization, .

Drug delivery

Khan BA, Ali A, Hosny KM, Halwani AA, Almehmady AM, Iqbal M, Alharbi WS, Abualsunun WA, Bakhaidar RB, Murshid SSA, Khan MK.
PMID: 34962186
Drug Deliv. 2022 Dec;29(1):52-61. doi: 10.1080/10717544.2021.2015483.

Urticaria affects all age groups of a population. It is triggered by allergens in foods, insect bites, medications, and environmental conditions. Urticaria is characterized by itching, a burning sensation, wheals and flares, erythema, and localized edema. The aim of...

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Khan BA, Ali A, Hosny KM, et al. Carbopol emulgel loaded with ebastine for urticaria: development, characterization, . Drug Deliv. 2022;29(1):52-61doi: 10.1080/10717544.2021.2015483.
Khan, B. A., Ali, A., Hosny, K. M., Halwani, A. A., Almehmady, A. M., Iqbal, M., Alharbi, W. S., Abualsunun, W. A., Bakhaidar, R. B., Murshid, S. S. A., & Khan, M. K. (2022). Carbopol emulgel loaded with ebastine for urticaria: development, characterization, . Drug delivery, 29(1), 52-61. https://doi.org/10.1080/10717544.2021.2015483
Khan, Barkat Ali, et al. "Carbopol emulgel loaded with ebastine for urticaria: development, characterization, ." Drug delivery vol. 29,1 (2022): 52-61. doi: https://doi.org/10.1080/10717544.2021.2015483
Khan BA, Ali A, Hosny KM, Halwani AA, Almehmady AM, Iqbal M, Alharbi WS, Abualsunun WA, Bakhaidar RB, Murshid SSA, Khan MK. Carbopol emulgel loaded with ebastine for urticaria: development, characterization, . Drug Deliv. 2022 Dec;29(1):52-61. doi: 10.1080/10717544.2021.2015483. PMID: 34962186.
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Design, formulation, and physicochemical evaluation of periodontal propolis mucoadhesive gel.

Dental research journal

Aslani A, Malekpour N.
PMID: 28182054
Dent Res J (Isfahan). 2016 Nov-Dec;13(6):484-493. doi: 10.4103/1735-3327.197037.

BACKGROUND: Periodontitis is a disease of tooth supporting tissues, and Gram-negative Bacteria are the main cause of this. Propolis has antibacterial, anti-inflammatory, and antioxidant effects due to its high polyphenol and flavonoids content. The aim of this study is...

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Aslani A, Malekpour N. Design, formulation, and physicochemical evaluation of periodontal propolis mucoadhesive gel. Dent Res J (Isfahan). 2016;13(6):484-493doi: 10.4103/1735-3327.197037.
Aslani, A., & Malekpour, N. (2016). Design, formulation, and physicochemical evaluation of periodontal propolis mucoadhesive gel. Dental research journal, 13(6), 484-493. https://doi.org/10.4103/1735-3327.197037
Aslani, Abolfazl, and Malekpour, Negar. "Design, formulation, and physicochemical evaluation of periodontal propolis mucoadhesive gel." Dental research journal vol. 13,6 (2016): 484-493. doi: https://doi.org/10.4103/1735-3327.197037
Aslani A, Malekpour N. Design, formulation, and physicochemical evaluation of periodontal propolis mucoadhesive gel. Dent Res J (Isfahan). 2016 Nov-Dec;13(6):484-493. doi: 10.4103/1735-3327.197037. PMID: 28182054; PMCID: PMC5256011.
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Improvement of solubility and dissolution properties of clotrimazole by solid dispersions and inclusion complexes.

Indian journal of pharmaceutical sciences

Balata G, Mahdi M, Bakera RA.
PMID: 22923864
Indian J Pharm Sci. 2011 Sep;73(5):517-26. doi: 10.4103/0250-474X.98995.

Solid dispersions of a slightly water-soluble drug, clotrimazole, were prepared in different weight ratios using polyethyleneglycol 4000 and different molecular weight polyvinyl pyrrolidones as carriers. Moreover, binary and ternary β-cyclodextrin complexes were prepared in different molar ratios. Both solid...

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Balata G, Mahdi M, Bakera RA. Improvement of solubility and dissolution properties of clotrimazole by solid dispersions and inclusion complexes. Indian J Pharm Sci. 2011;73(5):517-26doi: 10.4103/0250-474X.98995.
Balata, G., Mahdi, M., & Bakera, R. A. (2011). Improvement of solubility and dissolution properties of clotrimazole by solid dispersions and inclusion complexes. Indian journal of pharmaceutical sciences, 73(5), 517-26. https://doi.org/10.4103/0250-474X.98995
Balata, Gehan, et al. "Improvement of solubility and dissolution properties of clotrimazole by solid dispersions and inclusion complexes." Indian journal of pharmaceutical sciences vol. 73,5 (2011): 517-26. doi: https://doi.org/10.4103/0250-474X.98995
Balata G, Mahdi M, Bakera RA. Improvement of solubility and dissolution properties of clotrimazole by solid dispersions and inclusion complexes. Indian J Pharm Sci. 2011 Sep;73(5):517-26. doi: 10.4103/0250-474X.98995. PMID: 22923864; PMCID: PMC3425063.
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The Potency of Wound Healing of Nanogel Containing Mikania Micrantha Leaves Extract in Hyperglycemic Rats.

