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Showing 1 to 8 of 8 entries
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Physico-chemical aspects of the interaction between DNA and oppositely charged mixed liposomes.

Biophysical chemistry

Mel'nikova YS, Mel'nikov SM, Löfroth JE.
PMID: 17030332
Biophys Chem. 1999 Oct 04;81(2):125-41. doi: 10.1016/s0301-4622(99)00088-5.

The mechanism of complex formation between DNA and oppositely charged dioctadecyldimethylammonium bromide/dioleoyl phosphatidylethanolamine (DODAB/DOPE) and 1,2-dioleoyl-3-trimethylammonium propane (DOTAP)/DOPE mixed liposomes, as well as the physico-chemical properties of DNA-mixed liposome complexes, were examined. Fluorescence microscopy showed that the interaction between...

Synchrotron Characterization of Hexagonal and Cubic Lipidic Phases Loaded with Azolate/Phosphane Gold(I) Compounds: A New Approach to the Uploading of Gold(I)-Based Drugs.

Nanomaterials (Basel, Switzerland)

Astolfi P, Pisani M, Giorgini E, Rossi B, Damin A, Vita F, Francescangeli O, Luciani L, Galassi R.
PMID: 32947840
Nanomaterials (Basel). 2020 Sep 16;10(9). doi: 10.3390/nano10091851.

Gold(I) phosphane compounds have recently attracted a renewed interest as potential new protagonists in cancer therapy. A class of phosphane gold(I) complexes containing azolate ligands has been successfully tested against several cancer cell lines and, in particular, against basal-like...

Liposome-based Formulation for Intracellular Delivery of Functional Proteins.

Molecular therapy. Nucleic acids

Chatin B, Mével M, Devallière J, Dallet L, Haudebourg T, Peuziat P, Colombani T, Berchel M, Lambert O, Edelman A, Pitard B.
PMID: 26102064
Mol Ther Nucleic Acids. 2015 Jun 23;4:e244. doi: 10.1038/mtna.2015.17.

The intracellular delivery of biologically active protein represents an important emerging strategy for both fundamental and therapeutic applications. Here, we optimized in vitro delivery of two functional proteins, the β-galactosidase (β-gal) enzyme and the anti-cytokeratin8 (K8) antibody, using liposome-based...

Improvement of Peptide-Based Tumor Immunotherapy Using pH-Sensitive Fusogenic Polymer-Modified Liposomes.

Molecules (Basel, Switzerland)

Yoshizaki Y, Yuba E, Komatsu T, Udaka K, Harada A, Kono K.
PMID: 27681717
Molecules. 2016 Sep 26;21(10). doi: 10.3390/molecules21101284.

To establish peptide vaccine-based cancer immunotherapy, we investigated the improvement of antigenic peptides by encapsulation with pH-sensitive fusogenic polymer-modified liposomes for induction of antigen-specific immunity. The liposomes were prepared by modification of egg yolk phosphatidylcholine and l-dioleoyl phosphatidylethanolamine with...

Hydrophobic nanoparticles promote lamellar to inverted hexagonal transition in phospholipid mesophases.

Soft matter

Bulpett JM, Snow T, Quignon B, Beddoes CM, Tang TY, Mann S, Shebanova O, Pizzey CL, Terrill NJ, Davis SA, Briscoe WH.
PMID: 26391613
Soft Matter. 2015 Dec 07;11(45):8789-800. doi: 10.1039/c5sm01705j.

This study focuses on how the mesophase transition behaviour of the phospholipid dioleoyl phosphatidylethanolamine (DOPE) is altered by the presence of 10 nm hydrophobic and 14 nm hydrophilic silica nanoparticles (NPs) at different concentrations. The lamellar to inverted hexagonal...

Cationic liposome-mediated gene transfer to tumor cells in vitro and in vivo.

Methods in molecular medicine

Son K, Sorgi F, Gao X, Huang L.
PMID: 24493437
Methods Mol Med. 1997;7:329-37. doi: 10.1385/0-89603-484-4:329.

Development of safe and effective technology for delivering functional DNA into cells in an intact organism is crucial to broad applications of gene therapy to human disease. Both viral and nonviral vectors have been developed. Of the technologies currently...

Frequency-resolved intramolecular excimer fluorescence study of lipid bilayer and nonbilayer phases.

Biophysical journal

Liu LI, Cheng KH, Somerharju P.
PMID: 19431901
Biophys J. 1993 Jun;64(6):1869-77. doi: 10.1016/S0006-3495(93)81558-3.

Frequency-domain fluorescence intensity decays of the intramolecular excimer forming (DipyPE) in a fully hydrated dioleoyl-phosphatidylethanolamine (DOPE) suspension have been measured at the monomer (395 nm) and excimer (475 nm) emissions and at different temperatures (0-30 degrees C). A classical...

Study of Resveratrol's Interaction with Planar Lipid Models: Insights into Its Location in Lipid Bilayers.

Membranes

Meleleo D.
PMID: 33672841
Membranes (Basel). 2021 Feb 14;11(2). doi: 10.3390/membranes11020132.

Resveratrol, a polyphenolic molecule found in edible fruits and vegetables, shows a wide range of beneficial effects on human health, including anti-microbial, anti-inflammatory, anti-cancer, and anti-aging properties. Due to its poor water solubility and high liposome-water partition coefficient, the...

Showing 1 to 8 of 8 entries