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Different effects of N-ethylmaleimide on the binding characteristics of 5-hydroxytryptamine receptor subtypes in rat brain membranes.

Neurochemistry international

Imai S, Kitamura Y, Nomura Y.
PMID: 20504708
Neurochem Int. 1991;18(3):331-9. doi: 10.1016/0197-0186(91)90163-8.

To characterize 5-hydroxytryptamine (5-HT) receptor subtypes in the CNS in terms of their binding and coupling properties with GTP-binding proteins (G proteins), we examined the effects of serotonergic agents GTP?S and N-ethylmaleimide (NEM), on the binding of [(3)H]8-OH-DPAT, [(125)I]iodo-cyanopindolol...

Distinct 5-HT(1B) and 5-HT(1D) serotonin receptors in rat: Structural and pharmacological comparison of the two cloned receptors.

Molecular and cellular neurosciences

Hamblin MW, McGuffin RW, Metcalf MA, Dorsa DM, Merchant KM.
PMID: 19912901
Mol Cell Neurosci. 1992 Dec;3(6):578-87. doi: 10.1016/1044-7431(92)90070-i.

We and others have recently cloned the genes encoding the human 5-HT(1D) (5-HT(1Dalpha)) and 5-HT(1B) (5-HT(1Dbeta)) serotonin receptors. Because of the history of profound species differences in the pharmacology of these receptor subtypes, we also cloned the homologous genes...

Showing 1 to 2 of 2 entries