Pharmaceutical nanotechnology

Sumantri IB, Ismayadi, Mustanti LF.
PMID: 34886791
Pharm Nanotechnol. 2021 Dec 09; doi: 10.2174/2211738509666211209164105. Epub 2021 Dec 09.

INTRODUCTION: Mikania micrantha has been used traditionally for wound dressings and promoted the healing of sores. This is due to the content of alkaloids and terpenoids/steroids compounds. Hyperglycemic is a good medium for bacterial growth and inhibits the wound...

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Sumantri IB, Ismayadi, Mustanti LF. The Potency of Wound Healing of Nanogel Containing Mikania Micrantha Leaves Extract in Hyperglycemic Rats. Pharm Nanotechnol. 2021;doi: 10.2174/2211738509666211209164105.
Sumantri, I. B., Ismayadi, & Mustanti, L. F. (2021). The Potency of Wound Healing of Nanogel Containing Mikania Micrantha Leaves Extract in Hyperglycemic Rats. Pharmaceutical nanotechnology, . https://doi.org/10.2174/2211738509666211209164105
Sumantri, Imam Bagus, et al. "The Potency of Wound Healing of Nanogel Containing Mikania Micrantha Leaves Extract in Hyperglycemic Rats." Pharmaceutical nanotechnology vol. (2021). doi: https://doi.org/10.2174/2211738509666211209164105
Sumantri IB, Ismayadi, Mustanti LF. The Potency of Wound Healing of Nanogel Containing Mikania Micrantha Leaves Extract in Hyperglycemic Rats. Pharm Nanotechnol. 2021 Dec 09; doi: 10.2174/2211738509666211209164105. Epub 2021 Dec 09. PMID: 34886791.
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The Potency of Wound Healing of Nanogel Containing Mikania Micrantha Leaves Extract in Hyperglycemic Rats.

Pharmaceutical nanotechnology

Sumantri IB, Ismayadi, Mustanti LF.
PMID: 34886791
Pharm Nanotechnol. 2021 Dec 09; doi: 10.2174/2211738509666211209164105. Epub 2021 Dec 09.

INTRODUCTION: Mikania micrantha has been used traditionally for wound dressings and promoted the healing of sores. This is due to the content of alkaloids and terpenoids/steroids compounds. Hyperglycemic is a good medium for bacterial growth and inhibits the wound...

Cite
Sumantri IB, Ismayadi, Mustanti LF. The Potency of Wound Healing of Nanogel Containing Mikania Micrantha Leaves Extract in Hyperglycemic Rats. Pharm Nanotechnol. 2021;doi: 10.2174/2211738509666211209164105.
Sumantri, I. B., Ismayadi, & Mustanti, L. F. (2021). The Potency of Wound Healing of Nanogel Containing Mikania Micrantha Leaves Extract in Hyperglycemic Rats. Pharmaceutical nanotechnology, . https://doi.org/10.2174/2211738509666211209164105
Sumantri, Imam Bagus, et al. "The Potency of Wound Healing of Nanogel Containing Mikania Micrantha Leaves Extract in Hyperglycemic Rats." Pharmaceutical nanotechnology vol. (2021). doi: https://doi.org/10.2174/2211738509666211209164105
Sumantri IB, Ismayadi, Mustanti LF. The Potency of Wound Healing of Nanogel Containing Mikania Micrantha Leaves Extract in Hyperglycemic Rats. Pharm Nanotechnol. 2021 Dec 09; doi: 10.2174/2211738509666211209164105. Epub 2021 Dec 09. PMID: 34886791.
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Nisin loaded carbopol gel against Pseudomonas aeruginosa infected third-degree burns: A therapeutic intervention.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Preet S, Kaur J, Raza K.
PMID: 33721379
Wound Repair Regen. 2021 Sep;29(5):711-724. doi: 10.1111/wrr.12909. Epub 2021 Mar 15.

The emergence of multidrug resistant strains of Pseudomonas aeruginosa necessitates the exploration of novel therapeutic intervention (s). The present study aimed to develop a nisin loaded carbopol gel formulation (NLCG) and explore its therapeutic efficacy against P. aeruginosa infected...

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Preet S, Kaur J, Raza K. Nisin loaded carbopol gel against Pseudomonas aeruginosa infected third-degree burns: A therapeutic intervention. Wound Repair Regen. 2021;29(5):711-724doi: 10.1111/wrr.12909.
Preet, S., Kaur, J., & Raza, K. (2021). Nisin loaded carbopol gel against Pseudomonas aeruginosa infected third-degree burns: A therapeutic intervention. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 29(5), 711-724. https://doi.org/10.1111/wrr.12909
Preet, Simran, et al. "Nisin loaded carbopol gel against Pseudomonas aeruginosa infected third-degree burns: A therapeutic intervention." Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society vol. 29,5 (2021): 711-724. doi: https://doi.org/10.1111/wrr.12909
Preet S, Kaur J, Raza K. Nisin loaded carbopol gel against Pseudomonas aeruginosa infected third-degree burns: A therapeutic intervention. Wound Repair Regen. 2021 Sep;29(5):711-724. doi: 10.1111/wrr.12909. Epub 2021 Mar 15. PMID: 33721379.
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Carbopol emulgel loaded with ebastine for urticaria: development, characterization, .

