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A Phosphoramidite Analogue of Cyclotriphosphate Enables Iterative Polyphosphorylations.

Angewandte Chemie (International ed. in English)

Singh J, Steck N, De D, Hofer A, Ripp A, Captain I, Keller M, Wender PA, Bhandari R, Jessen HJ.
PMID: 30681761
Angew Chem Int Ed Engl. 2019 Mar 18;58(12):3928-3933. doi: 10.1002/anie.201814366. Epub 2019 Feb 14.

An iterative polyphosphorylation approach is described, which is based on a phosphoramidite (P-amidite) derived reagent (c-PyPA) obtained from the cyclization of pyrophosphate with a reactive diisopropylaminodichlorophosphine. This type of reagent is unprecedented as it represents a reactive P-amidite without...

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