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Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively.

Journal of molecular signaling

Donnellan PD, Kinsella BT.
PMID: 19781057
J Mol Signal. 2009 Sep 25;4:7. doi: 10.1186/1750-2187-4-7.

BACKGROUND: The human prostacyclin receptor (hIP) undergoes agonist-induced phosphorylation, desensitisation and internalisation and may be recycled to the plasma membrane or targeted for degradation by, as yet, unknown mechanism(s).RESULTS: Herein it was sought to investigate the turnover of the...

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