Drug delivery

Khan BA, Ali A, Hosny KM, Halwani AA, Almehmady AM, Iqbal M, Alharbi WS, Abualsunun WA, Bakhaidar RB, Murshid SSA, Khan MK.
PMID: 34962186
Drug Deliv. 2022 Dec;29(1):52-61. doi: 10.1080/10717544.2021.2015483.

Urticaria affects all age groups of a population. It is triggered by allergens in foods, insect bites, medications, and environmental conditions. Urticaria is characterized by itching, a burning sensation, wheals and flares, erythema, and localized edema. The aim of...

Cite
Khan BA, Ali A, Hosny KM, et al. Carbopol emulgel loaded with ebastine for urticaria: development, characterization, . Drug Deliv. 2022;29(1):52-61doi: 10.1080/10717544.2021.2015483.
Khan, B. A., Ali, A., Hosny, K. M., Halwani, A. A., Almehmady, A. M., Iqbal, M., Alharbi, W. S., Abualsunun, W. A., Bakhaidar, R. B., Murshid, S. S. A., & Khan, M. K. (2022). Carbopol emulgel loaded with ebastine for urticaria: development, characterization, . Drug delivery, 29(1), 52-61. https://doi.org/10.1080/10717544.2021.2015483
Khan, Barkat Ali, et al. "Carbopol emulgel loaded with ebastine for urticaria: development, characterization, ." Drug delivery vol. 29,1 (2022): 52-61. doi: https://doi.org/10.1080/10717544.2021.2015483
Khan BA, Ali A, Hosny KM, Halwani AA, Almehmady AM, Iqbal M, Alharbi WS, Abualsunun WA, Bakhaidar RB, Murshid SSA, Khan MK. Carbopol emulgel loaded with ebastine for urticaria: development, characterization, . Drug Deliv. 2022 Dec;29(1):52-61. doi: 10.1080/10717544.2021.2015483. PMID: 34962186; PMCID: PMC8725930.
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Chitosan-bovine serum albumin-Carbopol 940 nanogels for mupirocin dermal delivery: ex-vivo permeation and evaluation of cellular binding capacity via radiolabeling.

Pharmaceutical development and technology

Ay Şenyiğit Z, Coşkunmeriç N, Çağlar EŞ, Öztürk İ, Atlıhan Gündoğdu E, Siafaka PI, Üstündağ Okur N.
PMID: 34193003
Pharm Dev Technol. 2021 Oct;26(8):852-866. doi: 10.1080/10837450.2021.1948570. Epub 2021 Jul 11.

The goal of this study was to develop and examine the nanogel-based topical delivery system of mupirocin. Nanogels were prepared with chitosan and bovine serum albumin by ionic gelation and Carbopol 940 was added to improve the gelling/adhesive properties....

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Ay Şenyiğit Z, Coşkunmeriç N, Çağlar EŞ, et al. Chitosan-bovine serum albumin-Carbopol 940 nanogels for mupirocin dermal delivery: ex-vivo permeation and evaluation of cellular binding capacity via radiolabeling. Pharm Dev Technol. 2021;26(8):852-866doi: 10.1080/10837450.2021.1948570.
Ay Şenyiğit, Z., Coşkunmeriç, N., Çağlar, E. �. �., Öztürk, �. �., Atlıhan Gündoğdu, E., Siafaka, P. I., & Üstündağ Okur, N. (2021). Chitosan-bovine serum albumin-Carbopol 940 nanogels for mupirocin dermal delivery: ex-vivo permeation and evaluation of cellular binding capacity via radiolabeling. Pharmaceutical development and technology, 26(8), 852-866. https://doi.org/10.1080/10837450.2021.1948570
Ay Şenyiğit, Zeynep, et al. "Chitosan-bovine serum albumin-Carbopol 940 nanogels for mupirocin dermal delivery: ex-vivo permeation and evaluation of cellular binding capacity via radiolabeling." Pharmaceutical development and technology vol. 26,8 (2021): 852-866. doi: https://doi.org/10.1080/10837450.2021.1948570
Ay Şenyiğit Z, Coşkunmeriç N, Çağlar EŞ, Öztürk İ, Atlıhan Gündoğdu E, Siafaka PI, Üstündağ Okur N. Chitosan-bovine serum albumin-Carbopol 940 nanogels for mupirocin dermal delivery: ex-vivo permeation and evaluation of cellular binding capacity via radiolabeling. Pharm Dev Technol. 2021 Oct;26(8):852-866. doi: 10.1080/10837450.2021.1948570. Epub 2021 Jul 11. PMID: 34193003.
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